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    • 4. 发明申请
    • Methods and Apparatus for Direct Calibration
    • US20220155462A1
    • 2022-05-19
    • US17491576
    • 2021-10-01
    • Woods Hole Oceanographic Institution
    • Paul Dominic FUCILE
    • G01S19/23G01S17/50
    • A device and method of use for the calibration of a detector. The calibration device includes a first source configured to produce first electromagnetic energy EMR. A first diffuser is connected to the first source and is configured to accept the first EMR and provide a first diffused portion of the first EMR. An integrating sphere defines an interior and is optically connected to the first diffuser, and is configured to accept the first diffused portion from the first diffuser into the interior. An exit port connected to the integrating sphere is configured to pass at least a portion of electromagnetic energy. A thermal mechanism is configured to adjust and maintain the temperature of at least the first source. The integrating sphere is configured to pass only a second portion of the first diffused portion of the first EMR from the first diffuser to the exit port. In another embodiment, the calibration device has an arm, an actuator, and a module. The module supports at least a first source that emits electromagnetic energy, a thermal mechanism, and a controller. The actuator is configured to move the arm and module to a calibration position enabling the first source to be within the line of sight of an external detector, while the controller is configured to control the thermal mechanism enabling precise temperature regulation of the source and therefore the regulation of the emitted electromagnetic energy. When the device is not in the calibration position, the actuator is configured to move the arm and module to a stowed position, protecting the device from ambient electromagnetic radiation and harm.
    • 10. 发明申请
    • Methods and Compositions for Increasing Antibiotic Activity
    • 增加抗生素活性的方法和组合
    • US20160015686A1
    • 2016-01-21
    • US14797951
    • 2015-07-13
    • Woods Hole Oceanographic Institution
    • Tracy MincerKristen Whalen
    • A61K31/4015A61K31/165A61K31/7048A61K31/65A61K31/5383A61K31/7036A61K31/431A61K45/06A61K31/496
    • A61K31/4015A61K31/165A61K31/43A61K31/431A61K31/496A61K31/5383A61K31/545A61K31/65A61K31/7036A61K31/7048A61K31/7052A61K45/06Y02A50/473Y02A50/481A61K2300/00
    • One aspect of the invention provides a method of inhibiting an efflux pump in a bacteria, the method comprising contacting the bacteria with 3,4-dibromopyrrole-2,5-dione, thereby inhibiting the efflux pump. Another aspect provides a method of inhibiting proliferation of a bacteria, the method comprising contacting the bacteria with 3,4-dibromopyrrole-2,5-dione and an antibiotic, thereby inhibiting the proliferation of the bacteria. Another aspect of the invention provides a method of increasing the efficacy of an antibiotic, the method comprising contacting a bacteria with 3,4-dibromopyrrole-2,5-dione and an antibiotic, thereby increasing the efficacy of the antibiotic. Another aspect provides a method of inhibiting development of antibiotic resistance in a bacteria, the method comprising contacting the bacteria with 3,4-dibromopyrrole-2,5-dione and an antibiotic, thereby inhibiting development of resistance to the antibiotic. Another aspect of the invention provides a pharmaceutical composition for treating a bacterial infection comprising an effective amount of 3,4-dibromopyrrole-2,5-dione in a pharmaceutically acceptable excipient.
    • 本发明的一个方面提供抑制细菌外排泵的方法,该方法包括使细菌与3,4-二溴吡咯-2,5-二酮接触,从而抑制外排泵。 另一方面提供抑制细菌增殖的方法,该方法包括使细菌与3,4-二溴吡咯-2,5-二酮和抗生素接触,从而抑制细菌的增殖。 本发明的另一方面提供了增加抗生素效力的方法,所述方法包括使细菌与3,4-二溴吡咯-2,5-二酮和抗生素接触,从而提高抗生素的功效。 另一方面提供抑制细菌中抗生素抗性发展的方法,该方法包括使细菌与3,4-二溴吡咯-2,5-二酮和抗生素接触,从而抑制抗生素耐药性的发展。 本发明的另一方面提供了用于治疗细菌感染的药物组合物,其在药学上可接受的赋形剂中包含有效量的3,4-二溴吡咯-2,5-二酮。