专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11603533B2 Incorporation of internal polya-encoded poly-lysine sequence tags and their variations for the tunable control of protein synthesis in bacterial and eukaryotic cells 有权
公开(公告)号：US11603533B2
公开(公告)日：2023-03-14
申请号：US16317761
申请日：2017-07-12
申请人： Washington University , The John Hopkins University
发明人： Sergej Djuranovic , Rachel Green
IPC分类号： C12N15/64 , C12N9/22 , C12N15/11
摘要： The present disclosure relates to modulation of protein expression.

2. 发明授权

US11602569B2 Synthetic DNA vectors and methods of use 有权
公开(公告)号：US11602569B2
公开(公告)日：2023-03-14
申请号：US17675899
申请日：2022-02-18
申请人： Intergalactic Therapeutics, Inc.
发明人： Bruce C. Schnepp , Philip R. Johnson
IPC分类号： A61K48/00 , C12N15/64 , C12N15/86
摘要： Provided herein are isolated DNA vectors comprising a heterologous gene, wherein the DNA vector is devoid of bacterial plasmid DNA and/or bacterial signatures, which can abrogate persistence in vivo. The invention also features pharmaceutical compositions (non-immunogenic pharmaceutical compositions) including the DNA vectors of the invention, which can be used for induction of long-term, episomal expression of a heterologous gene in a subject. The invention involves methods of treating a subject by administering the DNA vectors of the invention, including methods of treating disorders associated with a defect in a target gene.

3. 发明申请

US20230065495A1 MULTIPARTITE AND CIRCULARLY PERMUTED BETA-BARREL POLYPEPTIDES AND METHODS FOR THEIR USE 有权
公开(公告)号：US20230065495A1
公开(公告)日：2023-03-02
申请号：US17760165
申请日：2021-02-05
申请人： University of Washington
发明人： Jason C. KLIMA , David BAKER
IPC分类号： C07K14/00 , C12N15/64
摘要： Disclosed herein are β-barrel polypeptides including self-complementing multipartite β-barrel polypeptides and circularly permuted β-barrel polypeptides and methods for their design and use in mediating real-time monitoring of polypeptide-polypeptide association and dissociation events.

4. 发明申请

US20230044600A1 In-vivo Continuous Directed Evolution System and Application Thereof 有权
公开(公告)号：US20230044600A1
公开(公告)日：2023-02-09
申请号：US17935605
申请日：2022-09-27
申请人： Jiangnan University
发明人： Jing Wu , Zhanzhi Liu , Xinyu Zhang , Ying Xu
IPC分类号： C12N15/10 , C12N15/64
摘要： The disclosure discloses an in-vivo continuous directed evolution system and application thereof, and belongs to the fields of gene engineering and enzyme engineering. The system includes Escherichia coli host bacteria carrying a random mutation module mutagenesis plasmid, a programmed death module toxin-antitoxin system and a target gene expression module target plasmid. The modules are coupled with one another, and target genes are subjected to multiple rounds of continuous mutation by virtue of the random mutation module mutagenesis plasmid in the system, so that the mutation rate of the target genes is further increased, and ultimately, efficient evolution and screening of the target genes in the host bacteria are realized. According to the system, mutations are accurately positioned on the target genes, random mutations in non-target gene regions are reduced, and the system has good practical value and can be applied to directed evolution of various different functional proteins.

5. 发明申请

US20230021388A1 ANTI-ROR1 ANTIBODIES AND COMPOSITIONS 有权
公开(公告)号：US20230021388A1
公开(公告)日：2023-01-26
申请号：US17795949
申请日：2021-02-05
申请人： VelosBio Inc.
发明人： Jeffry D. WATKINS , Thanh-Trang VO , J. Monty WATKINS
IPC分类号： C07K16/28 , A61P35/00 , C12N15/64 , A61K47/68
摘要： This invention relates to anti-ROR1 antibodies and methods of using them in treating diseases and conditions related to ROR1 activity, e.g., cancer.

6. 发明申请

US20220402984A1 LYSIN-ANTIMICROBIAL PEPTIDE (AMP) POLYPEPTIDE CONSTRUCTS, LYSINS, ISOLATED POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF 有权
公开(公告)号：US20220402984A1
公开(公告)日：2022-12-22
申请号：US17816318
申请日：2022-07-29
申请人： CONTRAFECT CORPORATION
发明人： Raymond SCHUCH
IPC分类号： C07K14/47 , C12N15/64 , A61P31/04
摘要： The present disclosure is directed to a lysin-AMP polypeptide construct comprising: (a) a first component comprising the polypeptide sequence of: (i) SEQ ID NO: 118 (GN202); or (ii) a polypeptide having lysin activity and having at least 80% sequence identity with the polypeptide sequence of SEQ ID NO: 118 (GN202); or (iii) an active fragment of SEQ ID NO: 118 (GN202); and (b) a second component comprising the polypeptide sequence of at least one antimicrobial peptide (AMP), wherein the at least one AMP comprises SEQ ID NO: 114 (FIRL). Exemplary lysin-AMP polypeptides, such as GN370 (SEQ ID NO: 44) as well as methods of treating bacterial infections using the present lysin-AMP polypeptide constructs are also disclosed.

7. 发明授权

US11517583B2 Trans-splicing RNA (tsRNA) 有权
公开(公告)号：US11517583B2
公开(公告)日：2022-12-06
申请号：US16090226
申请日：2017-03-31
申请人： NATIONAL UNIVERSITY OF SINGAPORE
发明人： Volker Patzel , Sushmita Poddar
IPC分类号： A61K31/7105 , C12N15/85 , A61P25/14 , A61P25/28 , A61P31/12 , A61P31/04 , A61P35/00 , A61K48/00 , C12N15/113 , C12N15/64
摘要： The invention concerns a trans-splicing RNA (tsRNA) molecule comprising one or multiple unstructured binding domains; a cell or vector comprising said tsRNA; and a method for killing cells or treating a disease using said tsRNA.

8. 发明申请

US20220380784A1 UNIVERSAL DNA ASSEMBLY 有权
公开(公告)号：US20220380784A1
公开(公告)日：2022-12-01
申请号：US17599616
申请日：2020-04-02
申请人： Oxford University Innovation Limited
发明人： Da LIN , Katherine ROBINS , Chris O'CALLAGHAN
IPC分类号： C12N15/64 , C12N15/11 , C12N9/22 , C12N9/10 , C12N15/66
摘要： The invention relates to a nucleic acid comprising at least one methylation-protectable restriction element, the methylation-protectable restriction element comprising: (i) a type IIS restriction enzyme recognition sequence, or a partial type IIS restriction enzyme recognition sequence, that is recognised by a type IIS restriction enzyme that cleaves outside of the recognition sequence; (ii) a DNA methylase recognition sequence that is recognised and methylated by a DNA methylase, wherein the DNA methylase recognition sequence is identical to, or is encompassed within, the type IIS restriction recognition sequence, such that methylation of the nucleic acid by the DNA methylase methylates the type IIS restriction enzyme recognition sequence and protects the nucleic acid from cleavage by the type IIS restriction enzyme; and (iii) a recognition sequence for a sequence-specific DNA-binding protein, wherein the recognition sequence is positioned such that the binding of the sequence-specific DNA-binding protein overlaps with the DNA methylase recognition sequence such that binding of the sequence-specific DNA-binding protein is capable of preventing methylation of the type IIS restriction enzyme recognition sequence by the DNA methylase such that it is not protected from cleavage by the type IIS restriction enzyme. The invention further relates to associated methods of nucleic acid assembly.

9. 发明申请

US20220372455A1 CRISPR TYPE V-U1 SYSTEM FROM MYCOBACTERIUM MUCOGENICUM AND USES THEREOF 有权
公开(公告)号：US20220372455A1
公开(公告)日：2022-11-24
申请号：US17624439
申请日：2020-07-03
申请人： Wageningen Universiteit
发明人： John Van Der Oost , Prarthana Mohanraju , Wen Ying Wu , Sjoerd Creutzburg
IPC分类号： C12N9/22 , C12N15/11 , C12N9/78 , C12N15/62 , C12N15/64 , C12N15/90 , C07K16/46
摘要： The type V-U1 system from the bacterium Mycobacterium mucogenicum CCH10-A2 (Mmu) has a nuclease which binds dsDNA but it does not cleave it. Additionally, after dsDNA binding by the nuclease an RuvC-dependent interference of nascent transcript (mRNA) takes place and this mechanism has not been described before for any CRISPR system. CRISPR based gene manipulation can therefore use CRISPR endonucleases from the Type V-U1 system from Mycobacterium mucogenicum, including variant and modified endonucleases, so as to provide for methods of expression control and gene editing in cells of any living organism or of any nucleic acid in vitro.

10. 再颁专利

USRE49280E1 TGFbeta type II-type III receptor fusions 有权
公开(公告)号：USRE49280E1
公开(公告)日：2022-11-08
申请号：US16375242
申请日：2019-04-04
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： Andrew Hinck , Luzhen Sun , Christian Zwieb
IPC分类号： C07K14/00 , C12N15/85 , C07K14/495 , C07K14/71 , C12N15/64
摘要： Certain embodiments are directed to novel heterotrimeric fusions in which the ectodomain of the TGF-β type II receptor (TβP?II) is coupled to the N- and C-terminal ends of the endoglin-domain of the TGF-β type III receptor (TpRIIIE). Certain embodiments are directed to novel heterotrimeric polypeptides in which the ectodomain of the TGF-β type II receptor (TI3RII) is coupled to the N- and C-terminal ends of the endoglin-domain (E domain) of the TGF-β type III receptor (TI3RIII). This trimeric receptor, known as RER, can bind all three TGF-β isoforms with sub-nanomolar affinity and is effective at neutralizing signaling induced by all three TGF-β isoforms, but not other ligands of the TGF-β superfamily, such as activins, growth and differentiation factors (GDFs), and bone morphonogenetic proteins (BMPs).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式