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41. 发明申请

US20120067599A1 MINI-TYPE AUTOMATIC AEROSOL FIRE SUPPRESSION APPARATUS 审中-公开
标题翻译：迷你型自动喷气灭火装置
公开(公告)号：US20120067599A1
公开(公告)日：2012-03-22
申请号：US13322444
申请日：2010-06-06
申请人： Hongbao Guo , Weipeng Zhang , Zanfeng Zhang , Zhenping Deng , Qian Liu , Tengfei Zhai , Sanxue Zhang , Guoxing Zhang , Kun Zhang
发明人： Hongbao Guo , Weipeng Zhang , Zanfeng Zhang , Zhenping Deng , Qian Liu , Tengfei Zhai , Sanxue Zhang , Guoxing Zhang , Kun Zhang
IPC分类号： A62C35/11
CPC分类号： A62C35/10
摘要： The present invention relates to a mini-type automatic aerosol fire suppression apparatus, comprising top cap (1), thermal insulating layer (3), inner cylinder (4), outer cylinder (5), bottom cap (7), sensing element (8), screen (9) and igniter (11), wherein a chemical agent (6) and a cooling layer (10) are installed in the inner cylinder (4), the thermal insulating layer (3) is installed between the inner cylinder (4) and the outer cylinder (5), and the sensing element (8) is designed to sense fire. The volume of the apparatus is not greater than 0.05 m3. Compared to that in the prior art, the apparatus is delicate and easy to install, and is suitable for quick local fire suppression, and can get twice the result with half the effort in such applications.
摘要翻译：微型自动气雾灭火装置技术领域本发明涉及一种小型自动气溶胶灭火装置，其包括顶盖（1），绝热层（3），内筒（4），外筒（5），底盖（7），感测元件 8），屏幕（9）和点火器（11），其中化学试剂（6）和冷却层（10）安装在内筒（4）中，绝热层（3）安装在内筒（4）和外筒（5），感测元件（8）被设计成感测火焰。设备体积不大于0.05立方米。与现有技术相比，该装置细腻易于安装，适用于快速本地灭火，并可在此类应用中获得两倍的效果。

42. 发明申请

US20120025877A1 LATCH STRUCTURE, FREQUENCY DIVIDER, AND METHODS FOR OPERATING SAME 有权
标题翻译：绞合结构，频率分配器和操作方法
公开(公告)号：US20120025877A1
公开(公告)日：2012-02-02
申请号：US13253350
申请日：2011-10-05
申请人： KUN ZHANG , KENNETH BARNETT
发明人： KUN ZHANG , KENNETH BARNETT
IPC分类号： H03K21/00
CPC分类号： H03K3/356121 , H03K5/1565 , H03K23/544
摘要： A latch includes three circuits. The first circuit drives a first output (QB) to a first level when a first input (D) and a first clock phase (CK) are both low, to a second level when D and CK are both high, and provides high impedance (HI-Z) when different logic levels are applied to D and CK. The second circuit drives a second output (Q) to the first level when a third input (DB) and a complimentary clock phase (CKB) are both low, to the second level when DB and CKB are both high, and provides HI-Z when different logic levels are applied to DB and CKB. The third circuit maintains voltages of Q and QB when the first and second circuits provide HI-Z at Q and QB. Odd-number dividers constructed with such latches produce 50% duty cycle operation without restricting output pulse widths to integer multiples of input periods.
摘要翻译：闩锁包括三个电路。当D和CK均为高电平时，当第一输入（D）和第一时钟相位（CK）均为低电平时，第一电路将第一输出（QB）驱动到第一电平，并提供高阻抗（当对D和CK应用不同的逻辑电平时，HI-Z）。当DB和CKB均为高电平时，第三输入（DB）和互补时钟相位（CKB）均为低电平时，第二电路将第二输出（Q）驱动到第一电平，并提供HI-Z 当DB和CKB应用不同的逻辑电平时。当第一和第二电路在Q和QB提供HI-Z时，第三电路维持Q和QB的电压。使用这种锁存器构造的奇数分频器可以产生50％的占空比运算，而不会将输出脉冲宽度限制为输入周期的整数倍。

43. 发明授权

US07739725B1 Method and system to grant indefinite use of software options resident on a device 有权
标题翻译：允许不定期使用驻留在设备上的软件选项的方法和系统
公开(公告)号：US07739725B1
公开(公告)日：2010-06-15
申请号：US11162680
申请日：2005-09-19
申请人： Kun Zhang , Karamjeet Singh , William G. Blair , Winnie C. Durbin , Michael R. Minogue
发明人： Kun Zhang , Karamjeet Singh , William G. Blair , Winnie C. Durbin , Michael R. Minogue
IPC分类号： G06F7/04 , G06F15/16 , G06F17/30 , G06F29/06
CPC分类号： H04L63/10 , G06F21/10 , H04L2463/101 , Y10S707/99939
摘要： A system for granting indefinite use of inactivated software options pre-installed on a device is provided. The system includes receiving, at a remote processing facility, a recurrent use request from a user requesting access to an inactivated software option resident on the device. The system is further configured to validate the request and generate an activation key. The activation key is transmitted from the processing facility to the device automatically activating the option and granting recurrent access. The activation key or code is generated at the processing facility using data from at least one of a user identifier, a system identifier, a recurrent use identifier, and the selected option. A method to permit recurrent use of resident, yet, inactivated software of a device is also provided.
摘要翻译：提供了一种允许无限期使用预先安装在设备上的未激活软件选项的系统。该系统包括在远程处理设施处接收来自用户的经常使用请求，请求访问驻留在设备上的非激活软件选项。该系统还被配置为验证该请求并产生激活密钥。激活密钥从处理设备发送到设备，自动激活该选项并授予经常访问权限。使用来自用户标识符，系统标识符，循环使用标识符和所选择的选项中的至少一个的数据在处理设施处生成激活密钥或代码。还提供了一种允许经常使用常驻的，但是还未被激活的设备的软件的方法。

44. 发明申请

US20090202033A1 SHIFTER REGISTER FOR LOW POWER CONSUMPTION APPLICATION 有权
标题翻译：用于低功耗应用的更换寄存器
公开(公告)号：US20090202033A1
公开(公告)日：2009-08-13
申请号：US12420476
申请日：2009-04-08
申请人： Frederick P. Herrmann , Kun Zhang
发明人： Frederick P. Herrmann , Kun Zhang
IPC分类号： G11C19/00
CPC分类号： G11C19/28
摘要： A high voltage shift register stage which directly accepts low voltage clock signal inputs without using clock buffers. In particular, a shift register stage circuit is adapted to operate with a low voltage swing clock signal, with the stage circuit having a single state node, a, driven directly. This arrangement allows for reduced power consumption and higher operating speeds.
摘要翻译：高压移位寄存器级，可直接接收低电压时钟信号输入而不使用时钟缓冲器。特别地，移位寄存器级电路适于以低电压摆动时钟信号进行工作，其中级电路具有直接驱动的单个状态节点a。这种布置允许降低功耗和更高的运行速度。

45. 发明授权

US07491700B2 Conversion of apoptotic proteins 失效
标题翻译：凋亡蛋白转化
公开(公告)号：US07491700B2
公开(公告)日：2009-02-17
申请号：US11619965
申请日：2007-01-04
申请人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
IPC分类号： G01N33/53 , A61K38/00 , C07K1/00 , C07K16/00 , C07H21/02 , C07H21/00
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译：鉴定了调节抗凋亡蛋白（如Bcl-2和Bcl-XL）功能的化合物。这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。描述了诱导凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。

46. 发明申请

US20070117753A1 CONVERSION OF APOPTOTIC PROTEINS 失效
标题翻译：转化蛋白的转化
公开(公告)号：US20070117753A1
公开(公告)日：2007-05-24
申请号：US11619965
申请日：2007-01-04
申请人： John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
发明人： John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
IPC分类号： A61K38/17
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译：鉴定调节抗凋亡蛋白质如Bcl-2和Bcl-XL 的功能的化合物。这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。描述了诱导凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。

47. 发明申请

US20060014167A1 Amplification of trace amounts of nucleic acids 有权
标题翻译：微量核酸的扩增
公开(公告)号：US20060014167A1
公开(公告)日：2006-01-19
申请号：US11066559
申请日：2005-02-28
申请人： George Church , Kun Zhang
发明人： George Church , Kun Zhang
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6846 , C12Q1/6848 , C12Q2525/179 , C12Q2523/313
摘要： Methods of reducing background during amplification of small amounts of nucleic acids employ careful analysis of sources of low level contamination. Ultraviolet light can be used to reduce nucleic acid contaminants in reagents and equipment. “Primer-dimer” background can be reduced by judicious design of primers. We have shown clean signal-to-noise with as little as starting material as one single human cell (˜6 picogram), E. coli cell (˜5 femtogram) or Prochlorococcus cell (˜3 femtogram).
摘要翻译：在少量核酸扩增期间减少背景的方法采用对低水平污染源的仔细分析。紫外光可用于减少试剂和设备中的核酸污染物。通过引物的明智设计，可以减少“引物二聚体”背景。我们已经显示出干净的信噪比，与起始材料一样少于单个人类细胞（〜6皮克），大肠杆菌细胞（〜5个血型）或原绿球细胞（〜3个血型）。

48. 发明授权

US06829704B2 Method and system to automatically activate software options upon initialization of a device 有权
标题翻译：在设备初始化时自动激活软件选项的方法和系统
公开(公告)号：US06829704B2
公开(公告)日：2004-12-07
申请号：US09681481
申请日：2001-04-13
申请人： Kun Zhang , Karamjeet Singh , William G. Blair , Winnie C. Durbin , Michael R. Minogue
发明人： Kun Zhang , Karamjeet Singh , William G. Blair , Winnie C. Durbin , Michael R. Minogue
IPC分类号： G06P15177
CPC分类号： G06F8/61
摘要： A system and method are provided for activating inactive software options pre-installed on a device upon initialization of the device and thereby preventing installation during device operation. The invention includes receiving a request from a user at a centralized facility for access to an inactive option resident on the device. After validation of the request, an option-specific activation key or code is generated at the centralized facility using data from at least one of a user identifier, a system identifier, a host identifier, a use period identifier, and the selected option. The activation key is then transmitted from the centralized facility to the device whereupon only during initialization or reboot of the device is access to the inactive option automatically granted. The limiting of access to the inactive option until device initialization ensures that option enablement is prevented during device operation.
摘要翻译：提供了一种系统和方法，用于在设备初始化时激活预先安装在设备上的非活动软件选项，从而防止在设备操作期间的安装。本发明包括在集中式设备处接收来自用户的请求，以访问驻留在该设备上的非活动选项。在请求验证之后，使用来自用户标识符，系统标识符，主机标识符，使用周期标识符和所选择的选项中的至少一个的数据在集中式设备处生成特定于选项的激活密钥或代码。然后，激活密钥从集中式设备传输到设备，因此仅在设备的初始化或重新启动期间才能自动授予对非活动选项的访问。在设备初始化之前限制访问非活动选项可以确保在设备操作期间防止选项启用。

49. 发明授权

US5466861A Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors 失效
标题翻译：桥连双环芳族化合物及其在调节类视黄醇受体基因表达中的应用
公开(公告)号：US5466861A
公开(公告)日：1995-11-14
申请号：US982305
申请日：1992-11-25
申请人： Marcia L. Dawson , James F. Cameron , Peter D. Hobbs , Ling Jong , Magnus Pfahl , Xiao-kun Zhang , Jurgen M. Lehmann
发明人： Marcia L. Dawson , James F. Cameron , Peter D. Hobbs , Ling Jong , Magnus Pfahl , Xiao-kun Zhang , Jurgen M. Lehmann
IPC分类号： A61K31/19 , A61K31/36 , C07C63/49 , C07C63/66 , C07C69/738 , C07C69/76 , C07D317/30 , C07D319/06 , C07D327/04 , C07D333/38 , C07D339/06 , C07D339/08 , C07D409/04 , C07K14/705 , G01N33/68 , G01N33/74 , C07C63/36
CPC分类号： C07D409/04 , A61K31/19 , A61K31/36 , C07C63/49 , C07C63/66 , C07C69/738 , C07C69/76 , C07D317/30 , C07D319/06 , C07D327/04 , C07D333/38 , C07D339/06 , C07D339/08 , C07K14/70567 , G01N33/6875 , G01N33/74 , G01N2500/00
摘要： Bridged bicyclic aromatic compounds are provided having the structure ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and n are as defined herein. The novel compounds are useful for modulating gene expression of retinoic acid receptors, vitamin D receptors and thyroid receptors. Pharmaceutical compositions and methods for modulating gene expression are provided as well.
摘要翻译：提供具有结构“IMAGE”的桥连双环芳族化合物，其中R 1，R 2，R 3，R 4，R 5和n如本文所定义。新型化合物可用于调节视黄酸受体，维生素D受体和甲状腺受体的基因表达。还提供了用于调节基因表达的药物组合物和方法。

50. 发明申请

US20150266842A1 METHODS AND COMPOSITIONS RELATED TO A RETINOID RECEPTOR-SELECTIVE PATHWAY 有权
标题翻译：与RETINOID受体选择性途径相关的方法和组合物
公开(公告)号：US20150266842A1
公开(公告)日：2015-09-24
申请号：US13102475
申请日：2011-05-06
申请人： Xiao-kun Zhang , Ying Su , Hu Zhou , Wen Liu , Pei-Qiang Huang
发明人： Xiao-kun Zhang , Ying Su , Hu Zhou , Wen Liu , Pei-Qiang Huang
IPC分类号： C07D295/112 , C07D213/55 , C07C255/57 , C07C57/62 , C07C59/72
CPC分类号： C07D295/112 , A61K38/191 , C07C57/62 , C07C59/72 , C07C255/57 , C07D213/55 , G01N33/5011 , G01N2333/70567 , G01N2510/00
摘要： Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenvironment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.
摘要翻译：本文提供了与类视黄醇受体选择性途径相关的方法和组合物。如本文所述，该途径可以靶向操纵肿瘤微环境。例如，本文所述的方法和组合物可用于诱导癌细胞中的细胞凋亡。此外，本文所述的组合物（包括舒林酸及其类似物）可用于靶向该途径以治疗或预防人类患者的癌症。

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