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71. 发明授权

US3766136A Self extinguishing polymer compositions containing brominated arylidene ketons 失效
标题翻译：含自由基芳香酮的自发灭活聚合物组合物
公开(公告)号：US3766136A
公开(公告)日：1973-10-16
申请号：US3766136D
申请日：1971-01-21
申请人： KOPPERS CO INC
发明人： HOWELL H , KUTZ W
IPC分类号： C07C45/63 , C07C45/74 , C07C49/217 , C07C49/223 , C07C49/237 , C07C49/796 , C07C49/813 , C08K5/07 , C09K3/28
CPC分类号： C08K5/07 , C07C45/63 , C07C45/74 , C07C49/217 , C07C49/223 , C07C49/237 , C07C49/796 , C07C49/813 , C07C49/233 , C08L25/04
摘要： SOLID ORGANIC POLYMERS NORMALLY SUSCEPTIBLE TO BURNING ARE RENDERED SELF-EXTINGUISHING BY INCORPORATION THEREIN A BROMINATED ARYLIDENE KETONE SUCH AS A BROMINATED BENZILIDENE OR CINNAMLIDENE KETONE; FOR EXAMPLE, 1,5-DIPHENYL1,2,4,5-TETRABROMO-3-PENTANONE. THE SELF-EXTINGUISHING AGENTS USEFUL IN THE INVENTION ARE UNEXPECTEDLY STABLE TO HYDROLYSIS, YET ARE HIGHLY REACTIVE AS SELF-EXTINGUISHING AGENTS.

72. 发明公开

EP2361245A4 HYBRID -IONONE AND CURCUMIN MOLECULES AS ANTICANCER AGENTS 审中-公开
标题翻译：混合紫罗兰酮CURCUMINMOLEKÜLEAS抗癌物质
公开(公告)号：EP2361245A4
公开(公告)日：2012-06-13
申请号：EP09828505
申请日：2009-11-25
申请人： TRT PHARMA INC
发明人： WU JIAN HUI , BATIST GERALD , ZHOU JINMING , GENG GUOYAN , LIN RONGTUAN
IPC分类号： C07D209/12 , A61K31/12 , A61K31/335 , A61K31/381 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/47 , A61P35/00 , C07C49/237 , C07C49/255 , C07D209/86 , C07D215/14 , C07D231/06 , C07D333/56
CPC分类号： C07D209/86 , C07C49/252 , C07D213/64 , C07D215/14 , C07D231/12 , C07D239/26 , C07D303/32 , C07D403/04 , C07D409/04

73. 发明公开

EP1553916A2 NUCLEAR HORMONE RECEPTOR COMPOUNDS, PRODUCTS AND METHODS EMPLOYING SAME 审中-公开
标题翻译： NUKLEAR-HORMON-REZEPTOR-VERBINDUNGEN，DIESE VERWENDENDE PRODUKTE UND VERFAHREN
公开(公告)号：EP1553916A2
公开(公告)日：2005-07-20
申请号：EP03779359.3
申请日：2003-10-23
申请人： THE PROCTER & GAMBLE COMPANY
发明人： DELONG, Mitchell, Anthony , BIEDERMANN, Kimberly, Ann , BISSETT, Donald, Lynn , BOYER, Angelique, Sun , COHEN, Scott, Louis , SNIDER, Catherine, Elizabeth
IPC分类号： A61K7/02 , A61K7/40 , A61K7/48 , C07C35/08 , C07C43/23 , C07C49/23 , C07C49/237 , C07C49/252 , C07C69/76 , C07D333/16 , C07D493/00
CPC分类号： C07D471/06 , C07C33/38 , C07C43/162 , C07C43/1782 , C07C43/215 , C07C43/23 , C07C47/445 , C07C47/548 , C07C47/57 , C07C49/225 , C07C49/553 , C07C49/557 , C07C49/637 , C07C49/683 , C07C49/747 , C07C49/757 , C07C49/813 , C07C49/835 , C07C49/84 , C07C57/48 , C07C65/17 , C07C65/26 , C07C65/28 , C07C65/36 , C07C69/157 , C07C69/76 , C07C403/04 , C07C403/08 , C07C403/10 , C07C403/16 , C07C403/20 , C07C2601/08 , C07C2601/16 , C07C2602/28
摘要： Novel and nonobvious compounds that function, alone or in combination, as nuclear hormone receptors for the stimulation and/or improvement of murine, mammalian skin. Specifically, beta-ionol analog and fatty acid analog compounds that are believed to function as RXR, RAR and/or PPAR receptor ligands to encourage skin differentiation and discourage excess skin proliferation. The present invention further relates to one or more products, consumer and otherwise, comprising the novel, nuclear hormone receptor ligands disclosed herein. The present invention additionally seeks to encompass methods of employing both the compounds of the present invention and the products incorporating the present compounds.
摘要翻译：新颖和非显而易见的化合物，单独或组合起核激素受体的作用，用于刺激和/或改善鼠哺乳动物皮肤。具体来说，被认为起到RXR，RAR和/或PPAR受体配体作用的β-ionol类似物和脂肪酸类似物化合物，以促进皮肤分化并阻止多余的皮肤增生。本发明还涉及一种或多种包含本文公开的新型核激素受体配体的产品，消费者和其他产品。本发明另外寻求包括使用本发明化合物和掺入本发明化合物的产品的方法

74. 发明授权

EP0298332B1 Hydroxyalkyl-azolyl-Derivate 失效
标题翻译：羟基烷基衍生物
公开(公告)号：EP0298332B1
公开(公告)日：1990-11-28
申请号：EP88110197.6
申请日：1988-06-27
申请人： BAYER AG
发明人： Stroech, Klaus, Dr. , Frie, Monika, Dr. , Himmler, Thomas, Dr. , Brandes, Wilhelm, Dr. , Dutzmann, Stefan, Dr. , Hänssler, Gerd, Dr.
IPC分类号： C07D249/08 , C07D233/60 , C07D303/08 , C07D405/06 , C07D407/06 , C07D319/20 , C07C49/163 , C07C49/237 , C07C49/225 , C07C33/50
CPC分类号： C07D303/22 , A01N43/653 , C07C33/50 , C07C45/62 , C07C45/74 , C07C49/457 , C07C49/467 , C07C49/567 , C07C49/657 , C07C49/687 , C07C49/693 , C07C49/753 , C07C321/00 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/08 , C07D303/34 , C07D407/06 , C07C49/697

75. 发明公开

EP0363128A2 Anti-androgen compounds 失效
标题翻译：抗雄激素衍。
公开(公告)号：EP0363128A2
公开(公告)日：1990-04-11
申请号：EP89310063.6
申请日：1989-10-02
申请人： ARCH DEVELOPMENT CORPORATION
发明人： Liao. Shutsung , Harvey, Ronald, G , Pataki, John
IPC分类号： A61K31/56 , C07J1/00 , C07C49/225 , C07C33/34 , C07C69/017 , C07C39/17 , C07J63/00 , C07C49/237 , C07D303/04 , C07C33/36 , A61K31/045
CPC分类号： C07J63/008 , A61K31/045 , A61K31/05 , A61K31/12 , A61K31/22 , C07C39/17 , C07C45/513 , C07C45/516 , C07C49/657 , C07C49/665 , C07C49/747 , C07C49/753 , C07C49/792 , C07C2603/26 , C07J1/0055 , C07J1/0059 , C07J1/007 , C07J1/0088
摘要： Disclosed are novel classes of anti-androgens including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.
摘要翻译：公开了新型的抗雄激素，包括二氢菲衍生物，其合成方法及其在治疗与过度雄激素活性相关的病症中的用途。

76. 发明申请

US20120202066A1 Processes For Preparing Prasugrel And Pharmaceutically Acceptable Salts Thereof 审中-公开
标题翻译：准备普拉格雷及其药学上可接受的盐的方法
公开(公告)号：US20120202066A1
公开(公告)日：2012-08-09
申请号：US13500846
申请日：2010-10-07
申请人： Manne Satyanarayana Reddy , Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Karamala Rama Subba Reddy , Bairy Kondal Reddy , Ghojala Venkat Reddy
发明人： Manne Satyanarayana Reddy , Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Karamala Rama Subba Reddy , Bairy Kondal Reddy , Ghojala Venkat Reddy
IPC分类号： C07D495/04 , B65B31/04 , C07C259/06 , B01D3/14 , C07C45/68 , C07C49/237
CPC分类号： C07D495/04 , Y10T428/2982
摘要： Disclosed are improved processes for preparing prasugrel compound of formula-(1), its intermediates and pharmaceutically acceptable salts.
摘要翻译：公开了制备式（1）的普拉格雷化合物，其中间体和药学上可接受的盐的改进方法。

77. 发明授权

US5571449A Partially fluorinated benzene derivatives 失效
标题翻译：部分氟化苯衍生物
公开(公告)号：US5571449A
公开(公告)日：1996-11-05
申请号：US373283
申请日：1995-01-19
申请人： Ekkehard Bartmann , Herbert Plach , Rudolf Eidenschink
发明人： Ekkehard Bartmann , Herbert Plach , Rudolf Eidenschink
IPC分类号： G02F1/13 , C07C22/08 , C07C25/18 , C07C43/174 , C07C43/176 , C07C43/225 , C07C49/237 , C07C255/50 , C07D213/26 , C07D239/26 , C07D239/30 , C07D319/06 , C09K19/04 , C09K19/12 , C09K19/14 , C09K19/30 , C09K19/34 , C09K19/06 , C07C22/00
CPC分类号： C07D239/30 , C07C22/08 , C07C25/18 , C07D213/26 , C07D319/06 , C09K19/0403 , C09K19/12 , C09K19/14 , C09K19/3003 , C09K19/3028 , C09K19/3402 , C09K19/3444 , C09K19/3469 , C09K2019/0407 , C09K2019/0444 , C09K2019/3021 , C09K2019/3422
摘要： Partially fluorinated benzene derivatives of the formula I ##STR1## in which R, A.sup.1, A.sup.2, Z.sup.1, Z.sup.2, L.sup.1, L.sup.2 and m are as defined in claim 1, are suitable as components of liquid-crystalline media.
摘要翻译： PCT No.PCT / EP94 / 01487 371日期1995年1月19日 102（e）1995年1月19日PCT PCT 1994年5月9日PCT公布。公开号WO94 / 26839 日期：1994年11月24日，其中R 1，A 2，A 2，Z 1，Z 2，L 1，L 2和m如权利要求1中所定义的式I I I的部分氟化苯衍生物适合作为液晶介质的组分。

78. 发明授权

US5475113A Tetrahydronaphthyl and thiazole, oxazole or imidazole substituted ethene derivatives having retinoid-like activity, reduced skin toxicity and reduced teratogenecity 失效
标题翻译：四氢萘基和噻唑，具有维甲酸样活性的恶唑或咪唑取代的乙烯衍生物，皮肤毒性降低，致畸性降低
公开(公告)号：US5475113A
公开(公告)日：1995-12-12
申请号：US260181
申请日：1994-06-15
申请人： Roshantha A. Chandraratna
发明人： Roshantha A. Chandraratna
IPC分类号： A61K31/192 , A61K31/235 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/455 , A61P3/02 , A61P3/06 , A61P9/10 , A61P17/00 , A61P27/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , C07C13/28 , C07C15/52 , C07C22/04 , C07C25/24 , C07C33/28 , C07C33/48 , C07C43/20 , C07C47/232 , C07C47/238 , C07C47/24 , C07C47/277 , C07C49/223 , C07C49/225 , C07C49/235 , C07C49/237 , C07C49/255 , C07C49/553 , C07C49/567 , C07C59/48 , C07C59/56 , C07C59/64 , C07C63/331 , C07C63/66 , C07C63/74 , C07C65/19 , C07C65/24 , C07C69/76 , C07C69/94 , C07C211/45 , C07C211/52 , C07C233/43 , C07C233/80 , C07C237/42 , C07C321/28 , C07C323/16 , C07C323/62 , C07D213/80 , C07D277/56 , C07D307/24 , C07D307/68 , C07D311/58 , C07D311/74 , C07D333/38 , C07D333/40 , C07D401/06 , C07D405/06 , C07D409/06 , C07F9/54 , C07F9/58 , C07D233/76 , C07D263/44 , C07D277/34
CPC分类号： C07D213/80 , C07D307/68 , C07D311/74 , C07D333/38
摘要： Compounds of the formula ##STR1## as herein defined, have retinoid-like activity and are substantially non-teratogenic and non-irritating to the skin.
摘要翻译：如本文所定义的式“IMAGE”的化合物具有类视黄醇样活性，并且基本上是非致畸的并且对皮肤无刺激性。

79. 发明授权

US5079374A Fungicidal and plant growth-regulating hydroxyalkyl-azolyl derivatives 失效
标题翻译：杀菌剂和植物生长调节性羟基喹啉衍生物
公开(公告)号：US5079374A
公开(公告)日：1992-01-07
申请号：US464510
申请日：1990-01-12
申请人： Klaus Stroech , Monika Frie , Thomas Himmler , Wilhelm Brandes , Stefan Dutzmann , Gerd Hanssler
发明人： Klaus Stroech , Monika Frie , Thomas Himmler , Wilhelm Brandes , Stefan Dutzmann , Gerd Hanssler
IPC分类号： A01N31/04 , A01N31/14 , A01N43/32 , A01N43/50 , A01N43/653 , C07C33/50 , C07C45/62 , C07C45/74 , C07C49/163 , C07C49/225 , C07C49/237 , C07C49/293 , C07C49/327 , C07C49/457 , C07C49/467 , C07C49/533 , C07C49/563 , C07C49/567 , C07C49/657 , C07C49/687 , C07C49/693 , C07C49/753 , C07C317/24 , C07C323/22 , C07D20060101 , C07D233/60 , C07D233/61 , C07D249/08 , C07D303/08 , C07D303/22 , C07D303/34 , C07D319/16 , C07D319/18 , C07D319/20 , C07D405/06 , C07D407/06 , C07D521/00
CPC分类号： C07D303/22 , A01N43/653 , C07C321/00 , C07C33/50 , C07C45/62 , C07C45/74 , C07C49/457 , C07C49/467 , C07C49/567 , C07C49/657 , C07C49/687 , C07C49/693 , C07C49/753 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/08 , C07D303/34 , C07D407/06
摘要： Fungicidal and plant growth-regulating hydroxyalkyl-azolyl derivatives of the formula ##STR1## in which R represents hydrogen, alkyl or acyl,R.sup.1 represents halogen, optionally substituted phenyl or the grouping --z--R.sup.3, whereinz represents oxygen, sulphur, SO or SO.sub.2 andR.sup.3 represents optionally substituted alkyl, optionally substituted phenyl or optionally substituted phenylalkyl,R.sup.2 represents optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted naphthyl or the radical of the formula ##STR2## m represents the numbers 0, 1, 2 or 3, or R.sup.2 represents the radical or the formula ##STR3## X represents nitrogen or a CH group and Y represents the groupings --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, ##STR4## and their addition products with acids and metal salts. Intermediates of the formulas ##STR5## are also new.

80. 发明授权

US5070207A Phospholipase A2 inhibitors 失效
标题翻译：磷脂酶A2抑制剂
公开(公告)号：US5070207A
公开(公告)日：1991-12-03
申请号：US516023
申请日：1990-04-26
申请人： Guy A. Schiehser , Gregory F. Von Burg
发明人： Guy A. Schiehser , Gregory F. Von Burg
IPC分类号： C07C45/45 , C07C49/235 , C07C49/237 , C07C49/255 , C07D209/34 , C07D209/86 , C07D275/06
CPC分类号： C07D275/06 , C07C45/45 , C07C49/235 , C07C49/237 , C07C49/255 , C07D209/34 , C07D209/86
摘要： There is disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma, psoriasis, inflammatory bowel disease and inflammation in mammals which comprises administering to a mammal so afflicted an effective amount of a compound having the formula: ##STR1## wherein Z is a group having the formula ##STR2## R.sup.1 and R.sup.2 are each, independently, hydrogen or lower alkyl; R.sup.3 and R.sup.4 are each, independently, hydrogen, alkyl of 1-20 carbon atoms, halo, halo lower alkyl, halo lower alkoxy, lower alkoxy, halo lower alkylsulfonyl, nitro or trifluoromethyl, where at least one of R.sup.3 and R.sup.4 is other than hydrogen;R.sup.5 is hydrogen, lower alkyl or halo;A is --CH.sub.2 --, --O-- or --S--;m is 0-10;n is 1-8;X is hydrogen, fluoro, lower alkyl or aralkyl of 7-12 carbon atoms;or a pharmacologically acceptable salt thereof.
摘要翻译：公开了一种用于治疗哺乳动物中的过敏，过敏反应，哮喘，牛皮癣，炎症性肠病和炎症的免疫炎症病症的方法，其包括向受影响的哺乳动物施用有效量的具有下式的化合物：其中Z是具有下式的基团：R 1和R 2各自独立地为氢或低级烷基; R 3和R 4各自独立地为氢，1-20个碳原子的烷基，卤素，卤代低级烷基，卤代低级烷氧基，低级烷氧基，卤代低级烷基磺酰基，硝基或三氟甲基，其中R 3和R 4中的至少一个不是氢; R5是氢，低级烷基或卤素; A是-CH 2 - ， - O-或-S-; m为0-10; n为1-8; X是7-12个碳原子的氢，氟，低级烷基或芳烷基; 或其药理学上可接受的盐。

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