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41. 发明申请

US20050107441A1 Compositions and methods for altering glucose production 审中-公开
标题翻译：用于改变葡萄糖产量的组合物和方法
公开(公告)号：US20050107441A1
公开(公告)日：2005-05-19
申请号：US10499545
申请日：2002-12-18
申请人： Steven Kliewer , Bryan Goodwin , James Way
发明人： Steven Kliewer , Bryan Goodwin , James Way
IPC分类号： G01N33/50 , A61K38/28 , A61K45/00 , A61P3/08 , A61P3/10 , A61P9/00 , G01N33/15 , A61K49/00 , A61K31/426 , A61K31/4439
CPC分类号： A61K38/28 , G01N2333/70567
摘要： Methods for identifying agents which alter glucose production by modulating expression and/or activity of the nuclear receptor short heterodimer partner or SHP are provided. Also provided are compositions containing such agents and methods of using such agents to alter glucose production in a subject.
摘要翻译：提供了通过调节核受体短异二聚体配偶体或SHP的表达和/或活性来鉴定改变葡萄糖产生的试剂的方法。还提供了含有这些试剂的组合物和使用这些试剂改变受试者中葡萄糖产生的方法。

42. 发明申请

US20050106635A1 Compositions and methods for regulating thyroid hormone metabolism and cholesterol and lipid metabolism via the nuclear receptor car 审中-公开
标题翻译：通过核受体车调节甲状腺激素代谢和胆固醇和脂质代谢的组成和方法
公开(公告)号：US20050106635A1
公开(公告)日：2005-05-19
申请号：US10506647
申请日：2003-02-28
申请人： Jodi Maglich , John Moore
发明人： Jodi Maglich , John Moore
IPC分类号： A61K31/198 , A61K49/00 , G01N33/53 , G01N33/567 , G01N33/68 , G01N33/74 , G01N33/78 , G01N33/92
CPC分类号： A61K49/0004 , G01N33/6875 , G01N33/74 , G01N33/78 , G01N33/92 , G01N2333/70567 , G01N2500/04 , G01N2500/10 , G01N2800/044
摘要： Methods for identifying agents which alter thyroid hormone metabolism or cholesterol and lipid metabolism by modulating expression and/or activity of the nuclear receptor CAR are provided. Also provided are compositions containing such agents and methods of using such agents to alter thyroid hormone metabolism or cholesterol and lipid metabolism in a subject. Administration of such agents is useful in the treatment of conditions such as obesity, cholesterolemia and dyslipidemia.
摘要翻译：提供了通过调节核受体CAR的表达和/或活性来鉴定改变甲状腺激素代谢或胆固醇和脂质代谢的药物的方法。还提供了含有这些试剂的组合物和使用这些试剂改变受试者中的甲状腺激素代谢或胆固醇和脂质代谢的方法。这些药剂的给药可用于治疗肥胖，胆固醇血症和血脂异常等病症。

43. 发明申请

US20050084872A1 Methods for determining whether an agent possesses a defined biological activity 审中-公开
标题翻译：用于确定试剂是否具有确定的生物活性的方法
公开(公告)号：US20050084872A1
公开(公告)日：2005-04-21
申请号：US10764420
申请日：2004-01-23
申请人： Pek Lum , Yejun Tan , Hongyue Dai , Eric Muise , Joel Berger , John Thompson
发明人： Pek Lum , Yejun Tan , Hongyue Dai , Eric Muise , Joel Berger , John Thompson
IPC分类号： G01N33/48 , G01N33/50 , G06F19/00 , C12Q1/68
CPC分类号： G01N33/5014 , G01N33/48 , G01N2333/70567 , G16B25/00
摘要： In one aspect, the present invention provides methods for determining whether an agent (e.g., candidate drug) possesses a biological activity. In another aspect, the present invention provides populations of nucleic acid molecules useful in the practice of the present invention as probes for measuring the level of expression of populations of genes.
摘要翻译：一方面，本发明提供了用于确定试剂（例如候选药物）是否具有生物活性的方法。另一方面，本发明提供了可用于本发明实践的核酸分子群体，作为用于测量基因群体表达水平的探针。

44. 发明申请

US20050008624A1 Expansion of renewable stem cell populations 有权
标题翻译：扩大可再生干细胞群体
公开(公告)号：US20050008624A1
公开(公告)日：2005-01-13
申请号：US10774843
申请日：2004-02-09
申请人： Tony Peled , Avi Treves , Oren Rosen
发明人： Tony Peled , Avi Treves , Oren Rosen
IPC分类号： C12N15/09 , A61K35/12 , A61K35/14 , A61K35/28 , A61K35/44 , A61K39/00 , A61K47/22 , A61P43/00 , C07C51/09 , C12N20060101 , C12N5/071 , C12N5/0789 , C12N5/10 , C12Q1/02 , G01N33/50 , A61K48/00 , C12N5/08
CPC分类号： C12N5/0647 , A61K2035/122 , A61K2035/124 , A61K2039/515 , C07C51/09 , C12N5/067 , C12N2500/20 , C12N2500/38 , C12N2501/125 , C12N2501/145 , C12N2501/23 , C12N2501/26 , C12N2501/385 , C12N2501/599 , C12N2503/02 , C12N2510/00 , G01N33/5008 , G01N33/5023 , G01N33/5041 , G01N33/5073 , G01N33/5094 , G01N2333/70567 , C07C59/72
摘要： Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.
摘要翻译：可再生干细胞的体外和体内扩增方法，可再生干细胞的扩大种群及其用途。

45. 发明申请

US20040067500A1 Compositions and methods relating to the peroxisomal proliferator activated receptor-alpha mediated pathway 审中-公开
标题翻译：与过氧化物酶体增殖物激活的受体-α介导的途径相关的组合物和方法
公开(公告)号：US20040067500A1
公开(公告)日：2004-04-08
申请号：US10391706
申请日：2003-03-18
发明人： Bonnie Gould-Rothberg , Scott Sundseth , William Gottschalk
IPC分类号： C12Q001/68 , G01N033/53 , G01N033/567
CPC分类号： C12Q1/6883 , C07K14/70567 , C12Q1/6809 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/6875 , G01N2333/70567 , G01N2500/00 , G01N2800/52
摘要： The present invention describes polynucleotides and polypeptides associated with PPARnull-mediated pathways that are useful as therapeutic compositions in method for the treatment of peroxisomal disorders. These polynucleotides and polypeptides were identified through the use of differential gene expression analysis. In particular, the present invention discloses eleven novel gene fragments, and numerous single nucleotide polymorphisms, located in previously disclosed genes, all of which have been discovered to be associated with PPARnull-mediated pathways.
摘要翻译：本发明描述了与用于治疗过氧化物酶体紊乱的方法中的治疗组合物有用的PPARα介导的途径相关的多核苷酸和多肽。通过使用差异基因表达分析来鉴定这些多核苷酸和多肽。特别地，本发明公开了11个新的基因片段和许多单核苷酸多态性，位于先前公开的基因中，所有这些都被发现与PPARα介导的途径相关。

46. 发明授权

US06683047B1 Method of inhibiting transcription utilizing nuclear receptors 失效
标题翻译：使用核受体抑制转录的方法
公开(公告)号：US06683047B1
公开(公告)日：2004-01-27
申请号：US09139525
申请日：1998-08-25
申请人： Magnus Pfahl , Michael Karin
发明人： Magnus Pfahl , Michael Karin
IPC分类号： A61K3800
CPC分类号： G01N33/6875 , A61K38/00 , C07K14/70567 , C07K14/721 , C07K14/82 , C12N15/67 , G01N33/566 , G01N2333/70567 , G01N2333/723 , G01N2500/10
摘要： This invention provides a method of inhibiting the transcription of a gene, which is activated by AP-1 or an AP-1 component, comprising binding AP-1 or the component with a nuclear receptor so as to prevent the binding of AP-1 to the gene. The nuclear receptor can be the retinoic acid receptor, glucocorticoid receptor, vitamin D3 receptor, thyroid receptor, or estrogen receptor. Also provided is a composition of matter comprising AP-1 or an AP-1 component bound to a nuclear receptor. These methods and compositions can be used to treat arthritis and cancer.
摘要翻译：本发明提供一种抑制由AP-1或AP-1成分激活的基因转录的方法，其包括将AP-1或组分与核受体结合，以防止AP-1与基因。核受体可以是视黄酸受体，糖皮质激素受体，维生素D3受体，甲状腺受体或雌激素受体。还提供了包含AP-1或与核受体结合的AP-1成分的物质组合物。这些方法和组合物可用于治疗关节炎和癌症。

47. 发明授权

US06555326B1 Nuclear hormone receptor fluorescence polarization assay 失效
标题翻译：核激素受体荧光偏振测定
公开(公告)号：US06555326B1
公开(公告)日：2003-04-29
申请号：US08975614
申请日：1997-11-21
申请人： Kevin Lustig , Patrick Baeuerle , Holger Beckmann , Jin-Long Chen , Bei Shan
发明人： Kevin Lustig , Patrick Baeuerle , Holger Beckmann , Jin-Long Chen , Bei Shan
IPC分类号： G01N3352
CPC分类号： G01N33/542 , G01N33/74 , G01N2333/575 , G01N2333/70567
摘要： Methods for identifying modulators of nuclear hormone receptor function comprise the steps of (a) forming a mixture comprising a nuclear hormone receptor, a peptide sensor and a candidate agent, but not a natural coactivator protein of the receptor, wherein the sensor provides direct, in vitro binding to the receptor under assay conditions; (b) measuring an agent-biased binding of the sensor to the receptor; and (c) comparing the agent-biased binding with a corresponding unbiased binding of the sensor to the receptor. In particular embodiments, the sensor comprises an amphipathic alpha helix nuclear hormone interacting domain comprising a recited nuclear hormone transcriptional coactivator motif sequence, the sensor is present at sub-micromolar concentration, the binding reaction occurs in solution, the sensor comprises a fluorescent label and the measuring step comprises detecting fluorescence polarization of the label. Reagents include labeled sensor peptides and reaction mixtures consisting essentially of nuclear hormone receptor, a peptide and a candidate agent.
摘要翻译：用于鉴定核激素受体功能调节剂的方法包括以下步骤：（a）形成包含核激素受体，肽传感器和候选试剂但不是受体的天然共激活蛋白的混合物，其中所述传感器直接提供在测定条件下与受体的体外结合; （b）测量传感器与受体的药剂偏置结合; 和（c）将代理偏好的结合与传感器与受体的相应的无偏见的结合进行比较。在具体实施方案中，传感器包括包含所述核激素转录辅激动子序列的两亲性α螺旋核激素相互作用结构域，所述传感器以亚微摩尔浓度存在，所述结合反应发生在溶液中，所述传感器包含荧光标记和测量步骤包括检测标签的荧光偏振。试剂包括标记的传感器肽和基本上由核激素受体，肽和候选试剂组成的反应混合物。

48. 发明申请

US20020151569A1 PPAR gamma ligands 审中-公开
标题翻译： PPARγ配体
公开(公告)号：US20020151569A1
公开(公告)日：2002-10-17
申请号：US10115550
申请日：2002-04-03
发明人： Jon Loren Collins , Christopher Patrick Holmes , James Martin Lenhard , Timothy Mark Willson
IPC分类号： A61K031/4439 , C07D417/02 , A61K031/427
CPC分类号： A61K31/4439 , A61K31/426 , A61K31/443 , C07D277/14 , G01N33/566 , G01N2333/70567
摘要： The present invention discloses a method for treating osteoporosis by administration of a PPAR gamma antagonist.
摘要翻译：本发明公开了一种通过给予PPARγ拮抗剂治疗骨质疏松症的方法。

49. 发明申请

US20020132223A1 Methods for modulating activity of the FXR nuclear receptor 审中-公开
标题翻译：调节FXR核受体活性的方法
公开(公告)号：US20020132223A1
公开(公告)日：2002-09-19
申请号：US09971067
申请日：2001-10-05
申请人： City of Hope
发明人： Barry M. Forman , Haibo Wang
IPC分类号： C12Q001/00 , A61K031/496
CPC分类号： C07K14/70567 , A61K31/00 , A61K31/4174 , G01N33/6872 , G01N33/6875 , G01N33/74 , G01N33/92 , G01N2333/70567 , G01N2333/90245 , G01N2500/00 , G01N2500/04
摘要： The present invention relates to methods and compositions for modulating genes which are controlled by the FXR nuclear hormone receptor such as Cyp7a, Cyp8b, phospholipid transfer protein, ileal bile acid binding protein, sodium taurocholate cotransporter protein, liver fatty acid binding protein and bile salt export pump. In a preferred embodiment, the method involves modulation of the gene encoding Cyp7a, the enzyme responsible for a major pathway in the elimination of cholesterol. The invention also relates to methods for screening compounds which bind to and activate or inhibit the FXR nuclear hormone receptor and compounds which activate or inhibit the FXR nuclear hormone receptor.
摘要翻译：本发明涉及用于调节由FXR核激素受体如Cyp7a，Cyp8b，磷脂转移蛋白，回肠胆汁酸结合蛋白，牛磺胆酸协同转运蛋白，肝脏脂肪酸结合蛋白和胆汁盐出口控制的基因的方法和组合物泵。在优选的实施方案中，该方法包括调节编码Cyp7a的基因，该酶是负责消除胆固醇的主要途径的酶。本发明还涉及筛选结合并激活或抑制FXR核激素受体的化合物和激活或抑制FXR核激素受体的化合物的方法。

50. 发明授权

US06416957B1 Method for modulating process mediated by farnesoid activated receptors 有权
标题翻译：由法呢活性受体介导的调节过程的方法
公开(公告)号：US06416957B1
公开(公告)日：2002-07-09
申请号：US09696443
申请日：2000-10-24
申请人： Ronald M. Evans , Barry M. Forman , Cary A. Weinberger
发明人： Ronald M. Evans , Barry M. Forman , Cary A. Weinberger
IPC分类号： G01N3353
CPC分类号： A61K31/045 , A61K31/202 , A61K31/22 , A61K31/336 , C07K14/70567 , G01N33/74 , G01N2333/70567
摘要： Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in cellular growth and metabolism. A nuclear receptor has been identified that is transcriptionally activated by farnesol and related molecules. This novel signaling pathway can be modulated by the use of key metabolic intermediates (or analogs and/or derivatives thereof) as transcriptional regulatory signals.
摘要翻译：法呢基焦磷酸法呢酯是代谢活性形式的法呢醇，是合成胆固醇，类胡萝卜素，类固醇激素，胆汁酸和参与细胞生长和代谢的其他分子的关键前体。已经鉴定出由法呢醇和相关分子转录激活的核受体。可以通过使用关键的代谢中间体（或其类似物和/或其衍生物）作为转录调节信号来调节这种新的信号传导途径。

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