The invention discloses a laboratory ventilation pipe security cover with sealing and locking functions. The laboratory ventilation pipe security cover with the sealing and locking functions comprises flywheels, a wall body, chains, a magnet and neodymium magnets; the flywheels are fixed to the wall body; bearing bases are fixed to the bottom of the wall body, and the wall body and the bearing bases are provided with connecting grooves correspondingly; operating plates are connected with inner plates, and the inner plates are connected with the wall body and provided with penetrating windows; and the penetrating windows are connected with movable plates, and the neodymium magnets are installed at the ends, far away from the penetrating windows, of the movable plates. According to the laboratory ventilation pipe security cover with the sealing and locking functions, the novel structural design is adopted, therefore, the device can be quickly triggered to work when abnormal conditions occur in a laboratory, and stable sealing operation can be conducted on a pipeline port of a laboratory ventilation pipe; and in addition, a sealing structure can be stably locked, loosing and air leaking can not prone to occurring, indoor and outdoor air exchange channels are thoroughly sealed, and the good laboratory security effect is achieved.