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41. 发明申请

WO2014189854A2 GENETICALLY ENCODED SENSORS FOR IMAGING PROTEINS AND THEIR COMPLEXES 审中-公开
标题翻译：用于成像蛋白质及其复合物的基因编码传感器
公开(公告)号：WO2014189854A2
公开(公告)日：2014-11-27
申请号：PCT/US2014038644
申请日：2014-05-19
申请人： UNIV CALIFORNIA , YAN YULING
发明人： YAN YULING , MARRIOTT GERARD , HOEPKER ALEXANDER CHRIS
IPC分类号： C07K14/435
CPC分类号： G01N33/582 , C07K14/195 , C07K14/28 , C07K14/415 , C07K17/02 , C07K2319/00 , C07K2319/21 , C07K2319/50
摘要： Isolated truncated and mutated sensor proteins derived from flavoproteins that are 12-20KDa or less, genetically encoded for detection and imaging of protein complexes having long fluorescent lifetimes that can be 4.0 ns or greater.
摘要翻译：衍生自12-20KDa或更少的黄素蛋白的分离的截短和突变的传感器蛋白质被遗传编码用于具有长达4.0ns或更长的荧光寿命的蛋白质复合物的检测和成像。

42. 发明申请

WO2014150504A3 TISSUE SPECIFIC REDUCTION OF LIGNIN 审中-公开
标题翻译：组织特异性降低LIGNIN
公开(公告)号：WO2014150504A3
公开(公告)日：2014-11-06
申请号：PCT/US2014023443
申请日：2014-03-11
申请人： UNIV CALIFORNIA
发明人： LOQUE DOMINIQUE , EUDES AYMERICK
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： C12N15/8255 , C12P19/02 , C12P19/14
摘要： The present invention provides an expression cassette comprising a polynucleotide that encodes a protein that diverts a monolignol precursor from a lignin biosynthesis pathway in the plant, which is operably linked to a heterologous promoter. Also provided are methods of engineering a plant having reduced lignin content, as well as plant cells, plant parts, and plant tissues from such engineered plants.
摘要翻译：本发明提供了一种表达盒，其包含编码从植物中的木质素生物合成途径转移单螺旋前体的蛋白质的多核苷酸，其可操作地连接到异源启动子。还提供了工程化具有降低的木质素含量的植物以及来自这种工程植物的植物细胞，植物部分和植物组织的方法。

43. 发明申请

WO2014144815A3 VECTORS AND METHODS TO TREAT ISCHEMIA 审中-公开
标题翻译：治疗缺血的矢量和方法
公开(公告)号：WO2014144815A3
公开(公告)日：2014-11-06
申请号：PCT/US2014029386
申请日：2014-03-14
申请人： UNIV CALIFORNIA , NOLTA JAN , PEPPER KAREN , FIERRO FERNANDO , BAUER GERHARD
发明人： NOLTA JAN , PEPPER KAREN , FIERRO FERNANDO , BAUER GERHARD
IPC分类号： A61K48/00
CPC分类号： A61K38/1866 , A61K35/545 , A61K38/18 , A61K38/1891 , A61K48/00 , C07K14/52
摘要： This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
摘要翻译：本公开涉及用于治疗严重肢体缺血和相关病症的载体，分离的细胞，组合物和方法。本公开的一个方面涉及包含编码165A同种型VEGF蛋白的核酸和调节编码VEGF的核酸的表达的启动子的载体。

44. 发明申请

WO2014124339A3 USE OF TRANSLATIONAL PROFILING TO IDENTIFY TARGET MOLECULES FOR THERAPEUTIC TREATMENT 审中-公开
标题翻译：使用翻译分析来鉴定治疗性治疗的靶分子
公开(公告)号：WO2014124339A3
公开(公告)日：2014-10-23
申请号：PCT/US2014015428
申请日：2014-02-07
申请人： UNIV CALIFORNIA
发明人： RUGGERO DAVIDE , HSIEH ANDREW , EDLIND MERRITT , SHOKAT KEVAN M , APPLEMAN JAMES , WORLAND STEVE
IPC分类号： G01N33/50
CPC分类号： C12Q1/6883 , C12Q1/6874 , G01N33/5023
摘要： The present invention provides methods of identifying an agent or drug candidate molecule, validating a target, and identifying normalizing therapeutics that modulates translation, such as in an oncogenic signaling pathway, in a biological sample as determined by translational profiling of one or more genes in the biological sample. The present invention also provides diagnostic and therapeutic methods using the translational profiling methods described herein.
摘要翻译：本发明提供了鉴定试剂或候选药物分子，验证靶标和鉴定生物样品中调节翻译的正常化治疗剂的方法，所述正常化治疗例如在致癌信号传导途径中，如通过生物样品中一个或多个基因的翻译谱分析确定的生物样品。本发明还提供了使用本文所述的翻译谱分析方法的诊断和治疗方法。

45. 发明申请

WO2014131034A3 ANTIBODIES TO OXIDIZED PHOSPHOLIPIDS 审中-公开
标题翻译：用于氧化磷脂的抗体
公开(公告)号：WO2014131034A3
公开(公告)日：2014-10-16
申请号：PCT/US2014018402
申请日：2014-02-25
申请人： UNIV CALIFORNIA
发明人： WITZTUM JOSEPH L , TSIMIKAS SOTIRIOS , QUE XUCHU
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A01K67/0275 , A01K67/0278 , A01K2217/052 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/01 , A01K2267/0362 , A01K2267/0368 , A01K2267/0375 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/76
摘要： The disclosure provides for single chain variable fragments to oxidized phospholipid epitopes and methods of use thereof, including the production of transgenic animal models and the use of the fragments as therapeutic agents for treating CAS.
摘要翻译：本公开内容提供了氧化磷脂表位的单链可变片段及其使用方法，包括产生转基因动物模型以及使用所述片段作为用于治疗CAS的治疗剂。

46. 发明申请

WO2014100742A3 MODULATION OF EXPRESSION OF ACYLTRANSFERASES TO MODIFY HYDROXYCINNAMIC ACID CONTENT 审中-公开
标题翻译： ACYLTRANSES的表达调节改性羟基酸含量
公开(公告)号：WO2014100742A3
公开(公告)日：2014-10-09
申请号：PCT/US2013077266
申请日：2013-12-20
申请人： UNIV CALIFORNIA
发明人： BARTLEY LAURA E , RONALD PAMELA , SCHELLER HENRIK VIBE
IPC分类号： C12N15/87 , A01H5/00 , C12N15/82
CPC分类号： C12N15/8246 , C12N9/1025
摘要： Methods of engineering plants to modulate hydroxycinnamic acids content are provided. The methods comprising manipulating expression of acyltransferases genes, including over-expression of AT10, AT15, or AT7, or decreasing expression of AT5, for engineering grass plants to reduce ferulic acid (FA) content and increase saccharification. Further provided are compositions and recombinant plants produced and methods of using the plants for improved biofuel and feed production.
摘要翻译：提供工程植物调节羟基肉桂酸含量的方法。所述方法包括操作酰基转移酶基因的表达，包括AT10，AT15或AT7的过表达，或降低AT5的表达，用于工程草本植物以减少阿魏酸（FA）含量并增加糖化。还提供了生产的组合物和重组植物以及使用植物改善生物燃料和饲料生产的方法。

47. 发明申请

WO2013112212A3 METAL-ORGANIC FRAMEWORKS WITH EXCEPTIONALLY LARGE PORE APERATURES 审中-公开
标题翻译：金属有机框架具有特殊的大孔附加功能
公开(公告)号：WO2013112212A3
公开(公告)日：2014-10-09
申请号：PCT/US2012059877
申请日：2012-10-12
申请人： UNIV CALIFORNIA
发明人： YAGHI OMAR M , FURUKAWA HIROYASU , DENG HEXIANG
IPC分类号： B01J20/22 , B01J20/02 , B01J20/28 , C02F1/28 , C07F3/02 , C07F5/02 , C07F7/22
CPC分类号： A61K47/24 , A61K38/00 , B01D53/02 , B01D2253/204 , B01J20/0225 , B01J20/226 , B01J20/28016 , B01J20/28066 , B01J20/28073 , B01J20/28076 , B01J2220/58 , C02F1/285 , C07F3/02 , C07F3/06 , C07F5/025 , C07F7/2224 , C07K14/435
摘要： The disclosure relates to metal organic frameworks or isoreticular metal organic frameworks M-L-M, wherein M comprises a metal and L is a linking moiety of Formula I: (formula (I), methods of production thereof, and methods of use thereof.
摘要翻译：本公开涉及金属有机骨架或金属有机骨架M-L-M，其中M包括金属，L是式I的连接部分：（式（I）），其制备方法及其使用方法。

48. 发明申请

WO2014160037A2 ACTIVATABLE MEMBRANE-INTERACTING PEPTIDES AND METHODS OF USE 审中-公开
标题翻译：可活化的膜相互作用肽和使用方法
公开(公告)号：WO2014160037A2
公开(公告)日：2014-10-02
申请号：PCT/US2014025683
申请日：2014-03-13
申请人： UNIV CALIFORNIA
发明人： PAGE MICHAEL , CRAIK CHARLES S
IPC分类号： A61K49/00 , C08L89/00
CPC分类号： A61K49/0056 , A61K47/48246 , A61K47/48338 , A61K47/64 , A61K47/65 , A61K49/0032 , A61K49/0054 , C07K7/08 , C07K2319/00 , C07K2319/50 , C08L89/00 , C12N2501/385
摘要： The present disclosure provides activatable and detectable membrane-interacting peptides that, following activation, can interact with phospholipid bilayers, such as cell membranes. The present disclosure also provides methods of use of such compounds. The compounds of the present disclosure are of the general structure Xla-A-X2-Z-Xlb, where A is a membrane-interacting peptide region having a plurality of nonpolar hydrophobic amino acid residues that, following separation from portions Z, is capable of interaction with a phospholipid bilayer; Z is an inhibitory peptide region that can inhibit the activity of portion A; X2 is a cleavable linker that can be cleaved to release cleavage products from the compound; and Xla and Xlb are optionally-present chemical handles that facilitate conjugation of various cargo moieties to the compound. Prior to cleavage of the composition at X2, the composition acts as a promolecule that does not associate with cellular membranes to a significant or detectable level. Following cleavage at cleavable linker X2, the cleavage product including portion A is free to interact with a phospholipid bilayer (e.g., a cell membrane), and thus accumulate at a site associated with a cleavage-promoting environment. Detection of the membrane-associated cleavage product can be accomplished by detection of a moiety attached through Xla and/or Xlb. Such compositions can be used in a variety of methods, including, for example, use in directly imaging active clotting within a subject.
摘要翻译：本公开提供可激活和可检测的膜相互作用的肽，其在活化后可与磷脂双层如细胞膜相互作用。本公开还提供了使用这种化合物的方法。本公开的化合物具有通式结构Xla-A-X2-Z-Xlb，其中A是具有多个非极性疏水性氨基酸残基的膜相互作用肽区，其在与Z分离后能够与磷脂双层相互作用; Z是抑制A部分活性的抑制性肽区; X2是可切割的接头，其可以被切割以从化合物释放裂解产物; Xla和Xlb是任选存在的促进各种货物部分与化合物缀合的化学手柄。在组合物在X2切割之前，该组合物用作不与细胞膜缔合至显着或可检测水平的促分子。在可裂解接头X2切割后，包含部分A的切割产物与磷脂双层（例如，细胞膜）自由相互作用，因此在与切割促进环境相关的位点处积累。通过检测通过Xla和/或Xlb连接的部分可以检测膜相关切割产物。这样的组合物可以以各种方法使用，包括例如用于直接成像受试者内的活性凝血成像。

49. 发明申请

WO2014146111A2 ANALGESIC COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：化学化合物及其使用方法
公开(公告)号：WO2014146111A2
公开(公告)日：2014-09-18
申请号：PCT/US2014031089
申请日：2014-03-18
申请人： UNIV CALIFORNIA
发明人： LEVINE JON D , GALLARDO-GODOY ALEJANDRA
CPC分类号： C07D491/107 , C07D207/06 , C07D207/09 , C07D207/263 , C07D211/06 , C07D211/12 , C07D401/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D489/00 , C07D489/02
摘要： Provided herein, inter alia, are methods and compositions for achieving an analgesic effect in subjects in need thereof.
摘要翻译：本文提供的是用于在有需要的受试者中实现镇痛作用的方法和组合物。

50. 发明申请

WO2014144547A2 AMIDE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS 审中-公开
标题翻译：基于乳糖的N-酰基乙酰胺酸氨基酸（NAAA）抑制剂的酰胺衍生物
公开(公告)号：WO2014144547A2
公开(公告)日：2014-09-18
申请号：PCT/US2014029007
申请日：2014-03-14
申请人： UNIV CALIFORNIA , UNI DEGLI STUDI DI URBINO CARLO BO , FOND ISTITUTO ITALIANO DI TECNOLOGIA , UNIV PARMA
发明人： PIOMELLI DANIELE , MOR MARCO , TARZIA GIORGIO , BERTOZZI FABIO , NUZZI ANDREA , FIASELLA ANNALISA , BANDIERA TIZIANO , REGGIANI ANGELO MARIO
IPC分类号： A61K31/397
CPC分类号： C07D205/085
摘要： Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.
摘要翻译：本文描述了抑制N-酰基乙醇胺酸酰胺酶（NAAA）的化合物和药物组合物。本文描述的是合成本文所列化合物的方法和将这些化合物配制成包括这些化合物的药物组合物的方法。本文还描述了抑制NAAA的方法，以在NAE浓度降低的条件下维持作为NAAA底物的棕榈酰乙醇酰胺（PEA）和其它N-酰基乙醇胺（NAE）的水平。此外，这里描述的是治疗和改善疼痛，炎症，炎性疾病和其中调节脂肪酸乙醇酰胺临床或治疗相关或其中NAE水平降低与该病症相关的其它病症的方法。

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