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1. 发明申请

US20230126043A1 WRITING INSTRUMENT, SYSTEM AND METHOD FOR TRANSPARENT MONITORING AND ANALYSIS OF WRITING 有权
公开(公告)号：US20230126043A1
公开(公告)日：2023-04-27
申请号：US17915702
申请日：2021-03-30
申请人： POLITECNICO DI MILANO , UNIVERSITA' DEGLI STUDI DI MILANO
发明人： Simona FERRANTE , Alessandra Laura Giulia PEDROCCHI , Francesca LUNARDINI , Davide DI FEBBO , Milad MALAVOLTI , Nunzio Alberto BORGHESE
IPC分类号： B43K29/08 , G06F3/0354
摘要： A writing instrument that includes a writing element for depositing a writing material on a support and a plurality of sensors including at least a force sensor and a movement sensor, a communication unit that exchanges data with a remote device a control unit connected to the sensors and to the communication unit in order to transmit to the remote device the measurements provided by the sensors, a memory unit connected to the control unit that stores one or more measurements from the sensors; and a hollow casing that contains at least part of the writing element so that the writing end is exposed, and also houses the sensors, the control unit, the memory unit and the communication unit.

2. 发明申请

US20230120357A1 DEVICE, METHOD AND COMPOSITION FOR TRANSFECTION OF CELLS WITH NUCLEIC ACIDS 有权
公开(公告)号：US20230120357A1
公开(公告)日：2023-04-20
申请号：US17999445
申请日：2021-05-21
申请人： POLITECNICO DI MILANO
发明人： Gabriele Candiani , Nina Bono , Federica Ponti
IPC分类号： C12M1/42 , C12N13/00 , C12N15/88
摘要： Disclosed are a method, a composition and a device for the introduction of exogenous nucleic acids into eukaryotic cells by non-viral vectors (non-viral transfection). The method according to the invention is based on application of a high-frequency oscillatory motion to a solution containing nucleic acids and cationic polymers or lipids to obtain particles (complexes) with high transfection efficiency.

3. 发明申请

US20230091034A1 DEVICE AND ASSEMBLY TO REPAIR A HEART VALVE 有权
公开(公告)号：US20230091034A1
公开(公告)日：2023-03-23
申请号：US17992834
申请日：2022-11-22
申请人： Politecnico di Milano
发明人： Riccardo Vismara , Gianfranco Beniamino Fiore , Michal Jaworek , Edoardo Maronelli , Federico Lucherini , Eleonora Salurso , Gianmarco Provaroni , Guido Gelpi , Claudia Romagnoni , Monica Contino
IPC分类号： A61F2/24
摘要： An assembly for reshaping a cardiac ventricle in a patient comprising an implantable device for reshaping a ventricle comprising a tether, a non-implantable tool which is detachably connectable to said implantable device and has a proximal portion and a distal portion opposite to said proximal portion; the implantable device further comprises an active anchor adapted to be detachably connected to the distal portion of the tool; the active anchor comprises an abutment portion adapted to abut against a structure of the ventricle; the active anchor of the implantable device comprises an adjustment device adapted to adjust the tensional state of the tether; the distal portion of the tool comprises an adjustment key adapted to cooperate with the adjustment device of the active anchor; the proximal portion of the tool comprises a maneuvering interface which is operatively connectable to said adjustment key for adjusting the tensional state of the tether by acting on the maneuvering interface of the proximal portion of the tool.

4. 发明授权

US11578125B2 Anti-thyroid hormone (T4) recombinant antibody or antigen binding fragment 有权
公开(公告)号：US11578125B2
公开(公告)日：2023-02-14
申请号：US17059268
申请日：2019-05-28
申请人： Teknologian tutkimuskeskus VTT Oy , Politecnico di Milano
发明人： Tarja Nevanen , Henri Arola , Antti Tullila , Juha Rouvinen , Tarja Parkkinen , Pierangelo Metrangolo
IPC分类号： C07K16/26
摘要： The present invention relates to the fields of antibodies, antigen binding fragments and immunodiagnostics. Specifically, the invention relates to a recombinant anti-body or antigen binding fragment for binding thyroid hormone T4 (thyroxine) and halogenated bisphenol A. Also, the present invention relates to an isolated nucleic acid molecule comprising a nucleotide sequence that encodes the recombinant antibody or antigen binding fragment of the present invention, as well as an ex-pression vector and host cell comprising the nucleic acid molecule of the present invention. Still, the present invention relates to a method of producing a recombi-nant antibody or antigen binding fragment for binding T4 thyroid hormone and hal-ogenated bisphenol A, a test kit and an immunoassay comprising the recombinant antibody or antigen binding fragment of the present invention, and a method for determining T4 thyroid hormone and/or halogenated bisphenol A levels in a sam-ple of a subject. Still further, the present invention relates to a method of treating a sample, e.g. an immunoaffinity-based sample preparation method for enrich-ment of the halogenated bisphenol A from a sample.

5. 发明申请

US20220385358A1 OPTICAL SYSTEM COMPRISING A RECONFIGARABLE DEVICE AND OPTICAL SYSTEM CONTROL METHOD 有权
公开(公告)号：US20220385358A1
公开(公告)日：2022-12-01
申请号：US17775408
申请日：2020-11-04
申请人： Politecnico Di Milano
发明人： Francesco Morichetti , Andrea lvano Melloni , Douglas Oliveira Morais de Aguiar
IPC分类号： H04B10/077 , H04J14/02 , H04B10/2507
摘要： An optical system (100) is described including: a reconfigurable optical device (103) with multiplexing wavelength division, comprising a plurality of actuators (A1-AN) and having associated a number of optical channels (M) and a number of degrees of freedom (N) lower than the number of optical channels; an optical stimulus source (106) connected to said reconfigurable optical device (103) to provide an optical stimulation signal (Sin) having a wavelength band including a plurality of wavelengths associated with the optical channels; an optical-electric conversion device (200) configured to receive from said reconfigurable optical device (103) an optical monitoring signal (Sout) corresponding to the optical stimulation signal (Sin) and to provide a group of electrical signals of intensity (SEL1-SELK) each representative of an intensity of the optical monitoring signal (Sout) evaluated at a relative wavelength included in said band. The system also includes a control device (110) configured to control the plurality of actuators (A1-AN) according to said group of electrical signals (SEL1-SELK) and according to a control law.

6. 发明申请

US20220329042A1 LASER DRIVER INCORPORATING CLAMPING CIRCUIT WITH FREEWHEELING DIODE 有权
公开(公告)号：US20220329042A1
公开(公告)日：2022-10-13
申请号：US17852100
申请日：2022-06-28
申请人： STMicroelectronics S.r.l. , POLITECNICO DI MILANO
发明人： Marco ZAMPROGNO , Alireza TAJFAR
IPC分类号： H01S5/042 , H01S5/062 , H01S5/068
摘要： An input is coupled to a cathode of a laser diode having its anode coupled to a high-voltage-supply, with a cascoded current mirror having an input and output branches. The input branch is coupled between the high-voltage-supply and a sense resistor coupled to the input. The output branch is coupled between the high-voltage-supply and an output. A sense resistance is coupled between the output and ground, and includes a diode-coupled transistor coupled to the output and a resistor coupled between the diode-coupled transistor and ground. The input branch generates a current proportional to a voltage across the laser diode, and the output branch generates a mirrored current proportional to the current proportional to the voltage across the laser diode. A voltage proportional to the voltage across the laser diode is generated by the mirrored current flowing through the sense resistance. A comparison circuit compares this voltage to a threshold.

7. 发明申请

US20220326028A1 METHOD AND SYSTEM OF VEHICLE DRIVING ASSISTANCE 有权
公开(公告)号：US20220326028A1
公开(公告)日：2022-10-13
申请号：US17639948
申请日：2020-09-21
申请人： POLITECNICO DI MILANO
发明人： Sergio Matteo SAVARESI , Matteo CORNO , Luca FRANCESCHETTI , Marta RONCHI
IPC分类号： G01C21/36 , G06F3/01 , G06T7/70 , G06T3/20 , G06T3/60 , G02B27/01
摘要： A method for assisting the driving of a vehicle which can be implemented by a relative system including an HMD, and a positioning module mounted on the vehicle. The method can include detecting a vehicle position by the positioning module; determining a position of the HMD by applying a compensation law to the vehicle position, based on the position of the HMD, determining a view volume corresponding to a volume of space comprised in the field of view of the HMD; comparing a set of positions in the view volume with at least one position of interest associated with a stored object of interest , and, if one or more positions of interest are in the view volume, calculating a visualization position of the HMD in which to display an image associated with the object of interest and displaying on the HMD the image in said visualization position.

8. 发明申请

US20220324708A1 PROCESSES FOR PRODUCING SYNGAS STARTING FROM PRETREATED RECOVERY PLASTIC POLYMERS 有权
公开(公告)号：US20220324708A1
公开(公告)日：2022-10-13
申请号：US17630866
申请日：2020-07-28
申请人： POLITECNICO DI MILANO , CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI (INSTM)
发明人： Flavio MANENTI , Maurizio MASI , Sergio MIELE , Enrica BARGIACCHI
IPC分类号： C01B3/38 , B01J8/06 , C10K3/02 , C10J3/84
摘要： A process for producing syngas from pre-treated recovery plastic polymers comprising:
a) gasifying said recovery pre-treated polymers according to the following reaction scheme R1: [—CH2—]+H2O═CO+2H2; R1: b) hydrogenating said pre-treated polymers to higher hydrocarbons and methane by using hydrogen produced in R1, according to the following reaction scheme R3: [—CH2—]n+H2═CnH(2n+2) R3: wherein n is an integer of from 1 to 3, said reaction being optionally combined with oligomers and olefin formation reactions; c) steam reforming of methane according to the following reaction scheme R4: CH4+H2O═CO+3H2; R4: and optionally d) reforming reaction of methane according to the following reaction scheme R5: CH4+CO2=2CO+2H2; R5: said process being carried out in a plant (10), (20), (30), (40), (50) comprising a gasification section (11), (21), (31), (41), (51) and a reforming section (12), (22), (32), (42), (52) comprising a tube bundle (13), (23), (33), (43), (53) provided with a catalyst wherein, i) said gasification (11), (21), (31) and reforming sections (12),(22), (32) are part of a sole reactive unit (10), (20), (30), or said gasification (41), (51) and reforming section (42), (52) are two physically distinct reactive units (40), (50), ii) the gasification section (11), (21) or the reactive unit (41) provides respectively the energetical support to the reforming section (12), (22) or to the reforming reactive unit (42), thanks to the exothermic combustion reaction scheme R2: [—CH2-]+1.5O2═CO2+H2O; R2: or in alternative: the reforming section (32) or the reforming reactive unit (52) provides energetic support to the corresponding gasification section (31) or gasification reactive unit (51), thanks to the exothermic combustion reaction scheme R6: CH4+2O2═CO2+2H2O. R6:

9. 发明授权

US11458470B2 Systems and methods for analyzing platelet function 有权
公开(公告)号：US11458470B2
公开(公告)日：2022-10-04
申请号：US16624112
申请日：2018-06-22
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , POLITECNICO DI MILANO
发明人： Marvin Slepian , Alberto Redaelli
IPC分类号： B01L3/00 , G01N33/86
摘要： Provided herein are devices, systems, and methods for analyzing platelet function. In particular, provided herein are simple, portable, accurate and inexpensive small footprint platelet aggregometry devices, systems, and methods.

10. 发明授权

US11418007B2 Laser driver incorporating clamping circuit with freewheeling diode 有权
公开(公告)号：US11418007B2
公开(公告)日：2022-08-16
申请号：US17026495
申请日：2020-09-21
申请人： STMicroelectronics S.r.l. , Politecnico Di Milano
发明人： Marco Zamprogno , Alireza Tajfar
IPC分类号： H01S3/00 , H01S5/042 , H01S5/062 , H01S5/068
摘要： A level-shifter includes an input node coupled to a laser driver input receiving a trigger signal, the input node receiving a signal indicating generation of a laser drive-pulse. A p-channel transistor has a source coupled to a supply node, a drain coupled to an output node, and a gate coupled to the input node. An n-channel transistor has a drain coupled to the drain of the p-channel transistor, a source coupled to ground, and a gate coupled to the input node. A first switch couples the input node to the output node. Another p-channel transistor has a source coupled to the supply node, a drain coupled to the output node by a second switch, and a gate coupled to the input node. The first switch closes and second switch opens when the signal is low, and the first switch opens and second switch closes when the signal is high.

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