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1. 发明专利

BR112021009222A2 composições que contêm uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para produção das mesmas 未知
公开(公告)号：BR112021009222A2
公开(公告)日：2021-08-10
申请号：BR112021009222
申请日：2019-11-13
申请人： CN USA BIOTECH HOLDINGS INC , JIAN QING XU , JING WANG , LING YAN ZHU , XIAO YAN ZHANG
发明人： BEVERLY W LUBIT , JIAN QING XU , JING WANG , LING YAN ZHU , XIAO YAN ZHANG
IPC分类号： C12M3/02 , C12N5/0783
摘要： composições que contêm uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para produção das mesmas. a presente invenção refere-se uma composição farmacêutica que compreende um carreador farmaceuticamente aceitável e um produto celular que compreende uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para a fabricação do produto celular.

2. 发明专利

BR112022013573A2 VACINAS UNIVERSAIS CONTRA IMUNÓGENOS DE ORGANISMOS PATOGÊNICOS QUE CONFEREM PROTEÇÃO ESPECÍFICA PARA ORGANISMO E ENTRE GRUPOS 未知
公开(公告)号：BR112022013573A2
公开(公告)日：2022-09-13
申请号：BR112022013573
申请日：2020-12-18
申请人： CN USA BIOTECH HOLDINGS INC , JIAN QING XU , XIAO YAN ZHANG , JING WANG , LING YAN ZHU , BEVERLY W LUBIT
发明人： JIAN QING XU , XIAO YAN ZHANG , JING WANG , LING YAN ZHU , BEVERLY W LUBIT
IPC分类号： A61K39/12 , A61K39/145 , A61P31/16 , C07K7/06 , C12N5/0783 , C12N15/86
摘要： VACINAS UNIVERSAIS CONTRA IMUNÓGENOS DE ORGANISMOS PATOGÊNICOS QUE CONFEREM PROTEÇÃO ESPECÍFICA PARA ORGANISMO E ENTRE GRUPOS. A presente invenção refere-se, em parte, a uma plataforma com base em vetor de estimulação e reforço para desenvolver vacinas contra patógenos que são adaptadas para provocar uma ampla resposta de células T que têm como alvo epítopos virais conservados. As vacinas universais são preparadas contra um imunógeno de um organismo patogênico infeccioso selecionado a partir de um vírus, uma bactéria, um fungo ou um protozoário que compreende pelo menos um polinucleotídeo de ácido ribonucleico (RNA) que compreende um quadro de leitura aberta que codifica pelo menos um antígeno polipeptídico ou um fragmento imunogênico do mesmo, em que o antígeno polipeptídico, ou fragmento imunogênico do mesmo, compreende uma proteína interna conservada que é enriquecida em antígenos de reconhecimento de células T CD8(mais elevado). A eficácia da plataforma de estimulação e reforço é testada em um modelo de camundongo humanizado que compreende um sistema imune humano totalmente funcional.

3. 发明授权

US08975258B2 Heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译：用于治疗糖尿病和代谢紊乱的杂环受体激动剂
公开(公告)号：US08975258B2
公开(公告)日：2015-03-10
申请号：US13612451
申请日：2012-09-12
申请人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： A61K31/50 , C07D413/04 , C07D401/04 , C07D401/14 , C07D417/14 , C07D413/14 , C07D417/04
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

4. 发明授权

US08637526B2 Pyrazolopyrimidine JAK inhibitor compounds and methods 失效
标题翻译：吡唑并嘧啶JAK抑制剂化合物及方法
公开(公告)号：US08637526B2
公开(公告)日：2014-01-28
申请号：US13099179
申请日：2011-05-02
申请人： Jeffrey Blaney , Paul A. Gibbons , Emily Hanan , Joseph P. Lyssikatos , Steven R. Magnuson , Richard Pastor , Thomas E. Rawson , Aihe Zhou , Bing-Yan Zhu
发明人： Jeffrey Blaney , Paul A. Gibbons , Emily Hanan , Joseph P. Lyssikatos , Steven R. Magnuson , Richard Pastor , Thomas E. Rawson , Aihe Zhou , Bing-Yan Zhu
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention provides JAK kinase inhibitors of Formula Ia, enantiomers, diasteriomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and Z are defined herein, a pharmaceutical composition that includes a compound of Formula Ia and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a JAK kinase activity in a patient.
摘要翻译：本发明提供了式Ia的JAK激酶抑制剂，其对映体，非对映异构体或其药学上可接受的盐，其中R1，R2，R7和Z在本文中定义，药物组合物包括式Ia化合物和药学上可接受的载体，佐剂或载体以及对患者中JAK激酶活性的抑制作出反应的疾病或病症的严重程度的治疗或减轻的方法。

5. 发明申请

US20140024830A1 HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译：用于治疗糖尿病和代谢障碍的异位受体激动剂
公开(公告)号：US20140024830A1
公开(公告)日：2014-01-23
申请号：US13612451
申请日：2012-09-12
申请人： Xin Chen , Peng Cheng , L. Edwards Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jaingao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edwards Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jaingao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： C07D413/04 , C07D413/14
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

6. 发明授权

US08434544B2 Die casting process incorporating computerized pattern recognition techniques 有权
标题翻译：包含计算机化模式识别技术的压铸工艺
公开(公告)号：US08434544B2
公开(公告)日：2013-05-07
申请号：US13442628
申请日：2012-04-09
申请人： Arnie Fulton , Yan Zhu , Michael Bomar
发明人： Arnie Fulton , Yan Zhu , Michael Bomar
IPC分类号： B22D46/00
CPC分类号： B22D17/32 , B22D46/00
摘要： A die casting process using pattern recognition techniques to identify those die castings manufactured under conditions likely to produce a die casting which would subsequently prove unacceptable for use. By promptly identifying such die castings, they may be discarded before being shipped to a remote facility for further processing. As a result, the rejection rate of die castings at the remote facility may be reduced and the raw materials used to form the discarded die castings may be more readily recycled.
摘要翻译：使用模式识别技术的压铸方法来识别在可能产生压铸件的条件下制造的那些压铸件，随后将被证明是不可接受的。通过及时识别这种压铸件，在运送到远程设备进行进一步处理之前，可将其丢弃。结果，可以减少远程设备的压铸件的排出率，并且用于形成废弃压铸件的原材料可以更容易地再循环。

7. 发明申请

US20130049696A1 Series/parallel connection scheme for energy storage devices 有权
公开(公告)号：US20130049696A1
公开(公告)日：2013-02-28
申请号：US13199440
申请日：2011-08-29
申请人： Li-Yan Zhu , Jei Wei Chang , Ping Hua Deng
发明人： Li-Yan Zhu , Jei Wei Chang , Ping Hua Deng
IPC分类号： H02J7/00
CPC分类号： H02J7/0026 , H01M10/4207 , H02J7/0029 , H02J2007/0039
摘要： A battery pack has series-parallel connected battery cells. An inrush current limiting circuit has current limiting devices and a current limiting tracking means limits inrush current from shorted battery cells. Each current limiting tracking means is coupled to the current limiting devices such that they limit an inrush current from parallel neighbor battery cells when one battery cell on the column shorts. The current limiting devices are variable buffer resistors with a positive temperature coefficient. The current limiting tracking means are heat sinks that thermally couples the buffer resistors together such that the buffer resistors increase in resistance with a temperature increase caused by current flowing through the buffer resistor associated with the shorted battery cell. Current regulating elements are in series with columns of battery cells for preventing inrush current to the columns of the battery cells.

8. 发明授权

US08383620B2 Phosphoinositide 3-kinase inhibitor compounds and methods of use 有权
公开(公告)号：US08383620B2
公开(公告)日：2013-02-26
申请号：US12978106
申请日：2010-12-23
申请人： Tracy Bayliss , Irina Chuckowree , Adrian Folkes , Sally Oxenford , Nan Chi Wan , Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Simon Mathieu , Alan Olivero , Steven Staben , Daniel P. Sutherlin , Bing-Yan Zhu
发明人： Tracy Bayliss , Irina Chuckowree , Adrian Folkes , Sally Oxenford , Nan Chi Wan , Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Simon Mathieu , Alan Olivero , Steven Staben , Daniel P. Sutherlin , Bing-Yan Zhu
IPC分类号： A61K31/535
CPC分类号： A61K31/5377 , A61K31/519 , C07D413/14 , C07D491/04 , C07D495/04
摘要： Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

9. 发明授权

US08344931B2 N-bits successive approximation register analog-to-digital converting circuit 有权
标题翻译： N位逐次逼近寄存器模数转换电路
公开(公告)号：US08344931B2
公开(公告)日：2013-01-01
申请号：US13150508
申请日：2011-06-01
申请人： Yan Zhu , Chi-Hang Chan , U-Fat Chio , Sai-Weng Sin , Seng-Pan U , Rui Paulo Da Silva Martins , Franco Maloberti
发明人： Yan Zhu , Chi-Hang Chan , U-Fat Chio , Sai-Weng Sin , Seng-Pan U , Rui Paulo Da Silva Martins , Franco Maloberti
IPC分类号： H03M1/12
CPC分类号： H03M1/002 , H03M1/466
摘要： The present invention provides an n-bits successive approximation register (SAR) analog-to-digital converting (ADC) circuit, comprising: an n-bits SAR control logic, a p-type capacitor network including a DACp array and a sampling capacitor CSp, an n-type capacitor network including a DACn array and a sampling capacitor CSn; and a comparator for comparing outputs from the p-type capacitor network and the n-type capacitor network, wherein a power supply and ground are directly connected to the p-type capacitor network and the n-type capacitor network without using reference voltages produced by a reference voltage generator. The n-bits SAR control logic comprises n shift registers, n bit registers, and a switching logic. The comparator comprises a first pre-amplifier, a second pre-amplifier and a dynamic latch. Alternative, the comparator comprises a four-input pre-amplifier and a dynamic latch.
摘要翻译：本发明提供一种n位逐次逼近寄存器（SAR）模数转换（ADC）电路，包括：n位SAR控制逻辑，包括DACp阵列和采样电容器CSp的p型电容器网络包括DACn阵列和采样电容器CSn的n型电容器网络; 以及用于比较来自p型电容器网络和n型电容器网络的输出的比较器，其中电源和接地直接连接到p型电容器网络和n型电容器网络，而不使用由p型电容器网络和n型电容器网络产生的参考电压参考电压发生器。 n位SAR控制逻辑包括n个移位寄存器，n个位寄存器和一个开关逻辑。比较器包括第一前置放大器，第二前置放大器和动态锁存器。替代方案，比较器包括四输入前置放大器和动态锁存器。

10. 发明授权

US08183381B2 N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译：用于治疗糖尿病和代谢紊乱的N-连接的杂环受体激动剂
公开(公告)号：US08183381B2
公开(公告)日：2012-05-22
申请号：US12171209
申请日：2008-07-10
申请人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号： C07D401/00
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。

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