The invention discloses a double-control double-use anti-dismantle ball valve. The double-control double-use anti-dismantle ball valve comprises a valve body (1), a valve rod (2), a valve element (3) and a handle (4), wherein the valve element (3) is arranged in the valve body (1), the upper end of the valve body (1) is provided with a hollow convex neck (1.1), and the valve rod (2) is arranged in a convex neck (1.1); the lower end of the valve rod (2) is connected with the valve element (3), and the upper end of the valve rod (2) is connected with the handle (4); a longitudinal locking device is arranged between the valve body (2) and the handle (4), a transverse locking device is further arranged between the valve body (1) and the handle (4). The anti-dismantle ball valve can lock the handle and the valve body in a longitudinal direction and in a transverse direction so that the ball valve can be selectively locked according to a practical mounting position, and is more convenient to use; furthermore, the transverse direction and the longitudinal direction can be locked so that the anti-dismantle effect is more excellent when the ball valve is not limited by the installation position.