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71. 发明申请

US20080108630A1 SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开
标题翻译：取代三唑作为PPAR的调节剂及其制备方法
公开(公告)号：US20080108630A1
公开(公告)日：2008-05-08
申请号：US11932755
申请日：2007-10-31
申请人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
发明人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
IPC分类号： A61K31/497 , A61P3/06 , A61P3/10 , A61K31/4192 , C07D403/06 , C07D249/04
CPC分类号： C07D249/06 , C07D409/10
摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
摘要翻译：本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

72. 发明申请

US20080103292A1 Glycopeptide derivatives and pharmaceutical compositions containing the same 有权
标题翻译：糖肽衍生物和含有它们的药物组合物
公开(公告)号：US20080103292A1
公开(公告)日：2008-05-01
申请号：US11977377
申请日：2007-10-24
申请人： J. Judice , Paul Fatheree , Bernice Lam , Michael Leadbetter , Martin Linsell , YongQi Mu , Sean Trapp , Guang Yang , Yan Zhu
发明人： J. Judice , Paul Fatheree , Bernice Lam , Michael Leadbetter , Martin Linsell , YongQi Mu , Sean Trapp , Guang Yang , Yan Zhu
IPC分类号： C07K14/00
CPC分类号： C07K9/008 , A61K38/00 , C07K7/06
摘要： Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb-(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译：公开了具有至少一个下式的取代基的糖肽化合物的衍生物：<？in-line-formula description =“In-line formula”end =“lead”？> - < （Z） <？in-line-formula description =“In-line Formulas”end =“tail”？>其中R ^a

73. 发明授权

US06995987B2 DC—DC converters providing reduced deadtime 失效
标题翻译： DC-DC转换器可减少死区时间
公开(公告)号：US06995987B2
公开(公告)日：2006-02-07
申请号：US10499937
申请日：2002-12-27
申请人： Wei Song , Yan Zhu , Bradley M. Lehman
发明人： Wei Song , Yan Zhu , Bradley M. Lehman
IPC分类号： H02M3/335
CPC分类号： H02M3/33507 , H02M3/3353 , H02M3/33569 , H02M3/337 , H02M3/3372 , H02M3/3374 , H02M2001/007 , H02M2001/0074 , H02M2001/385
摘要： A DC-DC power converter (100) that provides increased power density, reduced size, and reduced costs of manufacture. The DC-DC power converter (100) includes first and second input terminals (101, 102), a plurality of output terminals (116, 117), and at least one electrical element (108/109) connected to at least one of the first and second input terminals (101, 102). In the event a first voltage is applied across the first and second input terminals (101, 102), the electrical element (108/109) provides a second voltage having a value between the first voltage value and a reference voltage value. The DC-DC power converter (100) further includes a transformer (110) having a primary winding (111) and a secondary winding (112), and a switch assembly (103–107) operatively connected to the first input terminal (101), the second input terminal (102), the electrical element (108/109), and the transformer primary winding (111). In the event the first voltage is applied across the first and second input terminals (101, 102), the switch assembly (103–107) switchably applies the first, second, and reference voltages across the transformer primary winding (111) to generate at least one third voltage across the transformer secondary winding (112). The DC-DC power converter (100) further includes a rectifier (113) connected between the transformer secondary winding (112) and the output terminals (116, 117).
摘要翻译： DC-DC电力转换器（100），其提供增加的功率密度，减小尺寸并降低制造成本。 DC-DC功率转换器（100）包括第一和第二输入端（101,102），多个输出端（116,117）以及至少一个电元件（108/109），其连接到至少一个第一和第二输入端子（101,102）。在第一和第二输入端（101,102）之间施加第一电压的情况下，电元件（108/109）提供具有在第一电压值和参考电压值之间的值的第二电压。 DC-DC电力转换器（100）还包括具有初级绕组（111）和次级绕组（112）的变压器（110）和可操作地连接到第一输入端子（101）的开关组件（103-107），第二输入端子（102），电气元件（108/109）和变压器初级绕组（111）。在第一电压施加在第一和第二输入端（101,102）之间的情况下，开关组件（103-107）可切换地施加跨越变压器初级绕组（111）的第一，第二和参考电压以产生变压器次级绕组（112）两端的至少三分之一电压。 DC-DC电力转换器（100）还包括连接在变压器次级绕组（112）和输出端子（116,117）之间的整流器（113）。

74. 发明申请

US20050272672A1 Ketolide anti-infective compounds 有权
标题翻译：酮类抗感染药物
公开(公告)号：US20050272672A1
公开(公告)日：2005-12-08
申请号：US10883317
申请日：2004-06-30
申请人： Yong Li , Yandong Li , Yan Zhu , Chaitan Khosla , David Myles
发明人： Yong Li , Yandong Li , Yan Zhu , Chaitan Khosla , David Myles
IPC分类号： A61K31/7052 , C07H17/08
CPC分类号： C07H17/08
摘要： Compounds according to formula I wherein m is 0 or 1; X is and R1, R2, R3 R4, and R5 are as defined herein, are useful as anti-infective agents.
摘要翻译：式I化合物，其中m为0或1; X是和R 1，R 2，R 3，R 4和R 5， SUP>如本文所定义，可用作抗感染剂。

75. 发明申请

US20050186198A1 Serine protease inhibitors 审中-公开
公开(公告)号：US20050186198A1
公开(公告)日：2005-08-25
申请号：US11088511
申请日：2005-03-24
申请人： Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
发明人： Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
IPC分类号： C07D333/34 , A61K31/18 , A61K31/196 , A61K31/216 , A61K31/381 , A61P7/02 , A61P9/10 , C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51 , A61K38/48 , A61K31/445 , A61K31/54 , A61K31/60
CPC分类号： C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要： Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.

76. 发明授权

US06903070B2 Glycopeptide carboxy-saccharide derivatives 有权
标题翻译：糖肽羧基糖衍生物
公开(公告)号：US06903070B2
公开(公告)日：2005-06-07
申请号：US10601847
申请日：2003-06-23
申请人： Martin S. Linsell , Paul R. Fatheree , Michael R. Leadbetter , Yan Zhu , J. Kevin Judice
发明人： Martin S. Linsell , Paul R. Fatheree , Michael R. Leadbetter , Yan Zhu , J. Kevin Judice
IPC分类号： A61K9/00 , A61K38/00 , A61K47/40 , A61K47/48 , A61K51/08 , C07K9/00 , A61K38/14
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译：公开了在C-末端和/或R末端被包含一个或多个糖基和羧基的取代基取代的糖肽衍生物; 和含有这些糖肽衍生物的药物组合物。所公开的糖肽衍生物可用作抗菌剂。

77. 发明申请

US20050078491A1 Dc-dc converters providing reduced deadtime 失效
标题翻译： Dc-dc转换器可减少死区时间
公开(公告)号：US20050078491A1
公开(公告)日：2005-04-14
申请号：US10499937
申请日：2002-12-27
申请人： Wei Song , Yan Zhu
发明人： Wei Song , Yan Zhu
IPC分类号： H02M3/335 , H02M3/337
CPC分类号： H02M3/33507 , H02M3/3353 , H02M3/33569 , H02M3/337 , H02M3/3372 , H02M3/3374 , H02M2001/007 , H02M2001/0074 , H02M2001/385
摘要： A DC-DC power converter (100) that provides increased power density, reduced size, and reduced costs of manufacture. The DC-DC power converter (100) includes first and second input terminals (101, 102), a plurality of output terminals (116, 117), and at least one electrical element (108/109) connected to at least one of the first and second input terminals (101, 102). In the event a first voltage is applied across the first and second input terminals (101, 102), the electrical element (108/109) provides a second voltage having a value between the first voltage value and a reference voltage value. The DC-DC power converter (100) further includes a transformer (110) having a primary winding (111) and a secondary winding (112), and a switch assembly (103-107) operatively connected to the first input terminal (101), the second input terminal (102), the electrical element (108/109), and the transformer primary winding (111). In the event the first voltage is applied across the first and second input terminals (101, 102), the switch assembly (103-107) switchably applies the first, second, and reference voltages across the transformer primary winding (111) to generate at least one third voltage across the transformer secondary winding (112). The DC-DC power converter (100) further includes a rectifier (113) connected between the transformer secondary winding (112) and the output terminals (116, 117).
摘要翻译： DC-DC电力转换器（100），其提供增加的功率密度，减小尺寸并降低制造成本。 DC-DC功率转换器（100）包括第一和第二输入端（101,102），多个输出端（116,117）以及至少一个电元件（108/109），其连接到至少一个第一和第二输入端子（101,102）。在第一和第二输入端（101,102）之间施加第一电压的情况下，电元件（108/109）提供具有在第一电压值和参考电压值之间的值的第二电压。 DC-DC电力转换器（100）还包括具有初级绕组（111）和次级绕组（112）的变压器（110）和可操作地连接到第一输入端子（101）的开关组件（103-107），第二输入端子（102），电气元件（108/109）和变压器初级绕组（111）。在第一电压施加在第一和第二输入端（101,102）之间的情况下，开关组件（103-107）可切换地施加跨越变压器初级绕组（111）的第一，第二和参考电压以产生变压器次级绕组（112）两端的至少三分之一电压。 DC-DC电力转换器（100）还包括连接在变压器次级绕组（112）和输出端子（116,117）之间的整流器（113）。

78. 发明授权

US06620781B2 Glycopeptide carboxy-saccharide derivatives 有权
公开(公告)号：US06620781B2
公开(公告)日：2003-09-16
申请号：US09847052
申请日：2001-05-01
申请人： Martin S. Linsell , Paul R. Fatheree , Michael R. Leadbetter , Yan Zhu , J. Kevin Judice
发明人： Martin S. Linsell , Paul R. Fatheree , Michael R. Leadbetter , Yan Zhu , J. Kevin Judice
IPC分类号： A61K3814
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.

79. 发明授权

US06455669B1 Glycopeptide derivatives and pharmaceutical compositions containing the same 有权
公开(公告)号：US06455669B1
公开(公告)日：2002-09-24
申请号：US09674456
申请日：2000-11-01
申请人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael Leadbetter , Martin Sheringham linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
发明人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael Leadbetter , Martin Sheringham linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
IPC分类号： C07K750
CPC分类号： C07K9/008 , A61K38/00 , C07K7/06
摘要： Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.

80. 发明授权

US06444786B1 Glycopeptide derivatives and pharmaceutical compositions containing the same 有权
标题翻译：糖肽衍生物和含有它们的药物组合物
公开(公告)号：US06444786B1
公开(公告)日：2002-09-03
申请号：US09656473
申请日：2000-09-06
申请人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
发明人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
IPC分类号： C07K750
CPC分类号： C07K9/008 , A61K38/00 , C07K7/06
摘要： Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译：公开了具有至少一个下式的取代基的糖肽化合物的衍生物：其中Ra，Rb，Y，Z和x如所定义，以及含有这些糖肽衍生物的药物组合物。所公开的糖肽衍生物可用作抗菌剂。

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