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1. 发明授权

US06835806B2 Cell growth regulation system 有权
标题翻译：细胞生长调节系统
公开(公告)号：US06835806B2
公开(公告)日：2004-12-28
申请号：US09822540
申请日：2001-03-30
申请人： Jaw-Kang Chang
发明人： Jaw-Kang Chang
IPC分类号： A61K3800
CPC分类号： C07K14/78 , A61K38/00
摘要： Stable water soluble polypeptides which are potent inhibitors of endothelial cell proliferation and of angiogenesis. Polypeptide inhibitors of endothelial cell growth may have important uses in the elucidation of the mechanism of angiogenesis, disease diagnosis and prognostication, and drug therapies for use in animals and humans.
摘要翻译：稳定的水溶性多肽，其是内皮细胞增殖和血管生成的有效抑制剂。内皮细胞生长的多肽抑制剂可能在阐明血管生成，疾病诊断和预后的机制以及用于动物和人类的药物治疗中具有重要用途。

2. 发明授权

US06831065B2 Anti-inflammatory compounds and uses thereof 有权
标题翻译：抗炎化合物及其用途
公开(公告)号：US06831065B2
公开(公告)日：2004-12-14
申请号：US09847940
申请日：2001-05-02
申请人： Michael J. May , Sankar Ghosh
发明人： Michael J. May , Sankar Ghosh
IPC分类号： A61K3800
CPC分类号： C07K14/4703 , A61K38/00 , C07K14/4747 , C12N9/1205
摘要： The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-&kgr;B-dependent target gene expression in a cell.
摘要翻译：本发明提供抗炎化合物，其药物组合物及其用于治疗炎症性疾病的方法。本发明还提供鉴定抗炎化合物的方法和抑制细胞中NF-κB依赖性靶基因表达的方法。

3. 发明授权

US06831059B2 Compositions and methods for treating gonadotrophin related illnesses 有权
标题翻译：用于治疗促性腺激素相关疾病的组合物和方法
公开(公告)号：US06831059B2
公开(公告)日：2004-12-14
申请号：US09810601
申请日：2001-03-15
申请人： Stephen Donovan
发明人： Stephen Donovan
IPC分类号： A61K3800
CPC分类号： C07K16/1282 , A61K38/00 , A61K47/64 , C07K14/575 , C07K2319/00 , C07K2319/24 , C07K2319/55 , C12N9/48 , C12N9/52
摘要： The present invention relates to an agent comprising a neurotoxin, methods for making the agents and methods for treating endocrine disorders, for example gonadotrophin related illnesses. Preferably, the agent comprises at least a portion of a botulinum toxin.
摘要翻译：本发明涉及包含神经毒素的药剂，制备药剂的方法和治疗内分泌疾病的方法，例如促性腺激素相关疾病。优选地，该试剂包含至少一部分肉毒杆菌毒素。

4. 发明授权

US06828304B1 Peptides for treatment of cancer 失效
标题翻译：用于治疗癌症的肽
公开(公告)号：US06828304B1
公开(公告)日：2004-12-07
申请号：US09630345
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Rajan Sharma
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Rajan Sharma
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K38/00 , C07K14/57563
摘要： This invention relates to novel antiproliferative and anti secrectory peptides that are inhibitory to vasoactive intestinal peptide receptor and are useful in the treatment of cancer. The invention particularly relates to the synthesis of lipid-peptide conjugates containing fatty acids of different sizes, which inhibits the binding of VIP to its receptors. The invention encompasses methods for generation of these peptides, composition containing these peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
摘要翻译：本发明涉及抑制血管活性肠肽受体并可用于治疗癌症的新型抗增殖和抗分解肽。本发明特别涉及含有不同大小的脂肪酸的脂质 - 肽缀合物的合成，其抑制VIP与其受体的结合。本发明包括用于产生这些肽的方法，含有这些肽的组合物以及这些肽的药理学应用，特别是在治疗和预防癌症中。

5. 发明授权

US06822074B1 Process for the preparation of cyclo(Asp-DPhe-NMeVal-Arg-Gly) 失效
标题翻译：制备环（Asp-DPhe-NMeVal-Arg-Gly）的方法
公开(公告)号：US06822074B1
公开(公告)日：2004-11-23
申请号：US09936230
申请日：2001-09-12
申请人： Alfred Jonczyk , Markus Arnold
发明人： Alfred Jonczyk , Markus Arnold
IPC分类号： A61K3800
CPC分类号： C07K7/06 , C07K5/06095 , C07K5/0819 , C07K7/64 , Y02P20/55
摘要： Process for the preparation of the cyclic pentapeptide cyclo(Arg-Gly-Asp-DPhe-NMeVal) by cyclization of a linear pentapeptide selected from the group consisting of H-Arg(Pbf)-Gly-Asp(OBzl)-DPhe-NMeVal-OH, H-Gly-Asp(OBzl)-DPhe-NMeVal-Arg(Pbf)-OH, H-Asp(OBzl)-DPhe-NMeVal-Arg(Pbf)-Gly-OH, H-DPhe-NMeVal-Arg(Pbf)-Gly-Asp(OBzl)-OH or H-NMeVal-Arg(Pbf)-Gly-Asp (OBzl)-DPhe-OH, subsequent protective group removal and, if appropriate, further conversion into its physiologically acceptable salts.
摘要翻译：通过环化选自H-Arg（Pbf）-Gly-Asp（OBz1）-DPhe-NMeVal-OH，H-Arg（Pbf）-Gly-Asp（OBz1）-DPhe-NMeVal-OH）的线性五肽制备环状五肽环（Arg-Gly-Asp-DPhe-NMeVal） H-Gly-Asp（OBz1）-DPhe-NMeVal-Arg（Pbf）-OH，H-Asp（OBz1）-DPhe-NMeVal-Arg（Pbf）-Gly-OH，H-DPhe-NMeVal-Arg（Pbf） -Gly-Asp（OBzl）-OH或H-NMeVal-Arg（Pbf）-Gly-Asp（OBzl）-DPhe-OH，随后保护基团去除，并且如果合适，进一步转化成其生理上可接受的盐。

6. 发明授权

US06822071B1 Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease 失效
标题翻译：来自肺炎衣原体的多肽及其在诊断，预防和治疗疾病中的应用
公开(公告)号：US06822071B1
公开(公告)日：2004-11-23
申请号：US09438185
申请日：1999-11-11
申请人： Richard S. Stephens , Wayne Mitchell , Sue S. Kalman , Ronald Davis
发明人： Richard S. Stephens , Wayne Mitchell , Sue S. Kalman , Ronald Davis
IPC分类号： A61K3800
CPC分类号： C07K14/295 , A61K39/00 , A61K2039/505 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/813 , Y10S530/814 , Y10S530/82 , Y10S530/825
摘要： Chlamydia pneumoniae polypeptides are provided. The C. pneumoniae polypeptides can be used to prepare pharmaceutical compositions for the treatment or prevention of disease. In addition, the proteins can be used in methods for the diagnosis of C. pneumoniae infection.
摘要翻译：提供肺炎衣原体多肽。肺炎支原体多肽可用于制备用于治疗或预防疾病的药物组合物。此外，蛋白质可用于诊断肺炎支原体感染的方法。

7. 发明授权

US06821952B1 Fluorescent vasoactive intestinal peptide (VIP) 有权
标题翻译：荧光血管活性肠肽（VIP）
公开(公告)号：US06821952B1
公开(公告)日：2004-11-23
申请号：US09285422
申请日：1999-04-02
申请人： Clarissa Desjardins , Jacek Slon-Usakievicz , Alain Beaudet
发明人： Clarissa Desjardins , Jacek Slon-Usakievicz , Alain Beaudet
IPC分类号： A61K3800
CPC分类号： C07K7/06 , C07K7/14 , C07K14/575 , C07K14/57536 , C07K14/57563 , G01N33/5094 , G01N33/56966
摘要： Light emitting compounds of the formula: wherein R1 is a light-emitting moiety and R2 is a VIP-based peptide, fragment, derivative or analog thereof, said peptide being linked at an amino acid position to (C—X), wherein (C—X) is selected from the group consisting of C═O, C═S, CH(OH), C═C═O, C═NH, CH2, CH(OR), CH(NR), CH(R), CR3R4, and C(OR3)OR4 where R, R3, and R4 are alkyl moieties or substituted alkyl moieties, wherein said compound exhibits substantial biological activity in the presence of a receptor having affinity for VIP-based peptides.
摘要翻译：下式的发光化合物：其中R1是发光部分，R2是基于VIP的肽，其片段，衍生物或类似物，所述肽在氨基酸位置连接到（CX），其中（CX）为选自C = O，C = S，CH（OH），C = C = O，C = NH，CH 2，CH（OR），CH（NR），CH（R），CR 3 R 4和C （OR 3）OR 4，其中R，R 3和R 4是烷基部分或取代的烷基部分，其中所述化合物在对VIP基肽具有亲和力的受体存在下显示出显着的生物学活性。

8. 发明授权

US06818620B2 Synthetic compounds and compositions with enhanced cell binding 失效
标题翻译：具有增强的细胞结合的合成化合物和组合物
公开(公告)号：US06818620B2
公开(公告)日：2004-11-16
申请号：US09816737
申请日：2001-03-23
申请人： Rajendra S. Bhatnagar
发明人： Rajendra S. Bhatnagar
IPC分类号： A61K3800
CPC分类号： A61L27/34 , A61K38/00 , A61L2430/02 , C07K14/78 , C12N5/0068 , C12N2533/30 , C12N2533/50 , C12N2533/54 , C08L89/06
摘要： Compositions of the invention include composites comprising a biomaterial having compounds thereon with enhanced cell binding with respect to collagen. These composites are useful for soft and hard tissue repair or reconstruction and for in vitro uses. Suitable compounds with enhanced cell binding include synthetic peptides that mimic the conformation necessary for recognition and docking of collagen binding species (such as cell surface receptors for collagen and fibronectin) and have the amino acid residues -Ile-Ala- folded in a &bgr;-bend.
摘要翻译：本发明的组合物包括包含其上具有增强的细胞相对于胶原蛋白结合的化合物的生物材料的复合材料。这些复合物可用于软组织修复或重建和体外应用。具有增强的细胞结合的合适的化合物包括模拟胶原结合物质（例如胶原和纤连蛋白的细胞表面受体）的识别和对接所必需的构象的合成肽，并且具有β-弯曲的氨基酸残基。

9. 发明授权

US06812211B2 Method for nonsurgical treatment of the intervertebral disc and kit therefor 有权
标题翻译：椎间盘非手术治疗方法及其试剂盒
公开(公告)号：US06812211B2
公开(公告)日：2004-11-02
申请号：US10102075
申请日：2002-03-19
申请人： Michael Andrew Slivka , Hassan Serhan
发明人： Michael Andrew Slivka , Hassan Serhan
IPC分类号： A61K3800
CPC分类号： A61L27/3612 , A61L27/24 , A61L27/3658 , A61L2430/38
摘要： This invention relates to a method and compositions for treating pathological intervertebral discs comprising the step of delivering an agent that causes chemical crosslinking of the native molecular components of the disc. Supplemental materials which are susceptible to crosslinking by the aforementioned agent are optionally delivered to the disc in order to increase and maintain disc height.
摘要翻译：本发明涉及一种用于治疗病理性椎间盘的方法和组合物，包括递送导致盘的天然分子成分的化学交联的试剂的步骤。易于被上述试剂交联的补充材料可任选地输送到盘中以增加和保持盘的高度。

10. 发明授权

US06809078B2 Compositions encoding lepidopteran-toxic polypeptides and methods of use 有权
标题翻译：编码鳞翅目昆虫毒性多肽的组合物和使用方法
公开(公告)号：US06809078B2
公开(公告)日：2004-10-26
申请号：US09972175
申请日：2001-10-05
申请人： James A. Baum , Amy Jelen Gilmer , Anne-Marie Light Mettus
发明人： James A. Baum , Amy Jelen Gilmer , Anne-Marie Light Mettus
IPC分类号： A61K3800
CPC分类号： C12R1/075 , C07K14/325 , C12N15/8286 , Y02A40/162
摘要： Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding &dgr;-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the &agr; helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.
摘要翻译：公开了编码对鳞翅目昆虫具有杀虫活性的δ-内毒素的新型合成修饰的苏云金芽孢杆菌核酸片段。还公开了由这些新型核酸序列编码的合成晶体蛋白质。公开了制备和使用这些基因和蛋白质的方法以及重组表达和合适宿主细胞转化的方法。转化的宿主细胞和表达修饰的内毒素的转基因植物也是本发明的方面。还公开了用于修饰，改变和诱变这些晶体蛋白（包括Cry1C）的结构域1中的α螺旋之间的特异性环区的方法，以产生遗传工程改造的重组cry *基因及其编码的具有改善的杀虫活性的蛋白质。在优选的实施方案中，公开了新的Cry1C *氨基酸片段和编码它们的经修饰的cry1C *核酸序列。

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