The invention discloses a multi-purpose hand-care mouse pad. The multi-purpose hand-care mouse pad comprises an anti-slip layer, an inflatable layer, a heat insulation layer, a heating layer, a reinforcement layer and a face layer in sequential connection from bottom to top. The inflatable layer is internally provided with a PVC (polyvinyl chloride) air bag, the heating layer is internally provided with a heating wire, the face layer is formed by synthesis of bamboo fibers, milk fibers and hemp fibers, the front end of the upper surface of the face layer is provided with an upwardly-convex arc projection, an infrared physiotherapy bulb is arranged between the arc projection and the face layer, an upper hand-care layer is arranged above the arc projection, and the upper hand-care layer and the face layer form a cavity with the front end open. The multi-purpose hand-care mouse pad has advantages that by addition of the inflatable layer, deformation resistance of the mouse pad is improved; heating and heat preservation functions are achieved through the heating layer; by design of the skin-care face layer and the hand-care layer, skin moisture retention and healthcare performances are improved, and functional diversity is realized.