The invention discloses a supersonic wind tunnel flow calibration pressure measuring hose protection device. In the airflow direction of a wind tunnel, the protection device is located behind a bent blade support of a wind tunnel test section and comprises an inner-layer protection mechanism and an outer-layer protection mechanism, and the inner-layer protection mechanism is integrally arranged inthe outer-layer protection mechanism; and the outer-layer protection mechanism is composed of a rear protection cover, an installation base, a front protection cover and a cover plate, and a communicating cavity is formed in the outer-layer protection mechanism and used for containing the inner-layer protection mechanism. After being bundled, pressure measuring hoses led out from a cross pressuremeasuring bent frame penetrate out of the protection device and enter a wind tunnel plenum to be connected with a wind tunnel pressure measuring system. According to the protection device, the pressure measuring hoses are protected by a metal corrugated pipe, the metal corrugated pipe moves back and forth along with the lead screw and acts together with the outer-layer protection mechanism, so that the influence and damage of supersonic airflow to the pressure measuring hoses are avoided, the pressure measuring hoses of the flow calibration mechanism is effectively protected, the problem of wiring of multiple pressure measuring pipes of a flow channel in a supersonic wind tunnel is solved, and reliable acquisition of test pressure measurement data of the supersonic wind tunnel is guaranteed.