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    • 1. 发明申请
    • ULTRASONIC SENSOR DEVICE
    • 超声波传感器装置
    • US20140157902A1
    • 2014-06-12
    • US14117050
    • 2012-06-12
    • Makiko SugiuraHirofumi Higuchi
    • Makiko SugiuraHirofumi Higuchi
    • G01S15/50
    • G01S15/50B06B1/0666G01S7/521
    • An ultrasonic sensor device includes a substrate, a piezoelectric vibrator, and a Q-factor adjuster. The piezoelectric vibrator includes a pair of detection electrodes that face each other in a thickness direction of the substrate and a piezoelectric body interposed between the electrodes. The piezoelectric vibrator provides a membrane structure which is formed on a surface of the substrate and has rigidity lower than that of a remaining portion of the substrate. An ultrasonic wave is transmitted by the piezoelectric vibrator, and its reflected wave is received by the same piezoelectric vibrator. The Q-factor adjuster adjusts a Q-factor of the piezoelectric vibrator so that the Q-factor can be larger during a transmission period where the piezoelectric vibrator transmits the ultrasonic wave than during a reception period where the piezoelectric vibrator receives the ultrasonic wave.
    • 超声波传感器装置包括基板,压电振动器和Q因子调节器。 压电振子包括在基板的厚度方向上彼此相对的一对检测电极和插在电极之间的压电体。 压电振动器提供形成在基板的表面上的膜结构,其刚性低于基板的剩余部分的刚度。 超声波由压电振子传递,其反射波被同一压电振子接收。 Q因子调节器调节压电振动器的Q因子,使得压电振动器发送超声波的传播期间的Q因子可以比在压电振动器接收超声波的接收时段期间更大。
    • 2. 发明授权
    • Humanized anti-human α9-integrin antibody
    • 人源化抗人α9整联蛋白抗体
    • US08603476B2
    • 2013-12-10
    • US12812341
    • 2009-01-09
    • Kenji UeharaHirofumi HiguchiToshihiro NakashimaDaisuke IshikawaNobuchika YamamotoHirotada FujitaFumihiko Sakai
    • Kenji UeharaHirofumi HiguchiToshihiro NakashimaDaisuke IshikawaNobuchika YamamotoHirotada FujitaFumihiko Sakai
    • A61K39/395
    • C07K16/2839C07K2317/24C07K2317/565C07K2317/76C07K2317/92C07K2317/94
    • The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
    • 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体,即包含重链可变区的人源化抗人α9整联蛋白抗体,其包含 的SEQ ID NO:11所示的氨基酸序列和由SEQ ID NO:17所示的氨基酸序列组成的轻链可变区,含有重链可变区的人源化抗人α9整联蛋白抗体包含由 由SEQ ID NO:13所示的氨基酸序列和由SEQ ID NO:17所示的氨基酸序列组成的轻链可变区,含有重链可变区的人源化抗人α9整联蛋白抗体 由SEQ ID NO:15所示的氨基酸序列和由SEQ ID NO:9所示的氨基酸序列组成的轻链可变区,以及预防或治疗涉及 人类α9整联蛋白在发病机制中使用抗体。
    • 4. 发明申请
    • Physical quantity sensor
    • 物理量传感器
    • US20090100931A1
    • 2009-04-23
    • US12232120
    • 2008-09-11
    • Hirofumi Higuchi
    • Hirofumi Higuchi
    • G01P15/125
    • G01P15/125G01P15/131
    • A physical quantity sensor has a weight mass movable in a detection direction. Auxiliary capacitors are formed at both side ends of the weight mass in a non-detection direction by auxiliary movable electrodes and auxiliary fixed electrodes, respectively. When capacitances of the auxiliary capacitors change due to movement of the weight mass in the non-detection direction, a limiter circuit feedback-controls voltages applied to the auxiliary fixed electrodes to maintain the position of the weight mass unchanged. Thus, the weight mass is limited from moving in the non-detection direction thereby to improve accuracy in detection of the movement in the detection direction.
    • 物理量传感器具有在检测方向上可移动的重量。 辅助电容器分别通过辅助可动电极和辅助固定电极在非检测方向上形成在重量块的两侧。 当辅助电容器的电容由于重量质量在非检测方向的移动而变化时,限制器电路对施加到辅助固定电极的电压进行反馈控制,以保持重量质量的位置不变。 因此,重量质量被限制为在非检测方向上移动,从而提高检测方向上的运动的检测精度。
    • 6. 发明申请
    • Electrostatically oscillated device
    • 静电摆动装置
    • US20050199063A1
    • 2005-09-15
    • US11075708
    • 2005-03-10
    • Hirofumi Higuchi
    • Hirofumi Higuchi
    • B81B5/00G01C19/5762G01P15/08
    • G01C19/5762
    • An oscillator is oscillatable in a predetermined direction. First and second driving electrodes are secured to the base and apply an electrostatic force to the oscillator to make drive oscillation of the oscillator in the predetermined direction. At the time of the drive oscillation of the oscillator, a predetermined electric charge is accumulated in the oscillator, and electric charges of opposite polarities are alternately and periodically accumulated in the first and second driving electrodes, respectively, to exert an attractive force between the oscillator and a corresponding one of the first and second driving electrodes and also to exert a repulsive force between the oscillator and the other one of the first and second driving electrodes, and vice versa.
    • 振荡器可在预定方向上振荡。 第一驱动电极和第二驱动电极固定到基座并向振荡器施加静电力,以使振荡器在预定方向上的驱动振荡。 在振荡器的驱动振荡时,在振荡器中累积预定的电荷,相反极性的电荷分别交替地周期地累积在第一和第二驱动电极中,以在振荡器之间施加吸引力 以及第一和第二驱动电极中的相应一个,并且还在振荡器和第一和第二驱动电极中的另一个之间施加排斥力,反之亦然。
    • 7. 发明授权
    • Process for preparing a carboxylic acid ester
    • 羧酸酯的制备方法
    • US5703272A
    • 1997-12-30
    • US707135
    • 1996-09-03
    • Mariko AbeShuji EbataTakafumi AbeHirofumi Higuchi
    • Mariko AbeShuji EbataTakafumi AbeHirofumi Higuchi
    • B01J21/06B01J21/08B01J37/03C07C67/08C07C69/02
    • B01J21/063B01J21/08B01J37/03C07C67/08
    • A process for preparing a carboxylic acid ester which includes subjecting a carboxylic acid and an alcohol or a phenol to an esterification reaction in the presence of a silica-titania catalyst. The silica-titania catalyst is prepared by adding an acidic solution containing a silicon compound and a titanium compound dissolved therein to a solution of a basic compound to bring about co-precipitation, in which the acidic solution is a nitric acid-acidic solution or a sulfuric acid-acidic solution, a ratio of the amount (gram equivalent) of nitric acid or sulfuric acid to the amount (mol) of the silicon compound in the acidic solution is 0.5 to 50 and the amount of the titanium compound in the acidic solution is such that a ratio of titania (TiO.sub.2) in the silica-titania catalyst is 1 to 50% by weight.
    • 一种制备羧酸酯的方法,包括在二氧化硅 - 二氧化钛催化剂的存在下使羧酸和醇或酚进行酯化反应。 二氧化硅 - 二氧化钛催化剂通过将含有硅化合物和溶解在其中的钛化合物的酸性溶液加入到碱性化合物的溶液中来进行共沉淀,其中酸性溶液是硝酸 - 酸性溶液或 硫酸 - 酸性溶液,酸性溶液中的硝酸或硫酸的量(克当量)与硅化合物的量(摩尔)的比例为0.5〜50,酸性溶液中钛化合物的量 使得二氧化硅 - 二氧化钛催化剂中的二氧化钛(TiO 2)的比例为1〜50重量%。