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61. 发明申请

WO2006017666A3 RADIOFREQUENCY ABLATION SYSTEM USING MULTIPLE-PRONG PROBES 审中-公开
标题翻译：使用多重探测器的射频消融系统
公开(公告)号：WO2006017666A3
公开(公告)日：2006-03-30
申请号：PCT/US2005027751
申请日：2005-07-29
申请人： WISCONSIN ALUMNI RES FOUND , LEE FRED T JR , WINTER THOMAS C III , HAEMMERICH DIETER G , SAMPSON LISA A
发明人： LEE FRED T JR , WINTER THOMAS C III , HAEMMERICH DIETER G , SAMPSON LISA A
IPC分类号： A61B18/14 , A61B18/12 , A61B18/16
CPC分类号： A61B18/1477 , A61B18/1206 , A61B18/16 , A61B2018/00654 , A61B2018/0075 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00875 , A61B2018/124 , A61B2018/143 , A61B2018/1432 , A61B2018/1467
摘要： Efficient ablation with multiple prong electrodes is obtained by electrically isolating the prongs from each other and rapidly switching electric power between the prongs, between a prong and a ground pad, or both. In this way, power distribution to a tumor can be controlled efficiently without the need to change probe geometry.
摘要翻译：通过将叉彼此电隔离并快速切换叉之间，叉和地垫之间或两者之间的电力，可获得具有多个叉形电极的有效消融。以这种方式，可以有效地控制肿瘤的功率分布，而不需要改变探头的几何形状。

62. 发明申请

WO2006029198A2 CULTURING HUMAN EMBRYONIC STEM CELLS 审中-公开
标题翻译：培养人胚胎干细胞
公开(公告)号：WO2006029198A2
公开(公告)日：2006-03-16
申请号：PCT/US2005031839
申请日：2005-09-08
申请人： WISCONSIN ALUMNI RES FOUND , THOMSON JAMES A , LUDWIG TENNEILLE
发明人： THOMSON JAMES A , LUDWIG TENNEILLE
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , C12N2500/12 , C12N2500/20 , C12N2500/25 , C12N2500/32 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/40 , C12N2500/44 , C12N2500/46 , C12N2500/90 , C12N2500/98 , C12N2501/115 , C12N2501/15 , C12N2501/415 , C12N2501/845 , C12N2501/999 , C12N2533/52 , C12N2533/54
摘要： Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium, which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if high levels of fibroblast growth factor are used in a medium with gamma amino butyric acid, pipecholic acid, lithium and lipids, the stem cells will remain undifferentiated indefinitely through multiple passages, even without feeder cells or conditioned medium. A humanized matrix of human proteins can be used as a basement matrix to culture the cells. New lines of human embryonic stem cells made using these culture conditions, the medium and the matrix, will never have been exposed to animal cells, animal products, feeder cells or conditioned medium.
摘要翻译：用于培养人胚胎干细胞的先前方法需要成纤维细胞饲养细胞或已经暴露于成纤维细胞饲养细胞以维持干细胞处于未分化状态的培养基。现已发现，如果在具有γ-氨基丁酸，叶酸，锂和脂质的培养基中使用高水平的成纤维细胞生长因子，那么即使没有饲养细胞或条件培养基，干细胞也将通过多次传代无限期地保持未分化。人类蛋白质的人源化基质可以用作培养细胞的基底基质。使用这些培养条件制成的新的人胚胎干细胞系，培养基和基质，决不会暴露于动物细胞，动物产品，饲养细胞或条件培养基。

63. 发明申请

WO2005110263A3 RADIOFREQUENCY ABLATION WITH INDEPENDENTLY CONTROLLABLE GROUND PAD CONDUCTORS 审中-公开
标题翻译：具有独立可控接地导线器的无线电放电
公开(公告)号：WO2005110263A3
公开(公告)日：2006-02-23
申请号：PCT/US2005016172
申请日：2005-05-09
申请人： WISCONSIN ALUMNI RES FOUND , LEE FRED T , WINTER THOMAS C III , HAEMMERICH DEITER G , SAMPSON LISA A , GOLDBERG S NAHUM
发明人： LEE FRED T , WINTER THOMAS C III , HAEMMERICH DEITER G , SAMPSON LISA A , GOLDBERG S NAHUM
IPC分类号： A61B18/12 , A61B18/14 , A61B18/16
CPC分类号： A61B18/1233 , A61B18/1477 , A61B18/16 , A61B2018/124 , A61B2018/1425
摘要： A radiofrequency ablation system provides multiple ground pads and active control of current flow through the ground pads to provide improved power sharing at the tissue near the ground pads reducing risk of patient skin bums for higher power ablation generators.
摘要翻译：射频消融系统提供多个接地焊盘并主动控制通过接地焊盘的电流，以在接地焊盘附近的组织处提供改善的功率共享，从而降低高功率消融发生器的患者皮肤灼伤的风险。

64. 发明申请

WO2005097089A3 Derivatives of leinamycin for use as anticancer agents 审中-公开
标题翻译：用作抗癌剂的莱茵霉素衍生物
公开(公告)号：WO2005097089A3
公开(公告)日：2006-02-09
申请号：PCT/US2005011325
申请日：2005-04-01
申请人： WISCONSIN ALUMNI RES FOUND , SHEN BEN
发明人： SHEN BEN
IPC分类号： A61K31/428 , C07D513/08 , A61K31/429 , A61P35/00 , C12R1/58
CPC分类号： A61K31/428 , C07D513/08
摘要： The present invention relates to TG-25 and/or analogs thereof and their use in the treatment of cancer. TG-25 inhibits the growth of prostate cells by inhibiting DNA synthesis, more particularly by DNA cleavage.

65. 发明申请

WO2006002141A2 DETECTION OF POST-TRANSLATIONALLY MODIFIED PEPTIDES WITH LIQUID CRYSTALS 审中-公开
标题翻译：用液晶检测后翻译修饰的肽
公开(公告)号：WO2006002141A2
公开(公告)日：2006-01-05
申请号：PCT/US2005021887
申请日：2005-06-20
申请人： WISCONSIN ALUMNI RES FOUND , ABBOTT NICHOLAS L , CLARE BRIAN H , BERTICS PAUL J
发明人： ABBOTT NICHOLAS L , CLARE BRIAN H , BERTICS PAUL J
IPC分类号： G01N33/553 , G01N33/543
CPC分类号： G01N33/6845 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N33/54353 , G01N33/553 , G01N33/68 , G01N33/6842
摘要： A method for differentiating between a post-translationally modified peptide and a peptide contained in a sample, comprising:(a) contacting the sample with a peptide attachment surface to create a peptidized surface, wherein the sample includes at least one functional group; (b) contacting the peptidized surface with a recognition reagent that selectively binds or forms a complex with the post-translationally modified peptide in the sample to provide an incubated surface; and (c) contacting a liquid crystal with the incubated surface and detecting presence of post-translationally modified peptide in the sample with the liquid crystal.
摘要翻译：一种用于区分样品中包含的翻译后修饰的肽和肽的方法，包括：（a）使样品与肽附着表面接触以产生肽化表面，其中所述样品包括至少一个官能团; （b）使肽化表面与识别试剂接触，所述识别试剂选择性地与样品中的翻译后修饰的肽结合或形成复合物以提供孵育的表面; 和（c）使液晶与孵育的表面接触并用液晶检测样品中翻译后修饰的肽的存在。

66. 发明申请

WO2005110386A3 METHOD OF DECREASING INFLAMMATION IN KIDNEY TRANSPLANTATION USING ANGIOTENSIN RECEPTOR BLOCKERS 审中-公开
标题翻译：使用血管紧张素受体阻断剂减少KIDNEY移植中的炎症的方法
公开(公告)号：WO2005110386A3
公开(公告)日：2006-01-05
申请号：PCT/US2005012474
申请日：2005-04-12
申请人： WISCONSIN ALUMNI RES FOUND , BECKER BRYAN N , JACOBSON LYNN M , HULLETT DEBRA A , WEIDANZ JON A , WITTMAN VAUGHAN P
发明人： BECKER BRYAN N , JACOBSON LYNN M , HULLETT DEBRA A , WEIDANZ JON A , WITTMAN VAUGHAN P
IPC分类号： A61K31/00 , A61K31/4178 , A61K31/4184 , A61P37/06
CPC分类号： A61K31/4184 , A61K31/4178
摘要： Disclosed is a method of inhibiting production of IFN-y in patients having a transplanted organ. The method involves administering to the patient an amount of an angiotensin receptor-blocking compound, the amount being effective to inhibit production of IFN-y by T cells. The method can be used to treat inflammation involving an allograft, to treat chronic allograft nephropathy, and to treat other pathologies associated with allograft rejection.
摘要翻译：公开了抑制具有移植器官的患者中IFN-γ产生的方法。该方法包括向患者施用一定量的血管紧张素受体阻断化合物，其量有效地抑制T细胞产生IFN-γ。该方法可用于治疗涉及同种异体移植物的炎症，治疗慢性同种异体移植肾病，以及治疗与同种异体移植排斥相关的其他病态。

67. 发明申请

WO2005058298B1 FK228 ANALOGS AND THEIR USE AS HDAC-INHIBITORS 审中-公开
标题翻译： FK228类似物及其作为HDAC-抑制剂的用途
公开(公告)号：WO2005058298B1
公开(公告)日：2005-12-08
申请号：PCT/US2004041678
申请日：2004-12-10
申请人： WISCONSIN ALUMNI RES FOUND , RAJSKI SCOTT R , WASSARMAN DAVID A , RESTITUYO JOSE A
发明人： RAJSKI SCOTT R , WASSARMAN DAVID A , RESTITUYO JOSE A
IPC分类号： A61K31/16 , A61K31/385 , C07C323/60 , C07C327/32 , C07D221/14 , C07D285/00 , C07F7/18 , A61P35/00
CPC分类号： C07D221/14 , A61K31/16 , A61K31/385 , C07C323/60 , C07C327/32 , C07D285/00 , C07F7/1852
摘要： The present invention provides FK228 analogs and methods of making and using the same. Such analogs are potent inhibitors of histone deacetylase and, in certain embodiments, are capable of specifically targeting cancerous cells and tissues. In preferred embodiments, these analogs are characterized by a cyclic disulfide design.
摘要翻译：本发明提供了FK228类似物及其制备和使用方法。此类类似物是组蛋白脱乙酰酶的有效抑制剂，并且在某些实施方案中，能够特异性靶向癌性细胞和组织。在优选的实施方案中，这些类似物的特征在于环状二硫键设计。

68. 发明申请

WO2005077038A2 SISO MODEL PREDICTIVE CONTROLLER 审中-公开
标题翻译： SISO模型预测控制器
公开(公告)号：WO2005077038A2
公开(公告)日：2005-08-25
申请号：PCT/US2005004011
申请日：2005-02-04
申请人： WISCONSIN ALUMNI RES FOUND
IPC分类号： G05B13/02 , G05B13/04
CPC分类号： G05B13/048
摘要： A method of predictive control for a single input, single output (SISO) system, including modeling the SISO system with model factors, detecting output from the SISO system, estimating a filtered disturbance from the output, determining a steady state target state from the filtered disturbance and a steady state target output, populating a dynamic optimization solution table using the model factors and a main tuning parameter, and determining an optimum input from the dynamic optimization solution table. Determining an optimum input includes determining a time varying parameter, determining a potential optimum input from the time varying parameter, and checking, whether the potential optimum input is the optimum input.
摘要翻译：一种用于单输入单输出（SISO）系统的预测控制方法，包括用模型因子对SISO系统进行建模，检测SISO系统的输出，从输出估计滤波后的干扰，从滤波器确定稳态目标状态干扰和稳态目标输出，使用模型因子和主调优参数填充动态优化解表，并从动态优化解决方案表确定最优输入。确定最佳输入包括确定时变参数，根据时变参数确定潜在最佳输入，以及检查潜在最佳输入是否是最佳输入。

69. 发明申请

WO2005076785A2 METHOD AND COMPOSITIONS FOR DETECTING BOTULINUM NEUROTOXIN 审中-公开
标题翻译：用于检测嗜碱性神经毒素的方法和组合物
公开(公告)号：WO2005076785A2
公开(公告)日：2005-08-25
申请号：PCT/US2004042366
申请日：2004-12-20
申请人： WISCONSIN ALUMNI RES FOUND , CHAPMAN EDWIN R , DONG MIN
发明人： CHAPMAN EDWIN R , DONG MIN
IPC分类号： C07K14/435 , G01N33/542 , G01N33/569
CPC分类号： G01N33/573 , C07K14/435 , C07K14/43595 , C07K14/705 , C07K2319/50 , C07K2319/60 , C12Y304/24069 , G01N33/542 , G01N33/56911 , G01N2333/33 , G01N2333/952
摘要： A molecular construct capable of fluorescent resonance energy transfer (FRET), comprising a linker peptide, a donor fluorophore moiety and an acceptor fluorophore moiety, wherein the linker peptide is a substrate of a botulinum neurotoxin selected from the group consisting of synaptobrevin, syntaxin and SNAP-25, or a fragment thereof capable being cleaved by the botulinum neurotoxin, and separates the donor and acceptor fluorophores by a distance of not more than 10 nm, and wherein emission spectrum of the donor fluorophore moiety overlaps with the excitation spectrum of the acceptor fluorophore moiety; or wherein the emission spectra of the fluorophores are detectably different. Also provided are isolated nucleic acid expressing the construct, kits comprising said construct and cell lines comprising said nucleic acid. Further provided are methods of detecting a BoNT using the above described construct via FRET, and methods for detecting a BoNT using surface plasmon resonance imaging.
摘要翻译：一种能够进行荧光共振能量转移（FRET）的分子构建体，其包含接头肽，供体荧光团部分和受体荧光团部分，其中所述连接肽是肉毒神经毒素的底物，其选自突触链突起目，突触蛋白和突触蛋白 -25或其能够被肉毒杆菌神经毒素切割的片段，并且将供体和受体荧光团分开不超过10nm的距离，并且其中供体荧光团部分的发射光谱与受体荧光团的激发光谱重叠部分; 或其中荧光团的发射光谱可检测地不同。还提供了表达构建体的分离的核酸，包含所述构建体的试剂盒和包含所述核酸的细胞系。还提供了通过FRET使用上述构建体检测BoNT的方法，以及使用表面等离子体共振成像检测BoNT的方法。

70. 发明申请

WO2005038071A3 HARD CARBON FILMS FORMED FROM PLASMA TREATED POLYMER SURFACES 审中-公开
标题翻译：从等离子体处理聚合物表面形成的硬碳膜
公开(公告)号：WO2005038071A3
公开(公告)日：2005-07-14
申请号：PCT/US2004033646
申请日：2004-10-12
申请人： WISCONSIN ALUMNI RES FOUND , DENES FERENCZ , MANOLACHE SORIN , CRUZ-BARBA LUIS
发明人： DENES FERENCZ , MANOLACHE SORIN , CRUZ-BARBA LUIS
IPC分类号： B32B27/00 , B32B27/30 , B32B27/32 , B32B27/36 , C23C20060101 , H05H1/24 , H05H1/26
CPC分类号： B29C59/14 , Y10T428/31504 , Y10T428/31507 , Y10T428/31525 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938
摘要： Hard-carbon films with unique structures, methods for producing the films, and articles coated by the films are provided. These hard-carbon films are synthesized by the plasma surface treatment of a polymer substrate or a polymer-coated substrate in a plasma containing SFx species, where x is less than 6, and may be produced under room temperature, low pressure environments.
摘要翻译：提供了具有独特结构的硬碳膜，制造薄膜的方法和由薄膜涂覆的制品。这些硬碳膜是通过等离子体表面处理聚合物衬底或涂覆有聚合物的衬底在包含SF x物质的等离子体中，其中x小于6，并且可以在室温，低压环境下制备。

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