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1. 发明授权

US11626275B2 Isotopic mass spectrometer 有权
公开(公告)号：US11626275B2
公开(公告)日：2023-04-11
申请号：US17266991
申请日：2019-08-13
申请人： Thermo Fisher Scientific (Bremen) GmbH , California Institute of Technology
发明人： John M. Eiler , Simon Cajetan Neubauer , Michael J. Sweredoski , Jens Griep-Raming
IPC分类号： H01J49/00 , H01J49/42
摘要： A method for determining an isotopic profile for a molecule is provided. The isotopic profile is indicative of an isotopic content for the molecule. The method comprises mass selecting ions of the molecule in a mass window, the mass window excluding a mass for a monoisotopic molecular ion and including a mass for at least one isotopic variant of the monoisotopic molecular ion. The method comprises fragmenting the mass selected ions into fragment ions, performing mass analysis on one or more of the fragment ions to produce a mass spectrum, and determining the isotopic profile for the molecule, the isotopic profile comprising at least one data value. Each data value is calculated for a fragment ion as a function of intensities of multiple peaks in the mass spectrum. A computer program is provided. A mass spectrometry system is provided. A method for identifying a sample is provided.

2. 发明授权

US11594405B2 Charge detection mass spectrometer including gain drift compensation 有权
公开(公告)号：US11594405B2
公开(公告)日：2023-02-28
申请号：US17468841
申请日：2021-09-08
申请人： THE TRUSTEES OF INDIANA UNIVERSITY
发明人： Martin F. Jarrold , Andrew W. Alexander , Aaron R. Todd
IPC分类号： H01J49/02 , H01J49/42 , H01J49/00
摘要： A CDMS may include an ELIT having a charge detection cylinder (CD), a charge generator for generating a high frequency charge (HFC), a charge sensitive preamplifier (CP) having an input coupled to the CD and an output configured to produce a charge detection signal (CHD) in response to a charge induced on the CD, and a processor configured to (a) control the charge generator to induce an HFC on the CD, (b) control operation of the ELIT to cause a trapped ion to oscillate back and forth through the CD each time inducing a charge thereon, and (c) process CHD to (i) determine a gain factor as a function of the HFC induced on the CD, and (ii) modify a magnitude of the portion of CHD resulting from the charge induced on the CD by the trapped ion passing therethrough as a function of the gain factor.

3. 发明申请

US20230046612A1 ION MOBILITY SPECTROMETRY-MASS SPECTROMETRY COMBINED ANALYSIS DEVICE 有权
公开(公告)号：US20230046612A1
公开(公告)日：2023-02-16
申请号：US17882803
申请日：2022-08-08
申请人： Shimadzu Corporation
发明人： Wenjian SUN , Kuo-Feng TSENG , Keke WANG , Xiaoqiang ZHANG
IPC分类号： G01N27/623 , H01J49/42
摘要： An ion mobility spectrometry-mass spectrometry combined analysis device includes an ionization source producing target analyte ions; an ion mobility filter receiving at least a part of the target analyte ions from the ionization source and operating in a sub-atmospheric environment to select ions within a specified mobility range from the target analyte ions to pass; and a mass filter connected to the rear stage of the ion mobility filter selecting ions in a specified mass-to-charge ratio range from the ions within the specified mobility range to pass. The ion mobility spectrometry-mass spectrometry combined device can separate the target ions based on a collision cross section under the combined action of a scanning electric field and an external gas flow, and operate at low gas pressure, which improves the efficiency of target analysis and an intra-spectrum dynamic range, and perform highly reliable and accurate quantitative analysis on specific target ions.

4. 发明申请

US20230039701A1 CHARGE FILTER ARRANGEMENT AND APPLICATIONS THEREOF 有权
公开(公告)号：US20230039701A1
公开(公告)日：2023-02-09
申请号：US17781485
申请日：2020-12-16
申请人： THE TRUSTEES OF INDIANA UNIVERSITY
发明人： Martin F. JARROLD , David E. CLEMMER
IPC分类号： H01J49/42 , H01J49/06
摘要： A charge filter instrument includes a field-free drift region, a plurality of charge detection cylinders in the drift region through which ions drifting axially therethrough pass, a plurality of charge sensitive amplifiers each coupled to at least one charge detection cylinder and configured to produce a charge detection signal corresponding to a charge of one or more of ions passing therethrough, a single inlet, single outlet charge deflector or a single inlet, multiple outlet charge steering device coupled to the outlet end of the drift region, means for determining charge magnitudes or charge states of ions drifting axially through the drift region based on the charge detection signals, and means for controlling the charge deflector or the charge steering device to pass through the single outlet or through a specified one of the multiple outlets only ions having a specified charge magnitude or charge state.

5. 发明申请

US20230035661A1 INTERPOSER WITH LOAD HOLE FOR ION TRAP 有权
公开(公告)号：US20230035661A1
公开(公告)日：2023-02-02
申请号：US17877261
申请日：2022-07-29
申请人： IonQ, Inc.
发明人： James Walker STEERE
IPC分类号： H01J49/42
摘要： An interposer is described that is made from an electrically insulating, thermally efficient substrate (e.g., sapphire) and has a load hole for use with ion traps in atomic-based QIP architectures. The interposer load hole aligns with a load hole in the ion trap such that atomic species can be provided from the back of the interposer to the front of the ion trap for ionization and confinement. The interposer may include angled traces for wire bonding to the ion trap, where the angled traces enable more open light access when using laser or optical beams during operation of the ion trap. Electrical routing in the interposer may involve more than one layer of routing, separated by an insulating dielectric material such as a polyimide. Routing in the interposer may also contain active electronic components. The load hole in the interposer may have a straight or tapered inner wall.

6. 发明申请

US20230016267A1 Mass Spectrometer 有权
公开(公告)号：US20230016267A1
公开(公告)日：2023-01-19
申请号：US17783008
申请日：2021-02-04
申请人： YOUNG IN ACE Co., Ltd.
发明人： Sung Won Kang , Hun Lee , Yoon Jin Jeong
IPC分类号： H01J49/04 , H01J49/42 , H01J49/10 , H01J49/00
摘要： Provided is a mass spectrometer including: an ion generation unit configured to provide an ion generation path; an ion selection unit configured to provide an ion selection path connected to the ion generation path; a reaction unit configured to provide a reaction path connected to the ion selection path; a second ion selection unit configured to provide a second ion selection path connected to the reaction path; and an ion detection unit coupled to the second ion selection unit. The ion selection path and the reaction path extend in a first direction, and the reaction unit includes: a reaction pipe extending in the first direction to define the reaction path; and a sample inflow pipe coupled to the reaction pipe. The sample inflow pipe provides a sample inflow path connected to the reaction path, and the sample inflow path includes an inclined path. The inclined path extends to form an acute angle (α) with respect to the first direction.

7. 发明申请

US20230013173A1 MASS SPECTROMETER WITH CHARGE MEASUREMENT ARRANGEMENT 有权
公开(公告)号：US20230013173A1
公开(公告)日：2023-01-19
申请号：US17781483
申请日：2020-12-16
申请人： THE TRUSTEES OF INDIANA UNIVERSITY
发明人： Martin F. JARROLD , David E. CLEMMER
IPC分类号： H01J49/02 , H01J49/42 , H01J49/40 , H01J49/16
摘要： A mass spectrometer may have an ion source region including an ion generator configured to generate ions from a sample, an ion detector configured to detect ions and produce corresponding ion detection signals, an electric field-free drift region disposed between the ion source region and the ion detector through which the generated ions drift axially toward the ion detector, a plurality of spaced-apart charge detection cylinders disposed in the drift region and through which the ions drifting axially through the drift region pass, and a plurality of charge amplifiers each coupled to a different one of the plurality of charge detection cylinders and each configured to produce a charge detection signal corresponding to a magnitude of charge of one or more of the generated ions passing through a respective one of the plurality of charge detection cylinders.

8. 发明授权

US11538675B2 Rapid identification and sequence analysis of intact proteins in complex mixtures 有权
公开(公告)号：US11538675B2
公开(公告)日：2022-12-27
申请号：US16307615
申请日：2017-06-05
申请人： Donald F. Hunt , Ann M. English , Scott A. Ugrin , Dina L. Bai , Jeffrey Shabanowitz , John Edward Philip Syka
发明人： Donald F. Hunt , Ann M. English , Scott A. Ugrin , Dina L. Bai , Jeffrey Shabanowitz , John Edward Philip Syka
IPC分类号： H01J49/00 , G01N33/68 , H01J49/04 , H01J49/42
摘要： The present disclosure relates to novel and improved methods of analyzing proteins, peptides and polypeptides by mass spectrometry using ion-ion reactions. More specifically the disclosure relates to improved methods for implementing the m/z selective arresting of ion-ion reactions within the ion-ion reaction cell of a mass spectrometer system during a period where ion-ion reactions are performed.

9. 发明授权

US11532471B2 Instrument for separating ions including an interface for transporting generated ions thereto 有权
公开(公告)号：US11532471B2
公开(公告)日：2022-12-20
申请号：US17468738
申请日：2021-09-08
申请人： THE TRUSTEES OF INDIANA UNIVERSITY
发明人： Martin F. Jarrold , Staci N. Anthony , Benjamin E. Draper
IPC分类号： H01J49/06 , H01J49/02 , H01J49/24 , H01J49/42
摘要： An instrument for separating ions may include an ion source in a first pressure environment at a first pressure and configured to generate ions from a sample, an ion separation instrument, controlled to an instrument pressure that is less than the first pressure, and configured to separate ions as a function of at least one molecular characteristic and an interface, controlled to a second pressure less than the first pressure and greater than the instrument pressure, for transporting the generated ions from the first pressure environment into the ion separation instrument operating at the instrument pressure. The interface may include a sealed ion funnel defining an axial passageway therethrough, and an ion carpet sealed to the first ion funnel. A portion of the axial passageway tapers from a first cross-sectional area to a reduced cross-sectional area such that the tapered axial passageway defining a virtual jet disrupter therein.

10. 发明授权

US11527395B2 Ion entry/exit device 有权
公开(公告)号：US11527395B2
公开(公告)日：2022-12-13
申请号：US17130636
申请日：2020-12-22
申请人： Micromass UK Limited
发明人： Kevin Giles , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/06 , G01N27/622 , H01J49/42 , H01J49/00 , H01J49/40
摘要： A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.

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