The invention discloses a food sterilization wet wipe suitable for hand-mouth contact and relates to the field of daily living equipment. The problems that the conventional sterilization product and wet wipe irritate the skin surface and are unsuitable for cleaning food and oral cavity can be solved. The food sterilization wet wipe comprises a wet wipe solution and a wet wipe solution carrier, and is characterized in that the raw material for preparing the wet wipe solution comprises the following components in percentage by weight: 0.4 to 0.6 percent of xylitol, 0.8 to 1.2 percent of sodium chloride, 0.04 to 0.07 percent of coconut oil amphiprotic disodium hydrogen diacetate, 0.04 to 0.07 percent of sodium fluoride, 0.01 to 0.03 percent of essence, 0.08 to 0.2 percent of potassium sorbate and the balance of water. The non-woven fabric serves as a carrier, a food-grade fungicide potassium sorbate is used, the food sterilization wet wipe is safe and reliable to use, does not contain alcohol and is natural and non-irritative; according to the addition of the xylitol, the food sterilization wet wipe is fresh in taste; and moreover, normal saline is used, and the cellular water in the oral cavity is kept. The food sterilization wet wipe is suitable for wiping hands, lip, oral cavity and other human parts which are easily infected by germs and wiping things which can be contacted by the skin or mouth, can achieve a protection function effectively, and prevents the bacteria attack.