The invention discloses an oxygen humidification disinfection device. The device comprises a water bottle, a cork, an air inlet pipe, an air outlet pipe, a disinfection module and a power supply, the cork is used for sealing the water bottle, an air inlet through hole and an air outlet through hole are arranged on the cork, the air inlet pipe is inserted in the water bottle bottom through the air inlet through hole, the air outlet pipe is inserted in the water bottle through the air outlet through hole, the bottom of the air outlet pipe is above the bottom of the air inlet pipe, the disinfection module is a ring-shape structure and is arranged in a sleeving mode on the air outlet pipe, the disinfection module comprises an infrared lamp and an ultrasonic wave vibration board, and the power supply supplies power for the disinfection module. According to the oxygen humidification disinfection device, oxygen flows into the water bottle bottom through the air inlet pipe, and flows out of the air outlet pipe after flowing pass the water in the water bottle, to achieve the humidification purpose; when flowing through the air outlet bottom, the humidified oxygen are irradiated by an infrared lamp for infrared disinfection, meanwhile the oxygen and the air outlet pipe are ultrasonically shocked using an ultrasonic vibration board, the air outlet pipe is kept clean, sufficient infrared transmittance rate in the air outlet pipe is guaranteed, meanwhile the bacteria and virus in oxygen are disinfected with ultrasound shocks.