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91. 发明授权

US09733228B2 Methods of analyzing crude oil 有权
公开(公告)号：US09733228B2
公开(公告)日：2017-08-15
申请号：US14426879
申请日：2014-01-23
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Fred Paul Mark Jjunju , Anyin Li , Iman S. Rogan
IPC分类号： H01J49/10 , G01N33/28 , G01N30/72 , H01J49/16 , H01J49/04 , H01J49/00
CPC分类号： G01N33/2823 , G01N30/724 , G01N30/7266 , H01J49/0031 , H01J49/04 , H01J49/10 , H01J49/164
摘要： The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.

92. 发明申请

US20170059535A1 NOVEL METHODS AND KITS FOR DETECTING OF UREA CYCLE DISORDERS USING MASS SPECTROMETRY 审中-公开
标题翻译：用质谱法检测尿素循环障碍的新方法和工具
公开(公告)号：US20170059535A1
公开(公告)日：2017-03-02
申请号：US15255905
申请日：2016-09-02
申请人： Labsystems Diagnostics Oy
发明人： Géraldine CARRARD , Ralph FINGERHUT
IPC分类号： G01N30/72 , G01N33/487
CPC分类号： G01N30/724 , G01N33/487 , G01N33/58 , G01N33/6848 , G01N2458/15 , H01J49/0045 , H01J49/0081
摘要： The present invention relates to newborn screening kits, methods, stable isotopically-labeled internal standards or internal standard solution for high throughput screening and analysis of metabolic disorders using liquid chromatography mass spectrometry (LC-MS) are provided. The metabolic disorders can be amino acid, organic acid or fatty acid oxidation disorders, and particularly urea cycle disorders or deficiencies, hyperammonemia, Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH), and/or argininosuccinic aciduria. The newborn screening kits, methods, stable isotopically-labeled internal standards or internal standard solution are particularly useful for newborn screening (NBS) of metabolic disorders.
摘要翻译：本发明涉及使用液相色谱质谱（LC-MS）的新生儿筛选试剂盒，方法，稳定同位素标记的内标或用于高通量筛选和分析代谢紊乱的内标溶液。代谢紊乱可以是氨基酸，有机酸或脂肪酸氧化障碍，特别是尿素循环障碍或缺陷，高氨血症，高山羊血脂 - 高氨血症 - 高蛋白尿尿症（HHH）和/或精氨基琥珀酸性尿症。新生儿筛查试剂盒，方法，稳定同位素标记的内标或内标溶液特别适用于代谢紊乱的新生儿筛查（NBS）。

93. 发明申请

US20140339420A1 ATMOSPHERIC PRESSURE ION SOURCE BY INTERACTING HIGH VELOCITY SPRAY WITH A TARGET 有权
标题翻译：通过将高速喷雾与目标相互作用的大气压力离子源
公开(公告)号：US20140339420A1
公开(公告)日：2014-11-20
申请号：US14451513
申请日：2014-08-05
申请人： Micromass UK Limited
发明人： Stevan Bajic
IPC分类号： G01N30/72 , H01J49/06 , H01J49/24 , G01N27/62 , H01J49/14
CPC分类号： H01J49/10 , G01N27/624 , G01N30/724 , H01J49/0445 , H01J49/0468 , H01J49/061 , H01J49/14 , H01J49/16 , H01J49/24 , H01J49/26
摘要： An ion source is disclosed comprising a nebuliser and a target. The nebuliser is arranged and adapted to emit, in use, a stream of analyte droplets which are caused to impact upon the target and to ionise analyte to form a plurality of analyte ions.
摘要翻译：公开了一种包括雾化器和靶的离子源。雾化器布置并适于在使用中发射被分析物液滴流，其被引起撞击目标物体并使分析物离子化以形成多个分析物离子。

94. 发明授权

US07829872B2 UV reactive spray chamber for enhanced sample introduction efficiency 有权
标题翻译： UV反应喷雾室，提高样品引入效率
公开(公告)号：US07829872B2
公开(公告)日：2010-11-09
申请号：US11721313
申请日：2005-12-12
申请人： Ralph Edward Sturgeon , Zoltan Mester , Xuming Guo
发明人： Ralph Edward Sturgeon , Zoltan Mester , Xuming Guo
IPC分类号： G21G4/00
CPC分类号： G01N21/631 , B01L3/0268 , G01N21/3103 , G01N30/724 , G01N2001/2223 , G01N2001/4066 , G01N2030/8447
摘要： An analyte for atomic spectrometry detection is prepared by introducing an aerosol of the analyte into a chamber, and irradiating the aerosol with ultraviolet light in the presence of a low molecular weight organic acid or other suitable photoactivatable ligand donor species to create vapor containing the analyte. The vapor containing the analyte is extracted from the chamber and used for atomic spectrometry detection.
摘要翻译：通过将分析物的气溶胶引入室中并在低分子量有机酸或其它合适的可光活化配体供体物质的存在下用紫外线照射气溶胶来制备用于原子光谱检测的分析物，以产生含有分析物的蒸气。从室中提取含有分析物的蒸汽，用于原子光谱检测。

95. 发明授权

US07820966B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07820966B2
公开(公告)日：2010-10-26
申请号：US11909996
申请日：2006-04-03
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： B01D59/44 , G01N30/724 , G01N2030/8447 , G01N2030/8868 , H01J49/004 , H01J49/04
摘要： A mass spectrometer is disclosed comprising a High Pressure Liquid Chromatography system (10) which is interfaced to a combustion chamber (16) and isotope ratio mass analyser (19) by means of an Electrospray Ionisation ion source (11) and a Field Asymmetric Ion Mobility Spectrometry device (13). Analyte and solvent molecules are ionised by the ion source (11). Desired analyte ions are substantially onwardly transmitted by the Field Asymmetric Ion Mobility Spectrometry device (13) to the combustion chamber (16) whereas undesired solvent ions are substantially attenuated by the Field Asymmetric Ion Mobility Spectrometry device (13).
摘要翻译：公开了一种质谱仪，其包括通过电喷雾离子源（11）和场非对称离子迁移率（11）与燃烧室（16）和同位素比质量分析器（19）相连的高压液相色谱系统（10）光谱测定装置（13）。分析物和溶剂分子被离子源（11）电离。期望的分析物离子通过场非对称离子迁移率分析装置（13）基本向上传输到燃烧室（16），而不期望的溶剂离子被场非对称离子迁移率装置（13）基本上衰减。

96. 发明申请

US20100155594A1 MASS SPECTROMETRY ASSAY FOR ESTROGENIC COMPOUNDS 审中-公开
标题翻译：雌激素化合物的质谱分析
公开(公告)号：US20100155594A1
公开(公告)日：2010-06-24
申请号：US12641227
申请日：2009-12-17
申请人： Mildred M. Goldman , Nigel J. Clarke
发明人： Mildred M. Goldman , Nigel J. Clarke
IPC分类号： H01J49/26
CPC分类号： G01N33/743 , G01N30/724 , G01N33/6848 , G01N33/6851 , G01N2458/15 , H01J49/00 , H01J49/0027
摘要： Methods are provided for detecting the amount of one or more HRT panel analytes (i.e., estrone (E1), estrone sulfate (E1s), 17α-estradiol (E2a), 17β-estradiol (E2b), estradiol sulfate (E2s), estriol (E3), equilin (EQ), 17α-dihydroequilin (EQa), 17β-dihydroequilin (EQb), Equilenin (EN), 17α-dihydroequilenin (ENa), 17β-dihydroequilenin (ENb), and Δ8,9-dehydroestrone (dE1)) in a sample by mass spectrometry. The methods generally involve ionizing one or more HRT panel analytes in a sample and quantifying the generated ions to determine the amount of one or more HRT panel analytes in the sample. In methods where amounts of multiple HRT panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
摘要翻译：提供了用于检测一种或多种HRT面板分析物（即雌酮（E1），硫酸雌酮（E1）），17α-雌二醇（E2a），17β-雌二醇（E2b），硫酸雌二醇（E2s），雌三醇（E3），平衡（EQ），17α-二氢比例蛋白（EQa），17b-二氢异构酶（EQb），均衡素（EN），17α-二氢马来西林（ENa），17b-二氢马来西林（ENb） - 脱氢雌酮（dE1））。所述方法通常涉及将样品中的一种或多种HRT面板分析物离子化并量化产生的离子以确定样品中一种或多种HRT面板分析物的量。在检测到多个HRT面板分析物的量的方法中，在相同的样品注入中检测到多种分析物的量。

97. 发明授权

US07640109B2 Fingerprinting of complex hydrocarbon containing mixtures 失效
标题翻译：复杂含烃混合物的指纹图谱
公开(公告)号：US07640109B2
公开(公告)日：2009-12-29
申请号：US10587805
申请日：2005-02-07
申请人： Ingvar Eide , Kolbjorn Zahlsen
发明人： Ingvar Eide , Kolbjorn Zahlsen
IPC分类号： G06F19/00
CPC分类号： H01J49/0431 , G01N30/724 , G01N30/7266 , G01N33/2823
摘要： The invention provides a method of analysing a complex hydrocarbon-containing mixture, the method comprising the steps of: obtaining a liquid sample of the complex hydrocarbon-containing mixture; injecting the sample into a liquid carrier flowing to a mass spectrometer, wherein the mass spectrometer is set so as to ionise molecules in the sample without causing fragmentation thereof; recording a mass spectrum for ions obtained from the sample; and using the mass spectrum to obtain fingerprint of the mixture. {dot over (a)}In one embodiment, two or more mass spectra are recorded and are combined to obtain a fingerprint of the mixture.
摘要翻译：本发明提供一种分析复合含烃混合物的方法，所述方法包括以下步骤：获得所述复合烃混合物的液体样品; 将样品注入流向质谱仪的液体载体中，其中设置质谱仪以使样品中的分子离子化而不引起其分裂; 记录从样品获得的离子的质谱; 并使用质谱获得混合物的指纹。 {dot over（a）}在一个实施例中，记录两个或更多个质谱，并将其组合以获得混合物的指纹。

98. 发明授权

US07332713B2 Mass spectrometric method and mass spectrometric system 有权
标题翻译：质谱法和质谱系统
公开(公告)号：US07332713B2
公开(公告)日：2008-02-19
申请号：US11210965
申请日：2005-08-25
申请人： Kiyomi Yoshinari , Toshiyuki Yokosuka , Atsushi Ootake , Kinya Kobayashi , Yuichiro Hashimoto
发明人： Kiyomi Yoshinari , Toshiyuki Yokosuka , Atsushi Ootake , Kinya Kobayashi , Yuichiro Hashimoto
IPC分类号： B01D59/44
CPC分类号： H01J49/04 , G01N30/24 , G01N30/467 , G01N30/7206 , G01N30/724 , G01N30/8658 , H01J49/0027
摘要： In a method for mass spectrometry, a plurality of juxtaposed chromatography apparatus connected to a mass spectrometer start eluting at a predetermined time difference and the following mass spectrometer conducts mass spectrometry. A chromatogram in a preceding chromatography apparatus is analyzed on real time base and results of the analysis are used on real time base to change an elusion condition of a succeeding chromatography apparatus. A mass spectrometric system suitable for carrying out the method is also provided.
摘要翻译：在质谱法中，与质谱仪连接的多个并置色谱装置开始以预定的时间差洗脱，随后的质谱仪进行质谱分析。在实时基础上分析先前色谱装置中的色谱图，并将实时分析结果用于改变后续色谱装置的脱色条件。还提供了适用于实施该方法的质谱系统。

99. 发明申请

US20040262513A1 Parallel concentration, desalting and deposition onto MALDI targets 失效
标题翻译：平行浓缩，脱盐和沉积到MALDI靶上
公开(公告)号：US20040262513A1
公开(公告)日：2004-12-30
申请号：US10834780
申请日：2004-04-29
申请人： WATERS INVESTMENTS LIMITED
发明人： Robert Karol , Jeffrey Finch , Daniel Wall
IPC分类号： H01J049/00
CPC分类号： G01N30/466 , G01N30/468 , G01N30/724 , G01N30/84 , G01N2030/027 , G01N2030/324 , G01N2030/8417 , H01J49/00 , H01J49/0418 , H01J49/165
摘要： A method and apparatus for the continuous deposition of RP HPLC eluent, from isocratic or gradient elutions, on to a MALDI target using a parallel sample desalting method, allows increased sensitivity of the MALDI sample by pre-concentration of the analyte, separation of interfering contaminants from the analyte and increased dynamic range of peptide abundance that can be analyzed. The parallel processing of sample material allows greater throughput than that of manual methods.
摘要翻译：使用平行样品脱盐方法从等度或梯度洗脱液将RP HPLC洗脱液连续沉积到MALDI靶上的方法和装置允许通过预浓缩分析物来增加MALDI样品的敏感性，分离干扰污染物从分析物和增加的肽丰度的动态范围可以分析。样品材料的并行处理能够提供比手工方法更高的产量。

100. 发明申请

US20010050337A1 Liquid chromatograph mass spectrometer 有权
标题翻译：液相色谱质谱仪
公开(公告)号：US20010050337A1
公开(公告)日：2001-12-13
申请号：US09845287
申请日：2001-05-01
申请人： SHIMADZU CORPORATION
发明人： Yasufumi Tanaka
IPC分类号： H01J049/00 , B01D059/44
CPC分类号： H01J49/067 , G01N30/724 , H01J49/044 , H01J49/063
摘要： A liquid chromatograph mass spectrometer includes a solvent removing tube, a first ion lens and a second ion lens. Voltages applied to the solvent removing tube, and the first and second ion lenses corresponding to each mass number of a standard sample are studied in advance so that efficiencies of passing ions become best. A voltage scanning pattern is made based on the impressed voltages, and stored in a memory portion. When a scanning measurement is carried out, a control portion controls a current voltage source and a high frequency voltage source according to the voltage scanning pattern, synchronizing with the scanning of the impressed voltage to the quadrupole filter. As a result of the control, an objective ion which is generated by being atomized from a nozzle may effectively pass through the entrance of a quadrupole filter.
摘要翻译：液相色谱质谱仪包括溶剂去除管，第一离子透镜和第二离子透镜。预先施加到溶剂去除管的电压以及与标准样品的每个质量数对应的第一和第二离子透镜，使得通过离子的效率变得最佳。基于外加电压进行电压扫描图案，并存储在存储器部分中。当执行扫描测量时，控制部分根据电压扫描图案控制电流电压源和高频电压源，与向四极滤波器的外加电压的扫描同步。作为控制的结果，通过从喷嘴雾化产生的客观离子可以有效地通过四极过滤器的入口。

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