The invention relates to a Chinese herbal medicinal wet wipe for cleaning and disinfection of the skin, which relates to the technical field of daily necessities. The wet wipe comprises a wet wipe solution and a carrier for the wet wipe solution. The invention is characterized in that raw materials for preparation of the wet wipe solution comprise, by weight, 0.5 to 1% of lavender essential oil, 0.4 to 0.8% of cassia twig essential oil, 0.3 to 1% of cablin patchouli herb essential oil, 0.01 to 0.1% of menthol, 0.01 to 0.2% of paeonol, 0.3 to 1% of a coptis extract, 0.2 to 1% of a witch hazel extract, 0.5 to 2% of hydrogenated castor oil and 5 to 10 % of ethanol, with the balance being water. According to the invention, a non-woven fabric is used as the carrier; the wet wipe is convenient to use and can kill common pathogenic bacteria like escherichia coli, staphylococcus aureus, bacillus subtilis, aspergillus flavus, Gram-positive cocci, shigella dysenteriae, helicobacter pylori and Candida albicans; the wet wipe is mild-natured, natural and safe because of utilization of a Chinese herbal medicine formula and can overcome the problems of irritation and corrosivity of currently-used chemical disinfection products.