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1. 发明公开

US20240280589A1 USE OF FIBRONECTIN IN PREDICTING PREECLAMPSIA 审中-公开
公开(公告)号：US20240280589A1
公开(公告)日：2024-08-22
申请号：US18391104
申请日：2023-12-20
申请人： Sinai Health System , The Hospital for Sick Children
发明人： Isabella Caniggia , Martin Post , Sruthi Alahari
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N2333/78 , G01N2333/90245 , G01N2800/368
摘要： A method and kit for predicting preeclampsia is provided. Levels of Jumonji C domain containing protein 6 (JMJD6) and fibronectin are measured in placenta-derived small extracellular vesicles isolated from a subject. The levels of JMJD6 and fibronectin are compared to a non-preeclamptic control. If levels of JMJD6 are depressed and levels of fibronectin are elevated, the subject may be monitored or treated for preeclampsia.

2. 发明公开

US20240182544A1 POLYPEPTIDES TARGETING DR4 AND/OR DR5 AND RELATED COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：US20240182544A1
公开(公告)日：2024-06-06
申请号：US18253483
申请日：2021-11-25
申请人： The Hospital for Sick Children
发明人： Jean-Philippe Julien , Edurne Rujas Diez
IPC分类号： C07K14/705 , A61P35/00 , C07K16/28
CPC分类号： C07K14/70578 , A61P35/00 , C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/52 , C07K2317/73 , C07K2319/30 , C07K2319/735
摘要： A fusion protein comprises a nanocage monomer or a subunit thereof linked to a DR4 and/or DR5 antigen-binding moiety, wherein a plurality of the fusion proteins self-assemble to form a nanocage. Also described is a nanocage comprising the fusion protein and related compositions as well as methods and uses for treating and/or preventing cancer.

3. 发明公开

US20240099652A1 APPARATUS FOR AUTOMATED PAIN TESTING IN RODENTS 审中-公开
公开(公告)号：US20240099652A1
公开(公告)日：2024-03-28
申请号：US18371847
申请日：2023-09-22
申请人： THE HOSPITAL FOR SICK CHILDREN
发明人： CHRISTOPHER DEDEK , MEHDI ABBASI AZADGOLEH , STEVE ALEC PRESCOTT
IPC分类号： A61B5/00 , A61F7/00 , A61N1/36
CPC分类号： A61B5/4824 , A61B5/0077 , A61F7/007 , A61N1/36014 , A61B2503/40 , A61B2560/04 , G16H10/20
摘要： Disclosed herein is a device that standardizes and automates pain testing in laboratory rodents by providing computer-controlled aiming and delivery of various somatosensory stimuli, and precisely measuring the evoked responses. For photostimuli, red light is incorporated into the light path and its reflectance off the paw is measured (at ≥1 kHz) by a photodetector mounted on the device. The reflectance signal changes rapidly when the target paw moves, thus enabling automated measurement of withdrawal latencies with millisecond precision. A camera mounted on the device, below the mouse, provides video for aiming and for behavior analysis before, during and after stimulation. The device can be aimed manually or automatically using artificial intelligence (AI), in the latter case, the target paw is identified and tracked by a pre-trained neural network, and real-time information about paw location is used to command motorized linear actuators to move the stimulator and to initiate stimulation.

4. 发明授权

US11920199B2 Methods and compositions for screening and treating developmental disorders 有权
公开(公告)号：US11920199B2
公开(公告)日：2024-03-05
申请号：US17722873
申请日：2022-04-18
申请人： THE HOSPITAL FOR SICK CHILDREN
发明人： Stephen Scherer
IPC分类号： C12Q1/68 , C07K14/47 , C07K14/705 , C12N9/00 , C12N9/20 , C12P19/34 , C12Q1/6883 , G01N33/68
CPC分类号： C12Q1/6883 , C07K14/47 , C07K14/4728 , C07K14/705 , C12N9/20 , C12N9/93 , G01N33/6896 , C12Q2600/156 , G01N2500/04 , G01N2800/2814
摘要： This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

5. 发明授权

US11730505B2 Flexible articulate surgical tool 有权
公开(公告)号：US11730505B2
公开(公告)日：2023-08-22
申请号：US16468042
申请日：2017-12-18
申请人： THE HOSPITAL FOR SICK CHILDREN
发明人： Kyle W. Eastwood , Peter Francis , Thomas Looi , Hani E. Naguib , James M. Drake
IPC分类号： A61B17/29 , A61B17/32 , A61B17/295 , A61B17/00
CPC分类号： A61B17/320016 , A61B17/295 , A61B2017/0034 , A61B2017/00309 , A61B2017/00314
摘要： A flexible elongate shaft assembly which includes an elongate flexible tube having at least one joint built into the elongate flexible tube, and the at least one joint comprised of at least one notch. Each notch includes a contact-aided compliant notch topology built into the elongate flexible shaft configured to cause each notch to mechanically interfere with itself and self-reinforce during bending of each notch resulting in an increase in stiffness of each notch to prevent buckling and plastic deformation of the elongate flexible shaft assembly, and assume a predetermined and designed bending shape of the elongate flexible shaft assembly. The flexible elongate shaft assembly is incorporated into a flexible articulate surgical tool that provides the needed stiffness in order to be able to manipulate tissue and bear loads in anatomically confined spaces. The surgical tool includes a clinician operated handle, the flexible elongated shaft assembly extending from the handle to a surgical tool with the flexible elongate tube having one or more joint sections located near the surgical tool. A flexible cable connects the handle to the surgical tool. The joint sections are configured so that when the clinician activates the surgical tool, a mechanical interference is generated in each of the notches and this mechanical interference not only increases stiffness throughout the articulation of the notch's range-of-motion but it also serves the dual purpose of controlling the bent “shape” of the flexible portion of the notch.

6. 发明申请

US20220265282A1 USE OF REMOTE ISCHEMIC CONDITIONING FOR TRAUMATIC INJURY 有权
公开(公告)号：US20220265282A1
公开(公告)日：2022-08-25
申请号：US17305000
申请日：2021-06-29
申请人： The Hospital for Sick Children
发明人： Christopher Caldarone
IPC分类号： A61B17/135 , A61H9/00 , A61B17/132
摘要： The invention provides methods for reducing traumatic injury through the use of ischemic conditioning.

7. 发明授权

US11376224B2 System for delivery of FK506 for enhancing nerve regeneration 有权
公开(公告)号：US11376224B2
公开(公告)日：2022-07-05
申请号：US16091153
申请日：2017-04-04
申请人： THE HOSPITAL FOR SICK CHILDREN
发明人： Kasra Tajdaran , Gregory Borschel , Tessa Gordon
IPC分类号： A61K9/50 , A61K9/70 , A61K9/00 , A61K9/14 , A61K47/42 , A61K9/06 , A61K9/16 , A61K47/38 , A61K31/453 , A61K31/436
摘要： The present disclosure provides delivery systems for delivering FK506 locally to damaged nerve sites. Particulate FK506 incorporated into a fibrin gel, with the amount of FK506 sufficient to give an FK506 release rate over at least 14 days of at least 5 micrograms per milliliter of the treated tissue per day has been shown to remarkably improve axon regeneration. The delivery systems include particulate FK506 having sizes between about 500 microns to about 1 millimeter encapsulated in a fibrin matrix, powdered FK506 encapsulated within electrospun films, powdered FK506 encapsulated within a cellulose matrix, and a flexible film of small intestinal submucosa having a plurality of solid islands located on one side thereof, with each island containing a preselected amount of FK506 and a polyester. The local application of FK506 via the local delivery system disclosed herein results in excellent nerve regeneration while preventing the toxicity of systemic FK506 that has prevented clinicians from using FK506 routinely for treating severe cases of peripheral nerve injuries. In addition to being used for treatment of damaged nerve sites, the present systems may be applied to other types of injuries, including but not limited to spinal cord Injuries, stroke, vascularized composite allotransplantation (VCA) and local applications during solid organ transplants.

8. 发明授权

US11339439B2 Methods and compositions for screening and treating developmental disorders 有权
公开(公告)号：US11339439B2
公开(公告)日：2022-05-24
申请号：US16239129
申请日：2019-01-03
申请人： THE HOSPITAL FOR SICK CHILDREN
发明人： Stephen Scherer
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6883 , G01N33/68 , C07K14/705 , C07K14/47 , C12N9/20 , C12N9/00
摘要： This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.

9. 发明申请

US20220112502A1 MODULATION OF GYS1 EXPRESSION 有权
公开(公告)号：US20220112502A1
公开(公告)日：2022-04-14
申请号：US17561095
申请日：2021-12-23
申请人： Ionis Pharmaceuticals, Inc. , The Hospital for Sick Children
发明人： Tamar R. Grossman , Susan M. Freier , Berge Minassian , Saija Ahonen
IPC分类号： C12N15/113 , A61P25/28 , A61K45/06 , A61P3/08 , A61K31/7088
摘要： Provided herein are methods, compounds, and compositions for reducing expression of GYS1 in an individual. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a glycogen storage disease or disorder in an individual in need.

10. 发明授权

US11254984B2 Biomarkers for autism spectrum disorders 有权
公开(公告)号：US11254984B2
公开(公告)日：2022-02-22
申请号：US16694314
申请日：2019-11-25
申请人： The Hospital for Sick Children , Centre for Addiction and Mental Health
发明人： Stephen W Scherer , John B Vincent
IPC分类号： C12Q1/68 , C12Q1/6883
摘要： Methods of determining the risk of ASD in an individual are provided which comprise identifying the presence of one or more genomic mutations in one or more of the genes, PTCHD1, SHANK3, NFIA, DPP6, DPP10, DYPD, GPR98, PQBP1, ZNF41 and FTSJ1.

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