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1. 发明授权

US11534410B2 Amphotericin loaded PEGylated lipid nanoparticles and methods of use 有权
公开(公告)号：US11534410B2
公开(公告)日：2022-12-27
申请号：US17265644
申请日：2019-08-05
申请人： University of Mississippi
发明人： Soumyajit Majumdar , Akash Patil , Prit Lakhani
IPC分类号： A61K9/51 , A61K9/10 , A61K31/7048 , A61K47/18
摘要： Compositions of nanolipid carrier molecules comprising PEG molecules and solid and liquid lipids wherein the PEG has a molecular weight of between about 1000 and 5000 are described. Methods of administering nanolipid carrier molecules are also described. Also described is a method for treating fungal ocular infections by topical ocular administration of nanolipid carrier molecules comprising PEG molecules and solid and liquid lipids wherein the PEG has a molecular weight of between about 1000 and 5000.

2. 发明申请

US20210330598A1 Amphotericin Loaded Pegylated Lipid Nanoparticles And Methods Of Use 有权
公开(公告)号：US20210330598A1
公开(公告)日：2021-10-28
申请号：US17265644
申请日：2019-08-05
申请人： University of Mississippi
发明人： Soumyajit MAJUMDAR , Akash PATIL , Prit LAKHANI
IPC分类号： A61K9/51 , A61K31/7048 , A61K9/10 , A61K47/18
摘要： Compositions of nanolipid carrier molecules comprising PEG molecules and solid and liquid lipids wherein the PEG has a molecular weight of between about 1000 and 5000 are described. Methods of administering nanolipid carrier molecules are also described. Also described is a method for treating fungal ocular infections by topical ocular administration of nanolipid carrier molecules comprising PEG molecules and solid and liquid lipids wherein the PEG has a molecular weight of between about 1000 and 5000.

3. 发明申请

US20200345643A1 TWIN-SCREW DRY GRANULATION FOR PRODUCING SOLID FORMULATIONS 审中-公开
公开(公告)号：US20200345643A1
公开(公告)日：2020-11-05
申请号：US16936008
申请日：2020-07-22
申请人： R.P. Scherer Technologies, LLC , UNIVERSITY OF MISSISSIPPI
发明人： Sampada Bhaskar Upadhye , Ronald S. Vladyka , Michael Andrew Repka , Jun-Bom Park , Roshan Vijay Tiwari , Hemlata Gunga Patil , Joseph Thomas Morott, JR. , Wenli Lu
IPC分类号： A61K9/16 , A61K9/00 , A61K9/20 , A61K31/4178 , A61K31/519 , B01J2/10
摘要： A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

4. 发明授权

US10322189B2 Kidney-targeted drug delivery systems 有权
公开(公告)号：US10322189B2
公开(公告)日：2019-06-18
申请号：US15517805
申请日：2015-11-12
申请人： University of Mississippi Medical Center
发明人： Alejandro R. Chade, III , Gene L. Bidwell, III
IPC分类号： A61K38/18 , A61K38/39 , A61K47/64 , A61P13/12
摘要： A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and. a therapeutic agent is provided. A method of delivering a therapeutic agent to a subject in need thereof comprising: administering to the subject an effective amount of a composition comprising: an elastin-like polypeptide (ELP), a kidney targeting agent coupled to the ELP and a targeting agent and/or a drug binding domain coupled to the ELP, wherein the ELP includes an amino acid sequence having at least about repeats of the amino acid sequence GVPGX (SEQ ID NO: 1), and wherein the composition enhances the deposition and retention of the therapeutic agent in the kidney relative to the non-conjugated therapeutic.

5. 发明授权

US10130295B2 Method for the detection and staging of liver fibrosis from image acquired data 有权
公开(公告)号：US10130295B2
公开(公告)日：2018-11-20
申请号：US14595122
申请日：2015-01-12
申请人： UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
发明人： Andrew Smith
IPC分类号： A61B5/00 , G06T7/00 , A61B5/055 , A61B8/08 , G06F19/00 , A61B6/03 , G16H50/20
摘要： This invention relates to methods for ascertaining at least one of liver fibrosis or cirrhosis in a subject, by processing of one or more medical images of the liver, using a computing machine, to quantify nodularity of the surface of the liver and calculate a liver surface nodularity score.

6. 发明授权

US09801837B2 Stabilized formulation of triamcinolone acetonide 有权
公开(公告)号：US09801837B2
公开(公告)日：2017-10-31
申请号：US12299753
申请日：2007-05-08
申请人： Michael A. Repka , Hossein Shabany , Angela Sutterer
发明人： Michael A. Repka , Hossein Shabany , Angela Sutterer
IPC分类号： A61K31/167 , A61K31/194 , A61K31/573 , A61K9/00 , A61K47/10 , A61K47/14 , A61K47/32
CPC分类号： A61K31/167 , A61K9/006 , A61K31/194 , A61K31/573 , A61K47/10 , A61K47/14 , A61K47/32 , A61K2300/00
摘要： A stabilized formulation of triamcinolone acetonide in a bioadhesive base material is provided. The present invention further includes a method of producing a stabilized non-aqueous TAA formulation and methods of measuring the stability of such TAA formulations.

7. 发明授权

US09439875B2 Anxiolytic effect of pterostilbene 有权
标题翻译： ter il烯的溶血作用
公开(公告)号：US09439875B2
公开(公告)日：2016-09-13
申请号：US13105470
申请日：2011-05-11
申请人： Agnes M. Rimando , Abir El-Alfy , Md Al Rahim
发明人： Agnes M. Rimando , Abir El-Alfy , Md Al Rahim
IPC分类号： A61K31/09 , A61P25/22 , A61K31/075 , A61K31/045
CPC分类号： A61K31/075 , A61K31/045
摘要： We report for the first time that pterostilbene, a natural analog of resveratrol, shows anxiolytic-like action by downregulating phosphorylated levels of ERKs in the hippocampus of mice. Mice administered pterostilbene (1-10 mg/kg BW) by oral gavage were subjected to the Elevated-plus maze (EPM) test. Pterostilbene manifested anxiolytic activity at 1 and 2 mg/kg doses, demonstrated by an increase in percent permanence time and number of entries in open arms, critical determinants correlated with anxiety. This anxiolytic activity of pterostilbene was comparable to that of diazepam at 1 and 2 mg/kg in the EPM. The percent traveled distance and the percent permanence time in the enclosed arms were decreased with the 1 and 2 mg/kg doses. The 5 and 10 mg/kg doses did not show any anxiolytic effect. Locomotor activity was unaffected in all doses. Western blot analysis corroborated the observed behaviors in the EPM, revealing a decrease in both ERK1 and ERK2 phosphorylation in hippocampal homogenates from mice treated with 1 and 2 mg/kg doses; the 5 and 10 mg/kg doses showed no significant effect on the phosphorylation of ERKs. Pterostilbene was detected in serum and brain tissue following a single oral administration, demonstrating that the compound can cross the blood-brain barrier to reach the brain regions, including hippocampus, and thereby exert its anxiolytic effect. Resveratrol, the parent molecule of pterostilbene, did not have any anxiolytic effect.
摘要翻译：我们首次报道，天冬氨酸萜烯是白藜芦醇的天然类似物，通过下调小鼠海马中ERKs的磷酸化水平显示抗焦虑样作用。通过口服管饲法施用ter芪烯（1-10mg / kg BW）的小鼠进行升高加迷宫（EPM）试验。 Pterostilbene以1和2mg / kg剂量表现出抗焦虑活性，通过持续时间百分比增加和开放臂中的入选数量增加，与焦虑相关的关键决定因素表现出抗焦虑活性。在EPM中，ter il烯的抗焦虑活性与1mg / kg剂量的地西泮相当。随着1和2mg / kg剂量，随机携带的距离百分比和持久时间百分比下降。 5和10mg / kg剂量没有显示任何抗焦虑作用。所有剂量的运动活动均不受影响。 Western印迹分析证实EPM中观察到的行为，揭示了用1和2mg / kg剂量处理的小鼠的海马匀浆中ERK1和ERK2磷酸化的降低; 5和10mg / kg剂量对ERK的磷酸化没有显着影响。在单次口服给药后，在血清和脑组织中检测到P芪烯，表明化合物可以穿过血脑屏障到达脑区域，包括海马，从而发挥其抗焦虑作用。白藜芦醇是ter il烯的母体分子，没有任何抗焦虑作用。

8. 发明授权

US09263043B2 Stuttering inhibition method and device 有权
标题翻译：口吃抑制方法及装置
公开(公告)号：US09263043B2
公开(公告)日：2016-02-16
申请号：US13513733
申请日：2010-12-03
申请人： Gregory John Snyder , Dwight E. Waddell, II , Paul Mallette Goggans
发明人： Gregory John Snyder , Dwight E. Waddell, II , Paul Mallette Goggans
IPC分类号： A61F5/58 , G10L15/24 , G10L21/06 , G10L21/057
CPC分类号： G10L15/24 , A61F5/58 , G10L21/06 , G10L2021/0575
摘要： A method and device is disclosed for reducing and controlling stuttering. The method involves tactile feedback of the stutterer's own speech to reducing stuttering. In one embodiment, the device may detect speech by audible or mechanical means, and the feedback may be produced by vibration mechanisms.
摘要翻译：公开了减少和控制口吃的方法和装置。该方法涉及到对吐痰者自己的言语的反馈，以减少口吃。在一个实施例中，设备可以通过声音或机械手段检测语音，并且反馈可以由振动机制产生。

9. 发明授权

US09193762B2 Selective inhibitors of prolylcarboxypeptidase 有权
标题翻译：脯氨酰羧肽酶的选择性抑制剂
公开(公告)号：US09193762B2
公开(公告)日：2015-11-24
申请号：US13991094
申请日：2011-12-01
申请人： Ziaeddin Shariat-Madar , John Matthew Rimoldi , Rama Sarma Venkata Subbarahmanya Gadepalli
发明人： Ziaeddin Shariat-Madar , John Matthew Rimoldi , Rama Sarma Venkata Subbarahmanya Gadepalli
IPC分类号： C07K5/078 , C07D403/06 , C07D205/04 , C07D207/16 , C07K5/02
CPC分类号： C07K5/06165 , C07D205/04 , C07D207/16 , C07D403/06 , C07K5/0205 , C07K5/06139
摘要： The present invention relates to compounds of the formulae: in which R is C5-C16 alkyl, R1 is and isosteres and salts thereof.
摘要翻译：本发明涉及下式的化合物：其中R为C 5 -C 16烷基，R 1为等价异构体及其盐。

10. 发明申请

US20120281832A1 SECURE WIRELESS COMMUNICATION TRANSCEIVER 审中-公开
标题翻译：安全无线通信收发器
公开(公告)号：US20120281832A1
公开(公告)日：2012-11-08
申请号：US13520215
申请日：2011-04-01
申请人： Mustafa Muhammad Matalgah , Amer Mohammad Almaqableh
发明人： Mustafa Muhammad Matalgah , Amer Mohammad Almaqableh
IPC分类号： H04K1/00
CPC分类号： H04L9/0631
摘要： An efficient hybrid encryption-coding algorithm is disclosed that requires using traditional encryption only for the first small amount of data. This amount of data, the first block, is determined by the traditional encryption algorithm to be applied on this first block. In this algorithm, all of the rest of the information will then be transmitted securely over the wireless channel, using network coding, without a need for using traditional encryption. Unlike the traditional and opportunistic encryption algorithms, the algorithm achieves higher data rates and less avalanche error effect, and, at the same time, it is as secure as traditional encryption algorithms. Assuming the additive white Gaussian noise (AWGN) channel model employing our disclosed algorithm, we analyze its performance in terms of throughput and security level.
摘要翻译：公开了一种有效的混合加密编码算法，其需要仅对第一少量数据使用传统加密。该数据量，第一个块，由传统的加密算法确定，以应用于该第一个块。在该算法中，所有其余的信息将通过无线信道被安全地传输，使用网络编码，而不需要使用传统的加密。与传统和机会主义加密算法不同，该算法实现了更高的数据速率和更少的雪崩误差效应，同时与传统的加密算法一样安全。假设采用我们公开的算法的加性白高斯噪声（AWGN）信道模型，我们分析其在吞吐量和安全级别方面的性能。

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