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    • 78. 发明申请
    • ANTI-TUMOUR AGENTS
    • 抗肿瘤药剂
    • WO99048857A1
    • 1999-09-30
    • PCT/GB1999/000787
    • 1999-03-16
    • C07D295/12A61K31/215A61K31/5375A61P35/00C07C219/24C07C219/34C07D295/135
    • C07D295/135C07C219/34
    • The invention concerns anti-tumour agents of formula (I) wherein each of R , R and R has the meanings defined in the specification including hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, amino, (1-4C)alkylamino and (1-4C)alkoxy; each of R and R is (1-4C)alkyl; each of R and R is hydrogen or (1-4C)alkyl; X is oxygen; m is 1 or 2 and each R is as defined in the specification; each of Y and Y is halogeno, (1-4C)alkanesulphonyloxy, benzenesulphonyloxy or phenyl-(1-4C)alkanesulphonyloxy; or a pharmaceutically-acceptable salt thereof; provided that at least one of R , R and R is other than hydrogen; a process for their preparation, pharmaceutical compositions containing them and their use in the production of an anti-proliferative effect.
    • 本发明涉及式(I)的抗肿瘤剂,其中R 1,R 2和R 3各自具有本说明书中定义的含义,包括氢,(1-4C)烷基,(3-4C )烯基,(3-4C)炔基,氨基,(1-4C)烷基氨基和(1-4C)烷氧基; R 4和R 5各自为(1-4C)烷基; R 6和R 7各自为氢或(1-4C)烷基; X是氧; m为1或2,每个R 8如说明书中所定义; Y 1和Y 2各自为卤代,(1-4C)烷磺酰氧基,苯磺酰氧基或苯基 - (1-4C)烷磺酰氧基; 或其药学上可接受的盐; 条件是R 1,R 2和R 3中的至少一个不是氢; 其制备方法,含有它们的药物组合物及其在产生抗增殖作用中的用途。