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1. 发明申请

US20140266197A1 TECHNIQUES, SYSTEMS AND MACHINE READABLE PROGRAMS FOR MAGNETIC RESONANCE 审中-公开
标题翻译：用于磁共振的技术，系统和机器可读程序
公开(公告)号：US20140266197A1
公开(公告)日：2014-09-18
申请号：US14210341
申请日：2014-03-13
申请人： Millikelvin Technologies LLC
发明人： Neil Kalechofsky
IPC分类号： G01R33/56
CPC分类号： G01R33/5601 , G01R33/485
摘要： The present disclosure provides various methods and systems for performing magnetic resonance studies. In accordance with many embodiments, image or other information of interest is derived from super radiant pulses.
摘要翻译：本公开提供用于执行磁共振研究的各种方法和系统。根据许多实施例，从超辐射脉冲导出感兴趣的图像或其它信息。

2. 发明申请

US20140247047A1 TECHNIQUES, SYSTEMS AND MACHINE READABLE PROGRAMS FOR MAGNETIC RESONANCE 有权
公开(公告)号：US20140247047A1
公开(公告)日：2014-09-04
申请号：US14188410
申请日：2014-02-24
申请人： Millikelvin Technologies LLC
发明人： Neal Kalechofsky , Mirko Hrovat
IPC分类号： G01R33/48 , A61B5/055
CPC分类号： G01R33/48 , A61B5/055 , G01R33/36 , G01R33/561
摘要： The present disclosure provides various methods and systems for performing magnetic resonance studies. In accordance with many embodiments, image or other information of interest is derived from super radiant pulses.

3. 发明申请

US20130253308A1 TECHNIQUES, SYSTEMS AND MACHINE READABLE PROGRAMS FOR MAGNETIC RESONANCE 审中-公开
公开(公告)号：US20130253308A1
公开(公告)日：2013-09-26
申请号：US13623759
申请日：2012-09-20
申请人： MILLIKELVIN TECHNOLOGIES LLC
发明人： Neal Kalechofsky
IPC分类号： A61B5/055 , G01R33/44 , A61M5/00
CPC分类号： A61B5/055 , A61M5/007 , G01R33/44 , G01R33/5601
摘要： The present disclosure provides various methods and systems for performing magnetic resonance studies. In accordance with many embodiments, image or other information of interest is derived from super radiant pulses.

4. 发明申请

US20110062392A1 SYSTEMS AND METHODS FOR PRODUCING HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF 失效
标题翻译：用于生产高分子材料的系统和方法及其混合物
公开(公告)号：US20110062392A1
公开(公告)日：2011-03-17
申请号：US12879634
申请日：2010-09-10
申请人： Neal Kalechofsky , Avrum Belzer
发明人： Neal Kalechofsky , Avrum Belzer
IPC分类号： C07C67/00 , F25B19/00 , A61B5/055 , C07C51/347
CPC分类号： A61K49/10 , G01R33/282 , G01R33/5601 , G01R33/5605
摘要： The present disclosure provides various methods and systems for manufacture, transport and delivery of material including highly polarized nuclei that is in a hyperpolarized state.
摘要翻译：本公开提供了用于制造，输送和输送包括处于超极化状态的高度极化的核的材料的各种方法和系统。

5. 发明授权

US10408895B2 Polarization sample geometry 有权
公开(公告)号：US10408895B2
公开(公告)日：2019-09-10
申请号：US14212695
申请日：2014-03-14
申请人： Bruker Biospin Corporation
发明人： Matthew Hirsch , Avrum Belzer , Neal Kalechofsky , Charles Monroe
IPC分类号： G01R33/20 , G01R33/28
摘要： A carrier for a sample of highly polarized material includes a shell having a radially exterior surface and a radially interior surface, and a sample of highly polarized material interiorly adjacent to the radially interior surface. The shell may be substantially cylindrical, and may be constructed from a magnetic or non-magnetic material. The sample of highly polarized material may comprise a methyl rotor group material. The sample of highly polarized material may comprise pyruvic acid or an acetic acid. The sample of highly polarized material may be co-axial with the cylindrical shell. The sample of highly polarized material may be bonded or frozen to the radially interior surface of the shell. The carrier may further comprise a wad of material that forms a volume and contacts an axially proximate end of at least one of the shell or the sample.

6. 发明授权

US09606200B2 Sample-preparation method to manipulate nuclear spin-relaxation times, including to facilitate ultralow temperature hyperpolarization 有权
公开(公告)号：US09606200B2
公开(公告)日：2017-03-28
申请号：US14161172
申请日：2014-01-22
申请人： Bruker Biospin Corporation , Millikelvin Technologies LLC
发明人： James G. Kempf , Neal Kalechofsky , Melanie Rosay
IPC分类号： G01V3/00 , G01R33/31 , G01R33/28
CPC分类号： G01R33/31 , G01R33/282
摘要： A method of providing a material sample in a state favorable to retaining spin polarization includes cooling a material sample from a temperature above a freezing point of the material sample down to a second temperature below the freezing point of the material sample; maintaining the sample at about the second temperature for a period of about several hours; and reducing temperature of the material sample to a third temperature lower than the second temperature to provide the material sample in a state favorable to retaining spin polarization, where the steps of cooling, maintaining and reducing are performed in the absence of an adulterant material. The method of providing a sample of pyruvic acid in a state favorable to retaining spin polarization may include cooling the sample of pyruvic acid in the absence of an adulterant material from a temperature above a freezing point of the sample of pyruvic acid down to less than about 200 Kelvin to provide the sample.

7. 发明授权

US09176208B2 Techniques, systems and machine readable programs for magnetic resonance 有权
公开(公告)号：US09176208B2
公开(公告)日：2015-11-03
申请号：US14519848
申请日：2014-10-21
申请人： Millikelvin Technologies LLC
发明人： Neal Kalechofsky
IPC分类号： G01R33/483 , G01R33/36 , G01R33/56 , G01R33/561 , G01R33/385
CPC分类号： G01R33/483 , G01R33/36 , G01R33/385 , G01R33/56 , G01R33/5601 , G01R33/5607 , G01R33/561
摘要： The present disclosure provides various methods and systems for performing magnetic resonance studies. In accordance with many embodiments, image or other information of interest is derived from super radiant pulses.

8. 发明授权

US08703201B2 Hyperpolarization methods, systems and compositions 失效
标题翻译：超极化方法，系统和组成
公开(公告)号：US08703201B2
公开(公告)日：2014-04-22
申请号：US13335076
申请日：2011-12-22
申请人： Avrum Belzer , Neal Kalechofsky
发明人： Avrum Belzer , Neal Kalechofsky
IPC分类号： A61K49/06 , A61K49/08 , A61K49/18 , A61B5/055 , G01N24/08 , G01R33/20
CPC分类号： A61K49/1815 , A61K49/1806
摘要： The disclosure provides various methods and systems for providing hyperpolarized materials as well as the hyperpolarized materials so provided. In addition, methods of providing hyperpolarized materials, such as agents, to end users from a remote location are also provided.
摘要翻译：本公开提供了用于提供超极化材料以及如此提供的超极化材料的各种方法和系统。此外，还提供了向远程位置的终端用户提供超极化材料（例如代理）的方法。

9. 发明授权

US09207298B2 Techniques, systems and machine readable programs for magnetic resonance 有权
公开(公告)号：US09207298B2
公开(公告)日：2015-12-08
申请号：US13844446
申请日：2013-03-15
申请人： Millikelvin Technologies LLC
发明人： Neal Kalechofsky , Mirko Hrovat
IPC分类号： G01R33/48 , A61B5/055 , G01R33/561 , G01R33/36
CPC分类号： G01R33/48 , A61B5/055 , G01R33/36 , G01R33/561
摘要： The present disclosure provides various methods and systems for performing magnetic resonance studies. In accordance with many embodiments, image or other information of interest is derived from super radiant pulses.

10. 发明申请

US20150061666A1 SAMPLE-PREPARATION METHOD TO MANIPULATE NUCLEAR SPIN-RELAXATION TIMES, INCLUDING TO FACILITATE ULTRALOW TEMPERATURE HYPERPOLARIZATION 有权
标题翻译：用于处理核心松弛时间的样品制备方法，包括加速超温度高效
公开(公告)号：US20150061666A1
公开(公告)日：2015-03-05
申请号：US14161172
申请日：2014-01-22
申请人： Millikelvin Technologies LLC , Buker Biospin Corporation
发明人： James G. Kempf , Neal Kalechofsky , Melanie Rosay
IPC分类号： G01R33/31 , G01R33/48
CPC分类号： G01R33/31 , G01R33/282
摘要： A method of providing a material sample in a state favorable to retaining spin polarization includes cooling a material sample from a temperature above a freezing point of the material sample down to a second temperature below the freezing point of the material sample; maintaining the sample at about the second temperature for a period of about several hours; and reducing temperature of the material sample to a third temperature lower than the second temperature to provide the material sample in a state favorable to retaining spin polarization, where the steps of cooling, maintaining and reducing are performed in the absence of an adulterant material. The method of providing a sample of pyruvic acid in a state favorable to retaining spin polarization may include cooling the sample of pyruvic acid in the absence of an adulterant material from a temperature above a freezing point of the sample of pyruvic acid down to less than about 200 Kelvin to provide the sample.
摘要翻译：以有利于保持自旋极化的状态提供材料样品的方法包括将材料样品从高于材料样品的凝固点的温度冷却至低于材料样品的凝固点的第二温度; 将样品保持在约第二温度约数小时; 并且将材料样品的温度降低到低于第二温度的第三温度，以提供有利于保持自旋极化的状态的材料样品，其中在没有掺杂材料的情况下进行冷却，保持和还原的步骤。以有利于保持自旋极化的状态提供丙酮酸样品的方法可包括在不存在掺杂材料的情况下将丙酮酸样品从高于丙酮酸样品的凝固点的温度冷却到小于约 200开尔文提供样品。

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