专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2015023858A3 USES OF PHOSPHOLIPID CONJUGATES OF SYNTHETIC TLR7 AGONISTS 审中-公开
标题翻译：使用合成TLR7激动剂的磷脂结合
公开(公告)号：WO2015023858A3
公开(公告)日：2015-11-26
申请号：PCT/US2014051090
申请日：2014-08-14
申请人： UNIV CALIFORNIA , CARSON DENNIS A , HAYASHI TOMOKO , COTTAM HOWARD B
发明人： CARSON DENNIS A , HAYASHI TOMOKO , COTTAM HOWARD B
IPC分类号： A61K31/52 , A61K39/39 , C07F9/6561
CPC分类号： A61K31/675
摘要： The invention provides uses for phospholipid conjugates of TLR agonists as enhancers of an innate immune response. Specifically, purine derivatives which are conjugated to a phospholipid or an analog thereof are disclosed as having activity as TLR7 agonists, capable of inducing an innate immune response upon administration in an effective amount to a subject. The phospholipid moiety of the TLR7 agonist contains one or more alkyl ether or ester moieties.
摘要翻译：本发明提供TLR激动剂的磷脂缀合物作为先天免疫应答的增强剂的用途。具体地，与磷脂或其类似物缀合的嘌呤衍生物被公开为具有作为TLR7激动剂的活性，其能够以有效量向受试者施用时诱导先天免疫应答。 TLR7激动剂的磷脂部分含有一个或多个烷基醚或酯部分。

22. 发明申请

WO2014197622A3 LIVER-MIMETIC DEVICE AND METHOD FOR SIMULATION OF HEPATIC FUNCTION USING SUCH DEVICE 审中-公开
标题翻译：肝脏装置和使用这种装置模拟肝功能的方法
公开(公告)号：WO2014197622A3
公开(公告)日：2015-11-05
申请号：PCT/US2014040946
申请日：2014-06-04
申请人： UNIV CALIFORNIA
发明人： QU XIN , GOU MALING , ZHU WEI , CHEN SHAOCHEN
IPC分类号： A61L27/40
CPC分类号： C12N5/0671 , C12N2506/45 , C12N2533/30 , C12N2533/54 , C12N2533/80
摘要： A liver-mimetic device and method include a 3D polymer scaffold having a matrix of liver-like lobules with hepatic-functioning particles encapsulated within the lobules. In some embodiments, each liver-like lobule is hexagonal in structure and the matrix is in a honeycomb arrangement. In some embodiments, the hepatic-functioning particles are hepatic progenitor cells. In other embodiments, the hepatic-functioning particles are polymer nanoparticles adapted to capture pore-forming toxins.
摘要翻译：肝模拟装置和方法包括具有包含在小叶内的肝功能颗粒的肝样小叶的基质的3D聚合物支架。在一些实施方案中，每个肝样小叶的结构是六边形的，并且基质是蜂窝状的。在一些实施方案中，肝功能颗粒是肝祖细胞。在其它实施方案中，肝功能颗粒是适于捕获成孔毒素的聚合物纳米颗粒。

23. 发明申请

WO2014172661A8 LONE STAR VIRUS 审中-公开
标题翻译：孤星星病毒
公开(公告)号：WO2014172661A8
公开(公告)日：2015-10-29
申请号：PCT/US2014034684
申请日：2014-04-18
申请人： UNIV CALIFORNIA , US GOV HEALTH & HUMAN SERV
发明人： CHIU CHARLES , SWEI ANDREA , JOHNSON BARBARA J B
IPC分类号： C12N7/00 , C07K14/175 , C07K16/10 , G01N33/569
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C07K14/005 , C07K16/10 , C07K2317/24 , C12N2760/12221 , C12N2760/12234 , C12N2760/12251 , C12Q1/701 , G01N33/56983 , G01N2333/175 , G01N2469/10
摘要： This disclosure concerns the isolation, identification and sequencing of a unique Phlebovirus, the Lone Star Virus. Lone Star Virus nucleic acid molecules, proteins and antibodies are disclosed. Methods are also disclosed for the detection, diagnostic and treatment of the Lone Star Virus.
摘要翻译：本公开涉及独特的疫苗病毒，孤星病毒的分离，鉴定和测序。公开了孤星病毒核酸分子，蛋白质和抗体。还公开了用于孤星病毒的检测，诊断和治疗的方法。

24. 发明申请

WO2015126499A3 SYSTEMS AND METHODS FOR GNSS SNR PROBABILISTIC LOCALIZATION AND 3-D MAPPING 审中-公开
标题翻译：用于GNSS SNR概率定位和3-D映射的系统和方法
公开(公告)号：WO2015126499A3
公开(公告)日：2015-10-15
申请号：PCT/US2014068220
申请日：2014-12-02
申请人： UNIV CALIFORNIA
发明人： IRISH ANDREW , ISAACS JASON , QUITIN FRANCOIS , HESPANHA JOAO , MADHOW UPAMANYU
IPC分类号： G01C21/24 , G01C21/12
CPC分类号： G01C21/005 , G01S19/22
摘要： Various embodiments each include at least one of systems, methods, devices, and software for GNSS simultaneous localization and mapping (SLAM). The disclosed techniques demonstrate that simultaneous localization and mapping (SLAM) can be performed using only GNSS SNR and geo-location data, collectively termed GNSS data henceforth. A principled Bayesian approach for doing so is disclosed. A 3-D environment map is decomposed into a grid of binary-state cells (occupancy grid) and the receiver locations are approximated by sets of particles. Using a large number of sparsely sampled GNSS SNR measurements and receiver/satellite coordinates (all available from off-the-shelf GNSS receivers), likelihoods of blockage are associated with every receiver-to-satellite beam. Loopy Belief Propagation is used to estimate the probabilities of each cell being occupied or empty, along with the probability of the particles for each receiver location.
摘要翻译：各种实施例各自包括用于GNSS同时定位和映射（SLAM）的系统，方法，设备和软件中的至少一个。所公开的技术证明可以仅使用GNSS SNR和地理位置数据来执行同时定位和映射（SLAM），以下统称为GNSS数据。披露了一个原则性的贝叶斯方法。一个3-D环境地图被分解成一个二元状态单元网格（占用网格），接收器位置通过粒子集合近似。使用大量稀疏采样的GNSS SNR测量和接收器/卫星坐标（全部可从现成的GNSS接收器获得），阻塞的可能性与每个接收器到卫星波束相关联。 Loopy Belief Propagation用于估计每个被占用或空的单元的概率以及每个接收器位置的粒子概率。

25. 发明申请

WO2015120343A3 CONSTRUCTS AND SYSTEMS AND METHODS FOR ENGINEERING A CO2 FIXING PHOTORESPIRATORY BY-PASS PATHWAY 审中-公开
标题翻译：二氧化碳固定光动力呼吸暂停通道工程的结构和系统及方法
公开(公告)号：WO2015120343A3
公开(公告)日：2015-10-15
申请号：PCT/US2015014929
申请日：2015-02-06
申请人： UNIV CALIFORNIA , KERFELD CHERYL A , SHIH PATRICK , ZARZYCKI JAN , NIYOGI KRISHNA K
发明人： KERFELD CHERYL A , SHIH PATRICK , ZARZYCKI JAN , NIYOGI KRISHNA K
IPC分类号： C12N1/00 , C12N1/21 , C12N15/03 , C12N15/05 , C12N15/09 , C12P1/00
CPC分类号： C12N15/8269 , C12N15/8243 , Y02P60/247
摘要： Methods and compositions to introduce a synthetic pathway based on the 3- hydroxypropionate bicycle into an organism such as the model cyanobacterium, Synechococcus elongatus sp. PCC 7942. The heterologously expressed pathway acts as a photorespiratory bypass as well as an additional carbon fixation cycle orthogonal to the endogenous Calvin-Benson cycle. We demonstrate the function of all six introduced enzymes, which not only has implications on increasing net-photosynthetic productivity, but also key enzymes in the pathway are involved in high-value products that are of biotechnological interest, such as 3-hydroxypropionate.
摘要翻译：将基于3-羟基丙酸酯自行车的合成途径引入生物体例如模型蓝细菌，细长聚球藻（Synechococcus elongatus sp。）中的方法和组合物。 PCC 7942。异源表达途径充当光呼吸旁路以及与内源性卡尔文 - 本森循环正交的另外的碳固定循环。我们展示了所有六种引入的酶的功能，这不仅对增加净光合生产力有影响，而且通路中的关键酶也涉及具有生物技术兴趣的高价值产品，例如3-羟基丙酸。

26. 发明申请

WO2015065539A3 A LONG-LIFE, HIGH RATE LITHIUM/SULFUR CELL UTILIZING A HOLISTIC APPROACH TO ENHANCING CELL PERFORMANCE 审中-公开
标题翻译：长寿命，高利润的锂/硫电池，利用提高细胞性能的方法
公开(公告)号：WO2015065539A3
公开(公告)日：2015-08-20
申请号：PCT/US2014043503
申请日：2014-06-20
申请人： UNIV CALIFORNIA
发明人： CAIRNS ELTON J , SONG MIN KYU , ZHANG YUEGANG
IPC分类号： H01M4/13
CPC分类号： H01M4/583 , H01M2/1653 , H01M4/133 , H01M4/136 , H01M4/1397 , H01M4/366 , H01M4/38 , H01M4/587 , H01M4/622 , H01M4/623 , H01M4/625 , H01M10/052 , H01M10/0567 , H01M10/0568 , H01M10/0569 , H01M2004/028 , H01M2300/0025 , H01M2300/0037 , H01M2300/0045 , Y02T10/7011
摘要： A long-life, high-rate lithium sulfur (Li/S ) cell with high specific energy uniquely combines cetyltrimethyl ammonium bromide (CTAB) -modified sulfur- graphene oxide (S-GO) nanocomposites with an elastomeric styrene butadiene rubber (SBR)/ carboxy methyl cellulose (CMC) binder and an ionic liquid-based novel electrolyte with the L1NO3 additive. A Li/S cell employing a CTAB-modified S-GO nanocomposite cathode can be discharged at rates as high as 6C (1C = 1.675 A/g of sulfur) and charged at rates as high as 3C while still maintaining high specific capacity (-800 mAh/g of sulfur at 6C), with a long cycle life exceeding 1500 cycles, the longest cycle life with extremely low decay rate (0.039% per cycle) demonstrated so far for a Li/S cell.
摘要翻译：具有高比能量的长寿命高速锂硫（Li / S）电池将十六烷基三甲基溴化铵（CTAB）改性的硫 - 氧化烯氧化物（S-GO）纳米复合材料与弹性体丁苯橡胶（SBR）/ 羧甲基纤维素（CMC）粘合剂和具有L1NO3添加剂的基于离子液体的新型电解质。使用CTAB改性的S-GO纳米复合阴极的Li / S电池可以以高达6C（1C = 1.675A / g硫）的速率排出，并以高达3C的速率充电，同时仍保持较高的比容量（ - 800mAh / g的硫在6C），循环寿命长于1500次循环，对于Li / S电池，迄今为止证明了极低的衰减速率（每循环0.039％）的最长循环寿命。

27. 发明申请

WO2014113436A8 ADENOVIRUSES AND THEIR USE 审中-公开
标题翻译： ADENOVIRUSES及其使用
公开(公告)号：WO2014113436A8
公开(公告)日：2015-07-23
申请号：PCT/US2014011624
申请日：2014-01-15
申请人： UNIV CALIFORNIA , TEXAS BIOMEDICAL RES INST , US GOV HEALTH & HUMAN SERV
发明人： CHIU CHARLES , PATTERSON JEAN L , LELAND MARY MICHELLE , CAREY KENNETH DEE , ERDMAN DEAN
IPC分类号： C12N15/34 , A61K39/12 , A61P31/20 , C07K14/075 , C07K16/08 , C12N5/10 , C12N15/63 , C12N15/861 , C12P21/02 , C12Q1/68
CPC分类号： C12Q1/701 , A61K2039/55566 , C07K14/005 , C07K14/075 , C07K16/081 , C07K2317/76 , C12N7/00 , C12N15/86 , C12N15/861 , C12N2710/10321 , C12N2710/10343 , C12Q1/68 , C12Q1/702 , C12Q2563/131 , C12Q2600/156 , G01N33/56983
摘要： Baboon Adenovirus (BaAdV)-2/4 and BaAdV-3 are disclosed herein. BaAdV-2/4 and BaAdV-3 polynucleotide, polypeptides and antibodies that specifically bind BaAdV-2/4 and/or BaAdV-3 are disclosed. Methods are disclosed for detecting BaAdV-2/4 and BaAdV-3. Methods are also disclosed for treating, preventing, and inducing an immune response to BaAdV-2/4 and/or BaAdV-3. Kits are also provided.
摘要翻译：本发明公开了狒狒腺病毒（BaAdV）-2/4和BaAdV-3。公开了BaAdV-2/4和BaAdV-3多核苷酸，特异性结合BaAdV-2/4和/或BaAdV-3的多肽和抗体。公开了用于检测BaAdV-2/4和BaAdV-3的方法。还公开了治疗，预防和诱导对BaAdV-2/4和/或BaAdV-3的免疫应答的方法。还提供套件。

28. 发明申请

WO2015102738A1 MULTIVALENT ANTIVIRAL COMPOSITIONS, METHODS OF MAKING, AND USES THEREOF 审中-公开
标题翻译：多价抗病毒组合物，制备方法及其用途
公开(公告)号：WO2015102738A1
公开(公告)日：2015-07-09
申请号：PCT/US2014061400
申请日：2014-10-20
申请人： DRAPER LAB CHARLES S , MASSACHUSETTS INST TECHNOLOGY , UNIV CALIFORNIA SANTA BARBARA UCSB , UNIV MASSACHUSETTS MEDICAL , COMOLLI JAMES , FINBERG ROBERT , FYGENSON DEBORAH K , SHRIVER ZACHARY , SASISEKHARAN RAM , WANG JENNIFER , VISWANATHAN KARTHIK
发明人： COMOLLI JAMES , FINBERG ROBERT , FYGENSON DEBORAH K , SHRIVER ZACHARY , SASISEKHARAN RAM , WANG JENNIFER , VISWANATHAN KARTHIK
IPC分类号： A61K31/702 , A61K31/715 , A61P31/12
CPC分类号： C08B37/0078 , A61K31/702 , A61K31/715 , A61K31/727 , A61K47/48053 , A61K47/544
摘要： This disclosure provides compositions, kits, and methods useful for treating or preventing viral infection. The methods comprise administering to a subject an effective amount of a sulfated polysaccharide composition.
摘要翻译：本公开提供了用于治疗或预防病毒感染的组合物，试剂盒和方法。该方法包括向受试者施用有效量的硫酸化多糖组合物。

29. 发明申请

WO2014123543A3 SKIN PERMEATING AND CELL ENTERING (SPACE) PEPTIDES AND METHODS OF USE THEREFOR 审中-公开
标题翻译：皮肤渗透和细胞进入（空间）肽及其使用方法
公开(公告)号：WO2014123543A3
公开(公告)日：2015-06-11
申请号：PCT/US2013025543
申请日：2013-02-11
申请人： CONVOY THERAPEUTICS , UNIV CALIFORNIA
发明人： MURASKI JOHN A JR , MITRAGOTRI SAMIR , CHEN MING
IPC分类号： A61K47/42 , A61K31/7088 , C12N15/11
CPC分类号： A61K31/728 , A61K31/713 , A61K38/13 , A61K47/6911 , C07K7/645 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： Compositions that facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells are provided. The compositions may include a peptide, an active agent, or a carrier that includes the active agent. The peptide is associated with and/or conjugated to the active agent, the carrier, or both. The carrier is a micelle, a liposome, an ethosome, and combinations thereof. The composition is capable of penetrating a stratum corneum (SC) layer or a cell when contacted therewith. The composition may further include one or more free peptides. Also provided are methods for delivering active agents to subjects, methods for treating subjects having dermatological diseases, and methods for attenuating expression of mRNAs of subjects in need thereof and/or for treating diseases and/or disorders thereby.
摘要翻译：提供促进递送活性剂或活性剂载体的组合物，其中组合物能够穿透活细胞的角质层（SC）和/或细胞膜。组合物可以包括肽，活性剂或包含活性剂的载体。肽与活性剂，载体或两者结合和/或缀合。载体是胶束，脂质体，药效学及其组合。当与其接触时，组合物能够穿透角质层（SC）层或细胞。组合物还可以包含一种或多种游离肽。还提供了将活性剂递送到受试者的方法，用于治疗患有皮肤病的受试者的方法，以及用于减弱有需要的受试者的mRNA表达和/或由此治疗疾病和/或病症的方法。

30. 发明申请

WO2015054439A3 HYBRID FACTOR VIII POLYPEPTIDES FOR USE TO TREAT HEMOPHILIA A 审中-公开
标题翻译：混合因子VIII多肽用于治疗HEMOPHILIA A
公开(公告)号：WO2015054439A3
公开(公告)日：2015-06-04
申请号：PCT/US2014059787
申请日：2014-10-08
申请人： HAPLOMICS INC , UNIV CALIFORNIA , US DEPT VETERANS AFFAIRS
发明人： HOWARD TOMMY E , LA TERZA VINCENT
IPC分类号： A61K38/37 , A61K35/14
CPC分类号： C07K14/755
摘要： Hybrid recombinant FVIII polypeptides (hrFVIII) comprising non-naturally occurring combinations of amino acid modifications, cDNAs encoding such hrFVIII, expression vectors comprising nucleic acids encoding such hrFVIII, cells comprising expression vectors comprising nucleic acids encoding such hrFVIII, and methods of treating subjects having hemophilia A by administering to the subject such hrFVIII are disclosed herein. The non- naturally occurring amino acid modifications occur at sites of naturally occurring nonsynonymous-Single Nucleotide Polymorphisms (ns-SNP). The hrFVIII can be full length, having a B-domain deletion (BDD), having a B-domain deletion 2 (BDD-2), or having a B-domain deletion 3 (BDD-3). Methods of making the hrFVIIIs, cDNAs, expression vectors, cells are also disclosed.
摘要翻译：包含非天然存在的氨基酸修饰组合，编码这种hrFVIII的cDNA，包含编码这种hrFVIII的核酸的表达载体，包含编码这种hrFVIII的核酸的表达载体的细胞的混合重组FVIII多肽（hrFVIII）和治疗患有血友病的受试者的方法本文公开了通过对受试者施用这种hrFVIII的A。非天然存在的氨基酸修饰发生在天然存在的非同义单核苷酸多态性（ns-SNP）的位点。 hrFVIII可以是全长的，具有B结构域缺失（BDD），具有B结构域缺失2（BDD-2）或具有B结构域缺失3（BDD-3））。还公开了制备hrFVIII，cDNA，表达载体，细胞的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式