
基本信息:
- 专利标题: 预测健康衰老的脂质生物标志物
- 申请号:CN201480062281.1 申请日:2014-11-05
- 公开(公告)号:CN105723223B 公开(公告)日:2019-04-09
- 发明人: S·科里诺 , I·蒙托柳 , 鲁拉 , F-P·马丁 , F·C·贝格兰 , S·A·D·莱兹
- 申请人: 雀巢产品技术援助有限公司
- 申请人地址: 瑞士沃韦
- 专利权人: 雀巢产品技术援助有限公司
- 当前专利权人: 雀巢产品技术援助有限公司
- 当前专利权人地址: 瑞士沃韦
- 代理机构: 北京市中咨律师事务所
- 代理人: 陈迎春; 黄革生
- 优先权: 13192937.4 2013.11.14 EP
- 国际申请: PCT/EP2014/073781 2014.11.05
- 国际公布: WO2015/071145 EN 2015.05.21
- 进入国家日期: 2016-05-13
- 主分类号: G01N33/68
- IPC分类号: G01N33/68 ; G01N33/92
In one aspect there is provided a method for predicting a risk of unhealthy ageing in a subject, comprising: (a) determining a level of two or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from two or more of the following groups: (i) a triacylglycerol (TAG) from TAG (46:5) to TAG (54:3); (ii) an ether phosphatidylcholine (PC-O) from PC-O(28:0) to PC-O(38:6); (iii) a sphingomyelin (SM) from SM (33:1) to SM(50:1); (iv) a phosphatidylcholine (PC) from PC (32:1) to PC (40:5); (v) a phosphatidylinositol (PI) from PI (36:1) to PI (38:3); (vi) a phosphatidylethanolamine (PE) from PE (36:2) to PE (38:4); and (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of the risk of unhealthy ageing in the subject.
公开/授权文献:
- CN105723223A 预测健康衰老的脂质生物标志物 公开/授权日:2016-06-29