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71. 发明申请

WO2013022503A3 COMPOSITIONAL VARIATIONS OF TUNGSTEN TETRABORIDE WITH TRANSITION METALS AND LIGHT ELEMENTS 审中-公开
标题翻译：过渡金属与光元素四配位钨的组成变化
公开(公告)号：WO2013022503A3
公开(公告)日：2013-05-10
申请号：PCT/US2012034685
申请日：2012-04-23
申请人： UNIV CALIFORNIA , KANER RICHARD B , TOLBERT SARAH H , MOHAMMADI REZA , LECH ANDREW T , XIE MIAO
发明人： KANER RICHARD B , TOLBERT SARAH H , MOHAMMADI REZA , LECH ANDREW T , XIE MIAO
IPC分类号： C22C27/04
CPC分类号： C22C27/04 , B22F9/04 , B22F2005/001 , B22F2009/041 , C22C1/02 , C22C1/045 , C22C1/1084 , C22C29/14 , C23C30/00 , C23C30/005
摘要： A composition includes tungsten (W); at least one element selected form the group of elements consisting of boron (B), beryllium (Be) and silicon (Si); and at least one element selected from the group of elements consisting of titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), zirconium (Zr), niobium (Nb), molybdenum (Mo), ruthenium (Ru), hafnium (Hf), tantalum (Ta), rhenium (Re), osmium (Os), iridium (Ir), lithium (Li) and aluminum (Al). The composition satisfies the formula W1-xMxXy wherein X is one of B, Be and Si; M is at least one of Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Zr, Nb, Mo, Ru, Hf, Ta, Re, Os, Ir, Li and Al; x is at least 0.001 and less than 0.999; and y is at least 4.0. A tool is made from or coated with this composition.
摘要翻译：一种组合物包含钨（W）; 选自由硼（B），铍（Be）和硅（Si）组成的元素组中的至少一种元素; 和选自由钛（Ti），钒（V），铬（Cr），锰（Mn），铁（Fe），钴（Co），镍（Ni），铜（ Cu，Zn，Zr，Nb，Mo，Ru，Ru，Hf，Ta，Re，Os，Os，铱，铱），锂（锂）和铝（铝）。该组合物满足公式W1-xMxXy，其中X是B，Be和Si之一; M是Ti，V，Cr，Mn，Fe，Co，Ni，Cu，Zn，Zr，Nb，Mo，Ru，Hf，Ta，Re，Os，Ir，Li和Al中的至少一种; x至少为0.001且小于0.999; y至少为4.0。一种工具由该组合物制成或涂覆。

72. 发明申请

WO2012167133A3 INHIBITORS OF ANANDAMIDE TRANSPORT AND THEIR THERAPEUTIC USES 审中-公开
标题翻译： ANANDAMIDE运输的抑制剂及其治疗用途
公开(公告)号：WO2012167133A3
公开(公告)日：2013-05-10
申请号：PCT/US2012040531
申请日：2012-06-01
申请人： UNIV CALIFORNIA , IIT ISTITUTO ITALIANO DI TECNOLOGIA , PIOMELLI DANIELE , FU JIN , BOTTEGONI GIOVANNI , CAVALLI ANDREA , BANDIERA TIZIANO
发明人： PIOMELLI DANIELE , FU JIN , BOTTEGONI GIOVANNI , CAVALLI ANDREA , BANDIERA TIZIANO
IPC分类号： A61K31/502 , A61K31/495 , A61P25/00 , A61P29/00
CPC分类号： C07D237/34 , A61K31/495 , A61K31/502 , C07K14/435 , C12N15/11 , G01N33/5008
摘要： Nucleic acid and polypeptide sequences corresponding to FLAT, a partly cytosolic variant of the intracellular anandamide-degrading enzyme, fatty acid amide hydrolase-1 (FAAH-1), are provided. FLAT lacks amidase activity but binds the endocannibinoid anandamide and facilitates its transport into cells. A chemical scaffold for the inhibition of anandamide transport is identified. Compositions of the invention prevent anandamide internalization in vitro, interrupt anandamide deactivation in vivo, and cause profound CB1 cannabinoid receptor-mediated analgesia in a mouse model of inflammatory pain. Accordingly, the invention also provides methods, and pharmaceutical compositions for treating conditions in which the modulation of anandamide transport would be of benefit.
摘要翻译：提供了对应于FLAT，细胞内anandamide降解酶的部分胞质变体，脂肪酸酰胺水解酶-1（FAAH-1）的核酸和多肽序列。 FLAT没有酰胺酶活性，但是结合内源性抗生素Aandamide并促进其转运到细胞中。鉴定了用于抑制anandamide转运的化学支架。本发明的组合物在体外阻止氨酰胺内化，在体内中断anandamide失活，并在炎性疼痛的小鼠模型中引起严重的CB1大麻素受体介导的镇痛。因此，本发明还提供了用于治疗其中调节anandamide转运有益的病症的方法和药物组合物。

73. 发明申请

WO2012112548A3 FIRMOCIDIN, AN ANTIMICROBIAL MOLECULE PRODUCED BY STAPHYLOCOCCUS EPIDERMIDIS 审中-公开
标题翻译： FIRMOCIDIN，由烟草油脂生产的抗微生物分子
公开(公告)号：WO2012112548A3
公开(公告)日：2013-05-10
申请号：PCT/US2012025044
申请日：2012-02-14
申请人： UNIV CALIFORNIA , GALLO RICHARD L , NAKATSUJI TERUAKI
发明人： GALLO RICHARD L , NAKATSUJI TERUAKI
IPC分类号： C07D487/04 , A61K31/5025 , A61P31/04 , C07D473/04 , C07D498/04
CPC分类号： A61K31/5395 , A61K9/0014 , A61K31/4188 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5365 , A61K45/06 , C07D413/04 , C07D473/18 , C07D473/34 , C07D487/04 , C07D498/04 , A61K2300/00
摘要： The disclosure provides for novel antimicrobial agents, methods of making, and methods of use thereof.
摘要翻译：本公开提供了新的抗微生物剂，制备方法及其使用方法。

74. 发明申请

WO2013012452A3 NANOPIPETTE APPARATUS FOR MANIPULATING CELLS 审中-公开
标题翻译：用于操作细胞的纳米技术装置
公开(公告)号：WO2013012452A3
公开(公告)日：2013-04-25
申请号：PCT/US2012026781
申请日：2012-02-27
申请人： UNIV CALIFORNIA , SEGER R ADAM , ACTIS PAOLO , VILOZNY BOAZ , POURMAND NADER
发明人： SEGER R ADAM , ACTIS PAOLO , VILOZNY BOAZ , POURMAND NADER
IPC分类号： C12M1/42 , C12N13/00
CPC分类号： B82Y5/00 , B01J2219/00371 , B01L3/502715 , B01L3/50273 , B01L2300/0645 , B82Y15/00 , G01N33/48728 , G01Q60/44
摘要： Disclosed herein are methods and systems for controlled ejection of desired material onto surfaces including single cells using nanopipettes, as well as ejection and into cells. Some systems are directed to a method and system comprising nanopipettes combined with an xyz controller for depositing a user defined pattern on an arbitrary substrate for the purpose of controlled cell adhesion and growth. Alternate embodiments are directed to a method and system comprising nanopipettes combined with an xyz controller and electronic control of a voltage differential in a bore of the nanopipette electroosmotically injecting material into a cell in a high-throughput manner and with minimal damage to the cell. Yet other embodiments are directed to method and system comprising functionalized nanopipettes combined with scanning ion conductance microscopy for studying molecular interactions and detection of biomolecules inside a single living cell.
摘要翻译：本文公开了用于将所需材料控制喷射到表面上的方法和系统，包括使用纳米移液管的单个细胞，以及喷射和进入细胞。一些系统涉及一种方法和系统，其包括与xyz控制器组合的纳米移液器，用于将用户定义的图案沉积在任意基底上，以便控制细胞粘附和生长。替代实施例涉及一种方法和系统，其包括与xyz控制器组合的纳米移液器，并且以高通量方式以高通量方式电动地将材料的孔中的电压差电子控制到电池中并以最小的细胞损伤来电子控制。其他实施方案涉及包括与扫描离子电导显微镜结合的功能化纳米小片剂用于研究单个活细胞内的分子相互作用和生物分子的检测的方法和系统。

75. 发明申请

WO2012050898A8 LIFESPACE DATA COLLECTION FROM DISCRETE AREAS 审中-公开
标题翻译：从离散区域生成数据收集
公开(公告)号：WO2012050898A8
公开(公告)日：2013-04-25
申请号：PCT/US2011053715
申请日：2011-09-28
申请人： UNIV NEBRASKA , UNIV CALIFORNIA , BONASERA STEPHEN J , SCHENK A KATRIN , GOULDING EVAN H
发明人： BONASERA STEPHEN J , SCHENK A KATRIN , GOULDING EVAN H
IPC分类号： G06F17/40 , G06F15/16 , G06F19/00
CPC分类号： H04L67/42 , G06F19/3418 , G06F19/345 , G06F19/3487 , G16H15/00 , G16H50/20
摘要： Techniques are described to collect data via a client device, such as a mobile phone. The data, referred to as "lifespace data," comprises one or more measurements of an individual's functionality, a transmitter identification associated with a transmitter positioned in a discrete area (e.g., a room in a subject's residence), and a timestamp indicating when the transmitter identification was transmitted or received. One or more transmitters can be positioned in one or more discrete areas (e.g., throughout an individual's residence or workspace), with each transmitter configured to transmit a unique transmitter identification. In implementations, a transmitter comprises a Bluetooth beacon, and a transmitter identification comprises a Bluetooth identification number. The client device may be configured to provide the lifespace data to a server for storage, analysis, and intervention functionalities.
摘要翻译：描述技术来通过诸如移动电话的客户端设备收集数据。称为“生命空间数据”的数据包括个人功能的一个或多个测量，与定位在离散区域（例如，受试者居住地中的房间）中的发射机相关联的发射机标识，以及指示何时发射机识别被发送或接收。一个或多个发射机可以被定位在一个或多个离散区域（例如，遍及个人的居住区或工作空间）中，每个发射机被配置成发送唯一的发射机标识。在实现中，发射机包括蓝牙信标，并且发射机标识包括蓝牙识别号码。客户端设备可以被配置为将服务器空间数据提供给服务器用于存储，分析和干预功能。

76. 发明申请

WO2013019985A9 2D/3D REGISTRATION OF A DIGITAL MOUSE ATLAS WITH X-RAY PROJECTION IMAGES AND OPTICAL CAMERA PHOTOS 审中-公开
标题翻译：用X射线投影图像和光学照相机拍摄2D / 3D数字鼠标地图
公开(公告)号：WO2013019985A9
公开(公告)日：2013-04-04
申请号：PCT/US2012049389
申请日：2012-08-02
申请人： UNIV CALIFORNIA , WANG HONGKAI , HADJIOANNOU ARION F
发明人： WANG HONGKAI , HADJIOANNOU ARION F
IPC分类号： A61B6/00
CPC分类号： G06T7/0032 , A61B6/03 , A61B6/508 , A61B6/5247 , A61B6/583 , A61B2503/40 , G06K2209/051 , G06T7/344 , G06T2207/10072 , G06T2207/10116 , G06T2207/30004
摘要： A method for preparing an image simulating the anatomy of a small subject test animal, and an apparatus for producing said image and an anatomical atlas for co-registering therewith, comprising the generation of two or more non-tomographic images of the test animals is described. Examples of the non-tomographic imaging modalities and the images generated include, but are not limited to one or more x-ray sources and resultant of x-ray projections, photographic cameras and resulting digital or optical images and surface scanners and resultant surface scans. The subject animal is positioned at a focal point in a carrier in an imaging enclosure. A combination of one or more of the non-tomographic images taken from different angles within the enclosure are combined and through an iterative process co-registered with the previously generated digital atlas of the anatomy of the same or similar test animals.
摘要翻译：描述了一种用于制备模拟小型受试者测试动物的解剖结构的图像的方法，以及用于产生所述图像的装置以及用于与其一起配准的解剖图谱，包括生成测试动物的两个或更多个非断层图像。所产生的非断层摄影成像模态和图像的例子包括但不限于一个或多个X射线源以及X射线投影，摄影照相机以及由此产生的数字或光学图像以及表面扫描仪和所得到的表面扫描的结果。目标动物位于成像围栏中载体的焦点处。从外壳内的不同角度拍摄的一个或多个非断层摄影图像的组合并且通过迭代过程与先前生成的相同或类似测试动物的解剖结构的数字图谱共同记录。

77. 发明申请

WO2012149497A3 VERTICAL CAVITY SURFACE EMITTING LASERS WITH SILICON-ON-INSULATOR HIGH CONTRAST GRATING 审中-公开
标题翻译：具有绝缘体绝缘体高对比度光栅的垂直孔表面发射激光
公开(公告)号：WO2012149497A3
公开(公告)日：2013-03-21
申请号：PCT/US2012035697
申请日：2012-04-28
申请人： UNIV CALIFORNIA , CHANG-HASNAIN CONNIE , CHASE CHRISTOPHER , RAO YI
发明人： CHANG-HASNAIN CONNIE , CHASE CHRISTOPHER , RAO YI
IPC分类号： H01S5/183
CPC分类号： H01S5/18386 , H01S5/021 , H01S5/0215 , H01S5/026 , H01S5/1032 , H01S5/18308 , H01S5/18319 , H01S5/18341 , H01S5/18355 , H01S5/18363 , H01S5/1838 , H01S5/187 , H01S5/2063 , H01S5/4025 , H01S5/4087 , H01S5/423
摘要： A surface emitting laser apparatus is formed using a patterned silicon-on- insulator (SOI)-like substrate which is patterned with a buried sub-wavelength high contrast grating and adapted for bonding of a half-VCSEL device containing at least an active region and an upper mirror, to create a VCSEL. The wavelength of the VCSEL, or any individual VCSEL within an array of VCSEL devices, can be set in response to changing HCG characteristics of the lower mirror in the SOI-like substrate, or in the region above the lower mirror within the half-VCSEL. The inventive VCSEL device and fabrication method are beneficial for a number of application and devices.
摘要翻译：表面发射激光装置使用图案化的绝缘体上绝缘体（SOI）样衬底形成，其被图案化为掩埋的亚波长高对比度光栅，并适用于将至少包含一个有源区域的半VCSEL器件和一个上镜子，创建一个VCSEL。 VCSEL器件的阵列内的VCSEL或任何单个VCSEL的波长可以被设置为响应SOI类衬底中的下反射镜的改变的HCG特性，或者在半VCSEL内的下反射镜上方的区域中。本发明的VCSEL器件和制造方法对于许多应用和器件是有益的。

78. 发明申请

WO2013036867A2 COMPOSITIONS AND METHODS FOR CANCER AND CANCER STEM CELL DETECTION AND ELIMINATION 审中-公开
标题翻译：癌症和癌症干细胞检测和消除的组合物和方法
公开(公告)号：WO2013036867A2
公开(公告)日：2013-03-14
申请号：PCT/US2012054307
申请日：2012-09-07
申请人： UNIV CALIFORNIA , JAMIESON CATRIONA H , JIANG QINGFEI , FRAZER KELLY A , BARRETT CHRISTIAN , SADARANGANI ANIL , SHIH ALICE , COURT ANGELE
发明人： JAMIESON CATRIONA H , JIANG QINGFEI , FRAZER KELLY A , BARRETT CHRISTIAN , SADARANGANI ANIL , SHIH ALICE , COURT ANGELE
IPC分类号： A61K48/00
CPC分类号： C07K16/40 , A61K31/7105 , A61K31/713 , A61K38/00 , C07K2/00 , C12N9/80 , C12N15/1137 , C12Y305/04004 , G01N33/57426 , G01N33/57484 , G01N2333/4703 , G01N2800/52
摘要： In alternative embodiments, the invention provides compositions and methods for inhibiting or ablating cancer stem cells. In alternative embodiments, the invention provides compositions and methods for inhibiting the action of double-stranded RNA-specific adenosine deaminases, or ADAR, enzymes. In alternative embodiments, the invention provides compositions and methods for treating, ameliorating or preventing diseases and conditions responsive to the inhibition of cell differentiation and/or self-renewal of dysfunctional cells, cancer cells, leukemia cells, hematopoietic stem cells or cancer stem cells, e.g., leukemia or Chronic Myeloid Leukemia (CML). In alternative embodiments, the invention provides compositions and methods for inhibiting a Sonic Hedgehog (Shh) pathway, e.g., by using a Smoothened (SMO) protein inhibitor. In alternative embodiments, the invention provides compositions and methods for measuring or determining, or predicting, chronic myelogenous leukemia (CML) progression, Leukemic Stem Cell (LSC) generation and/or tyrosine kinase inhibitor resistance. In alternative embodiments, the invention provides compositions and methods for determining or measuring the effectiveness of a treatment, a drug, a therapy or a diet for eliminating, killing or reducing the amounts of a leukemic stem cell (LSC) or cells.
摘要翻译：在替代实施方案中，本发明提供了用于抑制或消除癌症干细胞的组合物和方法。在替代实施方案中，本发明提供了用于抑制双链RNA特异性腺苷脱氨酶或ADAR酶的作用的组合物和方法。在可选的实施方案中，本发明提供了用于治疗，改善或预防对抑制功能失调细胞，癌细胞，白血病细胞，造血干细胞或癌症干细胞的细胞分化和/或自我更新有响应的疾病和病症的组合物和方法，如白血病或慢性粒细胞白血病（CML）。在可选的实施方案中，本发明提供了用于抑制Sonic Hedgehog（Shh）途径的组合物和方法，例如通过使用Smoothened（SMO）蛋白抑制剂。在可选的实施方案中，本发明提供了用于测量或确定或预测慢性骨髓性白血病（CML）进展，白血病干细胞（LSC）产生和/或酪氨酸激酶抑制剂抗性的组合物和方法。在可选的实施方案中，本发明提供了用于确定或测量用于消除，杀死或减少白血病干细胞（LSC）或细胞的量的治疗，药物，疗法或饮食的有效性的组合物和方法。

79. 发明申请

WO2012174551A3 INORGANIC SOLUTION AND SOLUTION PROCESS FOR ELECTRONIC AND ELECTRO-OPTIC DEVICES 审中-公开
标题翻译：无电解决方案和电子和电子设备的解决方法
公开(公告)号：WO2012174551A3
公开(公告)日：2013-03-14
申请号：PCT/US2012042989
申请日：2012-06-18
申请人： UNIV CALIFORNIA , YANG YANG , YANG WENBING , LI SHENGHAN , HSU WAN-CHING
发明人： YANG YANG , YANG WENBING , LI SHENGHAN , HSU WAN-CHING
IPC分类号： H01L51/48 , H01L51/46
CPC分类号： H01L31/18 , C23C18/1204 , H01B1/02 , H01B1/22 , H01L21/02557 , H01L21/0256 , H01L21/02568 , H01L21/02628 , H01L31/0326 , Y02E10/50
摘要： A solution for forming at least a portion of an active layer of an electronic or electro-optic device includes a solvent, an additive mixed with the solvent to provide a solvent-additive blend, and a solute that includes at least one of a transition metal, an alkali metal, an alkaline earth metal, Al, Ga, In, Ge, Sn, or Sb dissolved in elemental form in the solvent-additive blend. The additive is selected from the group of additives consisting of NR1R2NHCOOH, NH2NHCONHNH2, NH2COOH.NH3, NH2NHC(=NH)NH2.H2CO3, NH2NHCSNHNH2, NH2NHCSSH and all combinations thereof. R1 and R2 are each independently selected from hydrogen, aryl, methyl, ethyl and a linear, branched or cyclic alkyl of 3-6 carbon atoms. Methods of producing the solution, a method of producing a Kesterite film on a substructure and devices made with the solutions and methods are also provided.
摘要翻译：用于形成电子或电光器件的有源层的至少一部分的溶液包括溶剂，与溶剂混合以提供溶剂 - 添加剂共混物的添加剂和包含过渡金属中的至少一种的溶质，碱金属，碱土金属，Al，Ga，In，Ge，Sn或Sb以元素形式溶解在溶剂 - 添加剂共混物中。添加剂选自由NR1R2NHCOOH，NH2NHCONHNH2，NH2COOH.NH3，NH2NHC（= NH）NH2H2CO3，NH2NHCSNHNH2，NH2NHCSSH组成的添加剂及其所有组合。 R 1和R 2各自独立地选自氢，芳基，甲基，乙基和3-6个碳原子的直链，支链或环状烷基。还提供了生产该溶液的方法，在底层结构上生产Kesterite薄膜的方法以及用该溶液和方法制成的装置。

80. 发明申请

WO2013019711A2 NOVEL 17ß-HETEROARYL-SUBSTITUTED STEROIDS AS MODULATORS OF GABAA RECEPTORS 审中-公开
标题翻译：作为GABA A受体的调节剂的新型17β-取代的STEROIDS
公开(公告)号：WO2013019711A2
公开(公告)日：2013-02-07
申请号：PCT/US2012048816
申请日：2012-07-30
申请人： UNIV CALIFORNIA , HOGENKAMP DERK J
发明人： HOGENKAMP DERK J
IPC分类号： C07J71/00
CPC分类号： C07J43/003 , C07J41/0044 , C07J41/0094 , C07J51/00
摘要： The invention is directed to novel 17ß-heteroaryl substituted steroids of Formula I, pharmaceutical compositions thereof, and their use as modulators of GABAA receptors.
摘要翻译：本发明涉及式I的新型17β-杂芳基取代的类固醇，其药物组合物及其作为GABA A受体调节剂的用途。

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