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1. 发明授权

US08189737B2 Process and apparatus for microCT imaging of ex vivo specimens 有权
标题翻译：离体标本的微CT成像的方法和装置
公开(公告)号：US08189737B2
公开(公告)日：2012-05-29
申请号：US12162376
申请日：2007-01-26
申请人： Charles Keller , Ali N. Bahadur
发明人： Charles Keller , Ali N. Bahadur
IPC分类号： G01N23/00 , G06K9/00
CPC分类号： G01N1/30 , A61B6/508 , G01N23/046 , G01N2223/419 , G01N2223/612
摘要： Processes for producing a microCT image for virtual histology using x-ray microscopic computed tomography are described along with processes for rapid and inexpensive high-throughput methods of high resolution imaging for screening an ex vivo embryo for phenotype using computed tomography imaging. Staining of particular components of specimens with one or more staining agents is described which contributes to high quality image generation and identification of anatomical structures as well as localization of molecular targets. Inventive animal and specimen holders are detailed which allow for reduced post-imaging processing of generated images. In particular, animal and specimen holders are provided which include a highly transparent bed or liner which separates the animal or specimen from a less transparent structure. A further animal holder is provided for placing and/or maintaining the animal in a desired position during an imaging procedure or multiple imaging procedures including a bed conforming to the animal's body.
摘要翻译：用X射线显微镜计算机断层摄影技术生产用于虚拟组织学的微CT图像的过程与用于使用计算机断层摄影成像筛选用于表型的体外胚胎的快速且廉价的高分辨率成像方法进行了描述。描述了用一种或多种染色剂染色试样的特定组分，其有助于高质量的图像产生和解剖结构的鉴定以及分子靶标的定位。详细的发明动物和标本支架可以减少生成图像的成像后处理。特别地，提供动物和样本保持器，其包括高度透明的床或衬垫，其将动物或标本与较不透明的结构分开。提供另一个动物保持器，用于在成像过程期间将动物放置和/或维持在期望的位置，或者包括符合动物身体的床的多个成像过程。

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