The invention discloses a control method for an intelligent manufacturing interface program system. S0, a first module program sends a request signal; S1, the signal is sent to a first module interface program; S2, signal data are stored in a transfer database; S3, the signal data are extracted and judged, if the signal data are transmitted to equipment, S4 is carried out, and if the signal data are transmitted to a third module, S7 is carried out; S4, the signal data are transmitted to a monitoring signal directory of a second module interface program; S5, the signal data are transmitted to a second module program, and a reply is waited; S6, after the reply, the signal is replied to the second module interface program; S7, the signal data are transmitted to a monitoring signal directory of a third module interface program; S8, the signal data are transmitted to a third module program; and S9, after the reply, the signal is replied to a third module equipment interface program. The transmission efficiency is high, stability is high, and the maintenance cost is low.