发明申请
US20100068260A1 Methods, Compositions and Device for Directed and Controlled Heating and Release of Agents
审中-公开
基本信息:
- 专利标题： Methods, Compositions and Device for Directed and Controlled Heating and Release of Agents
- 专利标题（中）：用于定向和控制加热和释放试剂的方法，组合物和装置
- 申请号：US12508076 申请日：2009-07-23
- 公开(公告)号：US20100068260A1 公开(公告)日：2010-03-18
- 发明人： Dustin E. Kruse , Claude Meares , Katherine W. Ferrara , Eric Paoli , Douglas N. Stephens , Jeffrey Day
- 申请人： Dustin E. Kruse , Claude Meares , Katherine W. Ferrara , Eric Paoli , Douglas N. Stephens , Jeffrey Day
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61N7/02
摘要：
A composition coupled to an agent with a cleavable linker is provided. Specifically, the composition is used for releasing the agent through a temperature-sensitive mechanism at a targeted location in a subject with heat. It is advantageous to applications where there is a need to accurately deploy an agent in a targeted location to reduce adverse side effects or increase efficacy of the agent. A device and method for providing heat at the targeted location in the subject is also provided. The device and method allows release of the agents in a targeted manner and prevents overheating of the targeted location or the tissue surrounding the targeted location. It is advantageous to applications where there is a need to accurately control the temperature in a targeted location in a biological body, for instance, to deploy an agent in the targeted location.
摘要（中）：
提供了与具有可切割连接子的试剂偶联的组合物。 具体地说，该组合物用于通过热量在受试者的目标位置通过温度敏感性机构释放药剂。 需要在目标位置准确地部署试剂以减少不良副作用或增加试剂功效的应用是有利的。 还提供了一种用于在受试者的目标位置提供热量的装置和方法。 该装置和方法允许以有针对性的方式释放试剂，并防止目标位置或围绕目标位置的组织过热。 对于需要精确地控制生物体内的目标位置的温度的应用，例如在目标位置部署试剂是有利的。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/127 | ..脂质体 |