The invention belongs to the field of traditional Chinese medicine, and relates to application of a traditional Chinese medicinal composition in preparing a medicine for treating coronary artery disease. The traditional Chinese medicinal composition is prepared from the following raw materials in parts by weight: 10-20 parts of caulis spatholobi, 9-15 parts of radix curcumae longae, 9-15 parts of cortex phellodendri, 9-15 parts of radix coptis, 8-12 parts of fructus kochiae, 8-12 parts of coriolus versicolor, 8-12 parts of bulbus allii macrostemi, 3-10 parts of Chinese yam, 3-10 parts of concha ostreae, 3-10 parts of ginseng and 2-10 parts of liquorice root. The traditional Chinese medicinal composition disclosed by the invention has functions of clearing and activating channels and collaterals, removing stasis and eliminating stagnation, promoting circulation of qi and relieving pain, tonifying spleen and benefiting lung, and the like; and the traditional Chinese medicinal composition disclosed by the invention is capable of treating both symptoms and root causes, and the traditional Chinese medicinal composition is rapid to take effect, strongly targeted and free from any toxic and side effects.