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81. 发明授权

US08012941B2 Carba-nucleoside analogs for antiviral treatment 有权
标题翻译：卡巴核苷类似物用于抗病毒治疗
公开(公告)号：US08012941B2
公开(公告)日：2011-09-06
申请号：US12428234
申请日：2009-04-22
申请人： Aesop Cho , Choung U. Kim , Jay Parrish , Jie Xu
发明人： Aesop Cho , Choung U. Kim , Jay Parrish , Jie Xu
IPC分类号： A01N43/04 , A61K31/70 , C07H5/04 , C07H7/06
CPC分类号： C07H19/23 , C07D487/04
摘要： Provided are imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译：提供咪唑并[1,5-f] [1,2,4]三嗪基，咪唑并[1,2-f] [1,2,4]三嗪基和[1,2,4]三唑并[4,3- f] [1,2,4]三嗪基核苷，其核苷磷酸酯及其前药。所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。

82. 发明申请

US20110199612A1 METHOD FOR OPTICAL MEASUREMENT AND OPTICAL MEASUREMENT APPARATUS 有权
标题翻译：光学测量和光学测量装置的方法
公开(公告)号：US20110199612A1
公开(公告)日：2011-08-18
申请号：US13092740
申请日：2011-04-22
申请人： Ken TSUKII , Jie Xu , Kenichi Kimura
发明人： Ken TSUKII , Jie Xu , Kenichi Kimura
IPC分类号： G01N21/01
CPC分类号： G01N21/645 , G01N15/1434 , G01N15/1459
摘要： An optical measurement apparatus can be provided, in which the sample is optically measured without loss of the illuminating light with high sensitivity. A glass plate as the transparent member 50 is placed in the interface between the end face 43 of the optical waveguide 40 guiding the illuminating light L generated by the laser light source 20 and the wall face of the capillary 30. According to the above feature, the air layer is prevented from existing in the interface between the end face 43 of the optical fiber 40 and the wall face of the capillary 30, thus the sample S can be optically measured with high sensitivity and few variability without causing the loss of the illuminating light L.
摘要翻译：可以提供光学测量装置，其中在没有损失高灵敏度的照明光的情况下光学测量样品。作为透明构件50的玻璃板被放置在引导由激光光源20产生的照明光L和毛细管30的壁面的光波导40的端面43之间的界面中。根据上述特征，防止空气层存在于光纤40的端面43与毛细管30的壁面之间的界面中，因此可以以高灵敏度和少量的变化光学测量样品S，而不会导致照射损失光L.

83. 发明授权

US07775396B2 Automatic shoe cover dispenser 有权
标题翻译：自动鞋套机
公开(公告)号：US07775396B2
公开(公告)日：2010-08-17
申请号：US11729590
申请日：2007-03-28
申请人： Liang Jie Xu
发明人： Liang Jie Xu
IPC分类号： B65H3/00
CPC分类号： B65H1/00 , B65H2405/50 , B65H2701/1212
摘要： An automatic shoe cover dispenser includes a shoe cover feeding arrangement holding a plurality of shoe covers each having a shoe opening, a shoe cover pulling mechanism and a driving mechanism. The shoe cover pulling mechanism is capable of pulling one of the shoe covers from the shoe cover feeding arrangement as a standby shoe cover for being ready for wearing on a shoe of a user. The driving mechanism includes a pedal arranged in up and down movable manner for the shoe of the user to step thereon and a device for driving the pulling mechanism to deliver the standby shoe cover to the pedal and enlarging the shoe opening of the standby shoe cover to be large enough for the shoe of the user to place inside the standby shoe cover by means of up and down movements of the pedal.
摘要翻译：一种自动鞋套分配器，其包括：鞋套供给装置，其保持多个鞋套，每个鞋套均具有鞋开口，鞋套牵引机构和驱动机构。鞋套拉动机构能够将鞋套之一从鞋套进给装置拉出作为备用鞋套，以准备在用户的鞋上佩戴。该驱动机构包括：踏板，其可上下移动地设置，用于使用者踏进其上;以及用于驱动牵引机构以将待机靴盖传送到踏板并将备用鞋套的鞋口放大的装置，足够大以使用户的鞋通过踏板的上下运动放置在备用鞋套内。

84. 发明申请

US20100203015A1 CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT 有权
标题翻译：用于抗病毒治疗的CARBA-核苷类似物
公开(公告)号：US20100203015A1
公开(公告)日：2010-08-12
申请号：US12702957
申请日：2010-02-09
申请人： Thomas Butler , Aesop Cho , Choung U. Kim , Jie Xu
发明人： Thomas Butler , Aesop Cho , Choung U. Kim , Jie Xu
IPC分类号： A61K38/21 , C07H7/06 , A61K31/7042 , A61K31/7056 , A61P31/12
CPC分类号： C07D495/04
摘要： Provided are thieno[3,4-d]pyrimidin-7-yl and furo[3,4-d]pyrimidin-7-yl ribosides, riboside phosphates and prodrugs thereof as well as intermediates and methods of preparation. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.
摘要翻译：提供噻吩并[3,4-d]嘧啶-7-基和呋喃并[3,4-d]嘧啶-7-基核苷，其核苷酸磷酸酯及其前药以及其制备方法。所提供的化合物，组合物和方法可用于治疗黄病毒科感染。

85. 发明申请

US20080237277A1 Automatic shoe cover dispenser 有权
标题翻译：自动鞋套机
公开(公告)号：US20080237277A1
公开(公告)日：2008-10-02
申请号：US11729590
申请日：2007-03-28
申请人： Liang Jie Xu
发明人： Liang Jie Xu
IPC分类号： B67D5/00
CPC分类号： B65H1/00 , B65H2405/50 , B65H2701/1212
摘要： An automatic shoe cover dispenser includes a shoe cover feeding arrangement holding a plurality of shoe covers each having a shoe opening, a shoe cover pulling mechanism and a driving mechanism. The shoe cover pulling mechanism is capable of pulling one of the shoe covers from the shoe cover feeding arrangement as a standby shoe cover for being ready for wearing on a shoe of a user. The driving mechanism includes a pedal arranged in up and down movable manner for the shoe of the user to step thereon and a device for driving the pulling mechanism to deliver the standby shoe cover to the pedal and enlarging the shoe opening of the standby shoe cover to be large enough for the shoe of the user to place inside the standby shoe cover by means of up and down movements of the pedal.
摘要翻译：一种自动鞋套分配器，其包括：鞋套供给装置，其保持多个鞋套，每个鞋套均具有鞋开口，鞋套牵引机构和驱动机构。鞋套拉动机构能够将鞋套之一从鞋套进给装置拉出作为备用鞋套，以准备在用户的鞋上佩戴。该驱动机构包括：踏板，其可上下移动地设置，用于使用者踏进其上;以及用于驱动牵引机构以将待机靴盖传送到踏板并将备用鞋套的鞋口放大的装置，足够大以使用户的鞋通过踏板的上下运动放置在备用鞋套内。

86. 发明申请

US20070171893A1 Inter-domain routing method for a dual-mode terminal, registration system and method, gateway and signaling forking function 审中-公开
标题翻译：双模终端的域间路由方法，注册系统和方法，网关和信令分路功能
公开(公告)号：US20070171893A1
公开(公告)日：2007-07-26
申请号：US11490009
申请日：2006-07-19
申请人： Jie Xu , Wenyu Liu , Fang You
发明人： Jie Xu , Wenyu Liu , Fang You
IPC分类号： H04L12/66 , H04L12/56
CPC分类号： H04W8/10 , H04W40/00 , H04W88/16
摘要： The present invention discloses an inter-domain routing method for a dual-mode terminal, and a registration system and method. In the present invention, with an inter-domain IWGW, the dual-mode terminal registers respectively with the IWGW when it logins in the circuit domain or the packet domain; a GMSC or CSCF triggers to the IWGM upon receipt of a call for the terminal; the IWGW decides the route according to the registration state and a predefined policy; and the GMSC or CSCF continues the call according the decision result. A practical policy is to route the call to a domain where the terminal has a latest registration. A SFF is added between the HLR and the VLR, for duplicating and forwarding the interaction signaling between the VLR and the HLR to the IWGW. The present invention also discloses an Interwork Gateway and a Signaling Forking Function.
摘要翻译：本发明公开了一种双模终端的域间路由选择方法，以及注册系统和方法。在本发明中，通过域间IWGW，当双向终端登录电路域或分组域时，双模终端分别注册IWGW; GMSC或CSCF在接收到终端的呼叫时触发IWGM; IWGW根据注册状态和预定义策略决定路由; 并且GMSC或CSCF根据判定结果继续呼叫。实际的策略是将呼叫路由到终端具有最新注册的域。在HLR和VLR之间增加SFF，用于将VLR和HLR之间的交互信令复制并转发给IWGW。本发明还公开了一种互通网关和信令分叉功能。

87. 发明授权

US06714081B1 Active current bias network for compensating hot-carrier injection induced bias drift 有权
标题翻译：用于补偿热载流子注入的有源电流偏压网络引起的偏置漂移
公开(公告)号：US06714081B1
公开(公告)日：2004-03-30
申请号：US10241081
申请日：2002-09-11
申请人： Jie Xu
发明人： Jie Xu
IPC分类号： H03F304
CPC分类号： H03F1/301 , H03F2200/453
摘要： An active current bias network that compensates for Hot-Carrier Injection (HCI) induced bias drift, a common phenomenon existing in Metal-Oxide Semiconductor (MOS) transistors and especially in Laterally Diffused MOS (LDMOS) transistors. The active bias network of the present invention first senses the bias current flowing in the targeted transistor and then compares the bias current in the targeted transistor with a stable reference current. The difference between the bias current in the targeted transistor and the reference current is then utilized to adjust the bias of the targeted transistor via a current mirror feedback circuit. The bias current of the targeted transistor then is stable independent of any HCI induced bias changes and changes due to other adverse causes. The sensing MOS transistor used for monitoring bias current is operated in the triode region and has minimum effect on the performance of the targeted transistor.
摘要翻译：补偿热载流子注入（HCI）引起的偏置漂移的有源电流偏置网络，这是金属氧化物半导体（MOS）晶体管，特别是在侧向扩散MOS（LDMOS）晶体管中存在的常见现象。本发明的有源偏置网络首先感测在目标晶体管中流动的偏置电流，然后将目标晶体管中的偏置电流与稳定的参考电流进行比较。然后利用目标晶体管中的偏置电流与参考电流之间的差异来经由电流镜反馈电路调整目标晶体管的偏置。目标晶体管的偏置电流稳定，独立于任何HCl引起的偏置变化和由于其他不利原因引起的变化。用于监控偏置电流的感测MOS晶体管在三极管区域工作，对目标晶体管的性能影响最小。

88. 发明申请

US20230004126A1 Visual Timer 有权
公开(公告)号：US20230004126A1
公开(公告)日：2023-01-05
申请号：US17945105
申请日：2021-11-04
申请人： Jie Xu
发明人： Jie Xu
IPC分类号： G04G9/04 , G04F1/00 , G04G17/04
摘要： Disclosed is a visual timer, comprising a back shell, a PCB board, an encoder, a color display screen, an adjusting knob, a knob sleeve and a lens. The PCB board is arranged on the front of the back shell, the encoder is arranged at the bottom of the front of the PCB board, the color display screen is arranged on the front of the PCB board, the adjusting knob is arranged on the front of the encoder, the knob sleeve is arranged on the front of the adjusting knob, and the lens is arranged on the front of the color display screen. The timer provided by the invention has the characteristics of time visualization, low efficacy and convenient time adjustment by the adjusting knob, and the maximum timing range can be switched to 120 minutes and 60 minutes.

89. 发明授权

US11172021B2 File objects download and file objects data exchange 有权
公开(公告)号：US11172021B2
公开(公告)日：2021-11-09
申请号：US16959163
申请日：2018-02-06
申请人： Hewlett-Packard Development Company, L.P. , Christoph Graham , Jie Xu , Xiaofei Zhu
发明人： Christoph Graham , Jie Xu , Xiaofei Zhu
IPC分类号： H04L29/08 , G06F16/182
摘要： A set of computers can be grouped into a first group and second group of computers to receive a file object. The first group of computers are commanded to perform a peer-to-peer download of the file object from a source. The second group of computers are commanded to perform a peer-to-peer download of the file object from a computer in the first group of computers.

90. 发明申请

US20170081679A1 METHODS OF IMPROVING NUCLEASE MEDIATED HOMOLOGOUS RECOMBINATION 审中-公开
公开(公告)号：US20170081679A1
公开(公告)日：2017-03-23
申请号：US15265291
申请日：2016-09-14
申请人： Jie Xu , Yuqing Chen , Jifeng Zhang , Dongshan Yang , Jun Song
发明人： Jie Xu , Yuqing Chen , Jifeng Zhang , Dongshan Yang , Jun Song
IPC分类号： C12N15/90 , A61K38/17 , A01K67/027 , C12N15/89 , C12N13/00
CPC分类号： C12N15/907 , A01K67/0278 , A01K2207/15 , A01K2227/107 , A01K2267/0306 , A61K38/1709 , C12N15/89
摘要： The present invention relates to methods and compositions for improving nuclease mediated homologous recombination (HR). The invention is directly relevant to basic biomedical research, transgenic animal production, regenerative medicine, gene therapy, and other disciplines where HR is involved.

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