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    • 72. 发明授权
    • Process for preparing lactate
    • 制备乳酸盐的方法
    • US5824818A
    • 1998-10-20
    • US698478
    • 1996-08-15
    • Takafumi AbeToshiyuki GotohTakako UchiyamaHirofumi HiguchiYoshikazu ShimaKazuto Ikemoto
    • Takafumi AbeToshiyuki GotohTakako UchiyamaHirofumi HiguchiYoshikazu ShimaKazuto Ikemoto
    • C07C67/20C07C69/66
    • C07C67/20
    • A process for preparing a lactate which includes: (a) preparing lactonitrile from prussic acid and acetaldehyde, (b) hydrating the lactonitrile to form lactamide, (c) forming the desired lactate and formamide from lactamide and formate (or methanol and carbon monoxide), (d) separating and collecting components, having a lower boiling point than that of lactate from the reaction liquid in step (c), by distillation under specified conditions, and (e) dehydrating formamide from step (d) to form prussic acid and recycling the prussic acid to step (a). Heretofore, lactates had been manufactured by forming lactonitrile (cyanohydrin) from acetaldehyde and prussic acid, and then esterifying lactonitrile with a mineral acid or the like. However, in this conventional process, ammonium salts were formed as by-products in an amount equal to that of the lactate. According to the present invention, a lactate can be efficiently manufactured on a commercial scale without forming a large amount of the ammonium salts as by-products. In particular, the yield of the lactate can be increased by controlling the formation of 2-formyloxy propionate and also a dimer of a lactate.
    • 一种制备乳酸的方法,其包括:(a)从丙二酸和乙醛制备乳腈,(b)使乳腈水合形成乳酰胺,(c)从乳酰胺和甲酸盐(或甲醇和一氧化碳)形成所需的乳酸盐和甲酰胺, ,(d)在步骤(c)中通过蒸馏从特定条件下蒸馏分离和收集沸点低于乳酸盐的组分,并且(e)从步骤(d)中将甲酰胺脱水形成二甲苯, 将重要的酸回收到步骤(a)。 迄今为止,已经通过从乙醛和氢溴酸形成乳腈(氰醇),然后用无机酸等使乳腈酯化来制造乳酸盐。 然而,在该常规方法中,形成铵盐,其量等于乳酸盐的副产物。 根据本发明,可以以商业规模有效地制造乳酸盐,而不会形成大量的作为副产物的铵盐。 特别地,通过控制2-甲酰氧基丙酸酯和乳酸二聚体的形成可以提高乳酸产率。
    • 74. 发明授权
    • Process for producing methyl .alpha.-hydroxyisobutyrate
    • 制备α-羟基异丁酸甲酯的方法
    • US5391813A
    • 1995-02-21
    • US135247
    • 1993-10-12
    • Nobuyuki MuroTakafumi AbeHirofumi Higuchi
    • Nobuyuki MuroTakafumi AbeHirofumi Higuchi
    • C07B61/00C07C67/20C07C69/675
    • C07C67/20
    • There is disclosed a process for efficiently producing methyl .alpha.-hydroxyisobutyrate from .alpha.-hydroxyisobutyramide and methyl formate by means of reaction distillation which comprises feeding .alpha.-hydroxyisobutyramide and an alkali metal hydroxide in a continuous distillation column to prepare therein the dehydrated condensate of .alpha.-hydroxyisobutyramide with the alkali metal hydroxide as the catalyst and reacting remaining .alpha.-hydroxyisobutyramide with methyl formate in the presence of the dehydrated condensate as the catalyst.According to the above process, the objective methyl .alpha.-hydroxyisobutyrate is continuously obtained in high yield and high selectivity without any operational trouble.
    • 公开了一种通过反应蒸馏从α-羟基异丁酰胺和甲酸甲酯有效生产α-羟基异丁酸甲酯的方法,其中包括在连续蒸馏塔中加入α-羟基异丁酰胺和碱金属氢氧化物,以制备α-羟基异丁酰胺的脱水缩合物 与碱金属氢氧化物作为催化剂,并在脱水缩合物作为催化剂存在下使残余的α-羟基异丁酰胺与甲酸甲酯反应。 根据上述方法,以高产率和高选择性连续获得目标α-羟基异丁酸甲酯,没有任何操作故障。