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2. 发明申请

WO2010099573A1 DIOXOLANE NORBORNANE / NORBORNENE COMPOUNDS SUITABLE AS ANTIMICROBIAL AGENTS TO TREAT BACTERIAL INFECTIONS 审中-公开
标题翻译： DIOXOLANE NORBORNANE / NORBORNENE化合物适合用作治疗细菌感染的抗微生物剂
公开(公告)号：WO2010099573A1
公开(公告)日：2010-09-10
申请号：PCT/AU2010/000245
申请日：2010-03-03
申请人： DEAKIN UNIVERSITY , PFEFFER, Frederick , HENDERSON, Luke , LI, Jian , NATION, Roger
发明人： PFEFFER, Frederick , HENDERSON, Luke , LI, Jian , NATION, Roger
IPC分类号： C07D317/70 , A61K31/357 , A61P31/00 , A61P31/04
CPC分类号： C07D317/70
摘要： The invention provides a compound including : A core having a first face and a second face; A binding portion attached to the first face of the core, wherein the binding portion is capable of binding to an anionic group present in a cell membrane of a microorganism; and A hydrophobic portion attached to the second face of the core, wherein the hydrophobic portion is capable of interacting with the cell membrane of the microorganism; and The core comprises a dioxolane norbornane / norbornene of formula (II): Or a salt or ion thereof, wherein R' is a moiety forming part of a hydrophobic portion; R 2 is a first binding portion; and R 3 is a seconding binding portion. The invention also provides compositions including at least one such compound. The invention also provides methods and uses for treatment or prophylaxis of infection of a mammal by a microorganism, and methods and uses for treating or preventing contamination of a substrate by a microorganism, using the compounds and compositions.
摘要翻译：本发明提供了一种化合物，包括：具有第一面和第二面的芯; 附着于芯的第一面的结合部分，其中结合部分能够结合存在于微生物细胞膜中的阴离子基团; 和疏水部分，其连接到芯的第二面，其中疏水部分能够与微生物的细胞膜相互作用; 核心包括式（II）的二氧杂环戊烷降冰片烷/降冰片烯：或其盐或其离子，其中R'是形成疏水部分的部分的部分; R2是第一结合部分; R3是借装装订部。本发明还提供包含至少一种这样的化合物的组合物。本发明还提供了用于治疗或预防微生物感染哺乳动物的方法和用途，以及使用该化合物和组合物来治疗或预防微生物污染底物的方法和用途。

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