专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11490622B2 Substituted heterocycles as harmful arthropod controlling agents 有权
公开(公告)号：US11490622B2
公开(公告)日：2022-11-08
申请号：US16954871
申请日：2018-12-21
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Kohei Orimoto , Yuji Nakajima , Risa Kono , Ryota Maehata , Masayuki Tashiro
IPC分类号： A61K31/4184 , A61K31/4188 , C07D403/02 , C07D417/02 , A01N43/90 , A01C1/06 , A01N25/00 , A01N25/04 , A01N25/06 , A01N25/10 , A01N25/12 , A01N25/18 , A61K9/00 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides a compound substituted with an excellent control effect against a harmful arthropod, which is represented by formula (I) Het-Q (I) wherein Q represents a group represented by Q1, etc., Het represents a group represented by Het1, etc., R2 represents a C1-C6 alkyl group, etc., G1 represents a nitrogen atom or CR3a, G2 represents a nitrogen atom or CR3b, G3 represents a nitrogen atom or CR3c, G4 represents a nitrogen atom or CR3d, R3a, R3b, R3c, and R3d are identical to or different from each other and represent a C1-C6 chain hydrocarbon group, etc., n represents 0, 1, or 2, T represents a C1-C10 chain hydrocarbon group substituted with one or more halogen atoms, etc., A2 represents a nitrogen atom or CR4a, A3 represents a nitrogen atom or CR4b, R4a and R4b are identical to or different from each other and represent a C1-C6 chain hydrocarbon group, W1 represents an oxygen atom, etc., and R6 represents a C1-C6 chain hydrocarbon group, etc.

2. 发明申请

US20200370043A1 METHODS FOR MODIFYING RNA SPLICING 审中-公开
公开(公告)号：US20200370043A1
公开(公告)日：2020-11-26
申请号：US16622223
申请日：2018-06-13
申请人： PTC THERAPEUTICS, INC.
发明人： Anuradha BHATTACHARYYA , Amal DAKKA , Kerstin EFFENBERGER , Vijayalakshmi GABBETA , Minakshi B. JANI , Wencheng LI , Nikolai NARYSHKIN , Christopher TROTTA , Kari WIEDINGER
IPC分类号： C12N15/11 , C07D417/02 , C07D417/14 , C07D401/02 , C07D401/14
摘要： Described herein is an intronic recognition element for splicing modifier (iREMS) that can be recognized by a small en molecule splicing modifier compound of Formula (I) provided herein or a form thereof, wherein W, X, A and B are as defined herein. In one aspect, methods for modifying RNA splicing to modulate the amount of a product of a gene, wherein a precursor RNA transcript transcribed from the gene that contains an intronic REMS is modified utilizing a splicing modifier compound of Formula (I), are described herein. In another aspect, methods for modifying RNA splicing to modulate the amount of an RNA transcript or protein product encoded by a gene, wherein a precursor RNA transcript transcribed from the gene is modified to comprise an intronic REMS utilizing a splicing modifier compound of Formula (I), are described herein.

3. 发明申请

US20170226071A1 DICHROIC DYE COMPOUND, POLARIZING FILM, AND USES THEREOF 审中-公开
公开(公告)号：US20170226071A1
公开(公告)日：2017-08-10
申请号：US15519250
申请日：2015-10-14
申请人： Sumitomo Chemical Company, Limited
发明人： Noriyuki HIDA , Haruki OKAWA
IPC分类号： C07D277/60 , C08K5/372 , G02F1/13 , C08K5/55 , C08K5/04 , C07C22/08 , C08K5/23 , C07D417/02
CPC分类号： C07D277/60 , B29D11/00644 , B29D11/00788 , C07C22/08 , C07D417/02 , C07D513/04 , C08K5/04 , C08K5/23 , C08K5/3725 , C08K5/55 , C09B43/00 , C09K19/601 , C09K2019/0448 , G02B5/3033 , G02F1/13 , G02F1/133528 , G02F2001/133565 , G02F2202/022
摘要： A compound having a maximum absorption in a wavelength range of 350 nm to 550 nm that functions as a dichroic dye is provided. In particular, a compound represented by formula (1) is provided. In the compound of formula (1), R1 represents an alkyl group having 1 to 20 carbon atoms or the like; R2 represents an acyl group having 1 to 20 carbon atoms or the like; R3 represents a hydrogen atom or the like; and Y represents a group of formula (Y1). In the formula (Y1), * represents a bonding site with N, or a group of formula (Y2). In the formula (Y2), * represents a bonding site with N; P1 and P2 each independently represent —S— or the like; and Q1 and Q2 each independently represent ═N— or the like.

4. 发明授权

US09242993B2 Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors 有权
标题翻译：吗啉代取代的双环嘧啶脲或氨基甲酸酯衍生物作为mTOR抑制剂
公开(公告)号：US09242993B2
公开(公告)日：2016-01-26
申请号：US14350167
申请日：2012-10-05
申请人： CELLZOME LIMITED
发明人： Rosemary Lynch , Andrew David Cansfield , Daniel Paul Hardy , John Thomas Feutrill , Rita Adrego , Katie Ellard , Tammy Ladduwahetty
IPC分类号： A61K31/5377 , A61K31/5386 , A61K31/519 , C07D417/02 , C07D495/04 , C07D498/08
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/5386 , C07D417/02 , C07D498/08
摘要： The invention relates to compounds of formula (I) wherein m, o, Ra, Rb, R1 and T1 have the meaning as cited in the description and the claims. The compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including the compounds, the preparation of the compounds as well as their use as medicaments.
摘要翻译：本发明涉及式（I）化合物，其中m，o，Ra，Rb，R 1和T 1具有在说明书和权利要求书中引用的含义。该化合物可用作mTOR的抑制剂，用于治疗或预防mTOR相关疾病和病症。本发明还涉及药物组合物，包括化合物，化合物的制备以及它们作为药物的用途。

5. 发明授权

US09096558B2 N-sulfonylbenzamide compounds 有权
标题翻译： N-磺酰基苯甲酰胺化合物
公开(公告)号：US09096558B2
公开(公告)日：2015-08-04
申请号：US13808633
申请日：2011-07-01
申请人： Benjamin Scott Greener , Brian Edward Marron , David Simon Millan , David James Rawson , Robert Ian Storer , Nigel Alan Swain
发明人： Benjamin Scott Greener , Brian Edward Marron , David Simon Millan , David James Rawson , Robert Ian Storer , Nigel Alan Swain
IPC分类号： C07D285/08 , C07D417/02 , C07D417/06 , C07D417/12 , A61K31/433 , A61K31/501 , A61K31/4439 , C07D285/135 , C07D401/12 , A61K45/06
CPC分类号： C07D285/135 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K45/06 , C07D285/08 , C07D401/12 , C07D417/12
摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I) or pharmaceutically acceptable salts thereof, wherein X, Y1, Y2, Z, R1, R2 and R3 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译：本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。更具体地，本发明涉及式（I）的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐，其中X，Y1，Y2，Z，R1，R2和R3如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。

6. 发明授权

US08809326B2 Isoquinolinone Rho kinase inhibitors 有权
标题翻译：异喹啉酮Rho激酶抑制剂
公开(公告)号：US08809326B2
公开(公告)日：2014-08-19
申请号：US11856740
申请日：2007-09-18
申请人： Todd Bosanac , John David Ginn , Eugene Richard Hickey , Thomas Martin Kirrane, Jr. , Weimin Liu , Anthony S. Prokopowicz , Sabine K. Schlyer , Cheng-Kon Shih , Roger John Snow , Michael Robert Turner , Frank Wu , Erick Richard Young
发明人： Todd Bosanac , John David Ginn , Eugene Richard Hickey , Thomas Martin Kirrane, Jr. , Weimin Liu , Anthony S. Prokopowicz , Sabine K. Schlyer , Cheng-Kon Shih , Roger John Snow , Michael Robert Turner , Frank Wu , Erick Richard Young
IPC分类号： A61P9/00 , A61P13/00 , A61P15/10 , A61P27/06 , A61P11/06 , C07D217/24 , C07D401/02 , C07D417/02 , C07D239/88 , A61K31/541 , A61K31/4725 , A61K31/472 , C07D239/90 , C07D487/08 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/517 , A61K31/5377 , A61K31/496
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/541 , C07D217/24 , C07D239/88 , C07D239/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/08
摘要： Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.
摘要翻译：公开了用作Rho激酶抑制剂的新型取代的2H-异喹啉-1-酮和3H-喹唑啉-4-酮衍生物，并用于治疗通过Rho激酶（包括心血管疾病）的活性介导或维持的多种疾病和病症包含这些化合物的药物组合物，使用这些化合物的方法和制备这些化合物的方法。

7. 发明授权

US08604204B2 Fluorescent dyes 有权
标题翻译：荧光染料
公开(公告)号：US08604204B2
公开(公告)日：2013-12-10
申请号：US13733324
申请日：2013-01-03
申请人： Enzo Life Sciences, Inc.
发明人： Praveen Pande , Zaiguo Li , Maciej Szczepanik , Wayne Forrest Patton
IPC分类号： C07D417/02 , C12Q1/00
CPC分类号： C09B23/164 , C09B23/0066 , C09B23/0075 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146 , C12Q1/68 , G01N33/583
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.
摘要翻译：本发明提供可用于检测或定量所需靶分子（例如蛋白质，核酸和细胞器器）的染料，活性染料和标记试剂。提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。已经对本发明的新型染料进行了改进以提供有益的性质。

8. 发明授权

US08541592B2 Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 失效
标题翻译： 11-β-羟基类固醇脱氢酶抑制剂1型
公开(公告)号：US08541592B2
公开(公告)日：2013-09-24
申请号：US11598238
申请日：2006-11-13
申请人： Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric A. Bercot , Christopher H. Fotsch , Aiwen Li , Guolin Cai , Randall W. Hungate , Chester Chenguang Yuan , Christopher Tegley , David J. St. Jean, Jr. , Nianhe Han , Qi Huang , Qingyian Liu , Michael D. Bartberger , George A. Moniz , Matthew J. Frizzle , Teresa L. Marshall
发明人： Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric A. Bercot , Christopher H. Fotsch , Aiwen Li , Guolin Cai , Randall W. Hungate , Chester Chenguang Yuan , Christopher Tegley , David J. St. Jean, Jr. , Nianhe Han , Qi Huang , Qingyian Liu , Michael D. Bartberger , George A. Moniz , Matthew J. Frizzle , Teresa L. Marshall
IPC分类号： A61K31/454 , A61K31/4439 , A61K31/426 , A61K31/427 , C07D277/60 , C07D277/54 , C07D417/02
CPC分类号： C07D277/54 , C07D277/60 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译：本发明涉及噻唑啉酮以及包含该化合物的药物组合物，以及该化合物用于治疗与人类11-β-羟基类固醇脱氢酶1型酶有关的病症的用途的方法以及用于制备作用于人类11-β-羟基类固醇脱氢酶1型酶。

9. 发明授权

US08524753B2 Compounds that are useful for improving pharmacokinetics 有权
标题翻译：可用于改善药代动力学的化合物
公开(公告)号：US08524753B2
公开(公告)日：2013-09-03
申请号：US13362833
申请日：2012-01-31
申请人： Dale J. Kempf , Charles A. Flentge , John T. Randolph , Peggy Huang , Larry L. Klein
发明人： Dale J. Kempf , Charles A. Flentge , John T. Randolph , Peggy Huang , Larry L. Klein
IPC分类号： A61K31/427 , A61K31/426 , C07D417/02 , C07D277/38
CPC分类号： C07D277/30 , A61K31/426 , A61K31/427 , A61K45/06 , C07C53/18 , C07D213/30 , C07D231/12 , C07D233/64 , C07D263/32 , C07D277/24 , C07D277/38 , C07D277/587 , C07D333/16 , C07D417/04
摘要： Novel compounds of formula 1 or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.
摘要翻译：新的式1化合物或其药学上可接受的盐抑制细胞色素P450单加氧酶。

10. 发明授权

US08470855B2 Dual-use peptidase inhibitors as prodrugs for a therapy of inflammatory and other diseases 失效
标题翻译：双用肽酶抑制剂作为治疗炎症和其他疾病的前药
公开(公告)号：US08470855B2
公开(公告)日：2013-06-25
申请号：US12085096
申请日：2006-11-10
申请人： Siegfried Ansorge , Klaus Neubert , Ute Bank , Irene Reichstein , Jürgen Faust , Michael Täger , Petra Fuchs , Bianca Senns
发明人： Siegfried Ansorge , Klaus Neubert , Ute Bank , Irene Reichstein , Jürgen Faust , Michael Täger , Petra Fuchs , Bianca Senns
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/427 , A61K31/4025 , C07D277/04 , C07D207/04 , C07D401/02 , C07D401/14 , C07D417/02 , C07D417/14
CPC分类号： C07D277/04 , C07D295/185 , C07D417/12 , C07D417/14
摘要： Compounds of the general formulae (1) and (2) A-B-D-B′-A′ (1) and A-B-D-E (2) in which A and A′ may be identical or different and are the residue in which X is S, O, CH2, CH2CH2, CH2O or CH2NH, and Y is H or CN, and * designates a chiral carbon atom preferably in S- or L-configuration; B and B′ may be identical or different and are an O, N or S containing or non-containing, unsubstituted or substituted, unbranched or branched alkylene residue, cycloalkylene residue, aralkylene residue, heterocycloalkylene residue, heteroarylalkylene residue, arylamidoalkylene residue, heteroarylamidoalkylene residue, unsubstituted or mono- or poly-substituted arylene residue or heteroarylene residue having one or more five-, six- or seven-membered ring(s); D is —S—S— or —Se—Se—; and E is the group —CH2—CH(NH2)—R9 or —CH2—*CH(NH2)—R9 respectively in which R9 is an O, N or S containing or non-containing, unsubstituted or substituted, unbranched or branched alkyl residue, cycloalkyl residue, aralkyl residue, heterocycloalkyl residue, heteroarylalkyl residue, arylamidoalkyl residue, heteroarylamidoalkyl residue, unsubstituted or mono- or poly-substituted aryl residue or heteroaryl residue having one or more five-, six- or seven-membered ring(s) and * designates a chiral carbon atom preferably in the S- or L-configuration; or the acid addition salts thereof with organic and/or inorganic acids; as well as to the use of the compounds of the general formulae (1) and (2) in medicine.
摘要翻译：通式（1）和（2）ABD-B'-A'（1）和ABDE（2）的化合物，其中A和A'可以相同或不同，并且是其中X是S，O， CH2，CH2CH2，CH2O或CH2NH，Y是H或CN，*表示手性碳原子，优选为S-或L-构型; B和B'可以相同或不同，是含有或不含，未取代或未取代的未支化或支链的亚烷基，亚环烷基，亚芳基残基，杂环亚烷基残基，杂芳基亚烷基残基，芳基酰氨基亚烷基残基，杂芳基酰氨基亚烷基残基未取代的或单取代或多取代的亚芳基或具有一个或多个五元，六元或七元环的杂芳基残基; D是-S-S-或-Se-Se-; 并且E分别是基团-CH 2 -CH（NH 2）-R 9或-CH 2 - * CH（NH 2）-R 9，其中R 9是含有或不含有，未取代或取代的未支化或支链烷基的O，N或S 残基，环烷基残基，芳烷基残基，杂环烷基残基，杂芳基烷基残基，芳基酰氨基烷基残基，杂芳基氨基烷基残基，未取代的或单取代或多取代的芳基残基或具有一个或多个五元，六元或七元环的杂芳基残基，和*表示优选为S-或L-构型的手性碳原子; 或其与有机和/或无机酸的酸加成盐; 以及在药物中使用通式（1）和（2）的化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式