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    • 5. 发明申请
    • THREE-DIMENSIONAL NANOFIBER SCAFFOLD FOR TISSUE REPAIR AND PREPARATION METHOD THEREOF
    • 用于组织修复的三维NANOFIBER SCAFFOLD及其制备方法
    • US20140024760A1
    • 2014-01-23
    • US14008408
    • 2012-03-16
    • Il Keun KwonChun Ho KimDae Hyeok YangJung Bok LeeHa Na ParkSung In Jeong
    • Il Keun KwonChun Ho KimDae Hyeok YangJung Bok LeeHa Na ParkSung In Jeong
    • A61L27/14C08K5/05
    • A61L27/14A61L27/48A61L27/56A61L2400/12C08K5/05C08L5/08C08L89/06C08L2205/16C12N5/0068C12N2533/40
    • The present invention provides a three-dimensional nanofibrous scaffold for tissue regeneration, which is increased in porosity and thickness to enlarge the surface area thereof, thereby enabling cell adhesion at a high density, and a method for fabricating the same. The method for fabricating a three-dimensional nanofibrous scaffold for tissue regeneration includes the steps of: (a) preparing a polymer solution; (b) preparing a nanofiber matrix, in which a plurality of nanofibers is entangled with each other, from the polymer solution prepared in step (a) using electrospinning; and (c) immersing the prepared nanofiber matrix in a solution and subjecting the solution to ultrasonication, thereby increasing the thickness and porosity of the nanofiber matrix. According to the inventive scaffold fabricating method, the nanofiber matrix prepared by using electrospinning is ultrasonicated in a solution, so that a three-dimensional nanofibrous scaffold with improved thickness and porosity can be provided in a simple and low-cost manner.
    • 本发明提供一种用于组织再生的三维纳米纤维支架,其孔隙率和厚度增加以增加其表面积,从而使得能够以高密度进行细胞粘附及其制造方法。 用于组织再生的三维纳米纤维支架的制造方法包括以下步骤:(a)制备聚合物溶液; (b)使用静电纺丝从步骤(a)中制备的聚合物溶液制备多个纳米纤维彼此缠结的纳米纤维基质; 和(c)将制备的纳米纤维基质浸入溶液中并使溶液进行超声波处理,从而增加纳米纤维基质的厚度和孔隙率。 根据本发明的支架制造方法,将通过静电纺丝制备的纳米纤维基质在溶液中超声波处理,从而可以以简单且低成本的方式提供具有改善的厚度和孔隙率的三维纳米纤维支架。