The invention belongs to the field of preparation of chemical intermediates, and particularly relates to a preparation method of 1-(2,3-dichlorophenyl)piperazine hydrochloride. The preparation methodcomprises the following steps of using diethanol amine as the initial raw material, and performing chlorination reaction, so as to obtain beta,beta'-dichlorodiethylamine hydrochloride; performing cyclization reaction with 2,3-dichloroaniline in a water solution under the condition of no catalyst, so as to synthesize a target compound, namely the 1-(2,3-dichlorophenyl)piperazine hydrochloride. Thepreparation method of the 1-(2,3-dichlorophenyl)piperazine hydrochloride has the advantages that the reaction rate is obviously accelerated, the yield rate is increased, and the cost is reduced.