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11. 发明申请

US20120004196A1 Anti-Viral Compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US20120004196A1
公开(公告)日：2012-01-05
申请号：US13100827
申请日：2011-05-04
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号： A61K31/4184 , C07D401/14 , C07D405/14 , C07D413/14 , C07F7/10 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/438 , A61K31/4545 , A61K31/695 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P31/14 , C07D403/14
CPC分类号： A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译：描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

12. 发明授权

US07973724B2 Wireless chip and wireless device 有权
标题翻译：无线芯片和无线设备
公开(公告)号：US07973724B2
公开(公告)日：2011-07-05
申请号：US12080306
申请日：2008-04-02
申请人： Wenying Shan , Jianjun Zhi , Yi Gao , Ying Li
发明人： Wenying Shan , Jianjun Zhi , Yi Gao , Ying Li
IPC分类号： H01Q1/24 , H01Q1/52
CPC分类号： H01Q9/0407 , H01Q1/2283 , H01Q1/52 , H01Q1/526 , H01Q17/004
摘要： The present invention discloses a wireless chip comprising a circuit layer above which a microstrip antenna is provided, and a wave-absorbing body is provided between the circuit layer and the microstrip antenna. Since the microstrip antenna is disposed above the circuit layer, the wave-absorbing body capable of absorbing energy is utilized to isolate the circuit from the antenna, and the metal film in the microstrip antenna functions not only as the RF ground of the antenna but also as a shield against any interference, it is possible to effectively address the problem of the antenna interfering with the circuit; by selecting the medium with suitable dielectric constant, the height of the chip can be prevented from being unduly increased, thereby ensuring that the chip and the wireless device using the same are both small in size. The present invention also discloses the wireless device containing the wireless chip.
摘要翻译：本发明公开了一种无线芯片，包括电路层，在该电路层上设置有微带天线，并且在电路层和微带天线之间设置有吸波体。由于微带天线设置在电路层的上方，因此能够吸收能量的吸波体被用于将电路与天线隔离，并且微带天线中的金属膜不仅用作天线的RF地，而且还用作天线的RF地作为防止任何干扰的屏蔽，可以有效地解决天线干扰电路的问题; 通过选择具有适当介电常数的介质，可以防止芯片的高度不适当地增加，从而确保芯片和使用该芯片的无线设备尺寸都小。本发明还公开了包含无线芯片的无线设备。

13. 发明申请

US20070128278A1 Pharmaceutical formulations 审中-公开
公开(公告)号：US20070128278A1
公开(公告)日：2007-06-07
申请号：US11549005
申请日：2006-10-12
申请人： Tzuchi Ju , Kevin Engh , Yi Gao , Shyamala Jayaraman , Dennis Lee
发明人： Tzuchi Ju , Kevin Engh , Yi Gao , Shyamala Jayaraman , Dennis Lee
IPC分类号： A61K9/24 , A61K31/205 , A61K31/192
CPC分类号： A61K9/5026 , A61K9/0004 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2054 , A61K9/2077 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K31/192
摘要： The present invention relates to oral formulations comprising an active agent comprising at least one of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, salts of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid or buffered 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid.

14. 发明授权

US06491182B1 Treating pressure vessels 失效
标题翻译：处理压力容器
公开(公告)号：US06491182B1
公开(公告)日：2002-12-10
申请号：US08817435
申请日：1997-07-29
申请人： Nigel John Henry Holroyd , Warren Hepples , Yi Gao
发明人： Nigel John Henry Holroyd , Warren Hepples , Yi Gao
IPC分类号： B21D2602
CPC分类号： B21D51/24 , F17C2203/0617 , F17C2203/0646 , F17C2203/0648 , F17C2209/2181 , F17C2260/011
摘要： A pressure vessel has a cylindrical side wall and a closed end joined to the side wall at a knuckle. The fatigue resistance of the pressure vessel is improved by autofrettage which moves a region of peak stress from the internal surface of the vessel to a region within the knuckle. Preferred are pressurized gas vessels of 6000 or 7000 series aluminum alloys.
摘要翻译：压力容器具有圆柱形侧壁和在转向节处连接到侧壁的封闭端。压力容器的抗疲劳性通过自动摩擦而提高，该自动摩擦将峰值应力区域从容器的内表面移动到转向节内的区域。优选的是6000或7000系列铝合金的加压气体容器。

15. 发明申请

US20130078284A1 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：US20130078284A1
公开(公告)日：2013-03-28
申请号：US13618886
申请日：2012-09-14
申请人： Tzuchi R. Ju , Claudia M. Davila , Yi Gao , Linda E. Gustavson , David LeBlond , Tong Zhu
发明人： Tzuchi R. Ju , Claudia M. Davila , Yi Gao , Linda E. Gustavson , David LeBlond , Tong Zhu
IPC分类号： A61K31/205 , A61K45/06 , A61K9/00
CPC分类号： A61K31/205 , A61K9/00 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K31/192 , A61K45/06
摘要： The present invention relates to oral formulations comprising an active agent comprising at least one of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, salts of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid or buffered 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid.
摘要翻译：本发明涉及包含含有2- [4-（4-氯苯甲酰基）苯氧基] -2-甲基 - 丙酸中的至少一种的活性剂，2- [4-（4-氯苯甲酰基）苯氧基] -2-甲基 - 丙酸或缓冲的2- [4-（4-氯苯甲酰基）苯氧基] -2-甲基 - 丙酸。

16. 发明申请

US20120258909A1 Solid Compositions 有权
标题翻译：固体成分
公开(公告)号：US20120258909A1
公开(公告)日：2012-10-11
申请号：US13156783
申请日：2011-06-09
申请人： Bernd Liepold , Tina Jung , Peter Hölig , Rudolf Schroeder , Nancy E. Sever , Justin S. Lafountaine , Brent D. Sinclair , Yi Gao , Jianwei Wu
发明人： Bernd Liepold , Tina Jung , Peter Hölig , Rudolf Schroeder , Nancy E. Sever , Justin S. Lafountaine , Brent D. Sinclair , Yi Gao , Jianwei Wu
IPC分类号： A61K38/07 , A61P31/14
CPC分类号： A61K31/4025 , A61K9/146 , A61K9/1617 , A61K9/1635 , A61K9/1694 , A61K9/2027 , A61K9/2054 , A61K31/00
摘要： The present invention features solid compositions comprising amorphous Compound I. For instance, Compound I may be formulated in an amorphous solid dispersion which comprises a pharmaceutically acceptable hydrophilic polymer and preferably a pharmaceutically acceptable surfactant.
摘要翻译：本发明的特征在于包含无定形化合物I的固体组合物。例如，化合物I可以配制成包含药学上可接受的亲水聚合物，优选药学上可接受的表面活性剂的无定形固体分散体

17. 发明申请

US20120189580A1 ANTI-INFECTIVE AGENTS AND USES THEREOF 有权
公开(公告)号：US20120189580A1
公开(公告)日：2012-07-26
申请号：US13441528
申请日：2012-04-06
申请人： Pamela L. Donner , John T. Randolph , Allan C. Krueger , David A. Betebenner , Douglas K. Hutchinson , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , John K. Pratt , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , John E. Hengeveld , Rodger F. Henry , Xiaochun Lou , Geoff G.Z. Zhang
发明人： Pamela L. Donner , John T. Randolph , Allan C. Krueger , David A. Betebenner , Douglas K. Hutchinson , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , John K. Pratt , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , John E. Hengeveld , Rodger F. Henry , Xiaochun Lou , Geoff G.Z. Zhang
IPC分类号： A61K31/513 , C12N7/06 , A61K31/7056 , A61P31/14 , C07D239/54 , A61K38/21
CPC分类号： C07D239/22 , A61K31/513 , C07D239/54 , C07D239/553 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

18. 发明授权

US08188104B2 Anti-infective agents and uses thereof 有权
标题翻译：抗感染剂及其用途
公开(公告)号：US08188104B2
公开(公告)日：2012-05-29
申请号：US12212323
申请日：2008-09-17
申请人： Charles A. Flengte , Douglas K. Hutchinson , David A. Betebenner , David A. DeGoey , Pamela L. Donner , Warren M. Kati , Allan C. Krueger , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , Christopher E. Motter , John K. Pratt , John T. Randolph , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , Xiaochun Lou , Geoff G. Z. Zhang
发明人： Charles A. Flengte , Douglas K. Hutchinson , David A. Betebenner , David A. DeGoey , Pamela L. Donner , Warren M. Kati , Allan C. Krueger , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , Christopher E. Motter , John K. Pratt , John T. Randolph , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , Xiaochun Lou , Geoff G. Z. Zhang
IPC分类号： A61K31/505 , C07D401/00 , C07D239/02
CPC分类号： C07D239/54 , A61K31/513 , A61K45/06 , C07D239/22 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K2300/00
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译：本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

19. 发明申请

US20120045833A1 Bioreactor, control system and control method thereof 审中-公开
标题翻译：生物反应器，控制系统及其控制方法
公开(公告)号：US20120045833A1
公开(公告)日：2012-02-23
申请号：US13130582
申请日：2010-04-16
申请人： Yi Gao , Huangcheng Zhou , Yan Wang , Xiaoping Xu , Mingxin Pan
发明人： Yi Gao , Huangcheng Zhou , Yan Wang , Xiaoping Xu , Mingxin Pan
IPC分类号： C12N5/02 , C12M1/12
CPC分类号： C12M23/06 , C12M25/12 , C12M27/14
摘要： A bioreactor includes a cylinder, a mandrel and a filter film. The cylinder includes two end walls and a circumferential wall interconnected with the both end walls; the two end walls and circumferential wall define together a reaction chamber. The mandrel is disposed between the two end walls. The mandrel has an inlet path and an outlet path provided on its both ends; the filter film wraps the mandrel to prevent passage of the first kind of substance while permit the passage of the second kind of substance; a gap is defined between the filter film and mandrel; at least one portion of the filter film is tied so as to divide the gap into multiple separate and isolated gap regions to prevent the second fluid from direct exiting from the outlet path through the gap. Also disclosed are control system and method for the bioreactor.
摘要翻译：生物反应器包括圆筒，心轴和过滤膜。气缸包括两个端壁和与两个端壁相互连接的圆周壁; 两个端壁和圆周壁将反应室一起限定在一起。心轴设置在两个端壁之间。心轴具有设置在其两端的入口路径和出口路径; 过滤膜包裹心轴以防止第一种物质的通过，同时允许第二种物质的通过; 在过滤膜和心轴之间限定间隙; 过滤膜的至少一部分被捆扎以将间隙分成多个分离和隔离的间隙区域，以防止第二流体通过间隙从出口路径直接排出。还公开了用于生物反应器的控制系统和方法。

20. 发明申请

US20110306632A1 Solid Dispersions Containing Kinase Inhibitors 失效
标题翻译：含有激酶抑制剂的固体分散体
公开(公告)号：US20110306632A1
公开(公告)日：2011-12-15
申请号：US13154562
申请日：2011-06-07
申请人： Jonathan M. Miller , Rajeev Gokhale , Eric A. Schmitt , Yi Gao , Justin Lafountaine , Lloyd Dias
发明人： Jonathan M. Miller , Rajeev Gokhale , Eric A. Schmitt , Yi Gao , Justin Lafountaine , Lloyd Dias
IPC分类号： A61K31/437 , A61P35/00 , C07D495/14
CPC分类号： A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/2077 , A61K31/4743
摘要： A solid dispersion comprises, in essentially non-crystalline form, a kinase inhibitory compound, e.g., N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a cancer.
摘要翻译：固体分散体以基本上非结晶的形式包含激酶抑制化合物，例如N-（4- {4-氨基-7- [1-（2-羟乙基）-1H-吡唑-4-基]噻吩并[ 3,2-c]吡啶-3-基}苯基）-N' - （3-氟苯基）脲，分散在固体基质中，其包含（a）药学上可接受的水溶性聚合物载体和（b）药学上可接受的表面活性剂。制备这种固体分散体的方法包括将化合物，聚合物载体和表面活性剂溶解在合适的溶剂中，并除去溶剂以提供包含聚合物载体和表面活性剂的固体基质，并使化合物分散在基本上不结晶形成。固体分散体适合于有需要的受试者口服给药以治疗癌症。

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