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1. 发明申请

US20130224233A1 IMMUNOTHERAPEUTIC METHOD FOR TREATING PROSTATE CANCER 有权
标题翻译：用于治疗前列腺癌的免疫治疗方法
公开(公告)号：US20130224233A1
公开(公告)日：2013-08-29
申请号：US13819622
申请日：2011-08-29
申请人： Herman Jan Tijmen Coelingh Bennink
发明人： Herman Jan Tijmen Coelingh Bennink
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K38/00 , A61K38/17 , A61K38/1764 , A61K39/00
摘要： The invention relates to treatment of prostate cancer and metastases thereof. More specifically, the invention relates to immunogenic polypeptides comprising at least a portion of a prostatic tumor cell-associated protein or immunologically active variants thereof and to nucleic acids encoding such polypeptides and to the use thereof in immunotherapeutic methods of treatment of prostate cancer. Said immunogenic polypeptides are provided by the zona pellucida (ZP) (glyco)proteins. ZP (glyco)proteins and fragments thereof that can induce a CD8+ and/or CD4+ T cell response as well as nucleic acid sequences encoding them can suitably be used in the present immunotherapeutic strategies.
摘要翻译：本发明涉及治疗前列腺癌及其转移。更具体地，本发明涉及包含前列腺肿瘤细胞相关蛋白或其免疫活性变体的至少一部分和编码此类多肽的核酸及其在治疗前列腺癌的免疫治疗方法中的用途的免疫原性多肽。所述免疫原性多肽由透明带（ZP）（糖）蛋白提供。可以诱导CD8 +和/或CD4 + T细胞应答的ZP（glyco）蛋白及其片段以及编码它们的核酸序列可适用于本发明的免疫治疗策略。

2. 发明授权

US08518923B2 Treatment or prevention of hypertensive disorders of pregnancy or fetal growth retardation 有权
标题翻译：治疗或预防妊娠高血压疾病或胎儿发育迟缓
公开(公告)号：US08518923B2
公开(公告)日：2013-08-27
申请号：US12669778
申请日：2008-07-14
申请人： Monique Visser , Herman Jan Tijmen Coelingh Bennink
发明人： Monique Visser , Herman Jan Tijmen Coelingh Bennink
IPC分类号： A61K31/56
CPC分类号： A61K31/565
摘要： The present invention relates to the use of a steroid in the manufacture of a pharmaceutical composition for use in the therapeutic or prophylactic treatment of a hypertensive disorder of pregnancy (HDP) or fetal growth retardation, said treatment comprising administering to a female mammal a steroid selected from the group consisting of: substances represented by the following formula (formula I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors of such substances; and mixtures of one or more of the aforementioned substances and/or precursors.
摘要翻译：本发明涉及类固醇在制备用于治疗或预防性治疗妊娠高血压疾病（HDP）或胎儿生长迟缓的药物组合物中的用途，所述治疗包括向雌性哺乳动物施用选择的类固醇由下式（式I）表示的物质，其中式R1，R2，R3，R4独立地为氢原子，羟基或具有1-5个碳原子的烷氧基; R5，R6，R7各自为羟基; 不超过3个R 1，R 2，R 3，R 4为氢原子; 这些物质的前体; 和一种或多种上述物质和/或前体的混合物。

3. 发明授权

US07943604B2 Method of treating human skin and a skin care composition for use in such a method 有权
标题翻译：治疗人类皮肤的方法和用于这种方法的护肤组合物
公开(公告)号：US07943604B2
公开(公告)日：2011-05-17
申请号：US10517509
申请日：2003-06-11
申请人： Herman Jan Tijmen Coelingh Bennink , Evert Johannes Bunschoten , Christian Franz Holinka
发明人： Herman Jan Tijmen Coelingh Bennink , Evert Johannes Bunschoten , Christian Franz Holinka
IPC分类号： A61K31/56 , A61K8/02
CPC分类号： A61Q19/004 , A61K8/63 , A61K9/0014 , A61K31/565 , A61K47/22 , A61K47/26 , A61Q19/00 , A61Q19/08
摘要： The invention relates to cosmetic methods of treating human skin. The method includes applying to the skin a composition containing an estrogenic component and a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treating or preventing vaginal dryness or acne and a therapeutic method of promoting wound healing. Another aspect relates to a skin care composition comprising the aforementioned estrogenic component and a cosmetically acceptable vehicle.
摘要翻译：本发明涉及治疗人类皮肤的美容方法。该方法包括向皮肤施用含有雌激素成分和美容上可接受的载体的组合物。本发明的其它方面涉及治疗或预防阴道干燥或痤疮的治疗方法以及促进伤口愈合的治疗方法。另一方面涉及包含上述雌激素成分和美容上可接受的载体的护肤组合物。

4. 发明申请

US20100113346A1 Method of Treating or Preventing Infertility in a Female Mammal and Pharmaceutical Kit for Use in Such Method 有权
标题翻译：在这种方法中使用的雌性哺乳动物和药物试剂盒中治疗或预防不孕症的方法
公开(公告)号：US20100113346A1
公开(公告)日：2010-05-06
申请号：US12522313
申请日：2008-01-07
申请人： Herman Jan Tijmen Coelingh Bennink
发明人： Herman Jan Tijmen Coelingh Bennink
IPC分类号： A61K38/24 , A61P15/08
CPC分类号： A61K31/565
摘要： The present invention relates to a method of treating infertility in a female mammal that involves controlled ovarian hyperstimulation. The method includes administering to the female a combination of (i) an FSH substance in an amount effective to stimulate follicular development and (ii) a steroid in an effective amount to inhibit or suppress the secretion of luteinising hormone. The steroid can be substances represented by the following formula in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; derivatives of the aforementioned steroid substances; or mixtures of one or more of the aforementioned substances or derivatives.
摘要翻译：本发明涉及治疗涉及受控卵巢过度刺激的雌性哺乳动物不育症的方法。该方法包括向女性施用（i）有效刺激滤泡发育的量的FSH物质的组合，和（ii）有效量的类固醇以抑制或抑制黄体生成激素的分泌。类固醇可以是由下式表示的物质，其中式R1，R2，R3，R4独立地是氢原子，羟基或具有1-5个碳原子的烷氧基; R5，R6，R7各自为羟基; 不超过3个R 1，R 2，R 3，R 4为氢原子; 上述类固醇物质的衍生物; 或一种或多种上述物质或衍生物的混合物。

5. 发明申请

US20200276291A1 IMMUNOTHERAPEUTIC METHODS FOR TREATING AND/OR PREVENTING LUNG CANCER 审中-公开
公开(公告)号：US20200276291A1
公开(公告)日：2020-09-03
申请号：US16760457
申请日：2018-10-31
申请人： Pantarhei Bioscience B.V.
发明人： Herman Jan Tijmen Coelingh Bennink , Nafis Ahmed Rahman
IPC分类号： A61K39/00 , A61K35/17 , A61K39/395 , A61K39/39 , A61K47/68 , A61K51/00 , A61P35/04
摘要： The present invention relates to treatment and diagnosis of lung cancer and metastases thereof. More specifically, the invention relates to such therapeutic use of antigen sources providing immunogenic polypeptides comprising at least an immunogenic portion of a cancer cell associated protein, which preferably is a zona pellucida (ZP) protein, especially a ZP3 protein or the extracellular domain thereof, whereby the antigen source induces a cellular immune response against the lung cancer cells. The antigen source can be a proteinaceous composition comprising such immunogenic ZP polypeptide, a nucleic acid encoding the immunogenic ZP polypeptide, or a cell expressing or presenting the immunogenic ZP polypeptide. In addition, the invention relates to the therapeutic use of a T cell comprising a T cell receptor that binds an MHC-peptide complex, wherein the peptide is a peptide from the immunogenic ZP polypeptide. The invention further relates to the therapeutic and/or diagnostic use of antibodies that specifically binds to the immunogenic ZP polypeptide.

6. 发明授权

US09295720B2 Immunotherapeutic method for treating prostate cancer 有权
标题翻译：用于治疗前列腺癌的免疫治疗方法
公开(公告)号：US09295720B2
公开(公告)日：2016-03-29
申请号：US13819622
申请日：2011-08-29
申请人： Herman Jan Tijmen Coelingh Bennink
发明人： Herman Jan Tijmen Coelingh Bennink
IPC分类号： A61K38/00 , A61K39/00 , A61K38/17
CPC分类号： A61K39/0011 , A61K38/00 , A61K38/17 , A61K38/1764 , A61K39/00
摘要： The invention relates to treatment of prostate cancer and metastases thereof. More specifically, the invention relates to immunogenic polypeptides comprising at least a portion of a prostatic tumor cell-associated protein or immunologically active variants thereof and to nucleic acids encoding such polypeptides and to the use thereof in immunotherapeutic methods of treatment of prostate cancer. Said immunogenic polypeptides are provided by the zona pellucida (ZP) (glyco)proteins. ZP (glyco)proteins and fragments thereof that can induce a CD8+ and/or CD4+ T cell response as well as nucleic acid sequences encoding them can suitably be used in the present immunotherapeutic strategies.
摘要翻译：本发明涉及治疗前列腺癌及其转移。更具体地，本发明涉及包含前列腺肿瘤细胞相关蛋白或其免疫活性变体的至少一部分和编码此类多肽的核酸及其在治疗前列腺癌的免疫治疗方法中的用途的免疫原性多肽。所述免疫原性多肽由透明带（ZP）（糖）蛋白提供。可以诱导CD8 +和/或CD4 + T细胞应答的ZP（glyco）蛋白及其片段以及编码它们的核酸序列可适用于本发明的免疫治疗策略。

7. 发明授权

US09040509B2 Method of treating human skin and a skin care composition for use in such a method 有权
标题翻译：治疗人类皮肤的方法和用于这种方法的护肤组合物
公开(公告)号：US09040509B2
公开(公告)日：2015-05-26
申请号：US13017858
申请日：2011-01-31
申请人： Herman Jan Tijmen Coelingh Bennink , Evert Johannes Bunschoten , Christian Franz Holinka
发明人： Herman Jan Tijmen Coelingh Bennink , Evert Johannes Bunschoten , Christian Franz Holinka
IPC分类号： A61K31/565 , A61K8/63 , A61Q19/00 , A61K9/00 , A61Q19/08 , A61K47/22 , A61K47/26
CPC分类号： A61Q19/004 , A61K8/63 , A61K9/0014 , A61K31/565 , A61K47/22 , A61K47/26 , A61Q19/00 , A61Q19/08
摘要： One aspect of the invention concerns a cosmetic method of treating human skin by delivering an estrogenic component to said skin. The method comprises applying to the skin a composition containing: (i) at least 5 μg/g of an estrogenic component selected from the group consisting of substances represented by the following formula (I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors; and (ii) a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treating or preventing vaginal dryness or acne and a therapeutic method of promoting wound healing. Yet another aspect of the invention relates to a skin care composition comprising the aforementioned estrogenic component and a cosmetically acceptable vehicle.
摘要翻译：本发明的一个方面涉及通过将雌激素成分递送至所述皮肤来治疗人皮肤的美容方法。该方法包括向皮肤施用组合物，其含有：（i）至少5μg/ g的雌激素成分，其选自下式（I）表示的物质，其中式R1，R2，R3，R4独立地表示是氢原子，羟基或具有1-5个碳原子的烷氧基; R5，R6，R7各自为羟基; 不超过3个R 1，R 2，R 3，R 4为氢原子; 在本方法中使用时能够释放根据上述式的物质的前体; 和一种或多种上述物质和/或前体的混合物; 和（ii）美容上可接受的载体。本发明的其它方面涉及治疗或预防阴道干燥或痤疮的治疗方法以及促进伤口愈合的治疗方法。本发明的另一方面涉及包含上述雌激素成分和美容上可接受的载体的护肤组合物。

8. 发明授权

US09034854B2 Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy 有权
标题翻译：包含用于癌症治疗的雌酮衍生物的药物组合物
公开(公告)号：US09034854B2
公开(公告)日：2015-05-19
申请号：US10521040
申请日：2003-07-11
申请人： Herman Jan Tijmen Coelingh Bennink , Evert Johannes Bunschoten
发明人： Herman Jan Tijmen Coelingh Bennink , Evert Johannes Bunschoten
IPC分类号： A01N45/00 , A61K31/56 , A61K45/06 , A61K31/565
CPC分类号： A61K45/06 , A61K31/4196 , A61K31/565 , A61K2300/00
摘要： The present invention relates to a method of treating or preventing estrogen-sensitive tumors in a mammal, said method comprising the administration of a therapeutically effective amount of an estrogenic component to said mammal, wherein the estrogenic component is selected from the group consisting of:substances represented by the following formula in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors. The estrogenic component according to the invention does not have undesirable proliferative effects on breast and/or endometrial tissue and displays sufficient estrogenicity to prevent that its administration will lead to hypoestrogenism and/or climacteric complaints.
摘要翻译：本发明涉及治疗或预防哺乳动物中雌激素敏感性肿瘤的方法，所述方法包括向所述哺乳动物施用治疗有效量的雌激素成分，其中雌激素成分选自：物质由式R1，R2，R3，R4独立地为氢原子，羟基或具有1-5个碳原子的烷氧基的下式表示; 在本方法中使用时能够释放根据上述式的物质的前体; 和一种或多种上述物质和/或前体的混合物。根据本发明的雌激素成分对乳房和/或子宫内膜组织不具有不期望的增殖作用，并显示出足够的雌激素作用，以防止其施用将导致低雌激素过敏和/或更年期症状。

9. 发明授权

US08236785B2 Method of treating or preventing infertility in a female mammal and pharmaceutical kit for use in such method 有权
标题翻译：治疗或预防雌性哺乳动物的不孕症的方法和用于该方法的药物试剂盒
公开(公告)号：US08236785B2
公开(公告)日：2012-08-07
申请号：US12522313
申请日：2008-01-07
申请人： Herman Jan Tijmen Coelingh Bennink
发明人： Herman Jan Tijmen Coelingh Bennink
IPC分类号： A01N45/00 , A61K31/56
CPC分类号： A61K31/565
摘要： The present invention relates to a method of treating infertility in a female mammal that involves controlled ovarian hyperstimulation. The method includes administering to the female a combination of (i) an FSH substance in an amount effective to stimulate follicular development and (ii) a steroid in an effective amount to inhibit or suppress the secretion of luteinising hormone. The steroid can be substances represented by the following formula in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 15 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; derivatives of the aforementioned steroid substances; or mixtures of one or more of the aforementioned substances or derivatives.
摘要翻译：本发明涉及治疗涉及受控卵巢过度刺激的雌性哺乳动物不育症的方法。该方法包括向女性施用（i）有效刺激滤泡发育的量的FSH物质的组合，和（ii）有效量的类固醇以抑制或抑制黄体生成激素的分泌。类固醇可以是由下式表示的物质，其中式R1，R2，R3，R4独立地是氢原子，羟基或具有15个碳原子的烷氧基; R5，R6，R7各自为羟基; 不超过3个R 1，R 2，R 3，R 4为氢原子; 上述类固醇物质的衍生物; 或一种或多种上述物质或衍生物的混合物。

10. 发明申请

US20060094765A1 Use of a sri and vitamin b6 for the treatment of neurological and mental disorders 审中-公开
标题翻译：使用sri和维生素B6治疗神经和精神障碍
公开(公告)号：US20060094765A1
公开(公告)日：2006-05-04
申请号：US10526849
申请日：2003-09-05
申请人： Herman Coelingh Bennink , Rene Van Der Linden
发明人： Herman Coelingh Bennink , Rene Van Der Linden
IPC分类号： A61K31/4415
CPC分类号： A61K31/357 , A61K31/137 , A61K31/138 , A61K31/343 , A61K31/4415 , A61K31/495 , A61K31/55 , A61K2300/00
摘要： The invention is concerned with a method of treating neurological and/or mental disorders that are associated with, or pathogenetically related to deficient serotonin neurotransmission. The invention relates to a method of treating depressive disorders, anxiety disorders, post-traumatic stress syndrome or premenstrual syndrome, said method comprising the administration of serotonin re-uptake inhibitor (SRI) in a daily amount of at least 0.4 mg, wherein a vitamin B6 component is co-administered in a daily amount of between 0.01 and 10 mmoles to improve the responder rate or to advance the onset of action of the treatment with SRI, and wherein the method does not include the application to the brain of an AC pulsed magnetic field of at least 7.5 picotesia flux density for at least 15 minutes. The invention also encompasses pharmaceutical formulations containing SRI and vitamin B6 component and comprising a dosage unit that provides a sustained release of the vitamin B6 component.
摘要翻译：本发明涉及治疗与缺乏血清素神经传递相关或与病原有关的神经和/或精神障碍的方法。本发明涉及一种治疗抑郁障碍，焦虑症，创伤后应激综合征或经前期综合征的方法，所述方法包括以每日至少0.4mg的剂量施用5-羟色胺再摄取抑制剂（SRI），其中维生素 B6组分以0.01至10mmol之间的日剂量共同施用以改善应答者速率或推进SRI治疗的作用发作，并且其中该方法不包括向大脑施加AC脉冲至少7.5皮特通量密度的磁场至少15分钟。本发明还包括含有SRI和维生素B6组分的药物制剂，并且包含提供维生素B6组分的持续释放的剂量单位。

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