基本信息:
- 专利标题： 一种检测人葡萄膜黑色素瘤细胞的核酸适体
- 专利标题（英）：A nucleic acid aptamer for detecting human uveal melanoma cells
- 申请号：CN201711091811.7 申请日：2017-11-08
- 公开(公告)号：CN108034658A 公开(公告)日：2018-05-15
- 发明人： 叶茂 , 谭蔚泓 , 张慧 , 熊炜
- 申请人： 湖南大学 , 中南大学湘雅二医院
- 申请人地址： 湖南省长沙市岳麓区登高路1号;
- 专利权人： 湖南大学,中南大学湘雅二医院
- 当前专利权人： 湖南大学,中南大学湘雅二医院
- 当前专利权人地址： 湖南省长沙市岳麓区登高路1号;
- 代理机构： 北京知本村知识产权代理事务所
- 代理人： 刘江良
- 主分类号： C12N15/115
- IPC分类号： C12N15/115 ; G01N33/574
A nucleic acid aptamer used for detecting human uveal melanoma cells (OCM-1) and applications thereof in preparation of detection preparations are disclosed. Compared with the prior art, the nucleic acid aptamer and the applications are advantageous in that the prepared nucleic acid aptamer can specifically recognize the uveal melanoma cells, has good affinity, no immunogenicity, and a small molecular weight, and can be chemically synthesized in vitro; and different positions of the nucleic acid aptamer can be modified and substituted. In addition, the nucleic acid aptamer has advantages of astable sequence, capability of being convenient to store and mark, and the like. When the nucleic acid aptamer is adopted for detecting the human uveal melanoma cells, operation is simpler and rapider. The nucleic acid aptamer has a synthesis cost lower than antibody preparing costs, a short period and good reproducibility.
公开/授权文献:
- CN108034658B 一种检测人葡萄膜黑色素瘤细胞的核酸适体 公开/授权日：2023-09-05