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1. 发明公开

US20240269195A1 COMPOSITIONS AND METHODS RELATING TO POOLED FETAL SUPPORT TISSUE 审中-公开
公开(公告)号：US20240269195A1
公开(公告)日：2024-08-15
申请号：US18642534
申请日：2024-04-22
申请人： BIOTISSUE HOLDINGS INC.
发明人： Scheffer TSENG , Ek Kia TAN , Lorraine CHUA
IPC分类号： A61K35/54 , A61K35/50 , A61K35/51 , G01N33/50
CPC分类号： A61K35/54 , A61K35/50 , A61K35/51 , G01N33/5082 , G01N2800/52
摘要： Described herein is a composition, methods comprising, pooled fetal support tissue, wherein the pooled fetal support tissue comprises a therapeutically effective amount of native HC-HA/PTX3 complex.

2. 发明授权

US11883438B2 Sperm activator and uses thereof 有权
公开(公告)号：US11883438B2
公开(公告)日：2024-01-30
申请号：US16327817
申请日：2017-08-23
申请人： National University Corporation Nagoya University , Gifu University , Gifu Prefecture
发明人： Tokunori Yamamoto , Satoshi Suzuki , Yasuhito Funahashi , Yoshihisa Matsukawa , Momokazu Gotoh , Tomohiro Kitayama , Yoichiro Hoshino , Tetsuma Murase
IPC分类号： A61K35/50 , A61K35/51 , A61K35/52 , A61P15/08 , A61K35/32 , A61K35/54 , A61K35/28 , A61K35/35 , A61D19/00 , A61D19/02 , A61K35/00 , C12N5/076 , C12N5/0775
CPC分类号： A61K35/50 , A61D19/00 , A61D19/02 , A61K35/00 , A61K35/28 , A61K35/32 , A61K35/35 , A61K35/51 , A61K35/52 , A61K35/54 , A61P15/08 , C12N5/061 , C12N5/0664 , C12N5/0665 , C12N5/0667 , C12N2500/80
摘要： It is an object to provide a technique useful for embryo transfer and development of reproductive medical care. Provided are a sperm activator containing a disrupted product of one or more cells selected from the group consisting of adipose tissue-derived stem cells, dental pulp-derived stem cells, bone marrow-derived stem cells, and umbilical cord blood-derived stem cells as an active ingredient, and an artificial insemination method utilizing the same.

3. 发明授权

US11596745B2 Living cell transplanting tool 有权
公开(公告)号：US11596745B2
公开(公告)日：2023-03-07
申请号：US16375939
申请日：2019-04-05
申请人： Kitazato Corporation
发明人： Futoshi Inoue , Chie Inaba
IPC分类号： A61M5/315 , A61K35/54 , A61B17/425 , A61M25/00
摘要： A living cell transplanting device has a flexible tube capable of accommodating living cells and a cell pushing shaft inserted into the tube. The tube has a lumen penetrating therethrough and a reduced diameter front end open portion. The shaft has a small diameter end portion having a diameter smaller than that of the reduced diameter front end open portion and an enlarged diameter portion having an outer diameter larger than an inner diameter of reduced diameter front end open portion. Owing to contact between the enlarged diameter portion of the shaft and the reduced diameter front end open portion of the tube, a progress of the shaft is regulated. By pushing the shaft into the tube after the contact between the enlarged diameter portion and the reduced diameter front end open portion finishes, the enlarged diameter portion of the shaft passes through said reduced diameter front end open portion with expanding the reduced diameter front end open portion of the tube and projects beyond the reduced diameter front end open portion of the tube.

4. 发明申请

US20230058240A1 METHODS OF GENERATING HORMONE-PRODUCING ORGANOIDS AND REVERSING HYPOGONADISM 有权
公开(公告)号：US20230058240A1
公开(公告)日：2023-02-23
申请号：US17975686
申请日：2022-10-28
申请人： Craig S. Atwood
发明人： Craig S. Atwood
IPC分类号： A61K35/28 , A61K35/36 , A61K31/568 , A61K31/57 , A61K31/566 , A61K35/545 , A61K35/55 , A61K35/54 , A61K35/15 , A61K35/52
摘要： A method of improving integration and/or functionality of gonadal organoids introduced to a subject includes the steps of pre-treating the subject with a chorionic gonadotrophin (CG), administering a therapeutically effective amount of the gonadal organoids to the subject, and administering the CG to the subject over time post-treatment to maintain LHCG receptor expression and signaling.

5. 发明授权

US11351201B2 Bandage containing foetal fibroblasts and keratinocytes 有权
公开(公告)号：US11351201B2
公开(公告)日：2022-06-07
申请号：US14651887
申请日：2013-12-12
申请人： Universite De Nantes , Chu Nantes
发明人： Brigitte Dreno , Thomas Zuliani , Soraya Saiagh
IPC分类号： A61K35/36 , A61L15/32 , A61L15/40 , A61K35/33 , A61L15/44 , A61K35/54
摘要： The present invention describes a composition comprising a mixture of human foetal keratinocyte cells and human foetal fibroblast cells, the ratio between said keratinocyte and fibroblast cells ranging from 0.75 to 2.5, preferably being 1:1 or 7:3. This composition is advantageously included in a bandage, said bandage preferably being sterile and packaged in a container impermeable to microorganisms. The present invention finally concerns the use of this composition as a drug, in particular for treating a skin defect (wound, burn or ulcer).

6. 发明申请

US20220125856A1 USE OF OVARIAN-DERIVED HYDROGELS FOR RESTORATION OF REPRODUCTIVE FUNCTION AND HEALTH IN WOMEN 有权
公开(公告)号：US20220125856A1
公开(公告)日：2022-04-28
申请号：US17566504
申请日：2021-12-30
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , UPMC
发明人： Michael Joseph BUCKENMEYER , Kyle E. ORWIG , Bryan Nicklaus BROWN , Meena SUKHWANI
IPC分类号： A61K35/54 , A61K9/06 , A61K9/00 , A61P15/08
摘要： The present disclosure provides methods for restoring reproductive health and/or fertility in a subject by delivering immature follicles to the subject using an ovarian-derived hydrogel. The present disclosure also provides methods for treating ovarian-associated diseases using ovarian-derived hydrogels or their derivatives for delivery of therapeutic agents to the subject in need thereof. The present disclosure further provides kits for restoring reproductive health and/or fertility, and kits for treating ovarian-associated diseases.

7. 发明授权

US11253549B2 Methods to rebalance the hypothalamic-pituitary-gonadal axis 有权
公开(公告)号：US11253549B2
公开(公告)日：2022-02-22
申请号：US14718390
申请日：2015-05-21
申请人： JangoBio, LLC
发明人： Craig S. Atwood
IPC分类号： A61K35/28 , A61K35/36 , A61K31/568 , A61K31/57 , A61K31/566 , A61K35/545 , A61K35/55 , A61K35/54 , A61K35/15 , A61K35/52
摘要： A hypothalamic-pituitary-gonadal (HPG) axis of a patient in need thereof is rebalanced by administering a therapeutically effective amount of at least one donor cell.

8. 发明申请

US20210283191A1 FOLLICULAR FLUID 有权
公开(公告)号：US20210283191A1
公开(公告)日：2021-09-16
申请号：US17332268
申请日：2021-05-27
申请人： GIONAS S.R.L.
发明人： Cristina MAGGIONI
IPC分类号： A61K35/54 , A61K38/24 , A61K35/00 , A61P15/08 , A61K9/00
摘要： Follicular fluid is used in in vitro fertilization. The use includes introducing follicular fluid in the uterus in one or more administrations during a time period of between six days before embryo transfer and the transfer day.

9. 发明授权

US11085019B2 Precursory regulatory cytotrophoblast cells and uses thereof 有权
公开(公告)号：US11085019B2
公开(公告)日：2021-08-10
申请号：US16868905
申请日：2020-05-07
申请人： ACCELERATED BIOSCIENCES CORP.
发明人： Jau-Nan Lee , Yuta Lee , Tony Tung-Yin Lee
IPC分类号： C12N5/073 , A61K35/50 , A61K35/54 , A61K35/12
摘要： Disclosed herein are precursory regulatory cytotrophoblast cells produced in vitro and compositions thereof. Also disclosed herein are methods of treating a disorder or condition by utilizing the cells disclosed herein.

10. 发明授权

US10983111B2 Human trophoblast stem cells and uses thereof 有权
公开(公告)号：US10983111B2
公开(公告)日：2021-04-20
申请号：US16922595
申请日：2020-07-07
申请人： ACCELERATED BIOSCIENCES CORP.
发明人： Jau-Nan Lee , Tony Tung-Ying Lee , Yuta Lee
IPC分类号： G01N33/50 , A61K35/54 , A61K39/395 , C12N5/071 , C12N5/073 , C12N5/0735 , A61K35/39 , A61K35/12
摘要： Disclosed herein are human trophoblast stem (hTS) cells, differentiated cells thereof, derivatives thereof such as cellular mass, and uses thereof. The isolation of hTS cells can express FGF4, FGFR-2, Oct4, Thy-1, and stage-specific embryonic antigens distributed in different compartments of the cell. The hTS cells are able to derive into specific cell phenotypes of the three primitive embryonic layers, produce chimeric reactions in mice, and retain a normal karyotype and telomere length. In the hTS cells, Oct4 and fgfr-2 expressions can be knockdown by bFGF. The hTS cells could apply to human cell differentiation and for gene and cell-based therapies.

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