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21. 发明申请

WO2020210937A1 SYSTEMS AND METHODS FOR INTERPOLATIVE THREE-DIMENSIONAL IMAGING WITHIN THE VIEWING ZONE OF A DISPLAY 审中-公开
公开(公告)号：WO2020210937A1
公开(公告)日：2020-10-22
申请号：PCT/CN2019/082642
申请日：2019-04-15
申请人： SHANGHAI NEW YORK UNIVERSITY
发明人： BALLARD, Cameron , LUO, Bruce , SANTIANO, David , NAIMARK, Michael , HUANG, Grace , JUVERA MOLINA, Mateo , ZHAO, Ada
IPC分类号： H04N13/00 , H04N7/15
摘要： Methods and systems for three-dimensional video capture are provided. A plurality of cameras (112) attached to a frame (108), each camera (112) configured to generate a three-dimensional array of pixels of a viewing zone of a display (110), may provide the arrays to an interpolator (122) executed by a processor (116) of a device (100). The interpolator (122) may combine the plurality of three-dimensional arrays of pixels from the plurality of cameras (112) into an output three-dimensional array of pixels for rendering locally at a display (110) or transmission to a remote device (102) for rendering at a display (110) of the remote device (102).

22. 发明申请

WO2020209988A9 DIVERSE MARKER PANEL FOR PTSD DIAGNOSIS AND TREATMENT 审中-公开
公开(公告)号：WO2020209988A9
公开(公告)日：2020-10-15
申请号：PCT/US2020/023028
申请日：2020-03-16
申请人： INSTITUTE FOR SYSTEMS BIOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH , U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND , ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , NEW YORK UNIVERSITY , MCLEAN HOSPITAL CORPORATION , GENEVA FOUNDATION
发明人： DEAN, Kelsey R. , DOYLE III, Francis J. , MELLON, Synthia H. , WOLKOWITZ, Owen M. , LEE, Inyoul , HOOD, Leroy , YANG, Ruoting , HAMMAMIEH, Rasha , JETT, Marti , YEHUDA, Rachel , MARMAR, Charles R. , RESSLER, Kerry J. , GAUTAM, Aarti , FLORY, Janine , WANG, Kai
IPC分类号： C12Q1/686
摘要： The invention described is directed to a method to treat PTSD in a subject which method includes identifying the subject as suffering from PTSD or likely to suffer from PTSD by virtue of assessing one or more of the markers set forth herein, and treating the subject thus identified.

23. 发明申请

WO2020206314A8 LIPOSOMES ENCAPSULATING ADENOSINE 审中-公开
公开(公告)号：WO2020206314A8
公开(公告)日：2020-10-08
申请号：PCT/US2020/026658
申请日：2020-04-03
申请人： NEW YORK UNIVERSITY
发明人： ANGLE, Siddhesh, R. , CORCIULO, Carmen , CRONSTEIN, Bruce, N. , KAUFMAN, Jonathan
IPC分类号： A61K31/7048 , A61K33/24 , A61K47/48 , A61K31/7076
摘要： Provided are liposomes that encapsulate adenosine. The liposomes may be formed from sphingomyelin or a combination of sphingomyelin and l,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or a combination of sphingomyelin and l,2-dimyristoyl-sn-glycero-3-phosphorylglycerol (DMPG) or a combination of sphingomyelin, DMPG, and DMPC. The liposomes encapsulating adenosine may be used to induce cartilage regeneration, treat osteoarthritis, alleviate joint pain, and/or slow, arrest, and/or reverse progressive structural tissue damage associated with osteoarthritis or treat osteoarthritis, rheumatoid arthritis, acute gouty arthritis, and/or synovitis. The liposomes may release adenosine for up to two weeks.

24. 发明申请

WO2020172655A1 PHOTOSWITCHABLE PROTACS AND SYNTHESIS AND USES THEREOF 审中-公开
公开(公告)号：WO2020172655A1
公开(公告)日：2020-08-27
申请号：PCT/US2020/019458
申请日：2020-02-24
申请人： NEW YORK UNIVERSITY
发明人： TRAUNER, Dirk , REYNDERS, Martin , MATSUURA, Bryan , BEROUTI, Marleen , PAGANO, Michele
IPC分类号： C07J43/00
摘要： Provided are compounds, which may be referred to as PHOTACs (photoswitchable proteolysis targeting chimeras), and compositions, kits, and methods of making and using PHOTACs. PHOTACs have one or more E3 ligase ligand(s), one or more photoswitchable group(s), optionally, one or more linker(s), and one or more ligand(s) for a target protein. PHOTACs may be suitable for use in methods to treat diseases, such as, for example, cancer. PHOTACs may also be suitable for use in methods to induce selective degradation of a target protein.

25. 发明申请

WO2019060888A1 HETERODIMERIC-FC-FUSION PROTEINS 审中-公开
公开(公告)号：WO2019060888A1
公开(公告)日：2019-03-28
申请号：PCT/US2018/052639
申请日：2018-09-25
申请人： NEW YORK UNIVERSITY
发明人： KONG, Xiang-Peng , MOR, Adam , PHILIPS, Elliot
IPC分类号： A61K39/395 , A61K38/16 , A61K38/17 , C07K14/705 , C07K16/18 , C07K16/28 , A61P35/04 , A61P35/00
摘要： The present invention relates to immunomodulatory agents and methods of modulating a subject's T cell immune response. The immunomodulatory compositions described herein include heterodimeric-fusion proteins and peptides designed to mimic members of the B7 family of cell-surface protein ligands, which bind to and induce signal transduction through the CD28 family of receptors and others.

26. 发明申请

WO2019046540A1 METHODS AND COMPOSITIONS COMPRISING CRISPR-CPF1 AND PAIRED GUIDE CRISPR RNAS FOR PROGRAMMABLE GENOMIC DELETIONS 审中-公开
公开(公告)号：WO2019046540A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/048767
申请日：2018-08-30
申请人： NEW YORK GENOME CENTER, INC. , NEW YORK UNIVERSITY
发明人： SANJANA, Neville, Espi
IPC分类号： C12N15/11 , C12N15/82 , C12N15/85
CPC分类号： C12N9/22 , C12N15/111 , C12N2310/20 , C12N2330/51 , C12N2740/16043
摘要： Described are methods comprises transducing a mammalian cell with one or more virus vectors. Each vector comprises a nucleic acid sequence encoding a Cpfl (also known as Casl2a) protein and an optional selectable marker in operative association with an RNA pol II promoter which controls expression thereof; and a CRISPR RNA (crRNA) array comprising at least two spacers in operative association with an RNA pol III promoter. Each spacer encodes an RNA guide which hybridizes to a unique sequence located 3' from a T-rich protospacer-adjacent motif (PAM) in a genomic region of interest. The method further comprises culturing the transduced cells, thereby providing a plurality of cultured cell cultures, each cell culture comprising said deletion. Additionally, described are compositions used in methods as well as libraries generated by the methods. Such compositions comprise libraries of transduced cell cultures, viral vectors, nucleic acid sequences, CRISPR RNA spacers, and RNA guides, as described herein.

27. 发明申请

WO2018231993A1 SYSTEM AND METHOD FOR PAPER-BASED CRYOPRESERVATION 审中-公开
公开(公告)号：WO2018231993A1
公开(公告)日：2018-12-20
申请号：PCT/US2018/037347
申请日：2018-06-13
申请人： NEW YORK UNIVERSITY
发明人： QASAIMEH, Mohammad A. , ALNEMARI, Roaa
IPC分类号： A01N1/02 , A61J3/00 , B82Y30/00 , C12M1/16 , C12M3/00 , C12N1/00 , G01N33/50
CPC分类号： A01N1/0231 , C12M1/16 , C12M3/00 , C12M45/22
摘要： A system and method for cryopreservation of cells or spheroids of cells including obtaining a suspension of the isolated mammalian cells in a medium; applying the suspension to a fibrous substrate comprising a network of interconnected cellulosic fibers defining a plurality of pores therein and allowing the suspension to absorb into the fibrous substrate such that the isolated mammalian cells penetrate and settle to an interior of the fibrous substrate; and cooling the fibrous substrate to or below a temperature of -80°C.

28. 发明申请

WO2018145082A1 METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING PANCREATIC CANCERS 审中-公开
公开(公告)号：WO2018145082A1
公开(公告)日：2018-08-09
申请号：PCT/US2018/017052
申请日：2018-02-06
申请人： NEW YORK UNIVERSITY
发明人： MILLER, George , SAXENA, Deepak , PUSHALKAR, Smruti
IPC分类号： A61K35/66 , A61K35/741 , A61K35/742 , A61K35/745 , A61K35/747
摘要： The application relates to methods based on modulating mammalian intestinal and/or pancreatic microbiota and related probiotic, prebiotic, and anti-bacterial compositions. Specifically, the application relates to the use of microbiome for prevention, treatment and diagnosis of pancreatic cancers or tumors, such as pancreatic ductal adenocarcinoma.

29. 发明申请

WO2018136805A1 SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR ULTRASOUND ANALYSIS 审中-公开
公开(公告)号：WO2018136805A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014536
申请日：2018-01-19
申请人： NEW YORK UNIVERSITY , YEDA RESEARCH AND DEVELOPMENT CO., LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE
发明人： KEZURER, Itay , LUDOMIRSKY, Achiau , LIPMAN, Yaron
IPC分类号： A61B8/00 , A61B8/02 , G06K9/00 , G06K9/18
摘要： An exemplary system, method and computer-accessible medium for detecting an anomaly(ies) in an anatomical structure(s) of a patient(s) can be provided, which can include, for example, receiving imaging information related to the anatomical structure(s) of the patient(s), classifying a feature(s) of the anatomical structure(s) based on the imaging information using a neural network (s), and detecting the anomaly(ies) based on data generated using the classification procedure. The imaging information can include at least three images of the anatomical structure(s).

30. 发明申请

WO2018009863A1 SCRAMBLE OF HETEROZYGOUS DIPLOID YEAST 审中-公开
标题翻译：杂合双杂体酵母的混合物
公开(公告)号：WO2018009863A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/041194
申请日：2017-07-07
申请人： NEW YORK UNIVERSITY , TIANJIN UNIVERSITY
发明人： SHEN, Michael , BOEKE, Jef, D. , WU, Yi , YUAN, Yingjin
IPC分类号： C12N1/36 , C12N15/10 , C12N15/52 , C12N15/64 , C12N15/66 , C12N15/81
摘要： Provided are compositions and methods for making a diploid yeast having heterozygosity for at least one chromosome. The method includes mating haploid yeast having at least a first modified chromosome comprising a synthetic chromosome suitable for recombination-site-mediated evolution (as a SCRaMbLE-ready modification). The SCRaMbLE-ready modification includes introduced site-specific recombinase recognition sites that can be recognized by a recombinase. Yeast that have at least one SCRaMbLE-ready modification of a chromosome are mated with a haploid yeast devoid of the SCRaMbLE- ready modification to obtain diploid SCRaMbLE-ready yeast. Subsequent to mating the haploid SCRaMbLE-ready yeast to yeast devoid of the SCRaMbLE-ready modification the method includes using the recombinase to recombine the first modified chromosome to obtain heterozygous diploid yeast comprising at least one recombined (SCRaMbLEd) chromosome and a homologous non-SCRaMbLEd chromosome. The method further includes identifying heterozygous diploid yeast that comprise the at least one SCRaMbLEd chromosome that have a changed phenotype that is different from the phenotype of the diploid SCRaMbLE-ready yeast. Yeast made by the methods, compositions of matter made by the yeast, spores made by the yeast, and kits containing the yeast and/or their spores are included.
摘要翻译：提供了用于制造具有至少一个染色体的杂合性的二倍体酵母的组合物和方法。该方法包括交配具有至少第一修饰染色体的单倍体酵母，所述第一修饰染色体包含适合于重组位点介导的进化的合成染色体（作为SCRaMbLE就绪修饰）。 SCRaMbLE就绪修饰包括引入的位点特异性重组酶识别位点，可以被重组酶识别。对至少有一个SCRaMbLE就绪修饰染色体的酵母与没有SCRaMbLE-ready修饰的单倍体酵母交配以获得二倍体SCRaMbLE准备好的酵母。在将单倍体SCRaMbLE就绪酵母与不含SCRaMbLE就绪修饰的酵母交配之后，所述方法包括使用重组酶将第一修饰染色体重组以获得杂合二倍体酵母，所述杂合二倍体酵母包含至少一个重组（SCRaMbLEd）染色体和同源非SCRaMbLEd 染色体。该方法进一步包括鉴定杂合二倍体酵母，该杂合二倍体酵母包含至少一个SCRaMbLEd染色体，其具有改变的表型，该表型与二倍体SCRaMbLE就绪型酵母的表型不同。包括由该方法制造的酵母，由酵母制成的物质组成，由酵母制成的孢子和含有酵母和/或其孢子的试剂盒。

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