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11. 发明授权

US08507676B2 Heterocyclic oxime compounds 有权
标题翻译：杂环肟化合物
公开(公告)号：US08507676B2
公开(公告)日：2013-08-13
申请号：US13567386
申请日：2012-08-06
申请人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-Chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
发明人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-Chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
IPC分类号： C07D487/04 , C07D403/12 , A61K31/4985 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
摘要翻译：本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

12. 发明授权

US08410264B2 Heterocyclic oxime compounds 有权
公开(公告)号：US08410264B2
公开(公告)日：2013-04-02
申请号：US12859653
申请日：2010-08-19
申请人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
发明人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

13. 发明申请

US20110015232A1 Pyrrolydine Derivatives as IAP Inhibitors 失效
标题翻译：吡咯列酮衍生物作为IAP抑制剂
公开(公告)号：US20110015232A1
公开(公告)日：2011-01-20
申请号：US12445435
申请日：2007-10-10
申请人： Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
发明人： Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
IPC分类号： A61K31/4439 , C07D405/14 , C07D401/14 , C12N5/07
CPC分类号： C07K5/06191
摘要： The present invention relates to novel IAP inhibitor compounds of: Formula (I).
摘要翻译：本发明涉及式（I）的新型IAP抑制剂化合物。

14. 外观设计

USD625446S1 Hand dynamo rechargeable flash light with radio alarm clock and reading lamp 有权
标题翻译：手电筒充电闪光灯带收音机闹钟和阅读灯
公开(公告)号：USD625446S1
公开(公告)日：2010-10-12
申请号：US29316398
申请日：2009-09-21
申请人： Yu-Feng He
设计人： Yu-Feng He

15. 发明申请

US20070139357A1 Flat panel display 有权
标题翻译：平板显示器
公开(公告)号：US20070139357A1
公开(公告)日：2007-06-21
申请号：US11641485
申请日：2006-12-18
申请人： Te-Hsu Wang , Zhi-Yuan Cai , Jie-Feng He
发明人： Te-Hsu Wang , Zhi-Yuan Cai , Jie-Feng He
IPC分类号： G09G3/36
CPC分类号： G06F1/1601
摘要： An exemplary flat panel display (2) includes a front housing part (20), which has a frame (21) having a button through hole (222) defined in a lower side thereof; a button (221) corresponding to the button through hole, the button comprising a pressing end (2215), at least one claw (2213), and a contact portion (2219), the at least one claw extending inward from an inner side of the button, and the contact portion extending inward from an inner side of the button at the pressing end; and an elastic arm (225) fixed at an inner surface of the lower side of the frame. The at least one claw of the button is snappingly engaged adjacent an inner surface of the lower side of the frame such that the button is engaged in the button through hole and slidable in the button through hole.
摘要翻译：示例性的平板显示器（2）包括前壳体部分（20），其具有在其下侧限定有按钮通孔（222）的框架（21）与所述按钮通孔相对应的按钮（221），所述按钮包括按压端（2215），至少一个爪（2213）和接触部（2219），所述至少一个爪从内侧向内延伸所述按钮和所述接触部在所述按压端从所述按钮的内侧向内延伸; 以及固定在框架的下侧的内表面的弹性臂（225）。按钮的至少一个爪邻近框架的下侧的内表面紧密接合，使得按钮接合在按钮通孔中并可在按钮通孔中滑动。

16. 发明授权

US07153848B2 Inhibitors of HCV replication 有权
公开(公告)号：US07153848B2
公开(公告)日：2006-12-26
申请号：US11181639
申请日：2005-07-14
申请人： Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
发明人： Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/425 , A61K31/427 , A61K31/4178 , A61K31/4184 , A61K31/4025 , A61K31/403 , C07D233/32 , C07D413/14 , C07D409/14
CPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D513/14
摘要： Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.

17. 发明授权

US5679566A Yeast NMD2 gene 失效
标题翻译：酵母NMD2基因
公开(公告)号：US5679566A
公开(公告)日：1997-10-21
申请号：US375300
申请日：1995-01-20
申请人： Feng He , Allan S. Jacobson
发明人： Feng He , Allan S. Jacobson
IPC分类号： G01N33/53 , C07K14/395 , C12N1/19 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/67 , C12P21/02 , C12Q1/02 , C12R1/865 , G01N33/569 , C12N15/63 , C12N15/85
CPC分类号： C07K14/395 , C12N15/67
摘要： The invention relates to the discovery of a gene, NMD2, named after its role in the Nonsense-Mediated mRNA Decay pathway, and the protein, Nmd2p, encoded by the NMD2 gene. The amino acid sequence of Nmd2p and the nucleotide sequence of the NMD2 gene encoding it are disclosed. Nmd2p is shown herein to bind to another protein in the decay pathway, Upf1p. A C-terminal fragment of the protein is also shown to bind Upf1p and, when overexpressed in the host cell, the fragment inhibits the function of Upf1p, thereby inhibiting the nonsense-mediated mRNA decay pathway. The invention also relates to methods of inhibiting the nonsense-mediated mRNA decay pathway to stabilize mRNA transcripts containing a nonsense codon which normally would cause an increase in the transcript decay rate. Such stabilization of a transcript is useful for the production of a recombinant protein or fragment thereof.
摘要翻译：本发明涉及以其在无义介导的mRNA衰变途径中的作用命名的NMD2基因和由NMD2基因编码的蛋白质Nmd2p的发现。公开了Nmd2p的氨基酸序列和编码它的NMD2基因的核苷酸序列。 Nmd2p在本文中显示为与衰老途径Upf1p中的另一种蛋白结合。蛋白质的C末端片段还显示结合Upf1p，并且当在宿主细胞中过表达时，该片段抑制Upf1p的功能，从而抑制无义介导的mRNA衰减途径。本发明还涉及抑制无义介导的mRNA衰减途径以稳定含有无义密码子的mRNA转录物的方法，其通常将导致转录物衰减率的增加。转录物的这种稳定化对于重组蛋白质或其片段的产生是有用的。

18. 发明授权

US5591482A Conductive polyurethane foam and its manufacture 失效
标题翻译：导电聚氨酯泡沫及其制造
公开(公告)号：US5591482A
公开(公告)日：1997-01-07
申请号：US197983
申请日：1994-02-17
申请人： Fei-feng He , Toshihiro Yamamoto , Miwako Yamamoto
发明人： Fei-feng He , Toshihiro Yamamoto , Miwako Yamamoto
IPC分类号： C08G61/10 , C08G61/12 , C08J9/36 , C08J9/40 , H01B1/12 , B05D5/12 , B05D3/00
CPC分类号： C08J9/405 , C08G61/124 , H01B1/127 , C08J2375/04
摘要： A method of manufacturing a conductive polyurethane foam in which the polymerization is made easy, the refinement of pyrrole or the like is not required, the recovery rate of a solvent is enhanced, and the pre-treatment is not required at all; and a conductive polyurethane foam having excellent performances. This method includes a process: of coating an oxidizer solution (methanol solution containing FeCl.sub.3 and FeCl.sub.2) on surfaces of cells of a soft polyurethane foam; a process of perfectly removing the solvent of the oxidizer solution by vacuum drying; a process of polymerizing a compound (pyrrole or the like) with conjugated double bonds on the surfaces of cells of the continuous forming type polyurethane foam after being coated with the oxidizer in a vapor-phase atmosphere for forming a conductive electronic conjugated polymer layer (polypyrrole layer or the like) of the compound on the surfaces of the cells; a process of dipping the polyurethane foam formed with the polymer layer in a solvent for extracting the pyrrole and the oxide; and a process for vacuum-drying it. A conductive polyurethane foam can be continuously manufactured by this process. The conductive polyurethane foam thus manufactured has an electric conductivity ranging from 10.sup.-7 to 10.sup.-2 S/cm.
摘要翻译：制造其中使聚合变得容易的导电性聚氨酯泡沫体的方法，不需要精制吡咯等，溶剂的回收率提高，并且根本不需要预处理; 和具有优异性能的导电聚氨酯泡沫。该方法包括在软质聚氨酯泡沫体的表面上涂布氧化剂溶液（含有FeCl 3和FeCl 2的甲醇溶液）的方法; 通过真空干燥完全除去氧化剂溶液的溶剂的方法; 在形成导电性电子共轭聚合物层（聚吡咯）的气相气氛中用氧化剂涂布后，在连续成型型聚氨酯泡沫体的表面上使具有共轭双键的化合物（吡咯等）聚合的方法层等）化合物在细胞表面上; 将由聚合物层形成的聚氨酯泡沫浸渍在萃取吡咯和氧化物的溶剂中的方法; 以及真空干燥方法。可以通过该方法连续制造导电聚氨酯泡沫。由此制造的导电聚氨酯泡沫具有10-7至10-2S / cm的电导率。

19. 发明授权

US08843172B2 Method and base station for determining an initial transmission power 有权
标题翻译：用于确定初始发射功率的方法和基站
公开(公告)号：US08843172B2
公开(公告)日：2014-09-23
申请号：US13259780
申请日：2010-05-31
申请人： Feng He , Jianmin Fang
发明人： Feng He , Jianmin Fang
IPC分类号： H04B7/00 , H04W52/54 , H04W52/50 , H04W92/20
CPC分类号： H04W52/50 , H04B17/382 , H04W36/0077 , H04W36/30 , H04W52/146 , H04W52/241 , H04W52/242 , H04W52/283 , H04W52/325 , H04W52/367 , H04W92/20
摘要： A method for determining an initial transmission power and a base station is provided. The method comprises: a base station acquiring a measurement result of a second cell reported by said user equipment, wherein a first cell in which a user equipment (UE) is located belongs to the base station, and said first cell and said second cell belong to different base stations; and determining an initial transmission power of said user equipment when initiating a random access in said second cell according to a reference signal power of said second cell, said measurement result and a random access initial received target power of said second cell. Success rate of handover of user equipment is improved.
摘要翻译：提供了一种用于确定初始发送功率的方法和基站。该方法包括：基站获取由所述用户设备报告的第二小区的测量结果，其中用户设备（UE）所在的第一小区属于所述基站，并且所述第一小区和所述第二小区属于到不同的基站; 以及根据所述第二小区的参考信号功率，所述测量结果和所述第二小区的随机接入初始接收目标功率，在所述第二小区中发起随机接入时确定所述用户设备的初始发送功率。用户设备切换成功率提高。

20. 发明申请

US20130324526A1 [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINE COMPOUNDS AS INHIBITORS OF THE C-MET TYROSINE KINASE 审中-公开
标题翻译： [1,2,4]三唑并[4,3-B]吡啶化合物作为C-MET酪氨酸激酶的抑制剂
公开(公告)号：US20130324526A1
公开(公告)日：2013-12-05
申请号：US13984429
申请日：2012-02-08
申请人： Feng He , Haibing Deng , Xingnian Fu , Haibing Guo , Yuan Mi , Xiaoxia Yan , Hongping Yu , Ji Yue (Jeff) Zhang
发明人： Feng He , Haibing Deng , Xingnian Fu , Haibing Guo , Yuan Mi , Xiaoxia Yan , Hongping Yu , Ji Yue (Jeff) Zhang
IPC分类号： C07D471/04 , A61K31/5377 , A61K45/06 , A61K31/5025
CPC分类号： C07D471/04 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D487/04
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
摘要翻译：本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

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