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21. 发明申请

US20130022980A1 RNA- AND DNA-COPYING ENZYMES 审中-公开
标题翻译： RNA-和DNA复制酶
公开(公告)号：US20130022980A1
公开(公告)日：2013-01-24
申请号：US13147446
申请日：2010-02-04
申请人： Robert Michael Nelson , Thomas W. Schoenfeld , David A. Mead
发明人： Robert Michael Nelson , Thomas W. Schoenfeld , David A. Mead
IPC分类号： C12N9/96 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12N9/1241 , C07K2319/80 , C07K2319/85
摘要： The present invention is directed to DNA polymerase fusion proteins with increased processivity and nucleic acid affinity. The invention includes a fusion protein comprising a nucleic acid-binding domain fused to a polymerase domain. The nucleic acid binding domain contains at least one nucleic acid binding motif, such as a DNA-binding motif or an RNA-binding motif. The nucleic acid binding domain preferably embodies an oligonucleotide/oligosaccharide binding (OB) fold, among other conformations. The invention further includes methods of synthesizing nucleic acids using the fusion proteins described herein.
摘要翻译：本发明涉及具有增加的持续性和核酸亲和力的DNA聚合酶融合蛋白。本发明包括融合蛋白，其包含与聚合酶结构域融合的核酸结合结构域。核酸结合结构域含有至少一个核酸结合基序，例如DNA结合基序或RNA结合基序。核酸结合结构域优选体现寡核苷酸/寡糖结合（OB）折叠以及其他构象。本发明还包括使用本文所述的融合蛋白合成核酸的方法。

22. 发明授权

US08266404B2 Generating and using checkpoints in a virtual computer system 有权
标题翻译：在虚拟计算机系统中生成和使用检查点
公开(公告)号：US08266404B2
公开(公告)日：2012-09-11
申请号：US13171268
申请日：2011-06-28
申请人： Carl A. Waldspurger , Michael Nelson , Daniel J. Scales , Pratap Subrahmanyam
发明人： Carl A. Waldspurger , Michael Nelson , Daniel J. Scales , Pratap Subrahmanyam
IPC分类号： G06F12/02
CPC分类号： G06F11/1407 , G06F11/1435 , G06F11/1438 , G06F11/1458 , G06F11/1471 , G06F11/1482 , G06F11/1484 , G06F12/16 , G06F2201/815 , G06F2201/84
摘要： To generate a checkpoint for a virtual machine (VM), first, while the VM is still running, a copy-on-write (COW) disk file is created pointing to a parent disk file that the VM is using. Next, the VM is stopped, the VM's memory is marked COW, the device state of the VM is saved to memory, the VM is switched to use the COW disk file, and the VM begins running again for substantially the remainder of the checkpoint generation. Next, the device state that was stored in memory and the unmodified VM memory pages are saved to a checkpoint file. Also, a copy may be made of the parent disk file for retention as part of the checkpoint, or the original parent disk file may be retained as part of the checkpoint. If a copy of the parent disk file was made, then the COW disk file may be committed to the original parent disk file.
摘要翻译：要为虚拟机（VM）生成检查点，首先，当VM仍在运行时，会创建指向VM所使用的父磁盘文件的写时复制（COW）磁盘文件。接下来，VM停止，VM的内存被标记为COW，VM的设备状态被保存到内存，VM被切换为使用COW磁盘文件，并且VM再次开始运行，大部分剩下的检查点生成。接下来，将存储在存储器中的设备状态和未修改的VM内存页保存到检查点文件。另外，作为检查点的一部分，可以将父磁盘文件作为副本作为保留，也可以将原始的父磁盘文件作为检查点的一部分进行保留。如果生成了父磁盘文件的副本，则COW磁盘文件可能会提交到原始的父磁盘文件。

23. 发明授权

US08260904B2 Virtual machine migration 有权
标题翻译：虚拟机迁移
公开(公告)号：US08260904B2
公开(公告)日：2012-09-04
申请号：US12721899
申请日：2010-03-11
申请人： Michael Nelson
发明人： Michael Nelson
IPC分类号： G06F15/173
CPC分类号： G06F9/45558 , G06F3/0604 , G06F3/0647 , G06F3/0683 , G06F9/4856 , G06F2009/4557 , G06F2009/45583 , G06F2009/45595 , H04L47/783 , H04L67/148
摘要： A source virtual machine (VM) hosted on a source server is migrated to a destination VM on a destination server without first powering down the source VM. After optional pre-copying of the source VM's memory to the destination VM, the source VM is suspended and its non-memory state is transferred to the destination VM; the destination VM is then resumed from the transferred state. The source VM memory is either paged in to the destination VM on demand, or is transferred asynchronously by pre-copying and write-protecting the source VM memory, and then later transferring only the modified pages after the destination VM is resumed. The source and destination servers preferably share common storage, in which the source VM's virtual disk is stored; this avoids the need to transfer the virtual disk contents. Network connectivity is preferably also made transparent to the user by arranging the servers on a common subnet, with virtual network connection addresses generated from a common name space of physical addresses.
摘要翻译：托管在源服务器上的源虚拟机（VM）将迁移到目标服务器上的目标VM，而无需首先关闭源虚拟机。在将源虚拟机的内存可选地预先复制到目标虚拟机之后，源虚拟机被暂停，其非内存状态被传送到目标虚拟机; 目的地VM然后从转移状态恢复。根据需要将源VM内存分页到目标虚拟机，或通过预源复制和写保护源虚拟机内存异步传输，然后在目标虚拟机恢复之后稍后传输修改的页面。源服务器和目标服务器优选地共享存储源虚拟机的虚拟盘的公共存储器; 这避免了传输虚拟磁盘内容的需要。优选地，通过将服务器布置在公共子网上，通过从物理地址的公共名称空间生成的虚拟网络连接地址，网络连接性也对用户透明。

24. 发明申请

US20120185553A1 SELECTING A MASTER NODE USING A SUITABILITY VALUE 有权
标题翻译：使用适合性值选择主节点
公开(公告)号：US20120185553A1
公开(公告)日：2012-07-19
申请号：US13006132
申请日：2011-01-13
申请人： Michael NELSON
发明人： Michael NELSON
IPC分类号： G06F15/16
CPC分类号： H04L41/04 , G06F2009/45583 , H04L43/0817 , H04L67/10
摘要： Selecting a master node in a group of computing nodes. Computing nodes exchange suitability messages, candidate messages, and master messages to indicate the state of each node. A deterministic algorithm based on scores and timings is executed by each computing node to encourage each node to select the same master node.
摘要翻译：选择一组计算节点中的主节点。计算节点交换适配性消息，候选消息和主消息以指示每个节点的状态。基于分数和定时的确定性算法由每个计算节点执行，以鼓励每个节点选择相同的主节点。

25. 发明授权

US08145836B2 SCSI protocol emulation for virtual storage device stored on NAS device 有权
标题翻译：存储在NAS设备上的虚拟存储设备的SCSI协议仿真
公开(公告)号：US08145836B2
公开(公告)日：2012-03-27
申请号：US12959930
申请日：2010-12-03
申请人： Michael Nelson , Hao Xu , Daniel J. Scales , Matthew B. Amdur
发明人： Michael Nelson , Hao Xu , Daniel J. Scales , Matthew B. Amdur
IPC分类号： G06F13/00 , G06F13/28 , G06F9/455
CPC分类号： G06F12/145 , G06F13/42 , G06F2213/0028 , G06F2213/0058
摘要： A virtualization technique, in accordance with one embodiment of the present invention, includes emulating the small computing system interface (SCSI) protocol to access a virtual SCSI storage device backed by a file stored on network attached storage (NAS).
摘要翻译：根据本发明的一个实施例的虚拟化技术包括模拟小型计算系统接口（SCSI）协议以访问由存储在网络连接存储（NAS）上的文件支持的虚拟SCSI存储设备。

26. 发明授权

US07966615B2 Transitioning of virtual machine from replay mode to live mode 有权
标题翻译：将虚拟机从重播模式转换到实时模式
公开(公告)号：US07966615B2
公开(公告)日：2011-06-21
申请号：US12266171
申请日：2008-11-06
申请人： Ganesh Venkitachalam , Michael Nelson , Daniel J. Scales
发明人： Ganesh Venkitachalam , Michael Nelson , Daniel J. Scales
IPC分类号： G06F9/455 , G06F9/46 , G06F11/00
CPC分类号： G06F11/14 , G06F9/45558 , G06F11/1683 , G06F11/1695 , G06F11/2033 , G06F11/2038 , G06F11/2046 , G06F2009/45579 , G06F2201/815
摘要： A backup VM is allowed to enter live execution mode at instruction boundaries but not in the middle of emulation of a single instruction. This is accomplished by having the last log entry of multiple entries generated during emulation of an instruction to have an indication of a “go-live” point and by having the backup VM not replay log entries provided by the primary VM beyond the log entry that indicates the “go-live” point.
摘要翻译：允许备份虚拟机在指令边界进入实时执行模式，但不能在单个指令的仿真中进行。这是通过在仿真仿真指令期间生成的多个条目的最后日志条目来实现的，以便具有“go-live”点的指示，并且使得备份VM不重播由主VM提供的超出日志条目的日志条目，表示“上线”点。

27. 发明申请

US20110113428A1 SCSI Protocol Emulation for Virtual Storage Device Stored on NAS Device 有权
标题翻译：存储在NAS设备上的虚拟存储设备的SCSI协议仿真
公开(公告)号：US20110113428A1
公开(公告)日：2011-05-12
申请号：US12959930
申请日：2010-12-03
申请人： Michael NELSON , Hao XU , Daniel J. SCALES , Matthew B. AMDUR
发明人： Michael NELSON , Hao XU , Daniel J. SCALES , Matthew B. AMDUR
IPC分类号： G06F9/455
CPC分类号： G06F12/145 , G06F13/42 , G06F2213/0028 , G06F2213/0058
摘要： A virtualization technique, in accordance with one embodiment of the present invention, includes emulating the small computing system interface (SCSI) protocol to access a virtual SCSI storage device backed by a file stored on network attached storage (NAS).
摘要翻译：根据本发明的一个实施例的虚拟化技术包括模拟小型计算系统接口（SCSI）协议以访问由存储在网络连接存储（NAS）上的文件支持的虚拟SCSI存储设备。

28. 发明授权

US07865663B1 SCSI protocol emulation for virtual storage device stored on NAS device 有权
标题翻译：存储在NAS设备上的虚拟存储设备的SCSI协议仿真
公开(公告)号：US07865663B1
公开(公告)日：2011-01-04
申请号：US11707359
申请日：2007-02-16
申请人： Michael Nelson , Hao Xu , Daniel J. Scales , Matthew B. Amdur
发明人： Michael Nelson , Hao Xu , Daniel J. Scales , Matthew B. Amdur
IPC分类号： G06F13/00 , G06F13/28 , G06F9/455
CPC分类号： G06F12/145 , G06F13/42 , G06F2213/0028 , G06F2213/0058
摘要： A virtualization technique, in accordance with one embodiment of the present invention, includes emulating the small computing system interface (SCSI) protocol to access a virtual SCSI storage device backed by a file stored on network attached storage (NAS).
摘要翻译：根据本发明的一个实施例的虚拟化技术包括模拟小型计算系统接口（SCSI）协议以访问由存储在网络连接存储（NAS）上的文件支持的虚拟SCSI存储设备。

29. 发明申请

US20100242765A1 METHODS AND APPARATUS FOR INK DELIVERY TO NANOLITHOGRAPHIC PROBE SYSTEMS 审中-公开
标题翻译：用于墨水输送到纳米扫描探针系统的方法和装置
公开(公告)号：US20100242765A1
公开(公告)日：2010-09-30
申请号：US12732570
申请日：2010-03-26
申请人： Sylvain Cruchon-Dupeyrat , Michael Nelson , Robert Elghanian , Joseph S. Fragala , Igor Touzov , Debjyoti Banerjee
发明人： Sylvain Cruchon-Dupeyrat , Michael Nelson , Robert Elghanian , Joseph S. Fragala , Igor Touzov , Debjyoti Banerjee
IPC分类号： B41N3/00 , B41J2/015
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00
摘要： Inkwells adapted for use in direct-write nanolithography and other applications including use of wells, channels, and posts. The wells can possess a geometry which matches the geometry of tips which are dipped into the inkwells. The channels can be open or closed. Hydrophilicity and hydrophobicity can be used to control ink flow. SEM can be used to characterize the inkwells. Ink flow can be monitored with video. Hydrophobic material layers can be used to prevent cross contamination. Microsyringes can be used to fill reservoirs. Satellite reservoirs can be used to prevent bubble formation.
摘要翻译： Inkwells适用于直写纳米光刻技术和其他应用，包括使用井，通道和柱。孔可以具有与浸入墨水孔中的尖端的几何形状相匹配的几何形状。通道可以打开或关闭。亲水性和疏水性可用于控制油墨流动。 SEM可用于表征墨水。墨水流量可以用视频监控。疏水材料层可用于防止交叉污染。微量注射器可用于填充储存器。可以使用卫星储层来防止气泡形成。

30. 发明申请

US20090125904A1 VIRTUAL MACHINE MIGRATION 有权
标题翻译：虚拟机移动
公开(公告)号：US20090125904A1
公开(公告)日：2009-05-14
申请号：US12352242
申请日：2009-01-12
申请人： Michael NELSON
发明人： Michael NELSON
IPC分类号： G06F9/455 , G06F12/00
CPC分类号： G06F9/45558 , G06F3/0604 , G06F3/0647 , G06F3/0683 , G06F9/4856 , G06F2009/4557 , G06F2009/45583 , G06F2009/45595 , H04L47/783 , H04L67/148
摘要： A source virtual machine (VM) hosted on a source server is migrated to a destination VM on a destination server without first powering down the source VM. After optional pre-copying of the source VM's memory to the destination VM, the source VM is suspended and its non-memory state is transferred to the destination VM; the destination VM is then resumed from the transferred state. The source VM memory is either paged in to the destination VM on demand, or is transferred asynchronously by pre-copying and write-protecting the source VM memory, and then later transferring only the modified pages after the destination VM is resumed. The source and destination servers preferably share common storage, in which the source VM's virtual disk is stored; this avoids the need to transfer the virtual disk contents. Network connectivity is preferably also made transparent to the user by arranging the servers on a common subnet, with virtual network connection addresses generated from a common name space of physical addresses.
摘要翻译：托管在源服务器上的源虚拟机（VM）将迁移到目标服务器上的目标VM，而无需首先关闭源虚拟机。在将源虚拟机的内存可选地预先复制到目标虚拟机之后，源虚拟机被暂停，其非内存状态被传送到目标虚拟机; 目的地VM然后从转移状态恢复。根据需要将源VM内存分页到目标虚拟机，或通过预源复制和写保护源虚拟机内存异步传输，然后在目标虚拟机恢复之后稍后传输修改的页面。源服务器和目标服务器优选地共享存储源虚拟机的虚拟盘的公共存储器; 这避免了传输虚拟磁盘内容的需要。优选地，通过将服务器布置在公共子网上，通过从物理地址的公共名称空间生成的虚拟网络连接地址，网络连接性也对用户透明。

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