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1. 发明授权

US08507676B2 Heterocyclic oxime compounds 有权
标题翻译：杂环肟化合物
公开(公告)号：US08507676B2
公开(公告)日：2013-08-13
申请号：US13567386
申请日：2012-08-06
申请人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-Chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
发明人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-Chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
IPC分类号： C07D487/04 , C07D403/12 , A61K31/4985 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
摘要翻译：本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

2. 发明授权

US08410264B2 Heterocyclic oxime compounds 有权
公开(公告)号：US08410264B2
公开(公告)日：2013-04-02
申请号：US12859653
申请日：2010-08-19
申请人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
发明人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

3. 发明授权

US08497368B2 Heterocyclic hydrazone compounds 有权
标题翻译：杂环腙化合物
公开(公告)号：US08497368B2
公开(公告)日：2013-07-30
申请号：US13389912
申请日：2010-08-10
申请人： Feng He , Miao Dai , Xingnian Fu , Yue Li , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Zhengtian Yu , Ji Yue Zhang
发明人： Feng He , Miao Dai , Xingnian Fu , Yue Li , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Zhengtian Yu , Ji Yue Zhang
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00 , A61P19/02
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
摘要翻译：本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

4. 发明申请

US20120142681A1 HETEROCYCLIC HYDRAZONE COMPOUNDS 有权
标题翻译：杂环氢化合物
公开(公告)号：US20120142681A1
公开(公告)日：2012-06-07
申请号：US13389912
申请日：2010-08-10
申请人： Feng He , Miao Dai , Xingnian Fu , Yue Li , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Zhengtian Yu , Ji Yue Zhang
发明人： Feng He , Miao Dai , Xingnian Fu , Yue Li , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Zhengtian Yu , Ji Yue Zhang
IPC分类号： A61K31/5377 , A61K31/5025 , A61P29/00 , A61K31/4985 , A61K31/53 , A61P35/00 , C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
摘要翻译：本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

5. 发明申请

US20190298715A1 IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY 审中-公开
公开(公告)号：US20190298715A1
公开(公告)日：2019-10-03
申请号：US16338085
申请日：2017-09-29
申请人： Gregory Motz , Konstantinos John Mavrakias , Jinbiao Liu , Lei Liu , Qiangang Zheng , Guoliang Xun , Qitao Xiao , Novartis AG , The Trustees of the University of Pennsylvania
发明人： Gregory Motz , Konstantinos John Mavrakias , Jinbiao Liu , Lei Liu , Qiangang Zheng , Guoliang Xun , Qitao Xiao
IPC分类号： A61K31/496 , A61K31/444 , C12N15/113 , A61K31/404 , A61K35/17
摘要： Provided herein is the use of LSD1 inhibitors in connection with use and manufacture of immune effector cells (e.g., T cells, NK cells), e.g., engineered to express a chimeric antigen receptor (CAR), to treat a subject having a disease, e.g., a disease associated with expression of a tumor antigen.

6. 发明申请

US20190000880A1 IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY 审中-公开
公开(公告)号：US20190000880A1
公开(公告)日：2019-01-03
申请号：US16066855
申请日：2016-12-30
申请人： Gregory Motz , Konstantinos John Mavrakias , Jinbiao Liu , Lei Liu , Qiangang Zheng , Guoliang Xun , Qitao Xiao , Novartis AG , The Trustees of the University of Pennsylvania
发明人： Gregory Motz , Konstantinos John Mavrakias , Jinbiao Liu , Lei Liu , Qiangang Zheng , Guoliang Xun , Qitao Xiao
IPC分类号： A61K35/17 , C07D207/34 , C12N5/0783 , C07D401/14 , C12N15/113 , A61P35/00 , C07K16/28 , C07K16/24 , C07K16/30
摘要： Provided are the use of LSD1 inhibitors in connection with use and manufacture of immune effector cells (e.g., T cells, NK cells), e.g., engineered to express a chimeric antigen receptor (CAR), to treat a subject having a disease, e.g., a disease associated with expression of a tumor antigen.

7. 发明授权

US10001826B2 Power management mechanism for data storage environment 有权
公开(公告)号：US10001826B2
公开(公告)日：2018-06-19
申请号：US12354743
申请日：2009-01-15
申请人： Lei Liu
发明人： Lei Liu
IPC分类号： G06F1/30 , G06F11/30
CPC分类号： G06F1/305 , G06F1/30 , G06F11/3058
摘要： A method, system, and computer program product for facilitating power instability in a central electronics complex (CEC) of data storage computing environment in advance of a potential power failure is provided. Upon receipt of a first early power off warning (EPOW) signal indicating power instability, a first priority of execution of a first data storage task to be performed pursuant to a new data storage request is decreased, while a second priority of execution of a second data storage task to destage data in nonvolatile storage (NVS) to disk is increased. Upon receipt of a second EPOW signal indicating power failure, a system shutdown procedure is executed.

8. 发明授权

US09084418B2 Pesticide compositions of meso-sized particles with enhanced activity 有权
标题翻译：具有增强活性的中等尺寸颗粒的农药组成
公开(公告)号：US09084418B2
公开(公告)日：2015-07-21
申请号：US13197106
申请日：2011-08-03
申请人： Robert J. Ehr , Thomas H. Kalantar , Lei Liu , Dale C. Schmidt , Qiang Zhang , Min Zhao
发明人： Robert J. Ehr , Thomas H. Kalantar , Lei Liu , Dale C. Schmidt , Qiang Zhang , Min Zhao
IPC分类号： A01N25/28 , A01N25/04 , A01N25/12
CPC分类号： A01N25/28 , A01N25/04 , A01N25/12 , A01N43/40 , A01N43/653 , A01N43/70 , A01N43/90
摘要： The present disclosure relates to pesticide compositions consisting of meso-sized particles in combination with certain adjuvants such as built-in adjuvants which are added directly to the formulation or to an aqueous dilution of the formulation such as tank-mix adjuvants, to provide enhanced effectiveness for the control of agricultural pests. Mesoparticle compositions containing such adjuvants have been found to provide improved effectiveness compared to mesoparticle compositions not containing such adjuvants or to conventional formulations.
摘要翻译：本公开内容涉及由中等尺寸的颗粒与某些佐剂组合的农药组合物，所述佐剂直接加入制剂中的内置助剂或制剂的水稀释液，例如罐混合佐剂，以提供增强的效力用于控制农业害虫。已经发现含有此类佐剂的中粒子组合物与不含此类佐剂的介孔组合物或常规制剂相比提供了改善的效果。

9. 发明授权

US09009386B2 Systems and methods for managing read-only memory 有权
标题翻译：用于管理只读存储器的系统和方法
公开(公告)号：US09009386B2
公开(公告)日：2015-04-14
申请号：US12966055
申请日：2010-12-13
申请人： Brian D. Hatfield , Wenjeng Ko , Lei Liu
发明人： Brian D. Hatfield , Wenjeng Ko , Lei Liu
IPC分类号： G06F12/00 , G06F12/14 , G06F12/10
CPC分类号： G06F12/1009 , G06F12/0638 , G06F12/10 , G06F12/145 , G06F2212/1016 , G06F2212/1052 , G06F2212/202 , G06F2212/65
摘要： A system includes a memory device including a real memory and a tracking mechanism configured to track relationships between multiple virtual memory addresses and real memory. The system further includes a processor configured to perform the below method and/or execute the below computer program product. One method includes mapping a first virtual memory address to a real memory in a memory device and mapping a second virtual memory address to the real memory. Here, the first virtual memory address is authorized to modify data in the real memory and the second virtual memory address is not authorized to modify the data in the real memory. One computer storage medium includes a computer program product for performing the above method.
摘要翻译：一种系统包括存储器装置，其包括实际存储器和跟踪机构，其被配置为跟踪多个虚拟存储器地址与真实存储器之间的关系。该系统还包括配置成执行以下方法的处理器和/或执行以下计算机程序产品。一种方法包括将第一虚拟存储器地址映射到存储器设备中的实际存储器，并将第二虚拟存储器地址映射到真实存储器。这里，第一虚拟存储器地址被授权修改实际存储器中的数据，并且第二虚拟存储器地址不被授权修改真实存储器中的数据。一个计算机存储介质包括用于执行上述方法的计算机程序产品。

10. 发明授权

US09003161B2 Systems and methods for managing read-only memory 有权
标题翻译：用于管理只读存储器的系统和方法
公开(公告)号：US09003161B2
公开(公告)日：2015-04-07
申请号：US13493153
申请日：2012-06-11
申请人： Brian D. Hatfield , Wenjeng Ko , Lei Liu
发明人： Brian D. Hatfield , Wenjeng Ko , Lei Liu
IPC分类号： G06F12/00 , G06F12/14 , G06F12/10
CPC分类号： G06F12/1009 , G06F12/0638 , G06F12/10 , G06F12/145 , G06F2212/1016 , G06F2212/1052 , G06F2212/202 , G06F2212/65
摘要： A first virtual memory address is mapped to a real memory in a memory device, and a second virtual memory address is mapped to the real memory. Here, the first virtual memory address is authorized to modify data in the real memory and the second virtual memory address is not authorized to modify the data in the real memory.
摘要翻译：第一虚拟存储器地址被映射到存储器件中的真实存储器，并且第二虚拟存储器地址被映射到真实存储器。这里，第一虚拟存储器地址被授权修改实际存储器中的数据，并且第二虚拟存储器地址不被授权修改真实存储器中的数据。

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