专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11911449B2 Albumin-free botulinum toxin formulations 有权
公开(公告)号：US11911449B2
公开(公告)日：2024-02-27
申请号：US17322901
申请日：2021-05-18
申请人： REVANCE THERAPEUTICS, INC.
发明人： Stewart A. Thompson , Curtis L. Ruegg , Jacob M. Waugh
IPC分类号： A61K38/48 , A61K8/49 , A61K8/60 , A61K8/64 , A61K39/08 , A61K8/02 , A61K8/66 , A61K8/84 , A61K9/14 , A61K9/19 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/42 , A61Q19/00 , A61Q19/08 , C07K14/33 , A61K8/90
CPC分类号： A61K38/4893 , A61K8/022 , A61K8/4946 , A61K8/4973 , A61K8/4993 , A61K8/60 , A61K8/602 , A61K8/64 , A61K8/66 , A61K8/84 , A61K8/90 , A61K9/14 , A61K9/19 , A61K39/08 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/42 , A61Q19/008 , A61Q19/08 , C07K14/33 , C12Y304/24069 , Y02A50/30
摘要： This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.

2. 发明公开

US20240000906A1 Methods of Treating or Preventing Migraine or Repetitive Occurrence of Common Migraine Headaches in a Subject Having Underlying Condition(s) 审中-公开
公开(公告)号：US20240000906A1
公开(公告)日：2024-01-04
申请号：US18359633
申请日：2023-07-26
申请人： Revance Therapeutics, Inc.
发明人： Gary E. BORODIC
IPC分类号： A61K38/48 , A61K9/00
CPC分类号： A61K38/4893 , A61K9/0019 , C12Y304/24069 , Y02A50/30 , A61K9/0021
摘要： The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and CNS disorders comprising the administration of a neurotoxin.

3. 发明授权

US11466262B2 Methods and systems for purifying non-complexed botulinum neurotoxin 有权
公开(公告)号：US11466262B2
公开(公告)日：2022-10-11
申请号：US16700728
申请日：2019-12-02
申请人： Revance Therapeutics, Inc.
发明人： Curtis L. Ruegg
IPC分类号： C12N9/52
摘要： Methods and systems for chromatographically purifying a botulinum neurotoxin are provided. These methods and systems allow for efficient purification of a non-complexed form of the botulinum neurotoxin in high purity and yield that can be used as an active ingredient in pharmaceutical preparations.

4. 发明授权

US11351232B2 Albumin-free botulinum toxin formulations 有权
公开(公告)号：US11351232B2
公开(公告)日：2022-06-07
申请号：US16175434
申请日：2018-10-30
申请人： REVANCE THERAPEUTICS, INC.
发明人： Stewart A. Thompson , Curtis L. Ruegg , Jacob M. Waugh
IPC分类号： A61K38/48 , A61K8/49 , A61K39/08 , C07K14/33 , A61K9/14 , A61K8/60 , A61K8/64 , A61Q19/00 , A61Q19/08 , A61K8/02 , A61K8/66 , A61K8/84 , A61K8/90 , A61K9/19 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/42
摘要： This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.

5. 发明申请

US20210162026A1 TRANSMUCOSAL BOTULINUM TOXIN COMPOSITIONS, KITS, AND METHODS FOR TREATING BLADDER DISORDERS 有权
公开(公告)号：US20210162026A1
公开(公告)日：2021-06-03
申请号：US16643320
申请日：2018-08-28
申请人： REVANCE THERAPEUTICS, INC.
发明人： Sunita Babbar , Curtis L. Ruegg
IPC分类号： A61K38/48 , A61K9/00 , A61K47/64 , A61K9/127 , A61P13/06
摘要： The present invention provides methods, compositions, and kits for treating bladder disorders or conditions, in which botulinum toxin is topically administered to the mucosal inner lining or urothelium of the bladder, of a subject in need thereof, for transmucosal delivery across the urothelium to surrounding bladder wall musculature and/or neuronal tissue. Rather than requiring injection, the toxin instead may be administered by instillation in solution via the urethra. In particular, the botulinum toxin is administered in conjunction with a positively charged or lipophilic carrier comprising a positively charged polymeric backbone or a hydrophobic backbone with covalently attached groups that enhance transmucosal transport across the urothelium and may also stabilize the botulinum toxin in aqueous formulations.

6. 发明申请

US20150320781A1 Compositions and Methods for Topical Diagnostic and Therapeutic Transport 审中-公开
标题翻译：局部诊断和治疗运输的组成和方法
公开(公告)号：US20150320781A1
公开(公告)日：2015-11-12
申请号：US14642580
申请日：2015-03-09
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K31/7048 , A61K31/513 , A61K31/496 , A61K31/4164 , A61K9/00 , A61K31/4418 , A61K38/17 , A61K31/7076 , A61K38/48 , C07K16/32 , A61K31/4196 , A61K31/343
CPC分类号： A61K31/7048 , A61K9/0014 , A61K31/343 , A61K31/4164 , A61K31/4196 , A61K31/4418 , A61K31/496 , A61K31/513 , A61K31/7076 , A61K38/1767 , A61K38/4893 , A61K47/59 , A61K47/6455 , A61K49/0041 , A61K49/0043 , A61K49/0045 , A61K49/0054 , A61K49/0063 , C07K16/32 , C12Y304/24069
摘要： Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGF. The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternatively, the composition can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.
摘要翻译：提供了可用于递送（包括经皮递送）生物活性剂（例如非蛋白质非核苷酸治疗剂）和基于蛋白质的治疗剂（不包括胰岛素，肉毒杆菌毒素，抗体片段和VEGF）的组合物和方法。组合物和方法特别适用于局部递送抗真菌剂和适合免疫的抗原剂。或者，组合物可以用用于靶向组合物递送以及成像组分的组分制备。

7. 发明授权

US08815954B2 Arginine heteromers for topical administration 有权
标题翻译：用于局部给药的精氨酸异构体
公开(公告)号：US08815954B2
公开(公告)日：2014-08-26
申请号：US11617551
申请日：2006-12-28
申请人： Jacob M. Waugh
发明人： Jacob M. Waugh
IPC分类号： A61K31/07 , A23L1/30
CPC分类号： A61K8/44 , A61K8/67 , A61K8/676 , A61K8/678 , A61Q5/00 , A61Q7/00 , A61Q17/04 , A61Q19/00 , A61Q19/08
摘要： The invention is directed to a strategy for providing therapeutic or cosmetic benefit to skin by topically applying arginine chemically bound to a second (non-oligoarginine) compound in order to increase transepithelial delivery of arginine through a combination of increased solubility and flux across the skin. The arginine heteromers of the invention can add other complementary or beneficial properties for the skin beyond those that are arginine-related.
摘要翻译：本发明涉及通过局部施用与第二（非寡精氨酸）化合物化学结合的精氨酸来提供治疗或美容益处的策略，以通过增加溶解度和穿过皮肤的通量的组合来增加精氨酸的跨上皮递送。本发明的精氨酸异构体可以增加除了精氨酸相关的那些之外的皮肤的其它互补或有益的性质。

8. 发明授权

US08623811B2 Antimicrobial peptide, compositions, and methods of use 有权
标题翻译：抗微生物肽，组合物和使用方法
公开(公告)号：US08623811B2
公开(公告)日：2014-01-07
申请号：US12669705
申请日：2008-07-28
申请人： Hongran F. Stone , Jacob M. Waugh
发明人： Hongran F. Stone , Jacob M. Waugh
IPC分类号： A61K38/00 , A61K38/16
CPC分类号： A61K38/16 , A61K8/64 , A61K9/0014 , A61K9/0043 , A61K9/006 , A61K9/0063 , A61K38/04 , A61K38/17 , A61K47/10 , A61Q17/005 , C07K14/4723 , Y02A50/473
摘要： The present invention provides antimicrobial peptides that exhibit a broad range of antimicrobial activity to gram positive and gram negative bacteria, as well as fungi, mold, and virus. The antimicrobial peptide of the invention is a cationic peptide, and may contain an HIV-TAT or reverse HIV-TAT sequence, or derivative thereof. The present invention further provides antimicrobial compositions containing the cationic peptide. Such compositions are especially useful for topical application to the skin, hair, nail, vagina, urethra, ear, oral cavity, nasal passage, respiratory system, opthalmic region, and various mucosal regions. The compositions of the present invention improve the condition and/or appearance of the treated region, and are suited for long-term and/or routine use to, for example, prevent or prevent the recurrence of microbial infection. The present invention further provides kits for use in improving the condition or appearance of skin, nail, or treated area. These kits may facilitate ease of use, long-term storage, and/or efficacy of the compositions.
摘要翻译：本发明提供了抗菌肽，其对革兰氏阳性和革兰氏阴性菌以及真菌，霉菌和病毒具有广泛的抗微生物活性。本发明的抗微生物肽是阳离子肽，并且可以含有HIV-TAT或反向HIV-TAT序列或其衍生物。本发明还提供含有阳离子肽的抗微生物组合物。这些组合物特别适用于局部施用于皮肤，毛发，指甲，阴道，尿道，耳朵，口腔，鼻通道，呼吸系统，眼部区域和各种粘膜区域。本发明的组合物改善了处理区域的状态和/或外观，并且适于长期和/或常规使用以例如防止或预防微生物感染的复发。本发明还提供用于改善皮肤，指甲或治疗区域的状况或外观的试剂盒。这些试剂盒可以促进组合物的易用性，长期储存和/或功效。

9. 发明申请

US20130197397A1 Methods and Assessment Scales for Measuring Wrinkle Severity 审中-公开
标题翻译：测量皱纹严重程度的方法和评估量表
公开(公告)号：US20130197397A1
公开(公告)日：2013-08-01
申请号：US13751124
申请日：2013-01-27
申请人： REVANCE THERAPEUTICS, INC.
发明人： Jacob M. Waugh , Andrew Blitzer
IPC分类号： A61B5/00 , A61B5/107
CPC分类号： A61B5/442 , A61B5/1072 , A61B5/4839
摘要： This invention provides devices, methods, and assessment scales for assessing the severity of wrinkles. Wrinkle assessment using the devices, methods, and assessment scales of the invention can be performed in a clinical setting for the purpose of simply characterizing a wrinkle, or as part of a treatment regimen that varies according to the severity of the wrinkle. Thus, this invention also provides methods of reducing the appearance of wrinkles, and kits comprising for evaluating and treating wrinkles.
摘要翻译：本发明提供用于评估皱纹严重程度的装置，方法和评估量表。本发明的装置，方法和评估量表的皱纹评估可以在临床环境中进行，以简单地表征皱纹，或作为根据皱纹的严重程度而变化的治疗方案的一部分。因此，本发明还提供减少皱纹外观的方法，以及用于评估和治疗皱纹的试剂盒。

10. 发明申请

US20120014894A1 Compositions and Methods for Treating Hyperpigmentation 审中-公开
标题翻译：治疗色素沉着的组合物和方法
公开(公告)号：US20120014894A1
公开(公告)日：2012-01-19
申请号：US13141962
申请日：2009-12-28
申请人： Jacob M. Waugh
发明人： Jacob M. Waugh
IPC分类号： A61K8/64 , A61Q19/02 , A61K8/97
CPC分类号： A61Q19/02 , A61K8/64 , A61K2800/5426
摘要： This invention provides compositions and methods for reducing hyperpigmentation. In preferred embodiments, the compositions are topical compositions that contain kojic acid and a carrier molecule for enhancing the transdermal penetration of kojic acid. This invention also provides kits for treating hyperpigmentation.
摘要翻译：本发明提供减少色素沉着过量的组合物和方法。在优选的实施方案中，组合物是含有曲酸和用于增强曲酸透皮渗透的载体分子的局部组合物。本发明还提供了治疗色素沉着过度的试剂盒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式