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81. 发明申请

WO2012116181A3 SMALL MOLECULES FOR ENDOTHELIAL CELL ACTIVATION 审中-公开
标题翻译：用于内皮细胞活化的小分子
公开(公告)号：WO2012116181A3
公开(公告)日：2013-01-31
申请号：PCT/US2012026322
申请日：2012-02-23
申请人： UNIV CALIFORNIA , CRUZ DANIEL , KWON OHYUN
发明人： CRUZ DANIEL , KWON OHYUN
IPC分类号： G01N33/50 , C12Q1/02 , G01N33/15
CPC分类号： G01N33/5044 , C07D207/48 , C07D471/04 , C07D487/04 , G01N33/5047 , G01N33/5064
摘要： The present invention provides small molecules for endothelial cell activation and compositions thereof and methods of making and using the same.
摘要翻译：本发明提供用于内皮细胞活化的小分子及其组合物及其制备和使用方法。

82. 发明申请

WO2012159092A3 MEDICAL FOOD FOR COGNITIVE DECLINE 审中-公开
标题翻译：医疗食品认真的拒绝
公开(公告)号：WO2012159092A3
公开(公告)日：2013-01-24
申请号：PCT/US2012038720
申请日：2012-05-18
申请人： UNIV CALIFORNIA , SALK INST FOR BIOLOGICAL STUDI , COLE GREG M , FRAUTSCHY SALLY A , SCHUBERT DAVID R , MAHER PAMELA A
发明人： COLE GREG M , FRAUTSCHY SALLY A , SCHUBERT DAVID R , MAHER PAMELA A
IPC分类号： A61K31/352 , A61K31/20 , A61K31/23 , A61K31/35 , A61P25/00
CPC分类号： A61K31/353 , A23L33/105 , A23L33/12 , A23V2002/00 , A61K31/202 , A61K31/352 , A61K2300/00 , A23V2200/322 , A23V2250/1868 , A23V2250/2116
摘要： Nutraceutical formulations that improve cognitive function in adults diagnosed with neurodegenerative disease are provided, which comprise a combination of fisetin and DHA.
摘要翻译：提供了改善诊断为神经变性疾病的成年人认知功能的营养制剂，其包括非瑟酮和DHA的组合。

83. 发明申请

WO2011142781A3 PORE-LIMIT ELECTROPHORESIS (PLE) MICROCHANNEL ASSAYS 审中-公开
标题翻译：极限电极（PLE）微通道测定
公开(公告)号：WO2011142781A3
公开(公告)日：2013-01-24
申请号：PCT/US2010058590
申请日：2010-12-01
申请人： UNIV CALIFORNIA , HERR AMY E , CHEN XIOFANG , HUGHES ALEX JAMES
发明人： HERR AMY E , CHEN XIOFANG , HUGHES ALEX JAMES
IPC分类号： G01N33/53 , G01N27/447 , G01N33/532 , G01N33/68
CPC分类号： C12Q1/28 , G01N27/44791 , G01N33/561
摘要： Pore-limit electrophoresis (PLE) microchannel assay methods are provided. Aspects of the methods include sequentially introducing samples at least suspected of containing first and second assay members into a PLE microchannel and then evaluating the microchannel for interaction between the first and second assay members. Aspects of the invention further include devices, systems and kits configured for practicing methods of invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including enzyme activity assays and immunoassays.
摘要翻译：提供了孔极限电泳（PLE）微通道测定方法。方法的方面包括将至少怀疑含有第一和第二测定成员的样品顺序地引入PLE微通道中，然后评估微通道以用于第一和第二测定构件之间的相互作用。本发明的方面还包括被配置用于实施本发明的方法的装置，系统和套件。本发明的方法，装置，系统和试剂盒可用于各种不同的应用，包括酶活性测定和免疫测定。

84. 发明申请

WO2012154695A3 TREATMENT OF POLYCYSTIC DISEASE 审中-公开
标题翻译：治疗多发性疾病
公开(公告)号：WO2012154695A3
公开(公告)日：2013-01-10
申请号：PCT/US2012036841
申请日：2012-05-07
申请人： UNIV CALIFORNIA , INTELLIKINE INC , PEARCE DAVID , LIU YI , MARTIN MICHAEL , ROMMEL CHRISTIAN , REN PINGDA , WILSON TROY EDWARD
发明人： PEARCE DAVID , LIU YI , MARTIN MICHAEL , ROMMEL CHRISTIAN , REN PINGDA , WILSON TROY EDWARD
IPC分类号： A61K31/519 , A61K31/421 , A61K31/423 , A61K31/505
CPC分类号： A61K31/52 , A61K31/366 , A61K31/437 , A61K31/4709 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/63 , G01N2800/347 , G01N2800/50 , G01N2800/52
摘要： The present invention provides methods of treating polycystic disorders. In particular, methods include the use of inhibitors targeting certain protein kinases, such as mTOR, to treat polycystic disease.
摘要翻译：本发明提供治疗多囊性疾病的方法。特别地，方法包括使用靶向某些蛋白激酶（例如mTOR）的抑制剂来治疗多囊性疾病。

85. 发明申请

WO2012142625A3 MULTIFUNCTIONAL NANOPARTICLE DESIGNS AND APPLICATIONS 审中-公开
标题翻译：多功能纳米设计与应用
公开(公告)号：WO2012142625A3
公开(公告)日：2013-01-03
申请号：PCT/US2012033853
申请日：2012-04-16
申请人： UNIV CALIFORNIA , ORTAC INANC , ESENER SADIK C , YANG JIAN , TROGLER WILLIAM
发明人： ORTAC INANC , ESENER SADIK C , YANG JIAN , TROGLER WILLIAM
IPC分类号： B82B3/00 , B01J13/02
CPC分类号： A61K9/5192 , A61K9/5073 , A61K9/5115 , A61K9/5146 , B01J13/22 , B01J20/28021 , B22D25/02 , B22D29/001 , B29C67/202 , B29C67/205 , B82B3/0019 , C04B35/14 , C04B35/624 , Y10S977/773 , Y10S977/896 , Y10S977/906 , Y10T428/2989
摘要： Methods, structures, devices and systems are disclosed for fabricating and implementing nanoparticles with hollow core and sealable holes. In one aspect, a nanoparticle device can includes a shell structure including at least two layers including an internal layer and an external layer, the internal layer structured to enclose a hollow interior region and include one or more holes penetrating the internal layer, the external layer is of a porous material and formed around the internal layer and sealing the one or more holes, and a substance contained within the hollow interior region, the substance incapable of passing through the external layer.
摘要翻译：公开了用于制造和实现具有中空芯和可密封孔的纳米颗粒的方法，结构，装置和系统。一方面，纳米颗粒装置可以包括壳结构，其包括至少两层，包括内层和外层，所述内层被构造为包围中空内部区域，并且包括穿透内层的一个或多个孔，外层是多孔材料，并且形成在内层周围并密封一个或多个孔，以及包含在中空内部区域内的物质，该物质不能通过外部层。

86. 发明申请

WO2012149468A3 INSTRUMENTS AND METHODS FOR THE IMPLANTATION OF CELL-SEEDED SUBSTRATES 审中-公开
标题翻译：用于植入细胞种子基质的仪器和方法
公开(公告)号：WO2012149468A3
公开(公告)日：2012-12-27
申请号：PCT/US2012035654
申请日：2012-04-27
申请人： UNIV SOUTHERN CALIFORNIA , CALIFORNIA INST OF TECHN , UNIV CALIFORNIA AT SANTA BARBARA , HUMAYUN MARK , AHUJA ASHISH , TAI YU-CHONG , HINTON DAVID , GRUBBS ROBERT , BRANT RODRIGO , WELLS TRENT
发明人： HUMAYUN MARK , AHUJA ASHISH , TAI YU-CHONG , HINTON DAVID , GRUBBS ROBERT , BRANT RODRIGO , WELLS TRENT
IPC分类号： A61B17/00 , A61B17/28 , A61F2/00 , A61K35/12 , A61L27/56
CPC分类号： A61B17/2909 , A61B2017/2937 , A61B2017/2945 , A61B2017/305 , A61F2/14 , A61F2/4601 , A61F9/0017 , A61F9/00736 , A61K35/50 , A61L27/16 , A61L27/34 , A61L27/3813 , A61L27/50 , A61L2430/16 , A61M1/12 , A61M5/14 , A61M2202/09 , C12N5/0621 , C12N2506/02 , C12N2533/30 , C12N2533/40 , C12N2533/50 , C08L65/04 , C08L89/00
摘要： Disclosed herein are instruments and methods for delivery of substrates, including cell- seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译：本文公开了用于将包括细胞接种的底物在内的底物递送到需要治疗诱导细胞死亡，损伤或功能丧失的各种疾病的靶组织的器械和方法。衬底被配置为向包括干细胞的细胞提供允许细胞与目标组织之间的生物信号相互连接和传输的结构支撑。

87. 发明申请

WO2012121978A3 BIOMARKERS FOR THE DIAGNOSIS OF LACUNAR STROKE 审中-公开
标题翻译：用于诊断LACUNAR STROKE的生物标志物
公开(公告)号：WO2012121978A3
公开(公告)日：2012-12-27
申请号：PCT/US2012027316
申请日：2012-03-01
申请人： UNIV CALIFORNIA , SHARP FRANK , JICKLING GLEN C
发明人： SHARP FRANK , JICKLING GLEN C
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/6893 , G01N2800/2871
摘要： This invention provides gene expression profiles useful for diag lacunar stroke and for distinguishing lacunar stroke from non-lacunar stroke.
摘要翻译：本发明提供了可用于诊断间隙性卒中并用于区分腔隙性中风与非腔隙性中风的基因表达谱。

88. 发明申请

WO2012068499A4 HYBRID, PLANAR OPTOFLUIDIC INTEGRATION 审中-公开
标题翻译：混合，平面光通信集成
公开(公告)号：WO2012068499A4
公开(公告)日：2012-12-27
申请号：PCT/US2011061463
申请日：2011-11-18
申请人： UNIV CALIFORNIA , UNIV BRIGHAM YOUNG , SCHMIDT HOLGER , HAWKINS AARON ROE
发明人： SCHMIDT HOLGER , HAWKINS AARON ROE
IPC分类号： G01N21/41 , G01N33/483 , G01N35/08
CPC分类号： G01N21/0303 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0654 , B01L2300/0822 , B01L2300/0877 , G01N21/01 , G01N21/7703 , G01N2021/6482 , Y10T29/49826
摘要： An optofluidic platform is constructed so as to comprise a vertical integration of optical and fluidic layers. The optical layer enables interaction of light with a fluid for a variety of purposes, including particle detection, manipulation, and analysis. The vertical integration allows layers to be permanently or temporarily attached to each other. Temporary attachments provide the advantage of reusing the same optical layer with different fluidic layers. Most preferably, the optical layer comprises antiresonant reflecting optical waveguide (ARROWs). Further, a fluidic layer can be configured to act as an interface between the optical layer and other fluidic layers attached thereon. Moreover, the fluidic layers can be configured to perform fluidic functions. The optofluidic platform can also comprise a protective layer. As such, a liquid solution can be introduced in the optofluidic platform and single particles contained therein can be optically detected with extremely high sensitivity and without the need for advanced microscopy equipment.
摘要翻译：光流体平台被构建为包括光学层和流体层的垂直整合。光学层使光与流体发生相互作用，用于各种目的，包括粒子检测，处理和分析。垂直整合允许层永久或暂时相互连接。临时附件提供了重复使用具有不同流体层的相同光学层的优点。最优选地，光学层包括反谐振反射光波导（ARROW）。此外，流体层可以被配置成充当光学层和附接在其上的其他流体层之间的界面。而且，流体层可以构造成执行流体功能。光流体平台还可以包括保护层。因此，可以在光流控平台中引入液体溶液，并且可以以非常高的灵敏度光学地检测其中包含的单个颗粒，而不需要先进的显微镜设备。

89. 发明申请

WO2012167028A2 COMPOSITIONS AND METHODS FOR TREATING CANCER AND DISEASES AND CONDITIONS RESPONSIVE TO CELL GROWTH INHIBITION 审中-公开
标题翻译：治疗癌细胞生长抑制作用的组合物和方法
公开(公告)号：WO2012167028A2
公开(公告)日：2012-12-06
申请号：PCT/US2012040390
申请日：2012-06-01
申请人： UNIV CALIFORNIA , CHERESH DAVID , FRANOVIC ALEKSANDRA , SEGUIN LAETITIA
发明人： CHERESH DAVID , FRANOVIC ALEKSANDRA , SEGUIN LAETITIA
IPC分类号： G01N33/68 , A61K38/00 , A61K39/00
CPC分类号： A61K31/517 , A61K38/00 , C12Q1/485 , G01N33/566 , G01N33/574 , G01N2333/70557 , G01N2800/52
摘要： In alternative embodiments, the invention provides compositions and methods for identifying individuals that would be responsive to a treatment comprising (including) blocking activation of integrin polypeptide alphav-beta3 (or a?-ß3), or blocking the interaction of a ligand with integrin polypeptide alphav-beta3 (or a?-ß3). The invention provides compositions and methods for determining the effectiveness of such a treatment and can contribute to a prognosis for the patient.
摘要翻译：在替代实施方案中，本发明提供了用于鉴定对治疗有反应的个体的组合物和方法，包括（包括）阻断整联蛋白多肽α-β3（或β-β3）的活化，或阻断配体与整联蛋白多肽的相互作用 alphav-beta3（或α-β3）。本发明提供了用于确定这种治疗的有效性的组合物和方法，并可有助于患者的预后。

90. 发明申请

WO2012106451A3 PREPARATION OF METAL-CATECHOLATE FRAMEWORKS 审中-公开
标题翻译：金属钙钛合金框架的制备
公开(公告)号：WO2012106451A3
公开(公告)日：2012-12-06
申请号：PCT/US2012023516
申请日：2012-02-01
申请人： UNIV CALIFORNIA , YAGHI OMAR M , GANDARA-BARRAGAN FELIPE , WAN SHUN , LU ZHENG
发明人： YAGHI OMAR M , GANDARA-BARRAGAN FELIPE , WAN SHUN , LU ZHENG
IPC分类号： C07F15/04 , B01J31/12 , C07F3/06 , C07F15/06
CPC分类号： C07C49/92 , C07F1/005 , C07F3/003 , C07F5/003 , C07F7/006 , C07F9/005 , C07F13/005 , C07F15/045 , C07F15/065
摘要： The disclosure provides for metal catecholate frameworks, and methods of use thereof, including gas separation, gas storage, catalysis, tunable conductors, supercapacitors, and sensors.
摘要翻译：本公开提供金属儿茶酚酸酯骨架及其使用方法，包括气体分离，气体储存，催化，可调谐导体，超级电容器和传感器。

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