The invention belongs to the technical field of traditional Chinese medicines and discloses a pharmaceutical preparation containing argy wormwood leaves and used for preventing and treating pediatric intestinal parasites as well as a preparation method of the pharmaceutical preparation. The pharmaceutical preparation is prepared from raw materials in parts by weight as follows: 12-22 parts of the argy wormwood leaves, 10-22 parts of Japanese flowering fern rhizomes, 10-18 parts of grand torreya seeds, 8-14 parts of Digenea simplex, 8-16 parts of Phyllanthus urinaria, 6-14 parts of officinal asparagus roots, 6-16 parts of elm cakes, 4-12 parts of fortune eupatorium herbs, 4-8 parts of sweet wormwood herbs, 4-10 parts of orange fruits, 4-8 parts of purslane herbs and 4-8 parts of liquorice roots. Natural traditional Chinese medicines are adopted, the components are simple, the ratio is reasonable, toxic and side effects are small, and the pharmaceutical preparation is suitable for children and has functions of killing the parasites, removing stagnation, regulating the spleen and the stomach, clearing heat and removing toxins.