The invention relates to a panel fixing device made from aluminum profile, which comprises an aluminium profile frame and a fastener, wherein the fastener is a structure fashioned by blending a thin plate; the panel fixing device is characterized in that the fastener takes on C shape, the upper end of the fastener is provided with a downward raising structure, the lower end of the fastener is provided with an upward raising structure, and the inner side of the flanging at the back of the aluminium profile frame is provided with a raising structure. The panel fixing device made from aluminum profile utilizes the fastener for fixing the frame and the middle part of the profile together; the raising structure on the fastener and the raising structure on the frame profile can prevent the fastener from slipping; when the panel fixing device is assembled, the fastener is plugged without needing punching and tapping. Therefore, the panel fixing device is characterized by convenient installation, time and labor saving, and high finished product ratio.